手機(jī)版
化工儀器網(wǎng)手機(jī)版
化工儀器網(wǎng)小程序
官方微信
公眾號(hào)：chem17
掃碼關(guān)注視頻號(hào)
Anti-ARA24抗體,雄激素受體相關(guān)蛋白24抗體說(shuō)明書
Anti-ARA24抗體,雄激素受體相關(guān)蛋白24抗體說(shuō)明書 >>>>>>>點(diǎn)擊查看
Rabbit Anti-ARA24
Catalog Number : BYK-3751R
Quantity size : 100ug （0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide）
Quantity size : 100ug （0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide）
Background: Ran （ras-related nuclear protein） is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The Ran protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of Ran requires the presence of regulator of chromosome condensation 1 （RCC1）. Mutations in Ran disrupt DNA synthesis. Because of its many functions, it is likely that Ran interacts with several other proteins. Ran regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. Ran could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of Ran-GTP around chromatin which, in turn, induces the local nucleation of microtubules. Ran is an androgen receptor （AR） coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease （X-linked spinal and bulbar muscular atrophy）. Ran coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.
Specificity :
– Anti-ARA24 is a rabbit polyclonal antibody unconjugated
– specific for ARA24 of mo,rat,hu
– use for western blotting,elisa,immunoprecipitation and immunohistochemistry
– Protein G affinity chromatography purification, purity :>95%
– Isotype: IgG
– mol wt: 26kDa
Anti-ARA24抗體,雄激素受體相關(guān)蛋白24抗體說(shuō)明書Application :
– Western blotting 1:100-500
– Immunohistochemistry 1:100-500
– ELISA 1:500-1000
– IP=1:20-100
– IF=1:100-500
– Optimal working dilutions must be determined by the end user.
Storage: Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody, the antibody is stable for at least six weeks at 2-4 ℃
Anti-ARA24抗體,雄激素受體相關(guān)蛋白24抗體說(shuō)明書Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
相關(guān)產(chǎn)品
免責(zé)聲明
- 凡本網(wǎng)注明“來(lái)源：化工儀器網(wǎng)”的所有作品，均為浙江興旺寶明通網(wǎng)絡(luò)有限公司-化工儀器網(wǎng)合法擁有版權(quán)或有權(quán)使用的作品，未經(jīng)本網(wǎng)授權(quán)不得轉(zhuǎn)載、摘編或利用其它方式使用上述作品。已經(jīng)本網(wǎng)授權(quán)使用作品的，應(yīng)在授權(quán)范圍內(nèi)使用，并注明“來(lái)源：化工儀器網(wǎng)”。違反上述聲明者，本網(wǎng)將追究其相關(guān)法律責(zé)任。
- 本網(wǎng)轉(zhuǎn)載并注明自其他來(lái)源（非化工儀器網(wǎng)）的作品，目的在于傳遞更多信息，并不代表本網(wǎng)贊同其觀點(diǎn)和對(duì)其真實(shí)性負(fù)責(zé)，不承擔(dān)此類作品侵權(quán)行為的直接責(zé)任及連帶責(zé)任。其他媒體、網(wǎng)站或個(gè)人從本網(wǎng)轉(zhuǎn)載時(shí)，必須保留本網(wǎng)注明的作品第一來(lái)源，并自負(fù)版權(quán)等法律責(zé)任。
- 如涉及作品內(nèi)容、版權(quán)等問(wèn)題，請(qǐng)?jiān)谧髌钒l(fā)表之日起一周內(nèi)與本網(wǎng)聯(lián)系，否則視為放棄相關(guān)權(quán)利。
采購(gòu)中心