ARP Polyclonal Antibody

抗體，也叫免疫球蛋白（Ig），是一種能特異性結(jié)合抗原的糖蛋白，而抗原是在易感染動物體內(nèi)引發(fā)抗體產(chǎn)生的物質(zhì)。在體內(nèi)，抗體是由于外源性分子的侵襲而產(chǎn)生的。抗體以一個或者多個Y字形單體存在，每個Y字形單體由4條多肽鏈組成，包含兩條相同的重鏈和兩條相同的輕鏈。輕鏈和重鏈是根據(jù)它們的分子量大小來命名的。Y字形結(jié)構(gòu)的頂端是可變區(qū)，為抗原結(jié)合部位。任何一個抗體的輕鏈都可以分為κ或λ型（基于小分子多肽結(jié)構(gòu)上的差異），每一個抗體的重鏈則決定了它的類或型。

產(chǎn)品詳情

ARP Polyclonal Antibody detects endogenous levels of ARP protein.

免疫原詳細信息

The antiserum was produced against synthesized peptide derived from the Internal region of human MANF. AA range:11-60

相關(guān)試劑

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

背景

The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related. [provided by RefSeq, Apr 2014]

備注：圖片僅供參考。僅供科研，不可用于臨床。