種類為齊全的熒光標(biāo)記蛋白及活性改性（30種蛋白/20種熒光染料）
西安凱新生物科技有限公司是可以提供一系列的蛋白類產(chǎn)品改性熒光標(biāo)記，偶連抗體、多肽或者聚合物或其他小分子偶連蛋白產(chǎn)品，我們也可以把一些無(wú)機(jī)納米顆粒如納米金棒 磁性納米顆粒偶連蛋白。
我公司可以提供修飾改性熒光標(biāo)記的蛋白有以下：
BSA牛血清白蛋白, HAS人血清白蛋白, Streptavidins鏈霉親和素,Concanavalin A 刀豆球蛋白
Transferrin 轉(zhuǎn)鐵蛋白, Protein A 重組蛋白A, Protein G 重組蛋白G, Actin 肌動(dòng)蛋白, Histone 組蛋白, Ovalbumin 卵清蛋白, 乳清蛋白lactalbumin，Hemoglobin 血紅蛋白, Mucin 粘蛋白, Myoglobin 肌紅蛋白, Nucleohistone 核仁蛋白, Casein 絡(luò)蛋白，Lactoferrin乳鐵蛋白，Azo-Casein偶氮酪蛋白，Laminin 層粘蛋白，Keratin azure天青角蛋白，Protamine魚精蛋白，F(xiàn)erredoxin 鐵氧還蛋白, Green fluorescent protein (GFP)綠色熒光蛋白
供應(yīng)商：西安凱新生物科技有限公司
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我們可以提供以下熒光染料標(biāo)記上述蛋白：
FITC/Rhodamine/TRITC/Comarin/Bodipy/ICG/CY3/CY3.5/CY5/CY5.5/CY7/CY7.5/IR-800/IR-825或其他系列IR熒光染料
對(duì)以上蛋白進(jìn)行活性基團(tuán)改性的基團(tuán)包括有：
活化脂NHS/氨基NH2/生物素Biotin/疊氮N3/醛基CHO/巰基SH/馬來(lái)酰亞胺MAL/炔烴Alkyne/DBCO/Vinyl sulfone/DOTA/NOTA/TCO/Tetrazine
定制偶連的復(fù)合類產(chǎn)品包括有：
以上蛋白可以和納米金或納米金棒偶連或氧化硅納米顆粒偶連
以上蛋白可以和聚合物或者共聚物偶連
以上蛋白可以和點(diǎn)擊化學(xué)類產(chǎn)品或大環(huán)類小分子偶連
以上蛋白可以和其他生物活性產(chǎn)品交聯(lián) 如抗體 多肽 或活性酶
以上蛋白可以根據(jù)文獻(xiàn)制備特殊定制類產(chǎn)品
【熒光標(biāo)記人/牛血清白蛋白】：
Bovine serum albumin (BSA) is a slightly acidic ~66 kd protein. BSA is commonly used in biological research due to its low cost and inertness. Dilute enzymes can be stabilized by BSA (useful for restriction digests). BSA is a common blocking agent in western blotting and ELISA’s. Although, bovine serum albumin is exceptionally soluble (up to 50% w/v in buffered saline), it is typically used at a concentration of
牛血清白蛋和人血清白蛋白在藥物靶向和藥物傳遞方面的介紹：
與正常組織相比，腫瘤組織的血管豐富，結(jié)構(gòu)特殊 一個(gè)重要的表現(xiàn)就是血管內(nèi)皮間隙較大，這種病變情況下大分子可以透過(guò)腫瘤組織血管壁的原因，然而在健康組織的血管中只有小分子可以通過(guò)這一內(nèi)皮屏障，通常大分子藥物流體動(dòng)力學(xué)半徑大于2nm小于10nm 人血清白蛋白的有效半徑是7.2nm 因此可以滲入腫瘤組織而不能進(jìn)入正常組織。
