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供貨周期	現(xiàn)貨	應(yīng)用領(lǐng)域	醫(yī)療衛(wèi)生,環(huán)保,化工,生物產(chǎn)業(yè),制藥

LKT Labs 是一家專注于防癌抗癌特殊化學(xué)品研究和開(kāi)發(fā)的公司。主要提供：癌癥藥物、藥物發(fā)現(xiàn)試劑盒、天然產(chǎn)物、廣泛的生命科學(xué)研究試劑、定制合成。
美國(guó)LKT Labs 是1988年在美國(guó)成立的，為全球提供先端的藥物研發(fā)試劑、試劑盒、委托合成，并為藥物生產(chǎn)企業(yè)提供原料，最近幾年在農(nóng)藥、水產(chǎn)養(yǎng)殖業(yè)有很大程度的開(kāi)發(fā)。在LKT Labs 可以找到在其他地方找不到的產(chǎn)品。

LKT Labs D3447 Diltiazem Hydrochloride

LKT U5232 Uniconazole 10 g 84.3 Triazole; gibberellin inhibitor, potential 14-α demethylase inhibitor. 83657-22-1 ≥95% 291.78 C15H18ClN3O CC(C)(C)C(C(=CC1=CC=C(C=C1)Cl)N2C=NC=N2)O Ambient Ambient "Sasaki E, Ogura T, Takei K, et al. Uniconazole, a cytochrome P450 inhibitor, inhibits trans-zeatin biosynthesis in Arabidopsis. Phytochemistry. 2013 Mar;87:30-8. PMID: 23280040.

Sun J, Zhang A, Zhang J, et al. Enantiomeric resolution and growth-retardant activity in rice seedlings of uniconazole. J Agric Food Chem. 2012 Jan 11;60(1):160-4. PMID: 22148239.

Todoroki Y, Kobayashi K, Yoneyama H, et al. Structure-activity relationship of uniconazole, a potent inhibitor of ABA 8'-hydroxylase, with a focus on hydrophilic functional groups and conformation. Bioorg Med Chem. 2008 Mar 15;16(6):3141-52. PMID: 18164621.

Saito S, Okamoto M, Shinoda S, et al. A plant growth retardant, uniconazole, is a potent inhibitor of ABA catabolism in Arabidopsis. Biosci Biotechnol Biochem. 2006 Jul;70(7):1731-9. PMID: 16819156.

Hays DB, Yeung EC, Pharis RP. The role of gibberellins in embryo axis development. J Exp Bot. 2002 Aug;53(375):1747-51. PMID: 12147724.

" "UN number: 3077 Class: 9 Packing Group: III

Proper shipping name: Environmentally hazardous substance, solid, n.o.s. (Uniconazole)"

LKT U5232 Uniconazole 100 g 506.3 Triazole; gibberellin inhibitor, potential 14-α demethylase inhibitor. 83657-22-1 ≥95% 291.78 C15H18ClN3O CC(C)(C)C(C(=CC1=CC=C(C=C1)Cl)N2C=NC=N2)O Ambient Ambient "Sasaki E, Ogura T, Takei K, et al. Uniconazole, a cytochrome P450 inhibitor, inhibits trans-zeatin biosynthesis in Arabidopsis. Phytochemistry. 2013 Mar;87:30-8. PMID: 23280040.

Sun J, Zhang A, Zhang J, et al. Enantiomeric resolution and growth-retardant activity in rice seedlings of uniconazole. J Agric Food Chem. 2012 Jan 11;60(1):160-4. PMID: 22148239.

Saito S, Okamoto M, Shinoda S, et al. A plant growth retardant, uniconazole, is a potent inhibitor of ABA catabolism in Arabidopsis. Biosci Biotechnol Biochem. 2006 Jul;70(7):1731-9. PMID: 16819156.

Hays DB, Yeung EC, Pharis RP. The role of gibberellins in embryo axis development. J Exp Bot. 2002 Aug;53(375):1747-51. PMID: 12147724.

" "UN number: 3077 Class: 9 Packing Group: III

Proper shipping name: Environmentally hazardous substance, solid, n.o.s. (Uniconazole)"

LKT C2946 Chlorambucil 100 mg 24.8 Nitrogen mustard, DNA alkylator. 4-[Bis(2-chloroethyl)amino]benzenebutanoic acid Amboclorin; Leukeran 305-03-3 ≥98% 304.21 C14H19Cl2NO2 C1=CC(=CC=C1CCCC(=O)O)N(CCCl)CCCl Ambient 4°C Soluble in alcohol, chloroform or acetone (500 mg/mL). Insoluble in water. "Begleiter A, Mowat M, Israels LG, et al. Chlorambucil in chronic lymphocytic leukemia: mechanism of action. Leuk Lymphoma. 1996 Oct;23(3-4):187-201. PMID: 9031099.

Kundu GC, Schullek JR, Wilson IB. The alkylating properties of chlorambucil. Pharmacol Biochem Behav. 1994 Nov;49(3):621-4. PMID: 7862715.

" Carc., T, Xi "UN number: 2811 Class: 6.1 Packing Group: III

Proper shipping name: Toxic solids, organic, n.o.s. (Chlorambucil)

Reportable Quantity (RQ): 10 lbs. Poison inhalation hazard: No"

LKT U0618 Ubenimex 10 mg 81 Dipeptide; aminopeptidase (N/CD13) inhibitor. N-[(2S,3R)-3-Amino-2-hydroxy-1-oxo-4phenylbutyl]-L-leucine Bestatin 58970-76-6 ≥98% 308.37 C16H24N2O4 CC(C)CC(C(=O)O)NC(=O)C(C(CC1=CC=CC=C1)N)O Ambient -20°C Soluble in acetic acid, DMSO and methanol. Less soluble in water. Insoluble in ethyl acetate, benzene, hexane and chloroform. "Hitzerd SM, Verbrugge SE, Ossenkoppele G, et al. Positioning of aminopeptidase inhibitors in next generation cancer therapy. Amino Acids. 2014 Apr;46(4):793-808. PMID: 24385243.

Qian X, He J, Zhao Y, et al. Inhibition of p38 MAPK Phosphorylation Is Critical for Bestatin to Enhance ATRA-Induced Cell Differentiation in Acute Promyelocytic Leukemia NB4 Cells. Am J Ther. 2013 Oct 17. [Epub ahead of print]. PMID: 24141198.

Jia MR, Wei T, Xu WF. The Analgesic Activity of Bestatin as a Potent APN Inhibitor. Front Neurosci. 2010 Jun 28;4:50. PMID: 20631848.

" None Not dangerous goods.

LKT U0618 Ubenimex 50 mg 335.1 Dipeptide; aminopeptidase (N/CD13) inhibitor. N-[(2S,3R)-3-Amino-2-hydroxy-1-oxo-4phenylbutyl]-L-leucine Bestatin 58970-76-6 ≥98% 308.37 C16H24N2O4 CC(C)CC(C(=O)O)NC(=O)C(C(CC1=CC=CC=C1)N)O Ambient -20°C Soluble in acetic acid, DMSO and methanol. Less soluble in water. Insoluble in ethyl acetate, benzene, hexane and chloroform. "Hitzerd SM, Verbrugge SE, Ossenkoppele G, et al. Positioning of aminopeptidase inhibitors in next generation cancer therapy. Amino Acids. 2014 Apr;46(4):793-808. PMID: 24385243.

Jia MR, Wei T, Xu WF. The Analgesic Activity of Bestatin as a Potent APN Inhibitor. Front Neurosci. 2010 Jun 28;4:50. PMID: 20631848.

" None Not dangerous goods.

LKT U0618 Ubenimex 100 mg 520 Dipeptide; aminopeptidase (N/CD13) inhibitor. N-[(2S,3R)-3-Amino-2-hydroxy-1-oxo-4phenylbutyl]-L-leucine Bestatin 58970-76-6 ≥98% 308.37 C16H24N2O4 CC(C)CC(C(=O)O)NC(=O)C(C(CC1=CC=CC=C1)N)O Ambient -20°C Soluble in acetic acid, DMSO and methanol. Less soluble in water. Insoluble in ethyl acetate, benzene, hexane and chloroform. "Hitzerd SM, Verbrugge SE, Ossenkoppele G, et al. Positioning of aminopeptidase inhibitors in next generation cancer therapy. Amino Acids. 2014 Apr;46(4):793-808. PMID: 24385243.

Jia MR, Wei T, Xu WF. The Analgesic Activity of Bestatin as a Potent APN Inhibitor. Front Neurosci. 2010 Jun 28;4:50. PMID: 20631848.

" None Not dangerous goods.

LKT C2946 Chlorambucil 500 mg 50.6 Nitrogen mustard, DNA alkylator. 4-[Bis(2-chloroethyl)amino]benzenebutanoic acid Amboclorin; Leukeran 305-03-3 ≥98% 304.21 C14H19Cl2NO2 C1=CC(=CC=C1CCCC(=O)O)N(CCCl)CCCl Ambient 4°C Soluble in alcohol, chloroform or acetone (500 mg/mL). Insoluble in water. "Begleiter A, Mowat M, Israels LG, et al. Chlorambucil in chronic lymphocytic leukemia: mechanism of action. Leuk Lymphoma. 1996 Oct;23(3-4):187-201. PMID: 9031099.

Kundu GC, Schullek JR, Wilson IB. The alkylating properties of chlorambucil. Pharmacol Biochem Behav. 1994 Nov;49(3):621-4. PMID: 7862715.

" Carc., T, Xi "UN number: 2811 Class: 6.1 Packing Group: III

Proper shipping name: Toxic solids, organic, n.o.s. (Chlorambucil)

Reportable Quantity (RQ): 10 lbs. Poison inhalation hazard: No"

LKT C2946 Chlorambucil 1 g 71.6 Nitrogen mustard, DNA alkylator. 4-[Bis(2-chloroethyl)amino]benzenebutanoic acid Amboclorin; Leukeran 305-03-3 ≥98% 304.21 C14H19Cl2NO2 C1=CC(=CC=C1CCCC(=O)O)N(CCCl)CCCl Ambient 4°C Soluble in alcohol, chloroform or acetone (500 mg/mL). Insoluble in water. "Begleiter A, Mowat M, Israels LG, et al. Chlorambucil in chronic lymphocytic leukemia: mechanism of action. Leuk Lymphoma. 1996 Oct;23(3-4):187-201. PMID: 9031099.

Kundu GC, Schullek JR, Wilson IB. The alkylating properties of chlorambucil. Pharmacol Biochem Behav. 1994 Nov;49(3):621-4. PMID: 7862715.

" Carc., T, Xi "UN number: 2811 Class: 6.1 Packing Group: III

Proper shipping name: Toxic solids, organic, n.o.s. (Chlorambucil)

Reportable Quantity (RQ): 10 lbs. Poison inhalation hazard: No"

LKT C2946 Chlorambucil 10 g 590.4 Nitrogen mustard, DNA alkylator. 4-[Bis(2-chloroethyl)amino]benzenebutanoic acid Amboclorin; Leukeran 305-03-3 ≥98% 304.21 C14H19Cl2NO2 C1=CC(=CC=C1CCCC(=O)O)N(CCCl)CCCl Ambient 4°C Soluble in alcohol, chloroform or acetone (500 mg/mL). Insoluble in water. "Begleiter A, Mowat M, Israels LG, et al. Chlorambucil in chronic lymphocytic leukemia: mechanism of action. Leuk Lymphoma. 1996 Oct;23(3-4):187-201. PMID: 9031099.

Kundu GC, Schullek JR, Wilson IB. The alkylating properties of chlorambucil. Pharmacol Biochem Behav. 1994 Nov;49(3):621-4. PMID: 7862715.

" Carc., T, Xi "UN number: 2811 Class: 6.1 Packing Group: III

Proper shipping name: Toxic solids, organic, n.o.s. (Chlorambucil)

Reportable Quantity (RQ): 10 lbs. Poison inhalation hazard: No"

LKT T9974 [Asp371]-Tyrosinase (369-377), human 1 mg 168 Proteasome antigen. 9002-10-2 ≥98% 1031.2 C42H66N10O16S2 Ambient -20°C "Guillaume B, Stroobant V, Bousquet-Dubouch MP, et al. Analysis of the processing of seven human tumor antigens by intermediate proteasomes. J Immunol. 2012 Oct 1;189(7):3538-47. PMID: 22925930.

Mitchell MS, Darrah D, Yeung D, et al. Phase I trial of adoptive immunotherapy with cytolytic T lymphocytes immunized against a tyrosinase epitope. J Clin Oncol. 2002 Feb 15;20(4):1075-86. PMID: 11844833.

" Not dangerous goods.

LKT C2947 Chlorpromazine Hydrochloride 10 g 51.8 Phenothiazine, FIASMA; D1/2/3/4, 5-HT1/2, M1/2 mAChR, α1/2-adrenergic antagonist. 2-Chloro-N,N-dimethyl-10H-phenothiazine-10- propanamine hydrochloride Hebanil; Klorpromex; Largactil; Megaphen; Promacid; Chloractil; Sonazine; Marazine; Taroctyl; Torazina 69-09-0 ≥98% 355.33 C17H19ClN2S HCl CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl.Cl Ambient Ambient Soluble in methanol, ethanol (660 mg/mL), chloroform or water (1 g/mL). Insoluble in ether, or benzene. "Baral PK, Swayampakula M, Rout MK, et al. Structural basis of prion inhibition by phenothiazine compounds. Structure. 2014 Feb 4;22(2):291-303. PMID: 24373770.

Ramos MA. Drugs in context: a historical perspective on theories of psychopharmaceutical efficacy. J Nerv Ment Dis. 2013 Nov;201(11):926-33. PMID: 24177478.

Shin SY, Lee KS, Choi YK, et al. The antipsychotic agent chlorpromazine induces autophagic cell death by inhibiting the Akt/mTOR pathway in human U-87MG glioma cells. Carcinogenesis. 2013 Sep;34(9):2080-9. PMID: 23689352.

Baumeister AA. The chlorpromazine enigma. J Hist Neurosci. 2013;22(1):14-29. PMID: 23323529.

Kornhuber J, Muehlbacher M, Trapp S, et al. Identification of novel functional inhibitors of acid sphingomyelinase. PLoS One. 2011;6(8):e23852. PMID: 21909365.

Peroutka SJ, Synder SH. Relationship of neuroleptic drug effects at brain dopamine, serotonin, alpha-adrenergic, and histamine receptors to clinical potency. Am J Psychiatry. 1980 Dec;137(12):1518-22. PMID: 6108081.

Masuda K, Kimura A, Hanieh H, et al. Aryl hydrocarbon receptor negatively regulates LPS-induced IL-6 production through suppression of histamine production in macrophages. Int Immunol. 2011 Oct;23(10):637-645. PMID: 21930594.

" T+ "UN number: 2811 Class: 6.1 Packing group: I

Proper shipping name: Toxic solids, organic, n.o.s. (Chlorpromazine hydrochloride)

Marine pollutant: No Poison inhalation hazard: No"

LKT C2947 Chlorpromazine Hydrochloride 25 g 72.2 Phenothiazine, FIASMA; D1/2/3/4, 5-HT1/2, M1/2 mAChR, α1/2-adrenergic antagonist. 2-Chloro-N,N-dimethyl-10H-phenothiazine-10- propanamine hydrochloride Hebanil; Klorpromex; Largactil; Megaphen; Promacid; Chloractil; Sonazine; Marazine; Taroctyl; Torazina 69-09-0 ≥98% 355.33 C17H19ClN2S HCl CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl.Cl Ambient Ambient Soluble in methanol, ethanol (660 mg/mL), chloroform or water (1 g/mL). Insoluble in ether, or benzene. "Baral PK, Swayampakula M, Rout MK, et al. Structural basis of prion inhibition by phenothiazine compounds. Structure. 2014 Feb 4;22(2):291-303. PMID: 24373770.

Ramos MA. Drugs in context: a historical perspective on theories of psychopharmaceutical efficacy. J Nerv Ment Dis. 2013 Nov;201(11):926-33. PMID: 24177478.

Baumeister AA. The chlorpromazine enigma. J Hist Neurosci. 2013;22(1):14-29. PMID: 23323529.

Kornhuber J, Muehlbacher M, Trapp S, et al. Identification of novel functional inhibitors of acid sphingomyelinase. PLoS One. 2011;6(8):e23852. PMID: 21909365.

" T+ "UN number: 2811 Class: 6.1 Packing group: I

Proper shipping name: Toxic solids, organic, n.o.s. (Chlorpromazine hydrochloride)

Marine pollutant: No Poison inhalation hazard: No"

LKT C2947 Chlorpromazine Hydrochloride 100 g 216.4 Phenothiazine, FIASMA; D1/2/3/4, 5-HT1/2, M1/2 mAChR, α1/2-adrenergic antagonist. 2-Chloro-N,N-dimethyl-10H-phenothiazine-10- propanamine hydrochloride Hebanil; Klorpromex; Largactil; Megaphen; Promacid; Chloractil; Sonazine; Marazine; Taroctyl; Torazina 69-09-0 ≥98% 355.33 C17H19ClN2S HCl CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl.Cl Ambient Ambient Soluble in methanol, ethanol (660 mg/mL), chloroform or water (1 g/mL). Insoluble in ether, or benzene. "Baral PK, Swayampakula M, Rout MK, et al. Structural basis of prion inhibition by phenothiazine compounds. Structure. 2014 Feb 4;22(2):291-303. PMID: 24373770.

Ramos MA. Drugs in context: a historical perspective on theories of psychopharmaceutical efficacy. J Nerv Ment Dis. 2013 Nov;201(11):926-33. PMID: 24177478.

Baumeister AA. The chlorpromazine enigma. J Hist Neurosci. 2013;22(1):14-29. PMID: 23323529.

Kornhuber J, Muehlbacher M, Trapp S, et al. Identification of novel functional inhibitors of acid sphingomyelinase. PLoS One. 2011;6(8):e23852. PMID: 21909365.

