Caspase-10 Polyclonal Antibody
抗體，也叫免疫球蛋白（Ig），是一種能特異性結合抗原的糖蛋白，而抗原是在易感染動物體內引發抗體產生的物質。在體內，抗體是由于外源性分子的侵襲而產生的。抗體以一個或者多個Y字形單體存在，每個Y字形單體由4條多肽鏈組成，包含兩條相同的重鏈和兩條相同的輕鏈。輕鏈和重鏈是根據它們的分子量大小來命名的。Y字形結構的頂端是可變區，為抗原結合部位。任何一個抗體的輕鏈都可以分為κ或λ型（基于小分子多肽結構上的差異），每一個抗體的重鏈則決定了它的類或型。
產品詳情
Caspase-10 Polyclonal Antibody detects endogenous levels of Caspase-10 protein.
免疫原詳細信息
Synthesized peptide derived from the Internal region of human Caspase-10.
相關試劑
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
背景
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]
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