在病例條件下 腫瘤細(xì)胞在生長(zhǎng)或轉(zhuǎn)移時(shí)，病變細(xì)胞釋放的化學(xué)物質(zhì)和腫瘤衍生物的甲狀腺激素相關(guān)肽均通過(guò)產(chǎn)生NO和激活KATP來(lái)降低集合淋巴管“節(jié)律泵”的活性，從而影響了淋巴的生成 轉(zhuǎn)運(yùn) 使得腫瘤組織淋巴回流較小，分子量相對(duì)較小的物質(zhì)從腫瘤間質(zhì)中清除較快，而大分子被截留，因此大分子物質(zhì)還可以在腫瘤組織中選擇性的聚集。高血管通透性和截留率是白蛋白作為抗腫瘤藥物靶向載體的必要條件，白蛋白的這種效應(yīng)符合大分子物質(zhì)在腫瘤組織的透過(guò)性增強(qiáng)及滯留效應(yīng)。
我公司可以提供各種白蛋白熒光探針和活化基團(tuán)改性的牛血清白蛋白和人血清白蛋白產(chǎn)品，并且可以做一些白蛋白復(fù)合定制類產(chǎn)品。
已有產(chǎn)品列表：
(BSA-FITC), Bovine serum albumin Fluorescein labeled 異硫氰酸熒光素標(biāo)記牛血清白蛋白
(BSA-TRITC), Bovine serum albumin TRITC labeled 四甲基落地那么標(biāo)記牛血清白蛋白
(BSA-CY3), Bovine serum albumin CY3 labeled
(BSA-CY5), Bovine serum albumin CY5 labeled
(BSA-CY5.5), Bovine serum albumin CY5.5 labeled
(BSA-CY7), Bovine serum albumin CY7 labeled
(BSA-CY7.5), Bovine serum albumin CY7.5 labeled
(BSA-ICG), Bovine serum albumin ICG labeled 吲哚菁綠標(biāo)記牛血清白蛋白-近紅外
(BSA-SH), Bovine serum albumin thiol labeled 巰基功能化牛血清白蛋白
(BSA-Biotin), Bovine serum albumin Biotin labeled 生物素修飾牛血清白蛋白
(BSA-MAL), BSA, maleimide function 馬來(lái)酰亞胺功能化牛血清白蛋白
(BSA-LA), BSA, linoic acid labeled
(BSA-OA), BSA, oleic acid labeled 油酸包裹牛血清白蛋白
(BSA-N3), BSA, azide labeled 疊氮功能化牛血清白蛋白
IR825-BSA, Bovine serum albumin IR-825 labeled 近紅外染料標(biāo)記牛血清白蛋白
Gold-BSA, Bovine serum albumin Gold labeled 納米金偶連牛血清白蛋白
【熒光標(biāo)記和功能化人血清白蛋白】：
Ruixibio provides a variety of chemically functionalized and bioconjugated Human serum albumin (HSA) with different functionality. These functional HSA products were purified by size exclusion chromatography to remove non-conjugated molecules and ensure adequate applications both in-vitro and in-vivo.