" T+ "UN number: 2811 Class: 6.1 Packing group: I

Proper shipping name: Toxic solids, organic, n.o.s. (Chlorpromazine hydrochloride)

Marine pollutant: No Poison inhalation hazard: No"

LKT T9970 Tyrphostin AG1295 1 mg 63.8 PDGFR inhibitor. 6,7-Dimethyl-2-phenylquinoxaline 70897-07-9 ≥98% 234.3 C16H14N2 CC(C1C2CC(=C(N2C1=O)C(=O)O)C3=CC4=CC=CC=C4C=C3)O Ambient -20°C Soluble in DMSO. "Zheng Y, Ikuno Y, Ohj M, et al. Platelet-derived growth factor receptor kinase inhibitor AG1295 and inhibition of experimental proliferative vitreoretinopathy. Jpn J Ophthalmol. 2003 Mar-Apr;47(2):158-65. PMID: 12738549.

Banai S, Wolf Y, Golomb G, et al. PDGF-receptor tyrosine kinase blocker AG1295 selectively attenuates smooth muscle cell growth in vitro and reduces neointimal formation after balloon angioplasty in swine. Circulation. 1998 May 19;97(19):1960-9. PMID: 9609090.

" Not dangerous goods.

LKT T9970 Tyrphostin AG1295 5 mg 165.5 PDGFR inhibitor. 6,7-Dimethyl-2-phenylquinoxaline 70897-07-9 ≥98% 234.3 C16H14N2 CC(C1C2CC(=C(N2C1=O)C(=O)O)C3=CC4=CC=CC=C4C=C3)O Ambient -20°C Soluble in DMSO. "Zheng Y, Ikuno Y, Ohj M, et al. Platelet-derived growth factor receptor kinase inhibitor AG1295 and inhibition of experimental proliferative vitreoretinopathy. Jpn J Ophthalmol. 2003 Mar-Apr;47(2):158-65. PMID: 12738549.

" Not dangerous goods.

LKT C2948 Chloroadenosine 5 mg 38.1 Nucleoside (adenosine) analog; DNA chain terminator, adenosine agonist. 2-Chloroadenosine; 2-CADO; 6-Amino-2-chloropurine riboside 146-77-0 ≥98% 301.69 C10H12ClN5O4 C1=NC2=C(N1C3C(C(C(O3)CO)O)O)N=C(N=C2N)Cl Ambient Ambient Soluble in methanol. "Duan HY, Cao JX, Qi JJ, et al. E2F1 enhances 8-chloro-adenosine-induced G2/M arrest and apoptosis in A549 and H1299 lung cancer cells. Biochemistry (Mosc). 2012 Mar;77(3):261-9. PMID: 22803943.

Bender SB, Tune JD, Borbouse L, et al. Altered mechanism of adenosine-induced coronary arteriolar dilation in early-stage metabolic syndrome. Exp Biol Med (Maywood). 2009 Jun;234(6):683-92. PMID: 19307464.

Sakamaki F, Ishizaka A, Urano T, et al. Attenuation by intravenous 2-chloroadenosine of acute lung injury induced by live escherichia coli or latex particles added to endotoxin in the neutropenic state. J Lab Clin Med. 2003 Aug;142(2):128-35. PMID: 12960960.

" None Not dangerous goods.

LKT C2948 Chloroadenosine 10 mg 47.6 Nucleoside (adenosine) analog; DNA chain terminator, adenosine agonist. 2-Chloroadenosine; 2-CADO; 6-Amino-2-chloropurine riboside 146-77-0 ≥98% 301.69 C10H12ClN5O4 C1=NC2=C(N1C3C(C(C(O3)CO)O)O)N=C(N=C2N)Cl Ambient Ambient Soluble in methanol. "Duan HY, Cao JX, Qi JJ, et al. E2F1 enhances 8-chloro-adenosine-induced G2/M arrest and apoptosis in A549 and H1299 lung cancer cells. Biochemistry (Mosc). 2012 Mar;77(3):261-9. PMID: 22803943.

" None Not dangerous goods.

LKT C2948 Chloroadenosine 50 mg 129 Nucleoside (adenosine) analog; DNA chain terminator, adenosine agonist. 2-Chloroadenosine; 2-CADO; 6-Amino-2-chloropurine riboside 146-77-0 ≥98% 301.69 C10H12ClN5O4 C1=NC2=C(N1C3C(C(C(O3)CO)O)O)N=C(N=C2N)Cl Ambient Ambient Soluble in methanol. "Duan HY, Cao JX, Qi JJ, et al. E2F1 enhances 8-chloro-adenosine-induced G2/M arrest and apoptosis in A549 and H1299 lung cancer cells. Biochemistry (Mosc). 2012 Mar;77(3):261-9. PMID: 22803943.

" None Not dangerous goods.

LKT T9969 Tyrphostin AG490 5 mg 89.6 JAK2 inhibitor, potential EGFR inhibitor. N-Benzyl-3,4-dihydroxy-benzylidenecyanoacetamide Tyrphostin B42 133550-30-8 ≥98% 294.31 C17H14N2O3 C1=CC=C(C=C1)CNC(=O)C(=CC2=CC(=C(C=C2)O)O)C#N Ambient 4°C Soluble in DMSO. "Gyurkovska V, Stefanova T, Dimitrova P, et al. Tyrosine Kinase Inhibitor Tyrphostin AG490 Retards Chronic Joint Inflammation in Mice. Inflammation. 2014 Aug;37(4):995-1005. PMID: 24473905.

Davoodi-Semiromi A, Hassanzadeh A, Wasserfall CH, et al. Tyrphostin AG490 agent modestly but significantly prevents onset of type 1 in NOD mouse; implication of immunologic and metabolic effects of a Jak-Stat pathway inhibitor. J Clin Immunol. 2012 Oct;32(5):1038-47. PMID: 22661285.

Fenyo IM, Florea IC, Raicu M, et al. Tyrphostin AG490 reduces NAPDH oxidase activity and expression in the aorta of hypercholesterolemic apolipoprotein E-deficient mice. Vascul Pharmacol. 2011 Mar-Jun;54(3-6):100-6. PMID: 21457788.

Wang S, Yang N, Zhang L, et al. Jak/STAT signaling is involved in the inflammatory infiltration of the kidneys in MRL/lpr mice. Lupus. 2010 Sep;19(10):1171-80. PMID: 20501525.

Caceres-Cortes JR. A potent anti-carcinoma and anti-acute myeloblastic leukemia agent, AG490. Anticancer Agents Med Chem. 2008 Oct;8(7):717-22. PMID: 18855573.

" Xi "UN number: 2811 Class: 6.1 Packaging group: III

Proper shipping name: Toxic solids, organic, n.o.s. (Tyrphostin AG490) Marine pollutant: No Poison Inhalation Hazard: No"

LKT T9969 Tyrphostin AG490 10 mg 153.2 JAK2 inhibitor, potential EGFR inhibitor. N-Benzyl-3,4-dihydroxy-benzylidenecyanoacetamide Tyrphostin B42 133550-30-8 ≥98% 294.31 C17H14N2O3 C1=CC=C(C=C1)CNC(=O)C(=CC2=CC(=C(C=C2)O)O)C#N Ambient 4°C Soluble in DMSO. "Gyurkovska V, Stefanova T, Dimitrova P, et al. Tyrosine Kinase Inhibitor Tyrphostin AG490 Retards Chronic Joint Inflammation in Mice. Inflammation. 2014 Aug;37(4):995-1005. PMID: 24473905.

Wang S, Yang N, Zhang L, et al. Jak/STAT signaling is involved in the inflammatory infiltration of the kidneys in MRL/lpr mice. Lupus. 2010 Sep;19(10):1171-80. PMID: 20501525.

Caceres-Cortes JR. A potent anti-carcinoma and anti-acute myeloblastic leukemia agent, AG490. Anticancer Agents Med Chem. 2008 Oct;8(7):717-22. PMID: 18855573.

" Xi "UN number: 2811 Class: 6.1 Packaging group: III

Proper shipping name: Toxic solids, organic, n.o.s. (Tyrphostin AG490) Marine pollutant: No Poison Inhalation Hazard: No"

LKT T9969 Tyrphostin AG490 25 mg 341.5 JAK2 inhibitor, potential EGFR inhibitor. N-Benzyl-3,4-dihydroxy-benzylidenecyanoacetamide Tyrphostin B42 133550-30-8 ≥98% 294.31 C17H14N2O3 C1=CC=C(C=C1)CNC(=O)C(=CC2=CC(=C(C=C2)O)O)C#N Ambient 4°C Soluble in DMSO. "Gyurkovska V, Stefanova T, Dimitrova P, et al. Tyrosine Kinase Inhibitor Tyrphostin AG490 Retards Chronic Joint Inflammation in Mice. Inflammation. 2014 Aug;37(4):995-1005. PMID: 24473905.

Wang S, Yang N, Zhang L, et al. Jak/STAT signaling is involved in the inflammatory infiltration of the kidneys in MRL/lpr mice. Lupus. 2010 Sep;19(10):1171-80. PMID: 20501525.

Caceres-Cortes JR. A potent anti-carcinoma and anti-acute myeloblastic leukemia agent, AG490. Anticancer Agents Med Chem. 2008 Oct;8(7):717-22. PMID: 18855573.

" Xi "UN number: 2811 Class: 6.1 Packaging group: III

Proper shipping name: Toxic solids, organic, n.o.s. (Tyrphostin AG490) Marine pollutant: No Poison Inhalation Hazard: No"

LKT C2949 Chlorpheniramine Maleate 5 g 33.9 Alkylamine; histamine H1 antagonist, SERT and NET inhibitor. ψ-(4-Chlorophenyl)-N,N-dimethyl-2-pyridine- propanamine Maleate Allergisan; Anntagonate; Cloropiril; Histadur; Lorphen; Teldrin ≥98% 390.87 C16H19ClN2 C4H4O4 CN(C)CCC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2.C(=CC(=O)O)C(=O)O Ambient Ambient Soluble in water (250 mg/mL) and ethanol (100 mg/mL). "Gianlorenço AC, Serafim KR, Canto-de-Souza A, et al. Emotional memory consolidation impairment induced by histamine is mediated by H1 but not H2 receptors. Brain Res Bull. 2012 Dec 1;89(5-6):197-202. PMID: 22986235.

Hellbom E. Chlorpheniramine, selective serotonin-reuptake inhibitors (SSRIs) and over-the-counter (OTC) treatment. Med Hypotheses. 2006;66(4):689-90. PMID: 16413139.

" T "UN number: 2811 Class: 6.1 Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (Chlorpheniramine maleate)"

LKT C2949 Chlorpheniramine Maleate 25 g 67.9 Alkylamine; histamine H1 antagonist, SERT and NET inhibitor. ψ-(4-Chlorophenyl)-N,N-dimethyl-2-pyridine- propanamine Maleate Allergisan; Anntagonate; Cloropiril; Histadur; Lorphen; Teldrin ≥98% 390.87 C16H19ClN2 C4H4O4 CN(C)CCC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2.C(=CC(=O)O)C(=O)O Ambient Ambient Soluble in water (250 mg/mL) and ethanol (100 mg/mL). "Gianlorenço AC, Serafim KR, Canto-de-Souza A, et al. Emotional memory consolidation impairment induced by histamine is mediated by H1 but not H2 receptors. Brain Res Bull. 2012 Dec 1;89(5-6):197-202. PMID: 22986235.

Hellbom E. Chlorpheniramine, selective serotonin-reuptake inhibitors (SSRIs) and over-the-counter (OTC) treatment. Med Hypotheses. 2006;66(4):689-90. PMID: 16413139.

" T "UN number: 2811 Class: 6.1 Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (Chlorpheniramine maleate)"

LKT C2949 Chlorpheniramine Maleate 100 g 163.2 Alkylamine; histamine H1 antagonist, SERT and NET inhibitor. ψ-(4-Chlorophenyl)-N,N-dimethyl-2-pyridine- propanamine Maleate Allergisan; Anntagonate; Cloropiril; Histadur; Lorphen; Teldrin ≥98% 390.87 C16H19ClN2 C4H4O4 CN(C)CCC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2.C(=CC(=O)O)C(=O)O Ambient Ambient Soluble in water (250 mg/mL) and ethanol (100 mg/mL). "Gianlorenço AC, Serafim KR, Canto-de-Souza A, et al. Emotional memory consolidation impairment induced by histamine is mediated by H1 but not H2 receptors. Brain Res Bull. 2012 Dec 1;89(5-6):197-202. PMID: 22986235.

Hellbom E. Chlorpheniramine, selective serotonin-reuptake inhibitors (SSRIs) and over-the-counter (OTC) treatment. Med Hypotheses. 2006;66(4):689-90. PMID: 16413139.

" T "UN number: 2811 Class: 6.1 Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (Chlorpheniramine maleate)"

LKT C2950 Chloroquine Diphosphate 25 g 57.8 Aminoquinoline, binds heme, causes cell lysis. N4-(7-Chloro-4-quinolinyl)-N1,N1-diethyl-1,4- pentanediamine diphophate Chloroquine diphosphate; Arechin; Avloclor; Malaquin; Tresochin 50-63-5 ≥98% 515.87 C18H26ClN32H3PO4 CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl.OP(=O)(O)O.OP(=O)(O)O Ambient Ambient Soluble in water. "Liang X, Tang J, Liang Y, et al. Suppression of autophagy by chloroquine sensitizes 5-fluorouracil-mediated cell death in gallbladder carcinoma cells. Cell Biosci. 2014 Mar 3;4(1):10. PMID: 24581180.

Hempelmann E. Hemozoin biocrystallization in Plasmodium falciparum and the antimalarial activity of crystallization inhibitors. Parasitol Res. 2007 Mar;100(4):671-6. PMID: 17111179.

Savarino A, Boelaert JR, Cassone A, et al. Effects of chloroquine on viral infections: an old drug against today's diseases? Lancet Infect Dis. 2003 Nov;3(11):722-7. PMID: 14592603.

" Xn Not dangerous goods.

LKT C2950 Chloroquine Diphosphate 50 g 111 Aminoquinoline, binds heme, causes cell lysis. N4-(7-Chloro-4-quinolinyl)-N1,N1-diethyl-1,4- pentanediamine diphophate Chloroquine diphosphate; Arechin; Avloclor; Malaquin; Tresochin 50-63-5 ≥98% 515.87 C18H26ClN32H3PO4 CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl.OP(=O)(O)O.OP(=O)(O)O Ambient Ambient Soluble in water. "Liang X, Tang J, Liang Y, et al. Suppression of autophagy by chloroquine sensitizes 5-fluorouracil-mediated cell death in gallbladder carcinoma cells. Cell Biosci. 2014 Mar 3;4(1):10. PMID: 24581180.

Hempelmann E. Hemozoin biocrystallization in Plasmodium falciparum and the antimalarial activity of crystallization inhibitors. Parasitol Res. 2007 Mar;100(4):671-6. PMID: 17111179.

Savarino A, Boelaert JR, Cassone A, et al. Effects of chloroquine on viral infections: an old drug against today's diseases? Lancet Infect Dis. 2003 Nov;3(11):722-7. PMID: 14592603.

" Xn Not dangerous goods.

LKT C2950 Chloroquine Diphosphate 100 g 161.9 Aminoquinoline, binds heme, causes cell lysis. N4-(7-Chloro-4-quinolinyl)-N1,N1-diethyl-1,4- pentanediamine diphophate Chloroquine diphosphate; Arechin; Avloclor; Malaquin; Tresochin 50-63-5 ≥98% 515.87 C18H26ClN32H3PO4 CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl.OP(=O)(O)O.OP(=O)(O)O Ambient Ambient Soluble in water. "Liang X, Tang J, Liang Y, et al. Suppression of autophagy by chloroquine sensitizes 5-fluorouracil-mediated cell death in gallbladder carcinoma cells. Cell Biosci. 2014 Mar 3;4(1):10. PMID: 24581180.

Hempelmann E. Hemozoin biocrystallization in Plasmodium falciparum and the antimalarial activity of crystallization inhibitors. Parasitol Res. 2007 Mar;100(4):671-6. PMID: 17111179.

Savarino A, Boelaert JR, Cassone A, et al. Effects of chloroquine on viral infections: an old drug against today's diseases? Lancet Infect Dis. 2003 Nov;3(11):722-7. PMID: 14592603.

" Xn Not dangerous goods.

LKT T9968 Tyrphostin A25 5 mg 76.9 SK K+ channel blocker, EGFR inhibitor. (3,4,5-Trihydroxybenzylidene)malononitrile Tyrphostin 25; RG-50875 118409-58-8 ≥98% 202.17 C10H6N2O3 C1=C(C=C(C(=C1O)O)O)C=C(C#N)C#N Ambient 4°C Soluble in DMSO or ethanol. "Wu W, Sun HY, Deng XL, et al. EGFR tyrosine kinase regulates human small-conductance Ca2+-activated K+ (hSKCa1) channels expressed in HEK-293 cells. Biochem J. 2013 May 15;452(1):121-9. PMID: 23496660.

Nguyen J, Gogusev J, Knapnougel P, et al. Protein tyrosine kinase and p38 MAP kinase pathways are involved in stimulation of matrix metalloproteinase-9 by TNF-alpha in human monocytes. Immunol Lett. 2006 Jul 15;106(1):34-41. PMID: 16720051.

" Xi Not dangerous goods.

LKT T9968 Tyrphostin A25 25 mg 263.7 SK K+ channel blocker, EGFR inhibitor. (3,4,5-Trihydroxybenzylidene)malononitrile Tyrphostin 25; RG-50875 118409-58-8 ≥98% 202.17 C10H6N2O3 C1=C(C=C(C(=C1O)O)O)C=C(C#N)C#N Ambient 4°C Soluble in DMSO or ethanol. "Wu W, Sun HY, Deng XL, et al. EGFR tyrosine kinase regulates human small-conductance Ca2+-activated K+ (hSKCa1) channels expressed in HEK-293 cells. Biochem J. 2013 May 15;452(1):121-9. PMID: 23496660.

