MCE 的所有產品僅用作科學研究或藥證申報，我們不為任何個人用途提供產品和服務。

Cinacalcet

CAS No. : 226256-56-0

MCE 國際站：Cinacalcet

產品活性：Cinacalcet (AMG 073) 是一種可口服的 Ca receptor (CaR) 激動劑，用于心血管疾病研究。

研究領域：GPCR/G Protein  |  Metabolic Enzyme/Protease

作用靶點：CaSR  |  Endogenous Metabolite

In Vivo: Cinacalcet HCl (5 and 10 mg/kg) results in a significant reduction in parathyroid gland weight in 5/6 nephrectomy animals. In sham animals, Cinacalcet HCl has no effect on parathyroid gland cell proliferation or parathyroid weight compared with vehicle treatment. There are no differences in serum phosphorus levels in Cinacalcet HCl (10, 5, or 1 mg/kg) treated 5/6 nephrectomized animals compared with vehicle-treated 5/6 nephrectomized animals. Cinacalcet HCl treatment significantly reduces blood ionized calcium levels in sham animals. Cinacalcet (30 mg/kg/24 h) leads to a marked reduction in circulating parathyroid hormone and a modest reduction in serum Ca. Cinacalcet does not alter UCa when the GHS rats are fed the normal Ca diet but lowers UCa when they are fed the low Ca diet. Cinacalcet does not alter U supersaturation with respect to either CaOx or CaHPO4 on either diet.

相關產品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  GPCR/G Protein Compound Library  |  Metabolism/Protease Compound Library  |  FDA-Approved Drug Library  |  Anti-Cancer Compound Library  |  Drug Repurposing Compound Library  |  Anti-Cardiovascular Disease Compound Library  |  Orally Active Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Drug-Induced Liver Injury (DILI) Compound Library  |  Rare Diseases Drug Library  |  EMA-Approved Drug Library  |  FDA-Approved Anticancer Drug Library  |  Human Metabolite Library  |  Anti-Prostate Cancer Compound Library  |  Off-patent Drug Library  |  Membrane Protein-targeted Compound Library  |  Membrane Receptor-targeted Compound Library  |  Rapamycin  |  3-Methyladenine  |  Acetylcysteine  |  5-Fluorouracil  |  ATP  |  Retinoic acid  |  Hydrocortisone  |  Estradiol  |  AICAR  |  Prostaglandin E2  |  Nicotinamide  |  Docetaxel  |  Isoprenaline hydrochloride  |  Cytarabine  |  L-Ascorbic acid  |  Palmitic acid  |  Melatonin  |  Valproic acid  |  Capsaicin  |  Calcitriol  |  Arachidonic acid  |  Acetaminophen  |  β-Nicotinamide mononucleotide  |  Biotin  |  DHEA  |  NAD+  |  Corticosterone  |  Oleic acid  |  Cholesterol  |  Luteolin

熱門產品線：重組蛋白  |  化合物庫  |  天然產物  |  熒光染料  |  PROTAC  |  同位素標記物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds