目錄:MedChemExpress LLC>>信號(hào)通路>> Rifaximin | 利福昔明 | MedChemExpress (MCE)
參考價(jià) | ¥ 572 |
參考價(jià) | ¥ 572 |
更新時(shí)間:2024-01-10 11:28:38瀏覽次數(shù):149評(píng)價(jià)
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CAS | 80621-81-4 | 純度 | 99.88% |
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分子量 | 785.88 | 分子式 | C??H??N?O?? |
供貨周期 | 現(xiàn)貨 | 規(guī)格 | 10 mM * 1 mL |
貨號(hào) | HY-13234 | 應(yīng)用領(lǐng)域 | 醫(yī)療衛(wèi)生,化工,生物產(chǎn)業(yè),制藥 |
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CAS No. : 80621-81-4
MCE 國際站:Rifaximin
產(chǎn)品活性:Rifaximin是一種胃腸道選擇性的抗生素 (antibiotic),與細(xì)菌 DNA 依賴性 RNA 聚合酶的 β 亞基結(jié)合,從而抑制細(xì)菌 RNA 的合成 (bacterial RNA synthesis)。與革蘭氏陰性菌(MIC:8-50 毫克/毫升)相比,Rifaximin對(duì)革蘭氏陽性菌株(MIC:0.03-5 毫克/毫升)的敏感性更高。
研究領(lǐng)域:Anti-infection | Cell Cycle/DNA Damage
作用靶點(diǎn):Bacterial | Antibiotic | DNA/RNA Synthesis
In Vitro: Rifaximin has a good inhibitory activity against Staphylococcus, Streptococcus, Enterococcus, Escherichia coli, Shigella, Salmonella, Bacillus cereus, Moraxella catarrhalis, Haemophilus influenzae, Haemophilus ducreyi, Bacteroides bivius-disiens, Gardnerella vaginalis, Lactobacillus spp.,Mobiluncus spp.,Neisseria gonorrhoeae, Pseudomonas and Acinetobacter . Rifaximin rarely causes side effects.
Rifaximin (0.1, 1.0 and 10.0 µM) causes significant and concentration-dependent reduction of cell proliferation, cell migration and PCNA expression in the Caco-2 cells vs. untreated cells.
Rifaximin (0.1-10 μM) downregulates Akt/mTOR and p38MAPK/NF-κB pathways through a PXR-dependent mechanism.
In Vivo: Rifaximin administration (30 or 50 mg/kg/day) increases survival rates of colitic mice and reduces colitis severity by improvement of wasting syndrome, histologic scores, decrease in colon IL-2, IL-12, IFN-gamma and TNF-alpha (protein and mRNA) levels, and diminishes colon myeloperoxidase (MPO) activity.
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