" Xi Not dangerous goods.

LKT T9946 Tylosin Phosphate 1 g 32.4 Macrolide; peptidyl transferase inhibitor, protein translation inhibitor. Farmazin TB; Tylosin phophate salt 1405-53-4 ≥90% 1014.11 C46H77NO17 H3PO4 CCC1C(C=C(C=CC(=O)C(CC(C(C(C(CC(=O)O1)O)C)OC2C(C(C(C(O2)C)OC3CC(C(C(O3)C)O)(C)O)N(C)C)O)CC=O)C)C)COC4C(C(C(C(O4)C)O)OC)OC.OP(=O)(O)O Ambient Ambient Soluble in water, alcohol or chloroform. "Liu M, Douthwaite S. Resistance to the macrolide antibiotic tylosin is conferred by single methylations at 23S rRNA nucleotides G748 and A2058 acting in synergy. Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14658-63. PMID: 12417742.

Zalacain M, Cundliffe E. Methylation of 23S rRNA caused by tlrA (ermSF), a tylosin resistance determinant from Streptomyces fradiae. J Bacteriol. 1989 Aug;171(8):4254-60. PMID: 2753855.

" Not dangerous goods.

LKT T9946 Tylosin Phosphate 5 g 92.5 Macrolide; peptidyl transferase inhibitor, protein translation inhibitor. Farmazin TB; Tylosin phophate salt 1405-53-4 ≥90% 1014.11 C46H77NO17 H3PO4 CCC1C(C=C(C=CC(=O)C(CC(C(C(C(CC(=O)O1)O)C)OC2C(C(C(C(O2)C)OC3CC(C(C(O3)C)O)(C)O)N(C)C)O)CC=O)C)C)COC4C(C(C(C(O4)C)O)OC)OC.OP(=O)(O)O Ambient Ambient Soluble in water, alcohol or chloroform. "Liu M, Douthwaite S. Resistance to the macrolide antibiotic tylosin is conferred by single methylations at 23S rRNA nucleotides G748 and A2058 acting in synergy. Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14658-63. PMID: 12417742.

Zalacain M, Cundliffe E. Methylation of 23S rRNA caused by tlrA (ermSF), a tylosin resistance determinant from Streptomyces fradiae. J Bacteriol. 1989 Aug;171(8):4254-60. PMID: 2753855.

" Not dangerous goods.

LKT T9946 Tylosin Phosphate 10 g 161.9 Macrolide; peptidyl transferase inhibitor, protein translation inhibitor. Farmazin TB; Tylosin phophate salt 1405-53-4 ≥90% 1014.11 C46H77NO17 H3PO4 CCC1C(C=C(C=CC(=O)C(CC(C(C(C(CC(=O)O1)O)C)OC2C(C(C(C(O2)C)OC3CC(C(C(O3)C)O)(C)O)N(C)C)O)CC=O)C)C)COC4C(C(C(C(O4)C)O)OC)OC.OP(=O)(O)O Ambient Ambient Soluble in water, alcohol or chloroform. "Liu M, Douthwaite S. Resistance to the macrolide antibiotic tylosin is conferred by single methylations at 23S rRNA nucleotides G748 and A2058 acting in synergy. Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14658-63. PMID: 12417742.

Zalacain M, Cundliffe E. Methylation of 23S rRNA caused by tlrA (ermSF), a tylosin resistance determinant from Streptomyces fradiae. J Bacteriol. 1989 Aug;171(8):4254-60. PMID: 2753855.

" Not dangerous goods.

LKT T9945 Tylosin Tartrate 1 g 32.4 Macrolide; peptidyl transferase inhibitor, protein translation inhibitor. (R-(R*,R*))-2,3-dihydroxybutanedioate Tylosin (salt) Pharmasin 1405-54-5 ≥90% 1066.2 C46H77NO17 C4H4O6 CCC1C(C=C(C=CC(=O)C(CC(C(C(C(CC(=O)O1)O)C)OC2C(C(C(C(O2)C)OC3CC(C(C(O3)C)O)(C)O)N(C)C)O)CC=O)C)C)COC4C(C(C(C(O4)C)O)OC)OC.C(C(C(=O)O)O)(C(=O)O)O Ambient Ambient Soluble in water. "Liu M, Douthwaite S. Resistance to the macrolide antibiotic tylosin is conferred by single methylations at 23S rRNA nucleotides G748 and A2058 acting in synergy. Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14658-63. PMID: 12417742.

Zalacain M, Cundliffe E. Methylation of 23S rRNA caused by tlrA (ermSF), a tylosin resistance determinant from Streptomyces fradiae. J Bacteriol. 1989 Aug;171(8):4254-60. PMID: 2753855.

" Not dangerous goods.

LKT T9945 Tylosin Tartrate 5 g 92.5 Macrolide; peptidyl transferase inhibitor, protein translation inhibitor. (R-(R*,R*))-2,3-dihydroxybutanedioate Tylosin (salt) Pharmasin 1405-54-5 ≥90% 1066.2 C46H77NO17 C4H4O6 CCC1C(C=C(C=CC(=O)C(CC(C(C(C(CC(=O)O1)O)C)OC2C(C(C(C(O2)C)OC3CC(C(C(O3)C)O)(C)O)N(C)C)O)CC=O)C)C)COC4C(C(C(C(O4)C)O)OC)OC.C(C(C(=O)O)O)(C(=O)O)O Ambient Ambient Soluble in water. "Liu M, Douthwaite S. Resistance to the macrolide antibiotic tylosin is conferred by single methylations at 23S rRNA nucleotides G748 and A2058 acting in synergy. Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14658-63. PMID: 12417742.

Zalacain M, Cundliffe E. Methylation of 23S rRNA caused by tlrA (ermSF), a tylosin resistance determinant from Streptomyces fradiae. J Bacteriol. 1989 Aug;171(8):4254-60. PMID: 2753855.

" Not dangerous goods.

LKT T9945 Tylosin Tartrate 10 g 161.9 Macrolide; peptidyl transferase inhibitor, protein translation inhibitor. (R-(R*,R*))-2,3-dihydroxybutanedioate Tylosin (salt) Pharmasin 1405-54-5 ≥90% 1066.2 C46H77NO17 C4H4O6 CCC1C(C=C(C=CC(=O)C(CC(C(C(C(CC(=O)O1)O)C)OC2C(C(C(C(O2)C)OC3CC(C(C(O3)C)O)(C)O)N(C)C)O)CC=O)C)C)COC4C(C(C(C(O4)C)O)OC)OC.C(C(C(=O)O)O)(C(=O)O)O Ambient Ambient Soluble in water. "Liu M, Douthwaite S. Resistance to the macrolide antibiotic tylosin is conferred by single methylations at 23S rRNA nucleotides G748 and A2058 acting in synergy. Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14658-63. PMID: 12417742.

Zalacain M, Cundliffe E. Methylation of 23S rRNA caused by tlrA (ermSF), a tylosin resistance determinant from Streptomyces fradiae. J Bacteriol. 1989 Aug;171(8):4254-60. PMID: 2753855.

" Not dangerous goods.

LKT M9368 Myristicin 100 mg 138.9 Allylbenzene found in spices and umbelliferous plants. 4-Methoxy-6-(2-propenyl)-1,3-benzodioxole 5-Allyl-1-methoxy-2,3-(methylenedioxy)benzene 607-91-0 ≥97% 192.21 C11H12O3 COC1=CC(=CC2=C1OCO2)CC=C Ambient -20°C "Insoluble in water (46 mg/L). Soluble in ethanol, or acetone.

Density:1.1416" "Martins C, Doran C, Silva IC, et al. Myristicin from nutmeg induces apoptosis via the mitochondrial pathway and down regulates genes of the DNA damage response pathways in human leukaemia K562 cells. Chem Biol Interact. 2014 Jul 25;218:1-9. PMID: 24792648.

Lim HJ, Woo KW, Lee KR, et al. Inhibition of Proinflammatory Cytokine Generation in Lung Inflammation by the Leaves of Perilla frutescens and Its Constituents. Biomol Ther (Seoul). 2014 Jan;22(1):62-7. PMID: 24596623.

Fraternale D, Genovese S, Ricci D. Essential oil composition and antimicrobial activity of aerial parts and ripe fruits of Echinophora spinosa (Apiaceae) from Italy. Nat Prod Commun. 2013 Apr;8(4):527-30. PMID: 23738471.

" Not dangerous goods.

LKT M9368 Myristicin 500 mg 456 Allylbenzene found in spices and umbelliferous plants. 4-Methoxy-6-(2-propenyl)-1,3-benzodioxole 5-Allyl-1-methoxy-2,3-(methylenedioxy)benzene 607-91-0 ≥97% 192.21 C11H12O3 COC1=CC(=CC2=C1OCO2)CC=C Ambient -20°C "Insoluble in water (46 mg/L). Soluble in ethanol, or acetone.

" Not dangerous goods.

LKT M9368 Myristicin 1 g 788.7 Allylbenzene found in spices and umbelliferous plants. 4-Methoxy-6-(2-propenyl)-1,3-benzodioxole 5-Allyl-1-methoxy-2,3-(methylenedioxy)benzene 607-91-0 ≥97% 192.21 C11H12O3 COC1=CC(=CC2=C1OCO2)CC=C Ambient -20°C "Insoluble in water (46 mg/L). Soluble in ethanol, or acetone.

" Not dangerous goods.

LKT T8153 Tunicamycin 1 mg 40.7 Nucleoside antibiotic mixture; GlcNAc phosphotransferase inhibitor, glycoprotein synthesis inhibitor. 11089-65-9 ≥98% 0.84 C40H66N4O16 CC(C)CC=CC(=O)NC1C(C(C(OC1OC2C(C(C(C(O2)CO)O)O)NC(=O)C)CC(C3C(C(C(O3)N4C=CC(=O)NC4=O)O)O)O)O)O Solutions last up to 3 months. Ambient -20°C Soluble in DMSO and DMF. "Kim SY, Hwang JS, Han IO. Tunicamycin inhibits Toll-like receptor-activated inflammation in RAW264.7 cells by suppression of NF-κB and c-Jun activity via a mechanism that is independent of ER-stress and N-glycosylation. Eur J Pharmacol. 2013 Dec 5;721(1-3):294-300. PMID: 24056124.

Pertusa M, Madrid R, Morenilla-Palao C, et al. N-glycosylation of TRPM8 ion channels modulates temperature sensitivity of cold thermoreceptor neurons. J Biol Chem. 2012 May 25;287(22):18218-29. PMID: 22493431.

" T+ "UN number: 3462 Class: 6.1 Packing group: II

Proper shipping name: Toxins, extracted from living sources, solid, n.o.s. (Tunicamycin).

Marine pollutant: No, Poison inhalation hazard: No."

LKT T8153 Tunicamycin 5 mg 136 Nucleoside antibiotic mixture; GlcNAc phosphotransferase inhibitor, glycoprotein synthesis inhibitor. 11089-65-9 ≥98% 0.84 C40H66N4O16 CC(C)CC=CC(=O)NC1C(C(C(OC1OC2C(C(C(C(O2)CO)O)O)NC(=O)C)CC(C3C(C(C(O3)N4C=CC(=O)NC4=O)O)O)O)O)O Solutions last up to 3 months. Ambient -20°C Soluble in DMSO and DMF. "Kim SY, Hwang JS, Han IO. Tunicamycin inhibits Toll-like receptor-activated inflammation in RAW264.7 cells by suppression of NF-κB and c-Jun activity via a mechanism that is independent of ER-stress and N-glycosylation. Eur J Pharmacol. 2013 Dec 5;721(1-3):294-300. PMID: 24056124.

" T+ "UN number: 3462 Class: 6.1 Packing group: II

Proper shipping name: Toxins, extracted from living sources, solid, n.o.s. (Tunicamycin).

Marine pollutant: No, Poison inhalation hazard: No."

LKT T8153 Tunicamycin 10 mg 258.2 Nucleoside antibiotic mixture; GlcNAc phosphotransferase inhibitor, glycoprotein synthesis inhibitor. 11089-65-9 ≥98% 0.84 C40H66N4O16 CC(C)CC=CC(=O)NC1C(C(C(OC1OC2C(C(C(C(O2)CO)O)O)NC(=O)C)CC(C3C(C(C(O3)N4C=CC(=O)NC4=O)O)O)O)O)O Solutions last up to 3 months. Ambient -20°C Soluble in DMSO and DMF. "Kim SY, Hwang JS, Han IO. Tunicamycin inhibits Toll-like receptor-activated inflammation in RAW264.7 cells by suppression of NF-κB and c-Jun activity via a mechanism that is independent of ER-stress and N-glycosylation. Eur J Pharmacol. 2013 Dec 5;721(1-3):294-300. PMID: 24056124.

" T+ "UN number: 3462 Class: 6.1 Packing group: II

Proper shipping name: Toxins, extracted from living sources, solid, n.o.s. (Tunicamycin).

Marine pollutant: No, Poison inhalation hazard: No."

LKT T8145 Tulobuterol Hydrochloride 1 g 93.8 β2-adrenergic agonist. 56776-01-3 ≥98% 264.19 C12H18ClNO HCl CC(C)(C)NCC(C1=CC=CC=C1Cl)O Hygroscopic. Store under inert gas Ambient Ambient "Yamaya M, Nishimura H, Nadine L, et al. Tulobuterol inhibits rhinovirus infection in primary cultures of human tracheal epithelial cells. Physiol Rep. 2013 Aug;1(3):e00041. PMID: 24303127.

Katsunuma T, Fujisawa T, Nagao M, et al. Effects of transdermal tulobuterol in pediatric asthma patients on long-term leukotriene receptor antagonist therapy: results of a randomized, open-label, multicenter clinical trial in Japanese children aged 4-12 years. Allergol Int. 2013 Mar;62(1):37-43. PMID: 23000726.

Terpstra GK, Raaijmakers JA. Beta-agonistic properties of tulobuterol, a new beta-sympathicomimetic drug, and its effects on pulmonary beta-adrenoceptor characteristics. Lung. 1990;168 Suppl:179-85. PMID: 1974673.

Ruff F, Zander JF, Edoute Y, et al. Beta-2 adrenergic responses to tulobuterol in airway smooth muscle, vascular smooth muscle and adrenergic nerves. J Pharmacol Exp Ther. 1988 Jan;244(1):173-80. PMID: 2826765.

" Not dangerous goods.

LKT T8145 Tulobuterol Hydrochloride 5 g 375.1 β2-adrenergic agonist. 56776-01-3 ≥98% 264.19 C12H18ClNO HCl CC(C)(C)NCC(C1=CC=CC=C1Cl)O Hygroscopic. Store under inert gas Ambient Ambient "Yamaya M, Nishimura H, Nadine L, et al. Tulobuterol inhibits rhinovirus infection in primary cultures of human tracheal epithelial cells. Physiol Rep. 2013 Aug;1(3):e00041. PMID: 24303127.

" Not dangerous goods.

LKT C2951 Chlortetracycline Hydrochloride 5 g 40.7 Tetracycline; protein translation inhibitor, MMP and calpain inhibitor, NMDA antagonist. "7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-

3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-

naphthacenecarboxamide monohydrochloride

" Aureociclina; Isphamycin. 64-72-2 ≥85% 515.35 C22H23ClN2O8 HCl CC1(C2CC3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C(C=CC(=C41)Cl)O)O)O)O)C(=O)N)N(C)C)O.Cl Ambient Ambient Soluble at about 28oC of: water (13 mg/mL), methanol (17.4mg/mL) or ethanol (1.7mg/mL). "Nguyen F, Starosta AL, Arenz S, et al. Tetracycline antibiotics and resistance mechanisms. Biol Chem. 2014 May;395(5):559-75. PMID: 24497223.

K?adna A, Michalska T, Berczyński P, et al. Evaluation of the antioxidant activity of tetracycline antibiotics in vitro. Luminescence. 2012 Jul-Aug;27(4):249-55. PMID: 22887986.

Griffin MO, Fricovsky E, Ceballos G, et al. Tetracyclines: a pleitropic family of compounds with promising therapeutic properties. Review of the literature. Am J Physiol Cell Physiol. 2010 Sep;299(3):C539-48. PMID: 20592239.

Jiang SX, Lertvorachon J, Hou ST, et al. Chlortetracycline and demeclocycline inhibit calpains and protect mouse neurons against glutamate toxicity and cerebral ischemia. J Biol Chem. 2005 Oct 7;280(40):33811-8. PMID: 16091365.

" Xi Not dangerous goods.

LKT C2951 Chlortetracycline Hydrochloride 25 g 122.3 Tetracycline; protein translation inhibitor, MMP and calpain inhibitor, NMDA antagonist. "7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-

3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-

naphthacenecarboxamide monohydrochloride

K?adna A, Michalska T, Berczyński P, et al. Evaluation of the antioxidant activity of tetracycline antibiotics in vitro. Luminescence. 2012 Jul-Aug;27(4):249-55. PMID: 22887986.

" Xi Not dangerous goods.

LKT C2951 Chlortetracycline Hydrochloride 100 g 373.7 Tetracycline; protein translation inhibitor, MMP and calpain inhibitor, NMDA antagonist. "7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-

3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-

naphthacenecarboxamide monohydrochloride

K?adna A, Michalska T, Berczyński P, et al. Evaluation of the antioxidant activity of tetracycline antibiotics in vitro. Luminescence. 2012 Jul-Aug;27(4):249-55. PMID: 22887986.

" Xi Not dangerous goods.