(HSA-FITC), Human serum albumin Fluorescein 熒光素標(biāo)記人血清白蛋白
(HSA-TRITC), Human serum albumin TRITC 四甲基羅丹明標(biāo)記人血清白蛋白
(HSA-CY5), Human serum albumin CY5
(HSA-CY3), Human serum albumin CY3
(HSA-CY5.5), Human serum albumin CY5.5
(HSA-CY7), Human serum albumin CY7
(HSA-CY7.5), Human serum albumin CY7.5
(HSA-ICG), Human serum albumin ICG 吲哚菁綠標(biāo)記人血清白蛋白-近紅外
(HSA-SH), Human serum albumin thiol 巰基功能化人血清白蛋白
(HSA-Biotin), Human serum albumin Biotin 生物素修飾人血清白蛋白
(HSA-MAL), HSA, maleimide function 馬來(lái)酰亞胺功能化人血清白蛋白
(HSA-IR825), Human serum albumin IR-825 近紅外染料標(biāo)記人血清白蛋白
(HSA-Gold), Human serum albumin gold
Human serum albumin (HSA, without modification)
【熒光標(biāo)記和功能化卵清蛋白】
蛋清中的主要蛋白質(zhì)包括卵清蛋白、卵轉(zhuǎn)鐵球蛋白、類卵沾蛋白、卵沾蛋白、溶菌酶、球蛋白G2、球蛋白G3等。卵清蛋白等電點(diǎn)4.5，其本質(zhì)是含磷糖蛋白。卵清蛋白是蛋清中的主要蛋白組分，其結(jié)構(gòu)與性質(zhì)會(huì)顯著影響蛋清蛋白在食品加工過(guò)程中的功能性質(zhì)。因此研究卵清蛋白在熱處理或美拉德反應(yīng)后的變化對(duì)了解蛋清蛋白在食品加工過(guò)程中的結(jié)構(gòu)與性質(zhì)的變化有重要意義。
Ovalbumin (abbreviated OVA) is the main protein found in egg white. Ovalbumin has been used in the study of protein structure, proteomics and immunology. Ruixibio provides a variety of functionalized and bioconjugated ovalbumin conjugates.These labeled ovalbumin products were purified by size exclusion chromatography to remove non-conjugated molecules and ensure adequate applications both in-vitro and in-vivo.
產(chǎn)品列表：
FITC-Ovalbumin, Ovalbumin, FITC conjugate 綠色熒光標(biāo)記卵清蛋白
Rhodamine-Ovalbumin ,Ovalbumin, Rhodamine labeled 紅色熒光標(biāo)記卵清蛋白
CY3-Ovalbumin, Ovalbumin, CY3 conjugate
Cy5-Ovalbumin ,Ovalbumin, CY5 labeled 藍(lán)色熒光標(biāo)記卵清蛋白
Cy5.5-Ovalbumin ,Ovalbumin, CY5.5 labeled 紫色熒光標(biāo)記卵清蛋白
Cy7-Ovalbumin ,Ovalbumin, CY7 labeled
Cy7.5-Ovalbumin ,Ovalbumin, CY7.5 labeled
ICG-Ovalbumin ,Ovalbumin, ICG labeled 吲哚菁綠標(biāo)記卵清蛋白
Biotin-Ovalbumin ,Ovalbumin, Biotin function 生物素修飾卵清蛋白
Ovalbumin-Thiol, Ovalbumin, Thiol function 巰基化卵清蛋白
Ovalbumin-MAL, Ovalbumin, maleimide function 馬來(lái)酰亞胺修飾卵清蛋白
【乳清蛋白lactalbumin】
產(chǎn)品目錄：
FITC-lactalbumin, lactalbumin, FITC conjugate
Rhodamine-lactalbumin , lactalbumin, Rhodamine labeled
CY3-lactalbumin, lactalbumin, CY3 conjugate
Cy5-lactalbumin , lactalbumin, CY5 labeled
Cy5.5-lactalbumin , lactalbumin, CY5.5 labeled
Cy7-lactalbumin , lactalbumin, CY7 labeled
Cy7.5-lactalbumin , lactalbumin, CY7.5 labeled
ICG-lactalbumin , lactalbumin, ICG labeled
Biotin-lactalbumin, lactalbumin, Biotin function
lactalbumin-Thiol, lactalbumin, Thiol function
lactalbumin-MAL, lactalbumin, maleimide function
【熒光標(biāo)記豆求蛋白A】：
Concanavalin A (con A) is a homotetrameric, 26 kDa lectin derived from the jack bean, Canavalia ensiformis. Concanavalin A binds to alpha-D glucose and alpha-D-mannose containing saccharides. Concanavalin A requires both Mn2+ and Ca2+ ions as a co-factor for binding. Since each con A has four binding sites, it can agglutinate cells such as red blood cells. Con A can also cause cell surface receptor aggregation which can be mitogenic for some lymphocytes.
