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目錄:MedChemExpress LLC>>信號(hào)通路>> Rifaximin | 利福昔明 | MedChemExpress (MCE)

Rifaximin | 利福昔明 | MedChemExpress (MCE)
  • Rifaximin | 利福昔明 | MedChemExpress (MCE)
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CAS 80621-81-4 純度 99.88%
分子量 785.88 分子式 C??H??N?O??
供貨周期 現(xiàn)貨 規(guī)格 10 mM * 1 mL
貨號(hào) HY-13234 應(yīng)用領(lǐng)域 醫(yī)療衛(wèi)生,化工,生物產(chǎn)業(yè),制藥
Rifaximin是一種胃腸道選擇性的抗生素 (antibiotic),與細(xì)菌 DNA 依賴性 RNA 聚合酶的 β 亞基結(jié)合,從而抑制細(xì)菌 RNA 的合成 (bacterial RNA synthesis)。與革蘭氏陰性菌(MIC:8-50 毫克/毫升)相比,Rifaximin對(duì)革蘭氏陽性菌株(MIC:0.03-5 毫克/毫升)的敏感性更高。

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Rifaximin

CAS No. : 80621-81-4

MCE 國際站:Rifaximin

產(chǎn)品活性:Rifaximin是一種胃腸道選擇性的抗生素 (antibiotic),與細(xì)菌 DNA 依賴性 RNA 聚合酶的 β 亞基結(jié)合,從而抑制細(xì)菌 RNA 的合成 (bacterial RNA synthesis)。與革蘭氏陰性菌(MIC:8-50 毫克/毫升)相比,Rifaximin對(duì)革蘭氏陽性菌株(MIC:0.03-5 毫克/毫升)的敏感性更高。

研究領(lǐng)域:Anti-infection  |  Cell Cycle/DNA Damage

作用靶點(diǎn):Bacterial  |  Antibiotic  |  DNA/RNA Synthesis

In Vitro: Rifaximin has a good inhibitory activity against Staphylococcus, Streptococcus, Enterococcus, Escherichia coli, Shigella, Salmonella, Bacillus cereus, Moraxella catarrhalis, Haemophilus influenzae, Haemophilus ducreyi, Bacteroides bivius-disiens, Gardnerella vaginalis, Lactobacillus spp.,Mobiluncus spp.,Neisseria gonorrhoeae, Pseudomonas and Acinetobacter . Rifaximin rarely causes side effects.
Rifaximin (0.1, 1.0 and 10.0 µM) causes significant and concentration-dependent reduction of cell proliferation, cell migration and PCNA expression in the Caco-2 cells vs. untreated cells.
Rifaximin (0.1-10 μM) downregulates Akt/mTOR and p38MAPK/NF-κB pathways through a PXR-dependent mechanism.

In Vivo: Rifaximin administration (30 or 50 mg/kg/day) increases survival rates of colitic mice and reduces colitis severity by improvement of wasting syndrome, histologic scores, decrease in colon IL-2, IL-12, IFN-gamma and TNF-alpha (protein and mRNA) levels, and diminishes colon myeloperoxidase (MPO) activity.

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