LKT C2957 Cholesterol 5 g 42 Endogenous sterol component of animal cell membranes, precursor to steroid hormones, bile acids, and vitamin D compounds. Cholest-5-en-3-ol (3beta)-ol Chloesterin; Cholesterine; Cordulan; Dusoline; Dusoran; Dythol; Hydrocerin. 57-88-5 ≥97% 386.65 C27H46O CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C Ambient Ambient Practically insoluble in water. Soluble in benzene, petroleum ether, ether, chloroform or oils. Slowly dissolves in ethanol (10 mg.mL). "Labrie F, Simard J, Luu-The V, et al. Structure, function and tissue-specific gene expression of 3β-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase enzymes in classical and peripheral intracrine steroidogenic tissues. J Steroid Biochem Mol Biol. 1992 Dec;43(8):805-26. PMID: 22217825.

Smith LL. Another cholesterol hypothesis: cholesterol as antioxidant. Free Radic Biol Med. 1991;11(1):47-61. PMID: 1937129.

" None Not dangerous goods.

LKT C2957 Cholesterol 25 g 63 Endogenous sterol component of animal cell membranes, precursor to steroid hormones, bile acids, and vitamin D compounds. Cholest-5-en-3-ol (3beta)-ol Chloesterin; Cholesterine; Cordulan; Dusoline; Dusoran; Dythol; Hydrocerin. 57-88-5 ≥97% 386.65 C27H46O CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C Ambient Ambient Practically insoluble in water. Soluble in benzene, petroleum ether, ether, chloroform or oils. Slowly dissolves in ethanol (10 mg.mL). "Labrie F, Simard J, Luu-The V, et al. Structure, function and tissue-specific gene expression of 3β-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase enzymes in classical and peripheral intracrine steroidogenic tissues. J Steroid Biochem Mol Biol. 1992 Dec;43(8):805-26. PMID: 22217825.

Smith LL. Another cholesterol hypothesis: cholesterol as antioxidant. Free Radic Biol Med. 1991;11(1):47-61. PMID: 1937129.

" None Not dangerous goods.

LKT C2957 Cholesterol 100 g 199.6 Endogenous sterol component of animal cell membranes, precursor to steroid hormones, bile acids, and vitamin D compounds. Cholest-5-en-3-ol (3beta)-ol Chloesterin; Cholesterine; Cordulan; Dusoline; Dusoran; Dythol; Hydrocerin. 57-88-5 ≥97% 386.65 C27H46O CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C Ambient Ambient Practically insoluble in water. Soluble in benzene, petroleum ether, ether, chloroform or oils. Slowly dissolves in ethanol (10 mg.mL). "Labrie F, Simard J, Luu-The V, et al. Structure, function and tissue-specific gene expression of 3β-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase enzymes in classical and peripheral intracrine steroidogenic tissues. J Steroid Biochem Mol Biol. 1992 Dec;43(8):805-26. PMID: 22217825.

Smith LL. Another cholesterol hypothesis: cholesterol as antioxidant. Free Radic Biol Med. 1991;11(1):47-61. PMID: 1937129.

" None Not dangerous goods.

LKT C2960 Chondroitin Sulfate, cow 5 g 51.1 Polyanionic sulfated glycosaminoglycan, encogenoud component of connective tissues. Chondroitinsulfuric acid; Chonsurid; Structum 9007-28-7 ≥90% 50000 C13H21NO15S CC(=O)NC1C(C(C(OC1O)OS(=O)(=O)O)O)OC2C(C(C(C(O2)C(=O)O)O)O)O Hygroscopic. Ambient 4°C Soluble in water. "Henrotin Y, Mathy M, Sanchez C, et al. Chondroitin sulfate in the treatment of osteoarthritis: from in vitro studies to clinical recommendations. Ther Adv Musculoskelet Dis. 2010 Dec;2(6):335-48. PMID: 22870459.

Campo GM, Avenoso A, Campo S, et al. Glycosaminoglycans modulate inflammation and apoptosis in LPS-treated chondrocytes. J Cell Biochem. 2009 Jan 1;106(1):83-92. PMID: 19009563.

Campo GM, Avenoso A, Campo S, et al. Chondroitin-4-sulphate inhibits NF-kB translocation and caspase activation in collagen-induced arthritis in mice. Osteoarthritis Cartilage. 2008 Dec;16(12):1474-83. PMID: 18501644.

Chou MM, Vergnolle N, McDougall JJ, et al. Effects of chondroitin and glucosamine sulfate in a dietary bar formulation on inflammation, interleukin-1beta, matrix metalloprotease-9, and cartilage damage in arthritis. Exp Biol Med (Maywood). 2005 Apr;230(4):255-62. PMID: 15792947.

Cho SY, Sim JS, Jeong CS, et al. Effects of low molecular weight chondroitin sulfate on type II collagen-induced arthritis in DBA/1J mice. Biol Pharm Bull. 2004 Jan;27(1):47-51. PMID: 14709897.

Campo GM, Avenoso A, Campo S, et al. Efficacy of treatment with glycosaminoglycans on experimental collagen-induced arthritis in rats. Arthritis Res Ther. 2003;5(3):R122-31. PMID: 12723984.

Omata T, Itokazu Y, Inoue N, et al. Effects of chondroitin sulfate-C on articular cartilage destruction in murine collagen-induced arthritis. Arzneimittelforschung. 2000 Feb;50(2):148-53. PMID: 10719618.

" Not dangerous goods.

LKT C2960 Chondroitin Sulfate, cow 25 g 196.8 Polyanionic sulfated glycosaminoglycan, encogenoud component of connective tissues. Chondroitinsulfuric acid; Chonsurid; Structum 9007-28-7 ≥90% 50000 C13H21NO15S CC(=O)NC1C(C(C(OC1O)OS(=O)(=O)O)O)OC2C(C(C(C(O2)C(=O)O)O)O)O Hygroscopic. Ambient 4°C Soluble in water. "Henrotin Y, Mathy M, Sanchez C, et al. Chondroitin sulfate in the treatment of osteoarthritis: from in vitro studies to clinical recommendations. Ther Adv Musculoskelet Dis. 2010 Dec;2(6):335-48. PMID: 22870459.

Campo GM, Avenoso A, Campo S, et al. Glycosaminoglycans modulate inflammation and apoptosis in LPS-treated chondrocytes. J Cell Biochem. 2009 Jan 1;106(1):83-92. PMID: 19009563.

Cho SY, Sim JS, Jeong CS, et al. Effects of low molecular weight chondroitin sulfate on type II collagen-induced arthritis in DBA/1J mice. Biol Pharm Bull. 2004 Jan;27(1):47-51. PMID: 14709897.

Campo GM, Avenoso A, Campo S, et al. Efficacy of treatment with glycosaminoglycans on experimental collagen-induced arthritis in rats. Arthritis Res Ther. 2003;5(3):R122-31. PMID: 12723984.

" Not dangerous goods.

LKT C2965 Chromium Picolinate 5 g 46.8 Used to prevent chromium deficiency and to decrease serum glucose and insulin levels. Tris(2-pyridinecarboxylato-N1,O2)chromium Chromium(III) trispicolinate 14639-25-9 ≥98% 418.3 C18H12CrN3O6 C1=CC=NC(=C1)C(=O)[O-].C1=CC=NC(=C1)C(=O)[O-].C1=CC=NC(=C1)C(=O)[O-].[Cr+3] Ambient Ambient Soluble in 0.6 mM water (pH 7.0) or 2.0 mM chloroform. "Seif AA. Chromium picolinate inhibits cholesterol-induced stimulation of platelet aggregation in hypercholesterolemic rats. Ir J Med Sci. 2014 Mar 15. [Epub ahead of print]. PMID: 24633441.

Amooee S, Parsanezhad ME, Ravanbod Shirazi M, et al. Metformin versus chromium picolinate in clomiphene citrate-resistant patients with PCOs: A double-blind randomized clinical trial. Iran J Reprod Med. 2013 Aug;11(8):611-8. PMID: 24639797.

Abebe W, Liu JY, Wimborne H, et al. Effects of chromium picolinate on vascular reactivity and cardiac ischemia-reperfusion injury in spontaneously hypertensive rats. Pharmacol Rep. 2010 Jul-Aug;62(4):674-82. PMID: 20885007.

" Xi Not dangerous goods.

LKT C2965 Chromium Picolinate 25 g 121.9 Used to prevent chromium deficiency and to decrease serum glucose and insulin levels. Tris(2-pyridinecarboxylato-N1,O2)chromium Chromium(III) trispicolinate 14639-25-9 ≥98% 418.3 C18H12CrN3O6 C1=CC=NC(=C1)C(=O)[O-].C1=CC=NC(=C1)C(=O)[O-].C1=CC=NC(=C1)C(=O)[O-].[Cr+3] Ambient Ambient Soluble in 0.6 mM water (pH 7.0) or 2.0 mM chloroform. "Seif AA. Chromium picolinate inhibits cholesterol-induced stimulation of platelet aggregation in hypercholesterolemic rats. Ir J Med Sci. 2014 Mar 15. [Epub ahead of print]. PMID: 24633441.

" Xi Not dangerous goods.

LKT C2969 Chromomycin A3 1 mg 60 Anthraquinone, Mg2+/Zn2+ chelator; bacterial DNA gyrase and RNA polymerase inhibitor, potential alcohol dehydrogenase inhibitor. 7059-24-7 ≥97% 1183.2488 C57H82O26 CC1C(C(CC(O1)OC2C(CC3=C(C2=O)C(=C4C(=C3)C=C(C(=C4O)C)OC5CC(C(C(O5)C)OC(=O)C)OC6CC(C(C(O6)C)OC)O)O)C(C(=O)C(C(C)O)O)OC)OC7CC(C(C(O7)C)O)OC8CC(C(C(O8)C)OC(=O)C)(C)O)O Ambient 4°C "Devi PG, Chakraborty PK, Dasgupta D. Inhibition of a Zn(II)-containing enzyme, alcohol dehydrogenase, by anticancer antibiotics, mithramycin and chromomycin A3. J Biol Inorg Chem. 2009 Mar;14(3):347-59. PMID: 19034537.

Mir MA, Dasgupta D. Association of the anticancer antibiotic chromomycin A(3) with the nucleosome: role of core histone tail domains in the binding process. Biochemistry. 2001 Sep 25;40(38):11578-85. PMID: 11560508.

Simon H, Wittig B, Zimmer C. Effect of netropsin, distamycin A and chromomycin A3 on the binding and cleavage reaction of DNA gyrase. FEBS Lett. 1994 Oct 10;353(1):79-83. PMID: 7926028.

Inoue K, Fujimoto S, Ogawa M. Antitumor efficacy of seventeen anticancer drugs in human breast cancer xenograft (MX-1) transplanted in nude mice. Cancer Chemother Pharmacol. 1983;10(3):182-6. PMID: 6305523.

" "UN number: 3462 Class: 6.1 Packing Group: II

Proper shipping name: Toxins, extracted from living sources, solid, n.o.s. (Chromomycin A3)"

LKT C2969 Chromomycin A3 5 mg 209.8 Anthraquinone, Mg2+/Zn2+ chelator; bacterial DNA gyrase and RNA polymerase inhibitor, potential alcohol dehydrogenase inhibitor. 7059-24-7 ≥97% 1183.2488 C57H82O26 CC1C(C(CC(O1)OC2C(CC3=C(C2=O)C(=C4C(=C3)C=C(C(=C4O)C)OC5CC(C(C(O5)C)OC(=O)C)OC6CC(C(C(O6)C)OC)O)O)C(C(=O)C(C(C)O)O)OC)OC7CC(C(C(O7)C)O)OC8CC(C(C(O8)C)OC(=O)C)(C)O)O Ambient 4°C "Devi PG, Chakraborty PK, Dasgupta D. Inhibition of a Zn(II)-containing enzyme, alcohol dehydrogenase, by anticancer antibiotics, mithramycin and chromomycin A3. J Biol Inorg Chem. 2009 Mar;14(3):347-59. PMID: 19034537.

Simon H, Wittig B, Zimmer C. Effect of netropsin, distamycin A and chromomycin A3 on the binding and cleavage reaction of DNA gyrase. FEBS Lett. 1994 Oct 10;353(1):79-83. PMID: 7926028.

" "UN number: 3462 Class: 6.1 Packing Group: II

Proper shipping name: Toxins, extracted from living sources, solid, n.o.s. (Chromomycin A3)"

LKT C2969 Chromomycin A3 10 mg 375.1 Anthraquinone, Mg2+/Zn2+ chelator; bacterial DNA gyrase and RNA polymerase inhibitor, potential alcohol dehydrogenase inhibitor. 7059-24-7 ≥97% 1183.2488 C57H82O26 CC1C(C(CC(O1)OC2C(CC3=C(C2=O)C(=C4C(=C3)C=C(C(=C4O)C)OC5CC(C(C(O5)C)OC(=O)C)OC6CC(C(C(O6)C)OC)O)O)C(C(=O)C(C(C)O)O)OC)OC7CC(C(C(O7)C)O)OC8CC(C(C(O8)C)OC(=O)C)(C)O)O Ambient 4°C "Devi PG, Chakraborty PK, Dasgupta D. Inhibition of a Zn(II)-containing enzyme, alcohol dehydrogenase, by anticancer antibiotics, mithramycin and chromomycin A3. J Biol Inorg Chem. 2009 Mar;14(3):347-59. PMID: 19034537.

Simon H, Wittig B, Zimmer C. Effect of netropsin, distamycin A and chromomycin A3 on the binding and cleavage reaction of DNA gyrase. FEBS Lett. 1994 Oct 10;353(1):79-83. PMID: 7926028.

" "UN number: 3462 Class: 6.1 Packing Group: II

Proper shipping name: Toxins, extracted from living sources, solid, n.o.s. (Chromomycin A3)"

LKT C2970 Chrysophanol 10 mg 47.6 Anthraquinone found in Rheum. 1,8-Dihydroxy-3-methyl-9,10-anthracenedione, Chrysophanic acid Chrysophanic acid; Turkey rhubarb. 481-74-3 ≥98% 254.24 C15H10O4 CC1=CC(=C2C(=C1)C(=O)C3=C(C2=O)C(=CC=C3)O)O Store in a cool, dry place. Ambient 4°C Practically insoluble in water, freely. Soluble in boiling alcohol, benzene or acetone. "Zhang N, Zhang X, Liu X, et al. Chrysophanol Inhibits NALP3 Inflammasome Activation and Ameliorates Cerebral Ischemia/Reperfusion in Mice. Mediators Inflamm. 2014;2014:370530. PMID: 24876671.

Ni CH, Yu CS, Lu HF, et al. Chrysophanol-induced cell death (necrosis) in human lung cancer A549 cells is mediated through increasing reactive oxygen species and decreasing the level of mitochondrial membrane potential. Environ Toxicol. 2014 May;29(7):740-9. PMID: 22848001.

Chang SJ, Huang SH, Lin YJ, et al. Antiviral activity of Rheum palmatum methanol extract and chrysophanol against Japanese encephalitis virus. Arch Pharm Res. 2014 Jan 7. [Epub ahead of print]. PMID: 24395532.

Smolarz HD, Swatko-Ossor M, Ginalska G, et al. Antimycobacterial effect of extract and its components from Rheum rhaponticum. J AOAC Int. 2013 Jan-Feb;96(1):155-60. PMID: 23513971.

" Xi Not dangerous goods.

LKT C2970 Chrysophanol 25 mg 67.9 Anthraquinone found in Rheum. 1,8-Dihydroxy-3-methyl-9,10-anthracenedione, Chrysophanic acid Chrysophanic acid; Turkey rhubarb. 481-74-3 ≥98% 254.24 C15H10O4 CC1=CC(=C2C(=C1)C(=O)C3=C(C2=O)C(=CC=C3)O)O Store in a cool, dry place. Ambient 4°C Practically insoluble in water, freely. Soluble in boiling alcohol, benzene or acetone. "Zhang N, Zhang X, Liu X, et al. Chrysophanol Inhibits NALP3 Inflammasome Activation and Ameliorates Cerebral Ischemia/Reperfusion in Mice. Mediators Inflamm. 2014;2014:370530. PMID: 24876671.

Smolarz HD, Swatko-Ossor M, Ginalska G, et al. Antimycobacterial effect of extract and its components from Rheum rhaponticum. J AOAC Int. 2013 Jan-Feb;96(1):155-60. PMID: 23513971.

" Xi Not dangerous goods.

LKT C2970 Chrysophanol 100 mg 271.7 Anthraquinone found in Rheum. 1,8-Dihydroxy-3-methyl-9,10-anthracenedione, Chrysophanic acid Chrysophanic acid; Turkey rhubarb. 481-74-3 ≥98% 254.24 C15H10O4 CC1=CC(=C2C(=C1)C(=O)C3=C(C2=O)C(=CC=C3)O)O Store in a cool, dry place. Ambient 4°C Practically insoluble in water, freely. Soluble in boiling alcohol, benzene or acetone. "Zhang N, Zhang X, Liu X, et al. Chrysophanol Inhibits NALP3 Inflammasome Activation and Ameliorates Cerebral Ischemia/Reperfusion in Mice. Mediators Inflamm. 2014;2014:370530. PMID: 24876671.

Smolarz HD, Swatko-Ossor M, Ginalska G, et al. Antimycobacterial effect of extract and its components from Rheum rhaponticum. J AOAC Int. 2013 Jan-Feb;96(1):155-60. PMID: 23513971.

" Xi Not dangerous goods.

LKT C2971 Chromostatin, cow 0.5 mg 228 Peptide, chromogranin A fragment; PP2A activator. ≥95% 1953.97 C78H120N24O35 Ambient -20°C "Garcia GE, Gabbai FB, O'Connor DT, et al. Does chromostatin influence catecholamine release or blood pressure in vivo? Peptides. 1994 Jan;15(1):195-7. PMID: 8015978.

Aardal S, Galindo E, Aunis D, et al. Human chromostatin inhibits endothelin-1-induced contractures in human blood vessels. Regul Pept. 1993 Aug 13;47(1):25-32. PMID: 8210519.

Galindo E, Zwiller J, Bader MF, et al. Chromostatin inhibits catecholamine secretion in adrenal chromaffin cells by activating a protein phosphatase. Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7398-402. PMID: 1323834.

