目錄:MedChemExpress LLC>>信號(hào)通路>> Posenacaftor sodium | MCE
參考價(jià) | ¥ 4800 |
參考價(jià) | ¥ 4800 |
更新時(shí)間:2023-07-18 10:18:33瀏覽次數(shù):113評(píng)價(jià)
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CAS | 2095064-06-3 | 純度 | 99.65% |
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分子量 | 467.49 | 分子式 | C??H??NNaO? |
供貨周期 | 現(xiàn)貨 | 規(guī)格 | 5 mg |
貨號(hào) | HY-109187A | 應(yīng)用領(lǐng)域 | 醫(yī)療衛(wèi)生,化工,生物產(chǎn)業(yè),制藥 |
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產(chǎn)品活性:Posenacaftor (PTI-801) sodium 是一種囊性纖維化跨膜調(diào)節(jié)蛋白 (CFTR) 調(diào)節(jié)劑,可糾正 CFTR 蛋白的折疊和運(yùn)輸。Posenacaftor sodium 用于囊性纖維化 (CF) 的研究。
研究領(lǐng)域:Membrane Transporter/Ion Channel
作用靶點(diǎn):CFTR
In Vitro: Cystic fibrosis (CF) is an autosomal recessive disorder, caused by mutations of the cystic fibrosis transmembrane conductance regulator (CFTR).CFTR is a cAMP-regulated chloride channel that is primarily located at the apical membrane of epithelial cells.Mutations in the?CFTR?gene lead to the production of a defective and misfolded CFTR protein, and impairs the flow of ions in and out of cells.Posenacaftor is a?CFTR corrector, correctors are always designed to fix and restore the function of the defective CFTR protein. The corrected CFTR then moves to the cell surface, where it functions as a chloride channel and helps maintain the right balance of fluid in the airways.
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