產(chǎn)品列表：
Concanavalin A-CY5
Concanavalin A-CY3
Concanavalin A-CY5.5
Concanavalin A-CY7.5
Concanavalin A-CY7
Concanavalin A-Biotin
Concanavalin A-SH
Concanavalin A-TRITC
Concanavalin A-FITC
Concanavalin A-ICG
【熒光標(biāo)記肌動(dòng)蛋白】
Actin is a major cell cytoskeleton microfilament protein that plays an important role in cellular functions such as cell mobility and contraction during cell division. Ruixibio provides a broad range of fluorescent or biotin labeled actin bioconjugates. These conjugates include coumarin labeled actin, fluorescein (FITC, FAM) actins, rhodamine (TRITC, TMR, TAMRA, rhodamine B) actins, cyanine dye (cy3, cy5, cy5.5, cy7) actins and many other actin conjugates.
Actin from rabbit muscle
FITC-Actin, Actin from rabbit muscle, Fluorescein labeled
TMR-Actin, Actin from rabbit muscle, tetramethyl rhodamine (TMR) labeled
TRITC-Actin ,Actin from rabbit muscle, Rhodamine B (TRITC) labeled
CY3-Actin ,Actin from rabbit muscle, Cy3 labeled
CY5-Actin ,Actin from rabbit muscle, Cy5 labeled
CY5.5-Actin ,Actin from rabbit muscle, Cy5.5 labeled
CY7-Actin ,Actin from rabbit muscle, Cy7 labeled
CY7.5-Actin ,Actin from rabbit muscle, Cy7.5 labeled
ICG-Actin ,Actin from rabbit muscle, ICG labeled
Biotin-Actin, Actin from rabbit muscle, Biotin labeled
【熒光標(biāo)記的組蛋白】：
FITC-Histone
Rhodamine-Histone
CY3-Histone
CY5-Histone
CY5.5-Histone
CY7-Histone
CY7.5-Histone
ICG-Histone
【熒光標(biāo)記血紅蛋白】：
Hemoglobin-CY5
Hemoglobin-CY3
Hemoglobin-CY5.5
Hemoglobin-CY7.5
Hemoglobin-CY7
Hemoglobin-Biotin
Hemoglobin-SH
Hemoglobin-TRITC
Hemoglobin-FITC
【熒光標(biāo)記粘蛋白】：
Mucin-CY5
Mucin-CY3
Mucin-CY5.5
Mucin-CY7.5
Mucin-CY7
Mucin-Biotin
Mucin-SH
Mucin-TRITC
Mucin-FITC
【熒光標(biāo)記肌紅蛋白】：
Myoglobin-CY5
Myoglobin-CY3
Myoglobin-CY5.5
Myoglobin-CY7.5
Myoglobin-CY7
Myoglobin-Biotin
Myoglobin-SH
Myoglobin-TRITC
Myoglobin-FITC
【熒光標(biāo)記核仁蛋白】：
Nucleohistone-CY5
Nucleohistone-CY3
Nucleohistone-CY5.5
Nucleohistone-CY7.5
Nucleohistone-CY7
Nucleohistone-Biotin
Nucleohistone-SH
Nucleohistone-TRITC
Nucleohistone-FITC
【熒光標(biāo)記轉(zhuǎn)鐵蛋白】：
轉(zhuǎn)鐵蛋白又名運(yùn)鐵蛋白 transferrin，TRF，siderophilin）是血漿中主要的含鐵蛋白質(zhì)，負(fù)責(zé)運(yùn)載由消化管吸收的鐵和由紅細(xì)胞降解釋放的鐵。以TRF-Fe3+的復(fù)合物形式進(jìn)入骨髓中，供成熟紅細(xì)胞的生成
Fluorescein labeled transferrin, also called FITC transferrin, is one of fluorescent transferrin conjugates provided by Ruixibio. FITC transferrin is a green fluorescent transferrin conjugate with excitation/emission wavelength at 490 nm/515 nm. Nanocs also provides a number of orange, red, purple, blue and IR dye labeled transferrin products with excitation/emission wavelength. These labeled transferrin products were purified by size chromatography to remove non-conjugated molecules and ensure adequate applications both in-vitro and in-vivo.