LKT C2971 Chromostatin, cow 1 mg 387 Peptide, chromogranin A fragment; PP2A activator. ≥95% 1953.97 C78H120N24O35 Ambient -20°C "Garcia GE, Gabbai FB, O'Connor DT, et al. Does chromostatin influence catecholamine release or blood pressure in vivo? Peptides. 1994 Jan;15(1):195-7. PMID: 8015978.

Aardal S, Galindo E, Aunis D, et al. Human chromostatin inhibits endothelin-1-induced contractures in human blood vessels. Regul Pept. 1993 Aug 13;47(1):25-32. PMID: 8210519.

LKT C2971 Chromostatin, cow 2.5 mg 684.1 Peptide, chromogranin A fragment; PP2A activator. ≥95% 1953.97 C78H120N24O35 Ambient -20°C "Garcia GE, Gabbai FB, O'Connor DT, et al. Does chromostatin influence catecholamine release or blood pressure in vivo? Peptides. 1994 Jan;15(1):195-7. PMID: 8015978.

Aardal S, Galindo E, Aunis D, et al. Human chromostatin inhibits endothelin-1-induced contractures in human blood vessels. Regul Pept. 1993 Aug 13;47(1):25-32. PMID: 8210519.

LKT C2997 Chymostatin 1 mg 48.7 Protease inhibitor. N-(Nα-Carbonyl-Cpd-X-Phe-al)-Phe 9076-44-2 ≥98% 1809.1 C20H16N2O4 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C=O)NC(=O)C(C2CCN=C(N2)N)NC(=O)NC(CC3=CC=CC=C3)C Ambient -20°C Soluble in DMSO. "Paliwal D, Panda SK, Kapur N, et al. Hepatitis E virus (HEV) protease: a chymotrypsin-like enzyme that processes both non-structural (pORF1) and capsid (pORF2) protein. J Gen Virol. 2014 Aug;95(Pt 8):1689-700. PMID: 24795447.

Wang T, Han SX, Zhang SF, et al. Role of chymase in cigarette smoke-induced pulmonary artery remodeling and pulmonary hypertension in hamsters. Respir Res. 2010 Mar 31;11:36. PMID: 20356378.

" Not dangerous goods.

LKT C2997 Chymostatin 5 mg 146.3 Protease inhibitor. N-(Nα-Carbonyl-Cpd-X-Phe-al)-Phe 9076-44-2 ≥98% 1809.1 C20H16N2O4 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C=O)NC(=O)C(C2CCN=C(N2)N)NC(=O)NC(CC3=CC=CC=C3)C Ambient -20°C Soluble in DMSO. "Paliwal D, Panda SK, Kapur N, et al. Hepatitis E virus (HEV) protease: a chymotrypsin-like enzyme that processes both non-structural (pORF1) and capsid (pORF2) protein. J Gen Virol. 2014 Aug;95(Pt 8):1689-700. PMID: 24795447.

Wang T, Han SX, Zhang SF, et al. Role of chymase in cigarette smoke-induced pulmonary artery remodeling and pulmonary hypertension in hamsters. Respir Res. 2010 Mar 31;11:36. PMID: 20356378.

" Not dangerous goods.

LKT C2997 Chymostatin 25 mg 632.4 Protease inhibitor. N-(Nα-Carbonyl-Cpd-X-Phe-al)-Phe 9076-44-2 ≥98% 1809.1 C20H16N2O4 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C=O)NC(=O)C(C2CCN=C(N2)N)NC(=O)NC(CC3=CC=CC=C3)C Ambient -20°C Soluble in DMSO. "Paliwal D, Panda SK, Kapur N, et al. Hepatitis E virus (HEV) protease: a chymotrypsin-like enzyme that processes both non-structural (pORF1) and capsid (pORF2) protein. J Gen Virol. 2014 Aug;95(Pt 8):1689-700. PMID: 24795447.

Wang T, Han SX, Zhang SF, et al. Role of chymase in cigarette smoke-induced pulmonary artery remodeling and pulmonary hypertension in hamsters. Respir Res. 2010 Mar 31;11:36. PMID: 20356378.

" Not dangerous goods.

LKT C2997 Chymostatin 50 mg 1215.5 Protease inhibitor. N-(Nα-Carbonyl-Cpd-X-Phe-al)-Phe 9076-44-2 ≥98% 1809.1 C20H16N2O4 CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C=O)NC(=O)C(C2CCN=C(N2)N)NC(=O)NC(CC3=CC=CC=C3)C Ambient -20°C Soluble in DMSO. "Paliwal D, Panda SK, Kapur N, et al. Hepatitis E virus (HEV) protease: a chymotrypsin-like enzyme that processes both non-structural (pORF1) and capsid (pORF2) protein. J Gen Virol. 2014 Aug;95(Pt 8):1689-700. PMID: 24795447.

Wang T, Han SX, Zhang SF, et al. Role of chymase in cigarette smoke-induced pulmonary artery remodeling and pulmonary hypertension in hamsters. Respir Res. 2010 Mar 31;11:36. PMID: 20356378.

" Not dangerous goods.

LKT C3208 Ciclopirox Olamine 1 g 54.6 Hydroxypyridone, metal ion chelator; mTOR inhibitor. 41621-49-2 ≥98% 268.36 C12H17NO2 C2H7NO CC1=CC(=O)N(C(=C1)C2CCCCC2)O.C(CO)N Ambient Ambient "Sen S, Hassane DC, Corbett C, et al. Novel mTOR inhibitory activity of ciclopirox enhances parthenolide antileukemia activity. Exp Hematol. 2013 Sep;41(9):799-807.e4. PMID: 23660068.

Belenky P, Camacho D, Collins JJ. Fungicidal drugs induce a common oxidative-damage cellular death pathway. Cell Rep. 2013 Feb 21;3(2):350-8. PMID: 23416050.

Luo Y, Zhou H, Liu L, et al. The fungicide ciclopirox inhibits lymphatic endothelial cell tube formation by suppressing VEGFR-3-mediated ERK signaling pathway. Oncogene. 2011 May 5;30(18):2098-107. PMID: 21217783.

Subissi A, Monti D, Togni G, et al. Ciclopirox: recent nonclinical and clinical data relevant to its use as a topical antimycotic agent. Drugs. 2010 Nov 12;70(16):2133-52. PMID: 20964457.

Zhou H, Shen T, Luo Y, et al. The antitumor activity of the fungicide ciclopirox. Int J Cancer. 2010 Nov 15;127(10):2467-77. PMID: 20225320.

" Xi Not dangerous goods.

LKT C3208 Ciclopirox Olamine 5 g 173.3 Hydroxypyridone, metal ion chelator; mTOR inhibitor. 41621-49-2 ≥98% 268.36 C12H17NO2 C2H7NO CC1=CC(=O)N(C(=C1)C2CCCCC2)O.C(CO)N Ambient Ambient "Sen S, Hassane DC, Corbett C, et al. Novel mTOR inhibitory activity of ciclopirox enhances parthenolide antileukemia activity. Exp Hematol. 2013 Sep;41(9):799-807.e4. PMID: 23660068.

Belenky P, Camacho D, Collins JJ. Fungicidal drugs induce a common oxidative-damage cellular death pathway. Cell Rep. 2013 Feb 21;3(2):350-8. PMID: 23416050.

Subissi A, Monti D, Togni G, et al. Ciclopirox: recent nonclinical and clinical data relevant to its use as a topical antimycotic agent. Drugs. 2010 Nov 12;70(16):2133-52. PMID: 20964457.

Zhou H, Shen T, Luo Y, et al. The antitumor activity of the fungicide ciclopirox. Int J Cancer. 2010 Nov 15;127(10):2467-77. PMID: 20225320.

" Xi Not dangerous goods.

LKT C3210 Ciglitazone 1 mg 47.6 Thiazolidinedione; PPARγ agonist. (+/-)-5-[4-(1-Methylcyclohexylmethoxy)benzyl]thiazolidine-2,4-dione 74772-77-3 ≥98% 333.45 C18H23NO3S CC1(CCCCC1)COC2=CC=C(C=C2)CC3C(=O)NC(=O)S3 Ambient Ambient Soluble in DMSO or ethanol. "Shah DK, Menon KM, Cabrera LM, et al. Thiazolidinediones decrease vascular endothelial growth factor (VEGF) production by human luteinized granulosa cells in vitro. Fertil Steril. 2010 Apr;93(6):2042-7. PMID: 19342033.

Cheon CW, Kim DH, Kim DH, et al. Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20. PMID: 19140230.

Pershadsingh HA, Szollosi J, Benson S, et al. Effects of ciglitazone on blood pressure and intracellular calcium metabolism. Hypertension. 1993 Jun;21(6 Pt 2):1020-3. PMID: 8505086.

" Not dangerous goods.

LKT C3210 Ciglitazone 5 mg 136 Thiazolidinedione; PPARγ agonist. (+/-)-5-[4-(1-Methylcyclohexylmethoxy)benzyl]thiazolidine-2,4-dione 74772-77-3 ≥98% 333.45 C18H23NO3S CC1(CCCCC1)COC2=CC=C(C=C2)CC3C(=O)NC(=O)S3 Ambient Ambient Soluble in DMSO or ethanol. "Shah DK, Menon KM, Cabrera LM, et al. Thiazolidinediones decrease vascular endothelial growth factor (VEGF) production by human luteinized granulosa cells in vitro. Fertil Steril. 2010 Apr;93(6):2042-7. PMID: 19342033.

Cheon CW, Kim DH, Kim DH, et al. Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20. PMID: 19140230.

Pershadsingh HA, Szollosi J, Benson S, et al. Effects of ciglitazone on blood pressure and intracellular calcium metabolism. Hypertension. 1993 Jun;21(6 Pt 2):1020-3. PMID: 8505086.

" Not dangerous goods.

LKT C3246 Cilostazol 50 mg 184.8 Quinoline; PDE 3B inhibitor. 6-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)-butoxy]-3,4- dihydro-2(1H)-quinolinone OPC-13013; Pletal 73963-72-1 ≥98% 369.46 C20H27N5O2 C1CCC(CC1)N2C(=NN=N2)CCCCOC3=CC4=C(C=C3)NC(=O)CC4 Ambient Ambient Soluble in acetic acid, chloroform, and DMSO. Practically insoluble in water and ether. "Biscetti F, Pecorini G, Straface G, et al. Cilostazol promotes angiogenesis after peripheral ischemia through a VEGF-dependent mechanism. Int J Cardiol. 2013 Aug 10;167(3):910-6. PMID: 22473072.

Wada T, Onogi Y, Kimura Y, et al. Cilostazol ameliorates systemic insulin resistance in diabetic db/db mice by suppressing chronic inflammation in adipose tissue via modulation of both adipocyte and macrophage functions. Eur J Pharmacol. 2013 May 5;707(1-3):120-9. PMID: 23528355.

Patel DS, Anand IS, Bhatt PA. Evaluation of antidepressant and anxiolytic activity of phosphodiesterase 3 inhibitor - cilostazol. Indian J Psychol Med. 2012 Apr;34(2):124-8. PMID: 23162186.

" Xi Not dangerous goods.

LKT C3246 Cilostazol 100 mg 288.8 Quinoline; PDE 3B inhibitor. 6-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)-butoxy]-3,4- dihydro-2(1H)-quinolinone OPC-13013; Pletal 73963-72-1 ≥98% 369.46 C20H27N5O2 C1CCC(CC1)N2C(=NN=N2)CCCCOC3=CC4=C(C=C3)NC(=O)CC4 Ambient Ambient Soluble in acetic acid, chloroform, and DMSO. Practically insoluble in water and ether. "Biscetti F, Pecorini G, Straface G, et al. Cilostazol promotes angiogenesis after peripheral ischemia through a VEGF-dependent mechanism. Int J Cardiol. 2013 Aug 10;167(3):910-6. PMID: 22473072.

Patel DS, Anand IS, Bhatt PA. Evaluation of antidepressant and anxiolytic activity of phosphodiesterase 3 inhibitor - cilostazol. Indian J Psychol Med. 2012 Apr;34(2):124-8. PMID: 23162186.

" Xi Not dangerous goods.

LKT C3246 Cilostazol 500 mg 1155.2 Quinoline; PDE 3B inhibitor. 6-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)-butoxy]-3,4- dihydro-2(1H)-quinolinone OPC-13013; Pletal 73963-72-1 ≥98% 369.46 C20H27N5O2 C1CCC(CC1)N2C(=NN=N2)CCCCOC3=CC4=C(C=C3)NC(=O)CC4 Ambient Ambient Soluble in acetic acid, chloroform, and DMSO. Practically insoluble in water and ether. "Biscetti F, Pecorini G, Straface G, et al. Cilostazol promotes angiogenesis after peripheral ischemia through a VEGF-dependent mechanism. Int J Cardiol. 2013 Aug 10;167(3):910-6. PMID: 22473072.

Patel DS, Anand IS, Bhatt PA. Evaluation of antidepressant and anxiolytic activity of phosphodiesterase 3 inhibitor - cilostazol. Indian J Psychol Med. 2012 Apr;34(2):124-8. PMID: 23162186.

" Xi Not dangerous goods.

LKT C3250 Cimetidine 5 g 81 Histamine H2 and AR antagonist, catalase inhibitor. N-Cyano-N'-methyl-N''-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]guanidine Acibilin; Acinil; Cimetag; Edalene; Eureceptor; Gastromet; Peptol; Ulcerfen; Ulcomet 51481-61-9 ≥98% 252.34 C10H16N6S CC1=C(N=CN1)CSCCNC(=NC)NC#N Ambient 4°C Soluble in water at 37oC. "Masoud M, Ebrahimi F, Minai-Tehrani D. Effect of Cimetidine on Catalase Activity of Pseudomonas aeruginosa: A Suggested Mechanism of Action. J Mol Microbiol Biotechnol. 2014 Jul 2;24(3):196-201. PMID: 24993120.

Zheng Y, Xu M, Li X, et al. Cimetidine suppresses lung tumor growth in mice through proapoptosis of myeloid-derived suppressor cells. Mol Immunol. 2013 May;54(1):74-83. PMID: 23220070.

Matsumoto S, Imaeda Y, Umemoto S, et al. Cimetidine increases survival of colorectal cancer patients with high levels of sialyl Lewis-X and sialyl Lewis-A epitope expression on tumour cells. Br J Cancer. 2002 Jan 21;86(2):161-7. PMID: 11870500.

Richards DA. Comparative pharmacodynamics and pharmacokinetics of cimetidine and ranitidine. J Clin Gastroenterol. 1983;5 Suppl 1:81-90. PMID: 6317740.

" T Not dangerous goods.

LKT C3250 Cimetidine 10 g 104.3 Histamine H2 and AR antagonist, catalase inhibitor. N-Cyano-N'-methyl-N''-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]guanidine Acibilin; Acinil; Cimetag; Edalene; Eureceptor; Gastromet; Peptol; Ulcerfen; Ulcomet 51481-61-9 ≥98% 252.34 C10H16N6S CC1=C(N=CN1)CSCCNC(=NC)NC#N Ambient 4°C Soluble in water at 37oC. "Masoud M, Ebrahimi F, Minai-Tehrani D. Effect of Cimetidine on Catalase Activity of Pseudomonas aeruginosa: A Suggested Mechanism of Action. J Mol Microbiol Biotechnol. 2014 Jul 2;24(3):196-201. PMID: 24993120.

Zheng Y, Xu M, Li X, et al. Cimetidine suppresses lung tumor growth in mice through proapoptosis of myeloid-derived suppressor cells. Mol Immunol. 2013 May;54(1):74-83. PMID: 23220070.

Richards DA. Comparative pharmacodynamics and pharmacokinetics of cimetidine and ranitidine. J Clin Gastroenterol. 1983;5 Suppl 1:81-90. PMID: 6317740.

" T Not dangerous goods.

LKT C3250 Cimetidine 25 g 226.5 Histamine H2 and AR antagonist, catalase inhibitor. N-Cyano-N'-methyl-N''-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]guanidine Acibilin; Acinil; Cimetag; Edalene; Eureceptor; Gastromet; Peptol; Ulcerfen; Ulcomet 51481-61-9 ≥98% 252.34 C10H16N6S CC1=C(N=CN1)CSCCNC(=NC)NC#N Ambient 4°C Soluble in water at 37oC. "Masoud M, Ebrahimi F, Minai-Tehrani D. Effect of Cimetidine on Catalase Activity of Pseudomonas aeruginosa: A Suggested Mechanism of Action. J Mol Microbiol Biotechnol. 2014 Jul 2;24(3):196-201. PMID: 24993120.

Zheng Y, Xu M, Li X, et al. Cimetidine suppresses lung tumor growth in mice through proapoptosis of myeloid-derived suppressor cells. Mol Immunol. 2013 May;54(1):74-83. PMID: 23220070.

Richards DA. Comparative pharmacodynamics and pharmacokinetics of cimetidine and ranitidine. J Clin Gastroenterol. 1983;5 Suppl 1:81-90. PMID: 6317740.

" T Not dangerous goods.

LKT C3251 Cinnarizine 10 g 40.7 FIASMA, L-type Ca2+ channel blocker, D2 antagonist. 1-benzhydryl-4-cinnamyl-piperazine Aplactan; Aplexal; Apotomin; Artate; Carecin; Cerebolan; 1-trans-Cinnamyl-4-diphenylmethylpiperazine 298-57-7 ≥98% 368.51 C26H28N2 C1CN(CCN1CC=CC2=CC=CC=C2)C(C3=CC=CC=C3)C4=CC=CC=C4 Ambient Ambient Practically insoluble in water. Soluble in dichloromethane or ether. Slightly soluble in methanol. "Taghdiri F, Togha M, Razeghi Jahromi S, et al. Cinnarizine for the prophylaxis of migraine associated vertigo: a retrospective study. Springerplus. 2014 May 7;3:231. PMID: 24834377.

