目錄:MedChemExpress LLC>>信號通路>> Tovorafenib | MedChemExpress (MCE)
| CAS | 1096708-71-2 | 純度 | 99.89% |
|---|---|---|---|
| 分子量 | 506.29 | 分子式 | C??H??Cl?F?N?O?S |
| 供貨周期 | 現(xiàn)貨 | 規(guī)格 | 10 mM * 1 mL |
| 貨號 | HY-15246 | 應用領域 | 醫(yī)療衛(wèi)生,化工,生物產業(yè),制藥 |
MCE 的所有產品僅用作科學研究或藥證申報，我們不為任何個人用途提供產品和服務。
CAS No. : 1096708-71-2
MCE 國際站：Tovorafenib
產品活性：Tovorafenib (TAK-580, MLN 2480) 是一種可口服的，具有選擇性的廣譜的 Raf 抑制劑。
研究領域：MAPK/ERK Pathway
作用靶點：Raf
In Vitro: Tovorafenib (TAK-580, MLN 2480) has effect on reversing feedback activation of MEK in response to TAK-733, leading to more concerted MAPK pathway inhibition.
In Vivo: Tovorafenib (TAK-580, MLN 2480) inhibits MAPK pathway signaling in BRAF mutant and some RAS mutant preclinical cancer models at concentrations that are tolerated in vivo. TAK-580 (MLN 2480) is most potent in BRAF mutant melanoma models but also has single agent activity in some RAS mutant models. The combination of MLN2480 with TAK-733 inhibits the growth of a broader range of RAS mutant tumor models than single agent TAK-580 (MLN 2480), including primary human tumor xenograft models of melanoma and CRC.
相關產品：Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Kinase Inhibitor Library | MAPK Compound Library | Anti-Cancer Compound Library | Clinical Compound Library | Drug Repurposing Compound Library | Oxygen Sensing Compound Library | Ferroptosis Compound Library | Orally Active Compound Library | Glutamine Metabolism Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Obesity Compound Library | Targeted Diversity Library | Anti-Liver Cancer Compound Library | Anti-Colorectal Cancer Compound Library | Heterocyclic Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Highly Selective Inhibitors Library | Serine/Threonine Kinase Inhibitor Library | Sorafenib | Dabrafenib | Vemurafenib | Regorafenib | Doramapimod | Encorafenib | SB-590885 | PLX-4720 | Belvarafenib | GDC-0879 | LY3009120 | AZ 628 | Avutometinib | GW 5074 | LXH254 | Exarafenib | TAK-632 | Lifirafenib | Agerafenib | RAF265 | CCT196969 | Rineterkib | ZM 336372 | BI-882370 | R18 TFA
熱門產品線：重組蛋白 | 化合物庫 | 天然產物 | 熒光染料 | PROTAC | 同位素標記物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
3
化工儀器網(wǎng)