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Oxaliplatin

CAS No. : 61825-94-3

MCE 國際站：Oxaliplatin

產品活性：Oxaliplatin 是一種 DNA 合成 抑制劑。Oxaliplatin 會導致 DNA 交聯損傷，阻止 DNA 復制和轉錄并導致細胞死亡。Oxaliplatin 以時間依賴方式抑制人黑色素瘤細胞系 C32 和 G361，IC₅₀ 值分別為 0.98 μM 和 0.14 μM。Oxaliplatin 可以誘導細胞自噬 (autophagy)。

研究領域：Cell Cycle/DNA Damage  |  Apoptosis

作用靶點：DNA/RNA Synthesis  |  Apoptosis

In Vitro: Oxaliplatin (24-72 hours; 2-128 μM; HCC, HCCLM3 and Hep3B cells) inhibits cell growth and induces apoptosis.
?Oxaliplatin (10 μM; 15-240 mins; CEM cells ) induces primary and secondary DNA lesions, including DNA cross-links (ISC) and DNA-protein cross-links (DPC).
?Oxaliplatin (0.01 to 100 μM; 24 hours) potently inhibits bladder carcinoma cell lines RT4 and TCCSUP, ovarian carcinoma cell line A2780, colon carcinoma cell line HT-29, glioblastoma cell lines U-373MG and U-87MG, and melanoma cell lines SK-MEL-2 and HT-144 with IC₅₀ of 11 μM, 15 μM, 0.17 μM, 0.97 μM, 2.95 μM, 17.6 μM, 30.9 μM and 7.85 μM, respectively.

In Vivo: Oxaliplatin (5-10 mg/kg; i.p.; for 32 days; nude mice) inhibits tumor growth.

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