Brahmane RI, Wanmali VV, Pathak SS, et al. Role of cinnarizine and nifedipine on anticonvulsant effect of sodium valproate and carbamazepine in maximal electroshock and pentylenetetrazole model of seizures in mice. J Pharmacol Pharmacother. 2010 Jul;1(2):78-81. PMID: 21350614.

Dall'Igna OP, Tort AB, Souza DO, et al. Cinnarizine has an atypical antipsychotic profile in animal models of psychosis. J Psychopharmacol. 2005 Jul;19(4):342-6. PMID: 15982988.

" None Not dangerous goods.

LKT C3251 Cinnarizine 100 g 203.8 FIASMA, L-type Ca2+ channel blocker, D2 antagonist. 1-benzhydryl-4-cinnamyl-piperazine Aplactan; Aplexal; Apotomin; Artate; Carecin; Cerebolan; 1-trans-Cinnamyl-4-diphenylmethylpiperazine 298-57-7 ≥98% 368.51 C26H28N2 C1CN(CCN1CC=CC2=CC=CC=C2)C(C3=CC=CC=C3)C4=CC=CC=C4 Ambient Ambient Practically insoluble in water. Soluble in dichloromethane or ether. Slightly soluble in methanol. "Taghdiri F, Togha M, Razeghi Jahromi S, et al. Cinnarizine for the prophylaxis of migraine associated vertigo: a retrospective study. Springerplus. 2014 May 7;3:231. PMID: 24834377.

Dall'Igna OP, Tort AB, Souza DO, et al. Cinnarizine has an atypical antipsychotic profile in animal models of psychosis. J Psychopharmacol. 2005 Jul;19(4):342-6. PMID: 15982988.

" None Not dangerous goods.

LKT C3260 Ciprofibrate 25 mg 54.4 Fibrate; PPARα agonist. 52214-84-3 ≥98% 289.16 C13H14Cl2O3 CC(C)(C(=O)O)OC1=CC=C(C=C1)C2CC2(Cl)Cl Ambient 4°C Practically insoluble in water, freely soluble in anhydrous ethanol, soluble in toluene "Aguilar-Salinas CA, Assis-Luores-Vale A, Stockins B, et al. Ciprofibrate therapy in patients with hypertriglyceridemia and low high density lipoprotein (HDL)-cholesterol: greater reduction of non-HDL cholesterol in subjects with excess body weight (The CIPROAMLAT study). Cardiovasc Diabetol. 2004 Jul 23;3:8. PMID: 15272932.

Li Y, Glauert HP, Spear BT. Activation of nuclear factor-kappaB by the peroxisome proliferator ciprofibrate in H4IIEC3 rat hepatoma cells and its inhibition by the antioxidants N-acetylcysteine and vitamin E. Biochem Pharmacol. 2000 Feb 15;59(4):427-34. PMID: 10644051.

Zhou S, Wallace KB. The effect of peroxisome proliferators on mitochondrial bioenergetics. Toxicol Sci. 1999 Mar;48(1):82-9. PMID: 10330687.

" T Not dangerous goods.

LKT C3260 Ciprofibrate 100 mg 149.5 Fibrate; PPARα agonist. 52214-84-3 ≥98% 289.16 C13H14Cl2O3 CC(C)(C(=O)O)OC1=CC=C(C=C1)C2CC2(Cl)Cl Ambient 4°C Practically insoluble in water, freely soluble in anhydrous ethanol, soluble in toluene "Aguilar-Salinas CA, Assis-Luores-Vale A, Stockins B, et al. Ciprofibrate therapy in patients with hypertriglyceridemia and low high density lipoprotein (HDL)-cholesterol: greater reduction of non-HDL cholesterol in subjects with excess body weight (The CIPROAMLAT study). Cardiovasc Diabetol. 2004 Jul 23;3:8. PMID: 15272932.

Zhou S, Wallace KB. The effect of peroxisome proliferators on mitochondrial bioenergetics. Toxicol Sci. 1999 Mar;48(1):82-9. PMID: 10330687.

" T Not dangerous goods.

LKT C3262 Ciprofloxacin 5 g 43.5 Fluoroquinolone; topoisomerase IV and bacterial DNA gyrase inhibitor. 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1- piperazinyl)-3-quinolinecarboxylic acid Bay q 3939 85721-33-1 ≥98% 331.34 C17H18FN3O3 C1CC1N2C=C(C(=O)C3=CC(=C(C=C32)N4CCNCC4)F)C(=O)O Ambient 4°C Insoluble in water. Soluble in dilute hydrochloric acid. Soluble in hot DMSO or hot methanol. "Rajendram M, Hurley KA, Foss MH, et al. Gyramides Prevent Bacterial Growth by Inhibiting DNA Gyrase and Altering Chromosome Topology. ACS Chem Biol. 2014 Apr 22. [Epub ahead of print]. PMID: 24712739.

Oliphant CM, Green GM. Quinolones: a comprehensive review. Am Fam Physician. 2002 Feb 1;65(3):455-64. PMID: 11858629.

Drlica K, Zhao X. DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev. 1997 Sep;61(3):377-92. PMID: 9293187.

Aldred KJ, McPherson SA, Wang P, et al. Drug interactions with Bacillus anthracis topoisomerase IV: biochemical basis for quinolone action and resistance. Biochemistry. 2012 Jan 10;51(1):370-381. PMID: 22126453.

" None Not dangerous goods.

LKT C3262 Ciprofloxacin 25 g 115.4 Fluoroquinolone; topoisomerase IV and bacterial DNA gyrase inhibitor. 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1- piperazinyl)-3-quinolinecarboxylic acid Bay q 3939 85721-33-1 ≥98% 331.34 C17H18FN3O3 C1CC1N2C=C(C(=O)C3=CC(=C(C=C32)N4CCNCC4)F)C(=O)O Ambient 4°C Insoluble in water. Soluble in dilute hydrochloric acid. Soluble in hot DMSO or hot methanol. "Rajendram M, Hurley KA, Foss MH, et al. Gyramides Prevent Bacterial Growth by Inhibiting DNA Gyrase and Altering Chromosome Topology. ACS Chem Biol. 2014 Apr 22. [Epub ahead of print]. PMID: 24712739.

Oliphant CM, Green GM. Quinolones: a comprehensive review. Am Fam Physician. 2002 Feb 1;65(3):455-64. PMID: 11858629.

Drlica K, Zhao X. DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev. 1997 Sep;61(3):377-92. PMID: 9293187.

" None Not dangerous goods.

LKT C3262 Ciprofloxacin 50 g 173 Fluoroquinolone; topoisomerase IV and bacterial DNA gyrase inhibitor. 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1- piperazinyl)-3-quinolinecarboxylic acid Bay q 3939 85721-33-1 ≥98% 331.34 C17H18FN3O3 C1CC1N2C=C(C(=O)C3=CC(=C(C=C32)N4CCNCC4)F)C(=O)O Ambient 4°C Insoluble in water. Soluble in dilute hydrochloric acid. Soluble in hot DMSO or hot methanol. "Rajendram M, Hurley KA, Foss MH, et al. Gyramides Prevent Bacterial Growth by Inhibiting DNA Gyrase and Altering Chromosome Topology. ACS Chem Biol. 2014 Apr 22. [Epub ahead of print]. PMID: 24712739.

Oliphant CM, Green GM. Quinolones: a comprehensive review. Am Fam Physician. 2002 Feb 1;65(3):455-64. PMID: 11858629.

Drlica K, Zhao X. DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev. 1997 Sep;61(3):377-92. PMID: 9293187.

" None Not dangerous goods.

LKT C3374 Cisplatin 50 mg 66.9 Pt-based DNA cross-linker. cis-Dichlorodiammine platinum(II) Abiplatin; DDP; Platiblastin; cis- Dichlorodi- ammineplatinum 15663-27-1 ≥98% 300.04 Cl2H6N2Pt [Cl-][Pt+2]([NH3])([NH3])[Cl-] Ambient 4°C Slightly soluble in water. DMSO to 60mg/mL "Hato SV, Khong A, de Vries IJ, et al. Molecular pathways: the immunogenic effects of platinum-based chemotherapeutics. Clin Cancer Res. 2014 Jun 1;20(11):2831-7. PMID: 24879823.

Liu H, Yin J, Wang C, et al. FOXO3a mediates the cytotoxic effects of cisplatin in lung cancer cells. Anticancer Drugs. 2014 Sep;25(8):898-907. PMID: 24814195.

Stordal B, Davey M. Understanding cisplatin resistance using cellular models. IUBMB Life. 2007 Nov;59(11):696-9. PMID: 17885832.

Marcon L, Zhang X, Hales BF, et al. Effects of chemotherapeutic agents for testicular cancer on rat spermatogonial stem/progenitor cells. J Androl. 2011 Jul-Aug;32(4):432-443. PMID: 21088230.

" Mut., Carc., T, Repr., Xi "UN number: 3288 Class: 6.1 Packing group: II

Proper shipping name: Toxic solid, inorganic, n.o.s. (Cisplatin)

Reportable Quantity (RQ): Marine pollutant: No Poison Inhalation Hazard: No"

LKT C3374 Cisplatin 100 mg 87.4 Pt-based DNA cross-linker. cis-Dichlorodiammine platinum(II) Abiplatin; DDP; Platiblastin; cis- Dichlorodi- ammineplatinum 15663-27-1 ≥98% 300.04 Cl2H6N2Pt [Cl-][Pt+2]([NH3])([NH3])[Cl-] Ambient 4°C Slightly soluble in water. DMSO to 60mg/mL "Hato SV, Khong A, de Vries IJ, et al. Molecular pathways: the immunogenic effects of platinum-based chemotherapeutics. Clin Cancer Res. 2014 Jun 1;20(11):2831-7. PMID: 24879823.

Liu H, Yin J, Wang C, et al. FOXO3a mediates the cytotoxic effects of cisplatin in lung cancer cells. Anticancer Drugs. 2014 Sep;25(8):898-907. PMID: 24814195.

Stordal B, Davey M. Understanding cisplatin resistance using cellular models. IUBMB Life. 2007 Nov;59(11):696-9. PMID: 17885832.

Marcon L, Zhang X, Hales BF, et al. Effects of chemotherapeutic agents for testicular cancer on rat spermatogonial stem/progenitor cells. J Androl. 2011 Jul-Aug;32(4):432-443. PMID: 21088230.

" Mut., Carc., T, Repr., Xi "UN number: 3288 Class: 6.1 Packing group: II

Proper shipping name: Toxic solid, inorganic, n.o.s. (Cisplatin)

Reportable Quantity (RQ): Marine pollutant: No Poison Inhalation Hazard: No"

LKT C3374 Cisplatin 500 mg 260.9 Pt-based DNA cross-linker. cis-Dichlorodiammine platinum(II) Abiplatin; DDP; Platiblastin; cis- Dichlorodi- ammineplatinum 15663-27-1 ≥98% 300.04 Cl2H6N2Pt [Cl-][Pt+2]([NH3])([NH3])[Cl-] Ambient 4°C Slightly soluble in water. DMSO to 60mg/mL "Hato SV, Khong A, de Vries IJ, et al. Molecular pathways: the immunogenic effects of platinum-based chemotherapeutics. Clin Cancer Res. 2014 Jun 1;20(11):2831-7. PMID: 24879823.

Liu H, Yin J, Wang C, et al. FOXO3a mediates the cytotoxic effects of cisplatin in lung cancer cells. Anticancer Drugs. 2014 Sep;25(8):898-907. PMID: 24814195.

Stordal B, Davey M. Understanding cisplatin resistance using cellular models. IUBMB Life. 2007 Nov;59(11):696-9. PMID: 17885832.

Marcon L, Zhang X, Hales BF, et al. Effects of chemotherapeutic agents for testicular cancer on rat spermatogonial stem/progenitor cells. J Androl. 2011 Jul-Aug;32(4):432-443. PMID: 21088230.

" Mut., Carc., T, Repr., Xi "UN number: 3288 Class: 6.1 Packing group: II

Proper shipping name: Toxic solid, inorganic, n.o.s. (Cisplatin)

Reportable Quantity (RQ): Marine pollutant: No Poison Inhalation Hazard: No"

LKT C3446 Cilnidipine 100 mg 140.7 Dihydropyridine; L-type and N-type Ca2+ channel blocker. 132203-70-4 ≥98% 490.525 C27H26N2O7 CC1=C(C(C(=C(N1)C)C(=O)OCC=CC2=CC=CC=C2)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OCCOC Ambient Ambient "Soeki T, Kitani M, Kusunose K, et al. Renoprotective and antioxidant effects of cilnidipine in hypertensive patients. Hypertens Res. 2012 Nov;35(11):1058-62. PMID: 22763473.

Fan L, Yang Q, Xiao XQ, et al. Dual actions of cilnidipine in human internal thoracic artery: inhibition of calcium channels and enhancement of endothelial nitric oxide synthase. J Thorac Cardiovasc Surg. 2011 Apr;141(4):1063-9. PMID: 20599230.

Koganei H, Shoji M, Iwata S. Suppression of formalin-induced nociception by cilnidipine, a voltage-dependent calcium channel blocker. Biol Pharm Bull. 2009 Oct;32(10):1695-700. PMID: 19801830.

Sugiura T, Imai E, Moriyama T, et al. Calcium channel blockers inhibit proliferation and matrix production in rat mesangial cells: possible mechanism of suppression of AP-1 and CREB activities. Nephron. 2000 May;85(1):71-80. PMID: 10773759.

Harada N, Ohnaka M, Sakamoto S, et al. Cilnidipine improves insulin sensitivity in the Otsuka Long-Evans Tokushima fatty rat, a model of spontaneous NIDDM. Cardiovasc Drugs Ther. 1999 Nov;13(6):519-23. PMID: 10686661.

Fan YY, Kohno M, Nakano D, et al. Cilnidipine suppresses podocyte injury and proteinuria in metabolic syndrome rats: possible involvement of N-type calcium channel in podocyte. J Hypertens. 2010 May;28(5):1034-1043. PMID: 20411599.

" Xi Not dangerous goods.

LKT C3446 Cilnidipine 250 mg 234.5 Dihydropyridine; L-type and N-type Ca2+ channel blocker. 132203-70-4 ≥98% 490.525 C27H26N2O7 CC1=C(C(C(=C(N1)C)C(=O)OCC=CC2=CC=CC=C2)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OCCOC Ambient Ambient "Soeki T, Kitani M, Kusunose K, et al. Renoprotective and antioxidant effects of cilnidipine in hypertensive patients. Hypertens Res. 2012 Nov;35(11):1058-62. PMID: 22763473.

Koganei H, Shoji M, Iwata S. Suppression of formalin-induced nociception by cilnidipine, a voltage-dependent calcium channel blocker. Biol Pharm Bull. 2009 Oct;32(10):1695-700. PMID: 19801830.

" Xi Not dangerous goods.

LKT T8020 Tuftsin 5 mg 60 Tetrapeptide, IgG Fc region derivative; Nrp1 agonist. ≥95% 500.6 C21H40N8O6 CC(C(C(=O)NC(CCCCN)C(=O)N1CCCC1C(=O)NC(CCCN=C(N)N)C(=O)O)N)O Ambient -20°C "Nissen JC, Selwood DL, Tsirka SE. Tuftsin signals through its receptor neuropilin-1 via the transforming growth factor beta pathway. J Neurochem. 2013 Nov;127(3):394-402. PMID: 24033337.

Aronowski J, Wleklik M, Gumulka SW, et al. Modification of morphine withdrawal: effect of tuftsin, [Lys4]-tuftsinyltuftsin, tetrapeptide fragment (1-4) of substance P and its amide. Life Sci. 1985 Oct 28;37(17):1649-53. PMID: 2414628.

Nishioka K, Babcock GF, Phillips JH, et al. Antitumor effect of tuftsin. Mol Cell Biochem. 1981 Dec 4;41:13-8. PMID: 6895773.

Stabinsky Y, Bar-Shavit Z, Fridkin M, et al. On the mechanism of action of the phagocytosis-stimulating peptide tuftsin. Mol Cell Biochem. 1980 Apr 18;30(2):71-7. PMID: 6247642.

" Not dangerous goods.

LKT C3446 Cilnidipine 1 g 675.2 Dihydropyridine; L-type and N-type Ca2+ channel blocker. 132203-70-4 ≥98% 490.525 C27H26N2O7 CC1=C(C(C(=C(N1)C)C(=O)OCC=CC2=CC=CC=C2)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OCCOC Ambient Ambient "Soeki T, Kitani M, Kusunose K, et al. Renoprotective and antioxidant effects of cilnidipine in hypertensive patients. Hypertens Res. 2012 Nov;35(11):1058-62. PMID: 22763473.

Koganei H, Shoji M, Iwata S. Suppression of formalin-induced nociception by cilnidipine, a voltage-dependent calcium channel blocker. Biol Pharm Bull. 2009 Oct;32(10):1695-700. PMID: 19801830.

" Xi Not dangerous goods.

LKT T8020 Tuftsin 10 mg 101.9 Tetrapeptide, IgG Fc region derivative; Nrp1 agonist. ≥95% 500.6 C21H40N8O6 CC(C(C(=O)NC(CCCCN)C(=O)N1CCCC1C(=O)NC(CCCN=C(N)N)C(=O)O)N)O Ambient -20°C "Nissen JC, Selwood DL, Tsirka SE. Tuftsin signals through its receptor neuropilin-1 via the transforming growth factor beta pathway. J Neurochem. 2013 Nov;127(3):394-402. PMID: 24033337.

Nishioka K, Babcock GF, Phillips JH, et al. Antitumor effect of tuftsin. Mol Cell Biochem. 1981 Dec 4;41:13-8. PMID: 6895773.

Stabinsky Y, Bar-Shavit Z, Fridkin M, et al. On the mechanism of action of the phagocytosis-stimulating peptide tuftsin. Mol Cell Biochem. 1980 Apr 18;30(2):71-7. PMID: 6247642.

" Not dangerous goods.

