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CHLORAMPHENICOL 氯霉素
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產(chǎn)品簡介
產(chǎn)品介紹
CHLORAMPHENICOL 氯霉素
Product Description（產(chǎn)品描述）
Chloramphenicol is a synthetic antibiotic, which was first isolated from strains of Streptomyces venezuelae. It has a broad spectrum of activity against Gram-positive and Gram-negative bacteria. Chloramphenicol inhibits bacterial protein synthesis by blocking the peptidyl transferase step （elongation inhibition）. It binds to the 50S ribosomal subunit and prevents attachment of aminoacyl tRNA to the ribosome. It inhibits mitochondrial and chloroplast protein synthesis and ribosomal formation of （p）ppGpp, thus de-repressing rRNA transcription.
Applications（應用）
Chloramphenicol and several analogues inhibited DNA synthesis in Ehrlich Ascites cells under aerobic and anaerobic conditions in the presence and absence of glucose. It is used mainly for opthalmic （eye drops） and veterinary purposes. Used as a seletion agent for transformed cells containing chloramphenicol resistance genes.
Biochem/physiol Actions（生化/生理功能）
Mode of Action: Inhibits translation on the 50S ribosomal subunit at the peptidyltransferase step （elongation inhibition）. It is bacteriostatic. Mode of Resistance: Acetylation by chloramphenicol acetyltransferase.
Structure（結(jié)構(gòu)式）:
Molecular Formula（分子式）: C11H12Cl2N2O5
Molecular Weight（分子量）: 323.13
CAS #: 56-75-7
Synonym（別名）: D-（-）-threo-2,2-Dichloro-N-[b-hydroxy-a-（hydroxymethyl）-b-（4-nitrophenyl） ethylacetamide
Physical Description（物理描述）: White to cream colored crysalline powder
Stability（穩(wěn)定性）: Stable at 37°C for up to 5 days.
Suggested Working Concentration（建議使用濃度）: 5 -20 ug/ml.
Molecular Formula（分子式）: C11H12Cl2N2O5
Molecular Weight（分子量）: 323.13
CAS #: 56-75-7
Synonym（別名）: D-（-）-threo-2,2-Dichloro-N-[b-hydroxy-a-（hydroxymethyl）-b-（4-nitrophenyl） ethylacetamide
Physical Description（物理描述）: White to cream colored crysalline powder
Stability（穩(wěn)定性）: Stable at 37°C for up to 5 days.
Suggested Working Concentration（建議使用濃度）: 5 -20 ug/ml.
Solubility（溶解性）: Soluble in methanol （50 mg/ml - clear, pale yellow solution）, butanol, ethyl acetate, acetone, ethanol, propylene glycol; slightly soluble in water, ether; insoluble in benzene, petroleum ether, vegetable oils. Solutions should be aliquoted and stored at -20°C.
Storage & Handling（儲存和處理）：Store at Room Temperature （15-30 °C）.
Ordering Information（訂購信息）：
| 貨號 | 名稱 | 產(chǎn)地 | 規(guī)格 | 報價/元 | */元 |
| | CHLORAMPHENICOL 氯霉素 | MPBIO | 5g | 399 | 80 |
| 60205ES10 | Chloramphenicol 氯霉素（USP級） | Yeasen | 10G | 49 | 49 |
