WWOX Polyclonal Antibody
抗體,也叫免疫球蛋白(Ig),是一種能特異性結合抗原的糖蛋白,而抗原是在易感染動物體內引發抗體產生的物質。在體內,抗體是由于外源性分子的侵襲而產生的??贵w以一個或者多個Y字形單體存在,每個Y字形單體由4條多肽鏈組成,包含兩條相同的重鏈和兩條相同的輕鏈。輕鏈和重鏈是根據它們的分子量大小來命名的。Y字形結構的頂端是可變區,為抗原結合部位。任何一個抗體的輕鏈都可以分為κ或λ型(基于小分子多肽結構上的差異),每一個抗體的重鏈則決定了它的類或型。
產品詳情
WWOX Polyclonal Antibody detects endogenous levels of WWOX protein.
免疫原詳細信息
The antiserum was produced against synthesized peptide derived from human WWOX. AA range:1-50
相關試劑
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
背景
WWOX (WW domain containing oxidoreductase) encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. WWOX spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of WWOX is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants.
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備注:圖片僅供參考。僅供科研,不可用于臨床。