LKT T8020 Tuftsin 25 mg 180 Tetrapeptide, IgG Fc region derivative; Nrp1 agonist. ≥95% 500.6 C21H40N8O6 CC(C(C(=O)NC(CCCCN)C(=O)N1CCCC1C(=O)NC(CCCN=C(N)N)C(=O)O)N)O Ambient -20°C "Nissen JC, Selwood DL, Tsirka SE. Tuftsin signals through its receptor neuropilin-1 via the transforming growth factor beta pathway. J Neurochem. 2013 Nov;127(3):394-402. PMID: 24033337.

Nishioka K, Babcock GF, Phillips JH, et al. Antitumor effect of tuftsin. Mol Cell Biochem. 1981 Dec 4;41:13-8. PMID: 6895773.

Stabinsky Y, Bar-Shavit Z, Fridkin M, et al. On the mechanism of action of the phagocytosis-stimulating peptide tuftsin. Mol Cell Biochem. 1980 Apr 18;30(2):71-7. PMID: 6247642.

" Not dangerous goods.

LKT T8004 Tubeimoside I 10 mg 76.3 Triterpene saponin originally found in Bolbostemma; microtubule polymerization inhibitor. Tubeimoside 1 102040-03-9 ≥96% 1319.43 C63H98O29 CC1C(C(C(C(O1)OC2C(C(COC2OC(=O)C34CCC(CC3C5=CCC6C(C5(CC4)C)(CCC7C6(CC(C8C7(COC(=O)CC(CC(=O)OC9C(C(COC9OC1C(C(C(OC1O8)CO)O)O)O)O)(C)O)C)O)C)C)(C)C)O)O)O)OC1C(C(C(CO1)O)O)O)O Ambient Ambient "Wu Q, Sun G, Yuan X, et al. Tubeimoside-1 attenuates LPS-induced inflammation in RAW 264.7 macrophages and mouse models. Immunopharmacol Immunotoxicol. 2013 Aug;35(4):514-23. PMID: 23844578.

Xu Y, Wang G, Chen Q, et al. Intrinsic apoptotic pathway and G2/M cell cycle arrest involved in tubeimoside I-induced EC109 cell death. Chin J Cancer Res. 2013 Jun;25(3):312-21. PMID: 23825908.

Ma R, Song G, You W, et al. Anti-microtubule activity of tubeimoside I and its colchicine binding site of tubulin. Cancer Chemother Pharmacol. 2008 Sep;62(4):559-68. PMID: 18030471.

Yu L, Ma R, Wang Y, et al. Potent anti-tumor activity and low toxicity of tubeimoside 1 isolated from Bolbostemma paniculatum. Planta Med. 1994 Jun;60(3):204-8. PMID: 8073083.

Yu LJ, Ma RD, Jiang SB. Effects of tubeimoside-1 on HIV core protein p24 and cytopathogenesis in vitro. Zhongguo Yao Li Xue Bao. 1994 Mar;15(2):103-6. PMID: 8010099.

Yu LJ, Ma RD, Wang YQ, et al. Potent anti-tumorigenic effect of tubeimoside 1 isolated from the bulb of Bolbostemma paniculatum (Maxim) Franquet. Int J Cancer. 1992 Feb 20;50(4):635-8. PMID: 1537629.

" Not dangerous goods.

LKT T8004 Tubeimoside I 25 mg 152.7 Triterpene saponin originally found in Bolbostemma; microtubule polymerization inhibitor. Tubeimoside 1 102040-03-9 ≥96% 1319.43 C63H98O29 CC1C(C(C(C(O1)OC2C(C(COC2OC(=O)C34CCC(CC3C5=CCC6C(C5(CC4)C)(CCC7C6(CC(C8C7(COC(=O)CC(CC(=O)OC9C(C(COC9OC1C(C(C(OC1O8)CO)O)O)O)O)(C)O)C)O)C)C)(C)C)O)O)O)OC1C(C(C(CO1)O)O)O)O Ambient Ambient "Wu Q, Sun G, Yuan X, et al. Tubeimoside-1 attenuates LPS-induced inflammation in RAW 264.7 macrophages and mouse models. Immunopharmacol Immunotoxicol. 2013 Aug;35(4):514-23. PMID: 23844578.

Xu Y, Wang G, Chen Q, et al. Intrinsic apoptotic pathway and G2/M cell cycle arrest involved in tubeimoside I-induced EC109 cell death. Chin J Cancer Res. 2013 Jun;25(3):312-21. PMID: 23825908.

Ma R, Song G, You W, et al. Anti-microtubule activity of tubeimoside I and its colchicine binding site of tubulin. Cancer Chemother Pharmacol. 2008 Sep;62(4):559-68. PMID: 18030471.

Yu L, Ma R, Wang Y, et al. Potent anti-tumor activity and low toxicity of tubeimoside 1 isolated from Bolbostemma paniculatum. Planta Med. 1994 Jun;60(3):204-8. PMID: 8073083.

Yu LJ, Ma RD, Jiang SB. Effects of tubeimoside-1 on HIV core protein p24 and cytopathogenesis in vitro. Zhongguo Yao Li Xue Bao. 1994 Mar;15(2):103-6. PMID: 8010099.

Yu LJ, Ma RD, Wang YQ, et al. Potent anti-tumorigenic effect of tubeimoside 1 isolated from the bulb of Bolbostemma paniculatum (Maxim) Franquet. Int J Cancer. 1992 Feb 20;50(4):635-8. PMID: 1537629.

" Not dangerous goods.

LKT T8004 Tubeimoside I 100 mg 495.8 Triterpene saponin originally found in Bolbostemma; microtubule polymerization inhibitor. Tubeimoside 1 102040-03-9 ≥96% 1319.43 C63H98O29 CC1C(C(C(C(O1)OC2C(C(COC2OC(=O)C34CCC(CC3C5=CCC6C(C5(CC4)C)(CCC7C6(CC(C8C7(COC(=O)CC(CC(=O)OC9C(C(COC9OC1C(C(C(OC1O8)CO)O)O)O)O)(C)O)C)O)C)C)(C)C)O)O)O)OC1C(C(C(CO1)O)O)O)O Ambient Ambient "Wu Q, Sun G, Yuan X, et al. Tubeimoside-1 attenuates LPS-induced inflammation in RAW 264.7 macrophages and mouse models. Immunopharmacol Immunotoxicol. 2013 Aug;35(4):514-23. PMID: 23844578.

Xu Y, Wang G, Chen Q, et al. Intrinsic apoptotic pathway and G2/M cell cycle arrest involved in tubeimoside I-induced EC109 cell death. Chin J Cancer Res. 2013 Jun;25(3):312-21. PMID: 23825908.

Ma R, Song G, You W, et al. Anti-microtubule activity of tubeimoside I and its colchicine binding site of tubulin. Cancer Chemother Pharmacol. 2008 Sep;62(4):559-68. PMID: 18030471.

Yu L, Ma R, Wang Y, et al. Potent anti-tumor activity and low toxicity of tubeimoside 1 isolated from Bolbostemma paniculatum. Planta Med. 1994 Jun;60(3):204-8. PMID: 8073083.

Yu LJ, Ma RD, Jiang SB. Effects of tubeimoside-1 on HIV core protein p24 and cytopathogenesis in vitro. Zhongguo Yao Li Xue Bao. 1994 Mar;15(2):103-6. PMID: 8010099.

Yu LJ, Ma RD, Wang YQ, et al. Potent anti-tumorigenic effect of tubeimoside 1 isolated from the bulb of Bolbostemma paniculatum (Maxim) Franquet. Int J Cancer. 1992 Feb 20;50(4):635-8. PMID: 1537629.

" Not dangerous goods.

LKT C3477 Citalopram Hydrobromide 25 mg 94.4 SERT inhibitor. (RS)-1-[3-(dimethylamino)propyl]-1-(p-flurophenyl)- 5-phthalancarbonitrile, hydrobromide Celexa; Cipramil; Elopram; Seropram. 59729-32-7 ≥98% 405.31 C20H21FN2O HB4 CN(C)CCCC1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F.Br Ambient Ambient "DMSO (18 mg/ml)

Water (4 mg/ml)

Ethanol (20 mg/ml)" "Tan Y, Duan J, Li Y, et al. Effects of citalopram on serum deprivation induced PC12 cell apoptosis and BDNF expression. Pharmazie. 2010 Nov;65(11):845-8. PMID: 21155393.

Sacre S, Medghalchi M, Gregory B, et al. Fluoxetine and citalopram exhibit potent antiinflammatory activity in human and murine models of rheumatoid arthritis and inhibit toll-like receptors. Arthritis Rheum. 2010 Mar;62(3):683-93. PMID: 20131240.

Apparsundaram S, Stockdale DJ, Henningsen RA, et al. Antidepressants targeting the serotonin reuptake transporter act via a competitive mechanism. J Pharmacol Exp Ther. 2008 Dec;327(3):982-90. PMID: 18801947.

" None Not dangerous goods.

LKT C3477 Citalopram Hydrobromide 100 mg 304.6 SERT inhibitor. (RS)-1-[3-(dimethylamino)propyl]-1-(p-flurophenyl)- 5-phthalancarbonitrile, hydrobromide Celexa; Cipramil; Elopram; Seropram. 59729-32-7 ≥98% 405.31 C20H21FN2O HB4 CN(C)CCCC1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F.Br Ambient Ambient "DMSO (18 mg/ml)

Water (4 mg/ml)

Ethanol (20 mg/ml)" "Tan Y, Duan J, Li Y, et al. Effects of citalopram on serum deprivation induced PC12 cell apoptosis and BDNF expression. Pharmazie. 2010 Nov;65(11):845-8. PMID: 21155393.

" None Not dangerous goods.

LKT C3477 Citalopram Hydrobromide 500 mg 945 SERT inhibitor. (RS)-1-[3-(dimethylamino)propyl]-1-(p-flurophenyl)- 5-phthalancarbonitrile, hydrobromide Celexa; Cipramil; Elopram; Seropram. 59729-32-7 ≥98% 405.31 C20H21FN2O HB4 CN(C)CCCC1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F.Br Ambient Ambient "DMSO (18 mg/ml)

Water (4 mg/ml)

Ethanol (20 mg/ml)" "Tan Y, Duan J, Li Y, et al. Effects of citalopram on serum deprivation induced PC12 cell apoptosis and BDNF expression. Pharmazie. 2010 Nov;65(11):845-8. PMID: 21155393.

" None Not dangerous goods.

LKT C3479 Citrinin 1 mg 46.8 Mycotoxin produced by Penicillum, Aspergillus, and Monascus. 518-75-2 ≥98% 250.249 C13H14O5 CC1C(OC=C2C1=C(C(=C(C2=O)C(=O)O)O)C)C Ambient 4°C "Wu TS, Yang JJ, Yu FY, et al. Cardiotoxicity of mycotoxin citrinin and involvement of microRNA-138 in zebrafish embryos. Toxicol Sci. 2013 Dec;136(2):402-12. PMID: 24052562.

Liu S, Wang D, Zhang J, et al. Citrinin reduces testosterone secretion by inducing apoptosis in rat Leydig cells. Toxicol In Vitro. 2012 Sep;26(6):856-61. PMID: 22564900.

Flajs D, Peraica M. Toxicological properties of citrinin. Arh Hig Rada Toksikol. 2009 Dec;60(4):457-64. PMID: 20061247.

Da Lozzo EJ, Oliveira MB, Carnieri EG. Citrinin-induced mitochondrial permeability transition. J Biochem Mol Toxicol. 1998;12(5):291-7. PMID: 9664235.

Ribeiro SM, Chagas GM, Campello AP, et al. Mechanism of citrinin-induced dysfunction of mitochondria. V. Effect on the homeostasis of the reactive oxygen species. Cell Biochem Funct. 1997 Sep;15(3):203-9. PMID: 9377799.

" "UN number: 3462 Class: 6.1 Packing Group: III

Proper shipping name: Toxins, extracted from living sources, solid, n.o.s. (Citrinin)"

LKT C3479 Citrinin 5 mg 157.3 Mycotoxin produced by Penicillum, Aspergillus, and Monascus. 518-75-2 ≥98% 250.249 C13H14O5 CC1C(OC=C2C1=C(C(=C(C2=O)C(=O)O)O)C)C Ambient 4°C "Wu TS, Yang JJ, Yu FY, et al. Cardiotoxicity of mycotoxin citrinin and involvement of microRNA-138 in zebrafish embryos. Toxicol Sci. 2013 Dec;136(2):402-12. PMID: 24052562.

Liu S, Wang D, Zhang J, et al. Citrinin reduces testosterone secretion by inducing apoptosis in rat Leydig cells. Toxicol In Vitro. 2012 Sep;26(6):856-61. PMID: 22564900.

Flajs D, Peraica M. Toxicological properties of citrinin. Arh Hig Rada Toksikol. 2009 Dec;60(4):457-64. PMID: 20061247.

Da Lozzo EJ, Oliveira MB, Carnieri EG. Citrinin-induced mitochondrial permeability transition. J Biochem Mol Toxicol. 1998;12(5):291-7. PMID: 9664235.

" "UN number: 3462 Class: 6.1 Packing Group: III

Proper shipping name: Toxins, extracted from living sources, solid, n.o.s. (Citrinin)"

LKT C3479 Citrinin 10 mg 286.5 Mycotoxin produced by Penicillum, Aspergillus, and Monascus. 518-75-2 ≥98% 250.249 C13H14O5 CC1C(OC=C2C1=C(C(=C(C2=O)C(=O)O)O)C)C Ambient 4°C "Wu TS, Yang JJ, Yu FY, et al. Cardiotoxicity of mycotoxin citrinin and involvement of microRNA-138 in zebrafish embryos. Toxicol Sci. 2013 Dec;136(2):402-12. PMID: 24052562.

Liu S, Wang D, Zhang J, et al. Citrinin reduces testosterone secretion by inducing apoptosis in rat Leydig cells. Toxicol In Vitro. 2012 Sep;26(6):856-61. PMID: 22564900.

Flajs D, Peraica M. Toxicological properties of citrinin. Arh Hig Rada Toksikol. 2009 Dec;60(4):457-64. PMID: 20061247.

Da Lozzo EJ, Oliveira MB, Carnieri EG. Citrinin-induced mitochondrial permeability transition. J Biochem Mol Toxicol. 1998;12(5):291-7. PMID: 9664235.

" "UN number: 3462 Class: 6.1 Packing Group: III

Proper shipping name: Toxins, extracted from living sources, solid, n.o.s. (Citrinin)"

LKT C3578 L-Citrulline 1 g 33.8 Byproduct of L-arginine metabolism found in watermelon. 372-75-8 ≥98% 175.19 C6H13N3O3 C(CC(C(=O)O)N)CNC(=O)N Ambient Ambient "Munglue P, Eumkep G, Wray S, et al. The effects of watermelon (Citrullus lanatus) extracts and L-citrulline on rat uterine contractility. Reprod Sci. 2013 Apr;20(4):437-48. PMID: 22991380.

Gou L, Zhang L, Yin C, et al. Protective effect of L-citrulline against acute gastric mucosal lesions induced by ischemia-reperfusion in rats. Can J Physiol Pharmacol. 2011 May;89(5):317-27. PMID: 21619416.

Lee TJ, Sarwinski S, Ishine T, et al. Inhibition of cerebral neurogenic vasodilation by L-glutamine and nitric oxide synthase inhibitors and its reversal by L-citrulline. J Pharmacol Exp Ther. 1996 Feb;276(2):353-8. PMID: 8632296.

" Not dangerous goods.

LKT C3578 L-Citrulline 5 g 41.9 Byproduct of L-arginine metabolism found in watermelon. 372-75-8 ≥98% 175.19 C6H13N3O3 C(CC(C(=O)O)N)CNC(=O)N Ambient Ambient "Munglue P, Eumkep G, Wray S, et al. The effects of watermelon (Citrullus lanatus) extracts and L-citrulline on rat uterine contractility. Reprod Sci. 2013 Apr;20(4):437-48. PMID: 22991380.

" Not dangerous goods.

LKT C3578 L-Citrulline 25 g 121.9 Byproduct of L-arginine metabolism found in watermelon. 372-75-8 ≥98% 175.19 C6H13N3O3 C(CC(C(=O)O)N)CNC(=O)N Ambient Ambient "Munglue P, Eumkep G, Wray S, et al. The effects of watermelon (Citrullus lanatus) extracts and L-citrulline on rat uterine contractility. Reprod Sci. 2013 Apr;20(4):437-48. PMID: 22991380.

" Not dangerous goods.

LKT C3578 L-Citrulline 100 g 370.1 Byproduct of L-arginine metabolism found in watermelon. 372-75-8 ≥98% 175.19 C6H13N3O3 C(CC(C(=O)O)N)CNC(=O)N Ambient Ambient "Munglue P, Eumkep G, Wray S, et al. The effects of watermelon (Citrullus lanatus) extracts and L-citrulline on rat uterine contractility. Reprod Sci. 2013 Apr;20(4):437-48. PMID: 22991380.

" Not dangerous goods.

LKT C4274 CKS-17 1 mg 183 Synthetic peptide, retroviral envelope protein sequence analog. 99273-04-8 ≥95% 1942.31 C87H148N26O24 CC(C)CC(C(=O)NC(CCC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC(CCC(=O)O)C(=O)NCC(=O)NCC(=O)NC(CC(C)C)C(=O)O)N Ambient -20°C "Haraguchi S, Good RA, Day-Good NK. A potent immunosuppressive retroviral peptide: cytokine patterns and signaling pathways. Immunol Res. 2008;41(1):46-55. PMID: 18506644.

Fan Tx, Day NK, Luangwedchakarn V, et al. The phosphorylation of phospholipase C-gamma1, Raf-1, MEK, and ERK1/2 induced by a conserved retroviral peptide. Peptides. 2005 Nov;26(11):2165-74. PMID: 15978701.

