MCE 的所有產品僅用作科學研究或藥證申報，我們不為任何個人用途提供產品和服務。

Ramelteon

CAS No. : 196597-26-9

MCE 國際站：Ramelteon

產品活性：Ramelteon 是一種強效、高選擇性和具有口服活性的 MT1/MT2 激動劑，Ki 值分別為 14 和 112 pM。Ramelteon 具有研究失眠癥的潛力。Ramelteon長期使用持續減少睡眠發作，停藥后無翌日晨殘留效應或反彈性失眠或戒斷癥狀。

研究領域：GPCR/G Protein  |  Neuronal Signaling

作用靶點：Melatonin Receptor

In Vivo: Ramelteon (p.o.; 0.1 and 1 mg/kg) accelerates reentrainment of running wheel activity rhythm to the new lightdark cycle.
Ramelteon (p.o.; 3, 10, and 30 mg/kg) does not affect learning or memory in rats tested by the water maze task and the delayed match to position task, implying that MT1/MT2 receptor agonists have no abuse potential.
Ramelteon (0.0001, 0.001, 0.01, and 0.1 mg/kg; p.o.; 8 hours) significantly decreases wakefulness at doses of 0.001, 0.01, and 0.1 mg/kg, increases slow-wave sleep at doses of 0.001, 0.01, and 0.1 mg/kg, and increases rapid eye movement sleep at a dose of 0.1 mg/kg.

相關產品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  GPCR/G Protein Compound Library  |  Neuronal Signaling Compound Library  |  FDA-Approved Drug Library  |  Anti-Cancer Compound Library  |  CNS-Penetrant Compound Library  |  Drug Repurposing Compound Library  |  Endocrinology Compound Library  |  Orally Active Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Drug-Induced Liver Injury (DILI) Compound Library  |  Targeted Diversity Library  |  Rare Diseases Drug Library  |  FDA-Approved Anticancer Drug Library  |  Human Metabolite Library  |  Off-patent Drug Library  |  Membrane Protein-targeted Compound Library  |  Membrane Receptor-targeted Compound Library  |  Highly Selective Activators Library  |  Melatonin  |  Luzindole  |  4-P-PDOT  |  Agomelatine  |  S26131  |  2-Iodomelatonin  |  Tasimelteon  |  8-M-PDOT  |  Piromelatine  |  ACH-000143  |  UCM 608  |  Ramelteon metabolite M-II-d3  |  N-Acetyltryptamine  |  6-Chloromelatonin  |  7-Desmethyl-3-hydroxyagomelatine  |  Antidepressant agent 3  |  Antidepressant agent 4  |  DH97  |  GR 128107  |  GR 196429  |  Melatonin receptor agonist 1  |  Ramelteon-d3

熱門產品線：重組蛋白  |  化合物庫  |  天然產物  |  熒光染料  |  PROTAC  |  同位素標記物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds