MCE 的所有產品僅用作科學研究或藥證申報，我們不為任何個人用途提供產品和服務。

Procyanidin B1

CAS No. : 20315-25-7

產品活性：Procyanidin B1 is a polyphenolic flavonoid isolated from commonly eaten fruits, binds to TLR4/MD-2 complex, and has anti-inflammatory activity.

研究領域：Immunology/Inflammation

作用靶點：Toll-like Receptor (TLR)

結構分類：黃酮類  |  雙黃酮  |  酚類  |  多酚類

來源：植物  |  其他科

In Vitro: Procyanidin B1 is a polyphenolic flavonoid isolated from fruits and fruit juices, binds to TLR4/MD-2 complex, and has anti-inflammatory activity. Procyanidin B1 causes cellular toxicity at concentrations >100 μg/mL. Procyanidin B1 (100 μg/mL) inhibits LPS-induced TNF-α production, and expression of MD-2, TRAF6, NF-κB mRNA, phosphorylated p38 MAPK and NF-κB protein in THP1 cells. Procyanidin B1 (50-100 µM) protects against Aβ oligomer-induced neuronal death. Procyanidin B1 potently inhibits the activation of caspase-3 at 100 µM, caspase-8 at concentrations of 30, 50, and 100 µM and caspase-9 at concentrations of 10, 30, 50, and 100 µM. Procyanidin B1 (10, 20, 30 μM) significantly and dose-dependently induces expression of ACO and CPT1, with no obvious effect on mRNA expression of PPARα.

相關產品：Natural Product Library Plus  |  Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  Natural Product Library  |  Small Molecule Immuno-Oncology Compound Library  |  Antioxidant Compound Library  |  Lipid Compound Library  |  Oxygen Sensing Compound Library  |  Medicine Food Homology Compound Library  |  Phenols Library  |  Pyroptosis Compound Library  |  Traditional Chinese Medicine Active Compound Library  |  Flavonoids Library  |  Food-Sourced Compound Library   |  Anti-inflammatory Traditional Chinese Medicine Active Compound Library  |  Plant-Sourced Natural Product Library  |  Human Metabolite Library  |  Pain-Related Compound Library  |  Membrane Protein-targeted Compound Library  |  Membrane Receptor-targeted Compound Library  |  C29  |  ODN 1018  |  TLR7 agonist 5  |  AN-3485  |  ODN 2088  |  TLR4/NF-κB/MAPK-IN-1  |  TLR9-IN-1  |  ODN 105871  |  MC-Val-Cit-PAB-Amide-TLR7 agonist 4  |  Monophosphoryl lipid A  |  β-D-Glucan  |  Poly (I:C):Kanamycin (1:1) (sodium)  |  ODN TTAGGG  |  Bropirimine  |  Polygalasaponin F  |  Chloroquine-d₅ (diphosphate)  |  DB-3-291  |  ODN 24888  |  ODN 2216  |  Agatolimod  |  Enpatoran hydrochloride  |  BBIQ  |  UC-1V150  |  AZD8848  |  ODN 105870  |  CU-T12-9  |  TLR7/8 agonist 7  |  ODN 21158  |  TH1020  |  Lefitolimod

熱門產品線：重組蛋白  |  化合物庫  |  天然產物  |  熒光染料  |  PROTAC  |  同位素標記物  |  寡核苷酸  |  抗體  |  點擊化學

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介紹:
•   MCE (MedChemExpress) 擁有200 多種全球僅有化合物庫，我們致力于為全球科研客戶提供前沿的高品質小分子活性化合物；
•   50,000 多種高選擇性抑制劑、激動劑涉及各熱門信號通路及疾病領；
•   產品種類涵蓋各種重組蛋白，多肽，常用試劑盒 ，更有 PROTAC、ADC 等特色產品，廣泛應用于新藥研發、生命科學等科研項目；
•   提供虛擬篩選，離子通道篩選，代謝組學分析檢測分析，藥物篩選等專業技術服務；
•   設有專業的實驗中心和嚴格的質控、驗證體系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各項質檢報告，確保產品的高純度、高品質；
•   產品的生物活性多經各國客戶實驗驗證；
•   Nature, Cell, Science 等多種頂級期刊及制藥 Patent 收錄了MCE客戶的科研成果；
•   專業團隊跟蹤最新的制藥及生命科學研究進展，為您提供全球新的活性化合物；
•   與世界各大制藥公司及著名科研機構建立了長期的合作。