496849-46-8，分子式：C67H85N15O11螯合劑

英文名：Tyr-(D-Dab4,Arg5,D-Trp8)-cyclo-Somatostatin-14 (4-11) trifluoroacetate salt

H-TYR-CYCLO(-D-DAB-ARG-PHE-PHE-D-TRP-LYS-THR-PHE)

TYR-(D-DAB4,ARG5,D-TRP8)-CYCLO-SOMATOSTATIN-14 (4-11)

H-Tyr-cyclo(-D-Dab-Arg-Phe-Phe-D-Trp-Lys-Thr-Phe)

CAS號(hào)：496849-46-8

分子式：C67H85N15O11

分子量：1276.49

結(jié)構(gòu)式：

五種生長(zhǎng)抑素受體的高親和力配體（sst1-sst5）。在主要表達(dá)sst2和sst5受體的AtT-20小鼠垂體前葉腫瘤細(xì)胞中，發(fā)現(xiàn)這種生長(zhǎng)抑素類(lèi)似物的結(jié)合親和力高于生長(zhǎng)抑素14和奧曲肽。然而，在癲癇發(fā)生模型中，KE 108沒(méi)有表現(xiàn)出抗癲癇活性，這表明合成配體對(duì)所有已知生長(zhǎng)抑素受體的高效力和有效性可能不會(huì)*重現(xiàn)天然配體的作用。

相關(guān)化合物:

(D-Trp8)-Somatostatin-14 trifluoroacetate salt

58976-46-8

(D-Phe5,Cys6.11,N-Me-D-Trp8)-Somatostatin-14 (5-12) amide

340821-13-8

(D-2-Nal5,Cys6.11,Tyr7,D-Trp8,Val10,2-Nal12)-Somatostatin-14 (5-12) amide trifluoroacetate salt

111857-96-6

H-D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 trifluoroacetate salt (Disulfide bond)

103429-31-8

(Des-Ala1,des-Gly2,His4·5,D-Trp8)-Somatostatin-14

68463-41-2

Tyr-Somatostatin-14

58100-03-1

(Des-Gly10,D-Tyr5,D-His(Bzl)6,Pro-NHEt9)-LHRH trifluoroacetate salt

321709-40-4

(D-Arg2)-Dermorphin (1-4) amide trifluoroacetate salt

100304-60-7

(D-His(Bzl)6,Pro-NHEt9)-LHRH (4-9) trifluoroacetate salt

134009-09-9

496849-46-8，分子式：C67H85N15O11螯合劑