產(chǎn)品列表：
Transferrin, FITC labeled
Transferrin, Rhodamine labeled
Transferrin, Cy3 labeled
Transferrin, Cy5 labeled
Transferrin, Cy5.5 labeled
Transferrin, Cy7 labeled
Transferrin, Cy7.5 labeled
Transferrin, Biotin labeled
Transferrin, ICG labeled
【熒光標(biāo)記絡(luò)蛋白】：
Ruixibio offers a variety of fluorescently labeled and other functional casein conjugates, which include Fluorescein (FITC) labeled casein, Rhodamine labeled casein, Cy3 labeled casein, Cy5 labeled casein, Cy5.5 labeled casein, Alexa fluor and Biotin labeled casein and many other multifunctional casein products. If you have needs for any special conjugated casein products not listed here, please call us and let we make for you!
Casein, FITC labeled
Casein, Rhodamine labeled
Casein, Cy3 labeled
Casein, Cy5 labeled
Casein, Cy5.5 labeled
Casein, Cy7 labeled
Casein, Cy7.5 labeled
Casein, Biotin labeled
Casein, ICG labeled
【熒光標(biāo)記親和素和鏈霉親和素】：
鏈霉親和素(streptavidin下稱SA)是與親和素(avidin下稱AV)有相似生物學(xué)特性的一種蛋白質(zhì)，是streptomyces avidinii菌的分泌物，其分子量及結(jié)合生物素的能力與雞蛋清中的親和素相似，等電點(diǎn)6.0，非特異性結(jié)合遠(yuǎn)比親和素低。
鏈霉親和素是四聚體蛋白，大小為66KDa。一分子鏈霉親和素可以高度特異性地與四分子生物素結(jié)合，兩者之間的親和力極為強(qiáng)烈，鏈霉親和素-生物素復(fù)合物的解離常數(shù)處于數(shù)量級(jí)，這一性質(zhì)常用于分子生物學(xué)用途。其中一條完整的SA肽鏈中有159個(gè)氨基酸殘基，分子量為16450
Avidin is a tetrameric protein commonly isolated from egg whites. Avidin binds to biotin with strength approaching that of a covalent bond. Disruption of the avidin-biotin bond occurs only under extraordinary conditions, such as pH 1.5 with 6 M guanidium hydrocholoride. Fluorescent avidin can bind to biotinylated antibodies used in immunohistochemistry and immunocytochemistry. Avidin thiol can bind to gold surfaces and act as a glue for biotinylated proteins. Avidin agarose is useful for efficient removal of biotinylated proteins from a liquid phase.
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產(chǎn)品列表：
Neutravidin-thiol
Streptavidin (without modification)
Streptavidin-CY5
Streptavidin-CY3
Streptavidin-CY5.5
Streptavidin-CY7
Streptavidin-CY7.5
Streptavidin-ICG
Streptavidin-TRITC
Streptavidin-FITC
Streptavidin-thiol
Streptavidin-azide
Streptavidin, HRP labeled
Streptavidin, maleimide activated
Streptavidin, amine function
Streptavidin, DBCO function
Streptavidin, Dextran Conjugate
Streptavidin, R-phycoerythrin
Avidin-CY3
Avidin-CY5
Avidin-CY5.5
Avidin (without modification)
Avidin-Sepharose
Avidin-thiol
Avidin-FITC
Avidin-TRITC