Takahashi A, Day NK, Luangwedchakarn V, et al. A retroviral-derived immunosuppressive peptide activates mitogen-activated protein kinases. J Immunol. 2001 Jun 1;166(11):6771-5. PMID: 11359835.

Kabeya H, Ohashi K, Sugimoto C, et al. Bovine leukaemia virus envelope peptides cause immunomodulation in BALB/c mice. Vet Immunol Immunopathol. 1999 Mar 29;68(1):39-48. PMID: 10231950.

LKT C4274 CKS-17 0.5 mg 107.8 Synthetic peptide, retroviral envelope protein sequence analog. 99273-04-8 ≥95% 1942.31 C87H148N26O24 CC(C)CC(C(=O)NC(CCC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC(CCC(=O)O)C(=O)NCC(=O)NCC(=O)NC(CC(C)C)C(=O)O)N Ambient -20°C "Haraguchi S, Good RA, Day-Good NK. A potent immunosuppressive retroviral peptide: cytokine patterns and signaling pathways. Immunol Res. 2008;41(1):46-55. PMID: 18506644.

Takahashi A, Day NK, Luangwedchakarn V, et al. A retroviral-derived immunosuppressive peptide activates mitogen-activated protein kinases. J Immunol. 2001 Jun 1;166(11):6771-5. PMID: 11359835.

Kabeya H, Ohashi K, Sugimoto C, et al. Bovine leukaemia virus envelope peptides cause immunomodulation in BALB/c mice. Vet Immunol Immunopathol. 1999 Mar 29;68(1):39-48. PMID: 10231950.

LKT C4274 CKS-17 2.5 mg 324 Synthetic peptide, retroviral envelope protein sequence analog. 99273-04-8 ≥95% 1942.31 C87H148N26O24 CC(C)CC(C(=O)NC(CCC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC(CCC(=O)O)C(=O)NCC(=O)NCC(=O)NC(CC(C)C)C(=O)O)N Ambient -20°C "Haraguchi S, Good RA, Day-Good NK. A potent immunosuppressive retroviral peptide: cytokine patterns and signaling pathways. Immunol Res. 2008;41(1):46-55. PMID: 18506644.

Takahashi A, Day NK, Luangwedchakarn V, et al. A retroviral-derived immunosuppressive peptide activates mitogen-activated protein kinases. J Immunol. 2001 Jun 1;166(11):6771-5. PMID: 11359835.

Kabeya H, Ohashi K, Sugimoto C, et al. Bovine leukaemia virus envelope peptides cause immunomodulation in BALB/c mice. Vet Immunol Immunopathol. 1999 Mar 29;68(1):39-48. PMID: 10231950.

LKT C4402 Cladribine 5 mg 61.1 Nucleoside (deoxyadenosine) analog; DNA chain terminator, ribonucleotide reductase and DNA polymerase inhibitor. 2-CdA, 2-Chlorodeoxyadenosine 4291-63-8 ≥98% 285.69 C10H12ClN5O3 C1C(C(OC1N2C=NC3=C2N=C(N=C3N)Cl)CO)O Ambient Ambient "Singh V, Prajeeth CK, Gudi V, et al. 2-Chlorodeoxyadenosine (cladribine) induces apoptosis in human monocyte-derived dendritic cells. Clin Exp Immunol. 2013 Aug;173(2):288-97. PMID: 23607690.

Comi G, Hartung HP, Kurukulasuriya NC, et al. Cladribine tablets for the treatment of relapsing-remitting multiple sclerosis. Expert Opin Pharmacother. 2013 Jan;14(1):123-36. PMID: 23256518.

Leist TP, Weissert R. Cladribine: mode of action and implications for treatment of multiple sclerosis. Clin Neuropharmacol. 2011 Jan-Feb;34(1):28-35. PMID: 21242742.

Robak T, Korycka A, Robak E. Older and new formulations of cladribine. Pharmacology and clinical efficacy in hematological malignancies. Recent Pat Anticancer Drug Discov. 2006 Jan;1(1):23-38. PMID: 18221024.

" T Not dangerous goods.

LKT C4402 Cladribine 10 mg 101.9 Nucleoside (deoxyadenosine) analog; DNA chain terminator, ribonucleotide reductase and DNA polymerase inhibitor. 2-CdA, 2-Chlorodeoxyadenosine 4291-63-8 ≥98% 285.69 C10H12ClN5O3 C1C(C(OC1N2C=NC3=C2N=C(N=C3N)Cl)CO)O Ambient Ambient "Singh V, Prajeeth CK, Gudi V, et al. 2-Chlorodeoxyadenosine (cladribine) induces apoptosis in human monocyte-derived dendritic cells. Clin Exp Immunol. 2013 Aug;173(2):288-97. PMID: 23607690.

Comi G, Hartung HP, Kurukulasuriya NC, et al. Cladribine tablets for the treatment of relapsing-remitting multiple sclerosis. Expert Opin Pharmacother. 2013 Jan;14(1):123-36. PMID: 23256518.

Leist TP, Weissert R. Cladribine: mode of action and implications for treatment of multiple sclerosis. Clin Neuropharmacol. 2011 Jan-Feb;34(1):28-35. PMID: 21242742.

" T Not dangerous goods.

LKT C4402 Cladribine 25 mg 203.8 Nucleoside (deoxyadenosine) analog; DNA chain terminator, ribonucleotide reductase and DNA polymerase inhibitor. 2-CdA, 2-Chlorodeoxyadenosine 4291-63-8 ≥98% 285.69 C10H12ClN5O3 C1C(C(OC1N2C=NC3=C2N=C(N=C3N)Cl)CO)O Ambient Ambient "Singh V, Prajeeth CK, Gudi V, et al. 2-Chlorodeoxyadenosine (cladribine) induces apoptosis in human monocyte-derived dendritic cells. Clin Exp Immunol. 2013 Aug;173(2):288-97. PMID: 23607690.

Comi G, Hartung HP, Kurukulasuriya NC, et al. Cladribine tablets for the treatment of relapsing-remitting multiple sclerosis. Expert Opin Pharmacother. 2013 Jan;14(1):123-36. PMID: 23256518.

Leist TP, Weissert R. Cladribine: mode of action and implications for treatment of multiple sclerosis. Clin Neuropharmacol. 2011 Jan-Feb;34(1):28-35. PMID: 21242742.

" T Not dangerous goods.

LKT "C4502

" Clarithromycin 100 mg 67.9 Macrolide; protein translation inhibitor. 6-O-Methylerythromycin Biaxin; Cyllind; Klacid; Macladin; Naxy; Veclam; Zeclar 81103-11-9 ≥95% 747.95 C38H69NO13 CCC1C(C(C(C(=O)C(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)OC)C)C)O)(C)O Ambient Ambient Soluble in acetone, DMSO (18mg/mL). "Cobos-Trigueros N, Ateka O, Pitart C, et al. Macrolides and ketolides. Enferm Infecc Microbiol Clin. 2009 Aug-Sep;27(7):412-8. PMID: 19625112.

Hao Q, Li Y, Zhang ZJ, et al. New mutation points in 23S rRNA gene associated with Helicobacter pylori resistance to clarithromycin in northeast China. World J Gastroenterol. 2004 Apr 1;10(7):1075-7. PMID: 15052698.

" Xn Not dangerous goods.

LKT "C4502

" Clarithromycin 250 mg 95.1 Macrolide; protein translation inhibitor. 6-O-Methylerythromycin Biaxin; Cyllind; Klacid; Macladin; Naxy; Veclam; Zeclar 81103-11-9 ≥95% 747.95 C38H69NO13 CCC1C(C(C(C(=O)C(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)OC)C)C)O)(C)O Ambient Ambient Soluble in acetone, DMSO (18mg/mL). "Cobos-Trigueros N, Ateka O, Pitart C, et al. Macrolides and ketolides. Enferm Infecc Microbiol Clin. 2009 Aug-Sep;27(7):412-8. PMID: 19625112.

" Xn Not dangerous goods.

LKT C4502 Clarithromycin 1 g 339.8 Macrolide; protein translation inhibitor. 6-O-Methylerythromycin Biaxin; Cyllind; Klacid; Macladin; Naxy; Veclam; Zeclar 81103-11-9 ≥95% 747.95 C38H69NO13 CCC1C(C(C(C(=O)C(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)OC)C)C)O)(C)O Ambient Ambient Soluble in acetone, DMSO (18mg/mL). "Cobos-Trigueros N, Ateka O, Pitart C, et al. Macrolides and ketolides. Enferm Infecc Microbiol Clin. 2009 Aug-Sep;27(7):412-8. PMID: 19625112.

" Xn Not dangerous goods.

LKT P0093 Paclitaxel, semi-synthetic 5 mg 60 Semi-synthetic diterpene originally found in Taxus yunnanensis; microtubule depolymerization inhibitor. [2aR-[2aα,4β,4aβ,6β,9α-(αR*,βS*),11α,12α,12aα,12bα]]-β-(Benzoylamino)-α-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,- 5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy- 4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H- cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester Taxol; Taxol A; Paxene ≥98% 853.9 C47H51NO14 CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C Ambient -20°C Insoluble in water. Soluble in ethanol or DMSO (50mg/ml). "Kamath K, Smiyun G, Wilson L, et al. Mechanisms of inhibition of endothelial cell migration by taxanes. Cytoskeleton (Hoboken). 2013 Oct 23. [Epub ahead of print]. PMID: 24155271.

Caltová K, Cervinka M. Antiproliferative effects of selected chemotherapeutics in human ovarian cancer cell line A2780. Acta Medica (Hradec Kralove). 2012;55(3):116-24. PMID: 23297519.

Jia L, Zhang S, Ye Y, et al. Paclitaxel inhibits ovarian tumor growth by inducing epithelial cancer cells to benign fibroblast-like cells. Cancer Lett. 2012 Dec 30;326(2):176-82. PMID: 22902993.

Mielgo A, Torres VA, Clair K, et al. Paclitaxel promotes a caspase 8-mediated apoptosis through death effector domain association with microtubules. Oncogene. 2009 Oct 8;28(40):3551-62. PMID: 19668227.

Botta M, Forli S, Magnani M, et al. Molecular modeling approaches to study the binding mode on tubulin of microtubule destabilizing and stabilizing agents. Top Curr Chem. 2009;286:279-328. PMID: 23563616

Kumar N. Taxol-induced polymerization of purified tubulin. Mechanism of action. J Biol Chem. 1981 Oct 25;256(20):10435-41. PMID: 6116707.

Yu YH, Kim E, Park DE, et al. Cationic solid lipid nanoparticles for co-delivery of paclitaxel and siRNA. Eur J Pharm Biopharm. 2012 Feb;80(2):268-273. PMID: 22108492.

" Xi, Xn, Repr., Carc Not dangerous goods.

LKT P0093 Paclitaxel, semi-synthetic 25 mg 140.7 Semi-synthetic diterpene originally found in Taxus yunnanensis; microtubule depolymerization inhibitor. [2aR-[2aα,4β,4aβ,6β,9α-(αR*,βS*),11α,12α,12aα,12bα]]-β-(Benzoylamino)-α-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,- 5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy- 4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H- cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester Taxol; Taxol A; Paxene ≥98% 853.9 C47H51NO14 CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C Ambient -20°C Insoluble in water. Soluble in ethanol or DMSO (50mg/ml). "Kamath K, Smiyun G, Wilson L, et al. Mechanisms of inhibition of endothelial cell migration by taxanes. Cytoskeleton (Hoboken). 2013 Oct 23. [Epub ahead of print]. PMID: 24155271.

Caltová K, Cervinka M. Antiproliferative effects of selected chemotherapeutics in human ovarian cancer cell line A2780. Acta Medica (Hradec Kralove). 2012;55(3):116-24. PMID: 23297519.

Jia L, Zhang S, Ye Y, et al. Paclitaxel inhibits ovarian tumor growth by inducing epithelial cancer cells to benign fibroblast-like cells. Cancer Lett. 2012 Dec 30;326(2):176-82. PMID: 22902993.

Kumar N. Taxol-induced polymerization of purified tubulin. Mechanism of action. J Biol Chem. 1981 Oct 25;256(20):10435-41. PMID: 6116707.

Yu YH, Kim E, Park DE, et al. Cationic solid lipid nanoparticles for co-delivery of paclitaxel and siRNA. Eur J Pharm Biopharm. 2012 Feb;80(2):268-273. PMID: 22108492.

" Xi, Xn, Repr., Carc Not dangerous goods.

LKT P0093 Paclitaxel, semi-synthetic 100 mg 308.1 Semi-synthetic diterpene originally found in Taxus yunnanensis; microtubule depolymerization inhibitor. [2aR-[2aα,4β,4aβ,6β,9α-(αR*,βS*),11α,12α,12aα,12bα]]-β-(Benzoylamino)-α-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,- 5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy- 4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H- cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester Taxol; Taxol A; Paxene ≥98% 853.9 C47H51NO14 CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C Ambient -20°C Insoluble in water. Soluble in ethanol or DMSO (50mg/ml). "Kamath K, Smiyun G, Wilson L, et al. Mechanisms of inhibition of endothelial cell migration by taxanes. Cytoskeleton (Hoboken). 2013 Oct 23. [Epub ahead of print]. PMID: 24155271.

Caltová K, Cervinka M. Antiproliferative effects of selected chemotherapeutics in human ovarian cancer cell line A2780. Acta Medica (Hradec Kralove). 2012;55(3):116-24. PMID: 23297519.

Jia L, Zhang S, Ye Y, et al. Paclitaxel inhibits ovarian tumor growth by inducing epithelial cancer cells to benign fibroblast-like cells. Cancer Lett. 2012 Dec 30;326(2):176-82. PMID: 22902993.

Kumar N. Taxol-induced polymerization of purified tubulin. Mechanism of action. J Biol Chem. 1981 Oct 25;256(20):10435-41. PMID: 6116707.

Yu YH, Kim E, Park DE, et al. Cationic solid lipid nanoparticles for co-delivery of paclitaxel and siRNA. Eur J Pharm Biopharm. 2012 Feb;80(2):268-273. PMID: 22108492.

" Xi, Xn, Repr., Carc Not dangerous goods.

LKT S3353 Sinomenine Hydrochloride 10 g 72.2 Alkaloid found in Sinomenium; acid-sensing ion channel and L-type Ca2+ channel blocker. (9α,13α,14α)-7,8-Didehydro-4-hydroxy-3,7-di- methoxy-17-methylmorphinan-6-one hydrochloride 6080-33-7 ≥98% 365.86 C19H23NO4 HCl CN1CCC23CC(=O)C(=CC2C1CC4=C3C(=C(C=C4)OC)O)OC.Cl Ambient 4°C Soluble in chloroform, ethanol acetone or toluene. "Li X, Wang K, Ren Y, et al. MAPK signaling mediates sinomenine hydrochloride-induced human breast cancer cell death via both reactive oxygen species-dependent and -independent pathways: an in vitro and in vivo study. Cell Death Dis. 2014 Jul 31;5:e1356. PMID: 25077542.

Zhang MY, Li P, Wang DQ, et al. Analgesic effect of sinomenine on SSNI model rats and monoamine neurotransmitters in striatal extracellular fluid. Zhongguo Zhong Yao Za Zhi. 2013 Feb;38(4):597-604. PMID: 23713290.

Chen Z, Tao Z, Zhang N, et al. The role of sinomenine in treatment of allergic rhinitis mice model and its mechanism. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2013 Jan;27(2):81-4. PMID: 23650707.

Oh YC, Kang OH, Kim SB, et al. Anti-inflammatory effect of sinomenine by inhibition of pro-inflammatory mediators in PMA plus A23187-stimulated HMC-1 Cells. Eur Rev Med Pharmacol Sci. 2012 Sep;16(9):1184-91. PMID: 23047501.

Wu WN, Wu PF, Chen XL, et al. Sinomenine protects against ischaemic brain injury: involvement of co-inhibition of acid-sensing ion channel 1a and L-type calcium channels. Br J Pharmacol. 2011 Nov;164(5):1445-59. PMID: 21585344.

" Xn, Xi Not dangerous goods.

LKT S3353 Sinomenine Hydrochloride 25 g 245.1 Alkaloid found in Sinomenium; acid-sensing ion channel and L-type Ca2+ channel blocker. (9α,13α,14α)-7,8-Didehydro-4-hydroxy-3,7-di- methoxy-17-methylmorphinan-6-one hydrochloride 6080-33-7 ≥98% 365.86 C19H23NO4 HCl CN1CCC23CC(=O)C(=CC2C1CC4=C3C(=C(C=C4)OC)O)OC.Cl Ambient 4°C Soluble in chloroform, ethanol acetone or toluene. "Li X, Wang K, Ren Y, et al. MAPK signaling mediates sinomenine hydrochloride-induced human breast cancer cell death via both reactive oxygen species-dependent and -independent pathways: an in vitro and in vivo study. Cell Death Dis. 2014 Jul 31;5:e1356. PMID: 25077542.

" Xn, Xi Not dangerous goods.

LKT S3353 Sinomenine Hydrochloride 50 g 432.3 Alkaloid found in Sinomenium; acid-sensing ion channel and L-type Ca2+ channel blocker. (9α,13α,14α)-7,8-Didehydro-4-hydroxy-3,7-di- methoxy-17-methylmorphinan-6-one hydrochloride 6080-33-7 ≥98% 365.86 C19H23NO4 HCl CN1CCC23CC(=O)C(=CC2C1CC4=C3C(=C(C=C4)OC)O)OC.Cl Ambient 4°C Soluble in chloroform, ethanol acetone or toluene. "Li X, Wang K, Ren Y, et al. MAPK signaling mediates sinomenine hydrochloride-induced human breast cancer cell death via both reactive oxygen species-dependent and -independent pathways: an in vitro and in vivo study. Cell Death Dis. 2014 Jul 31;5:e1356. PMID: 25077542.

" Xn, Xi Not dangerous goods.

LKT L5873 Losartan Potassium 1 g 44.1 AT1 antagonist. 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'- biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol monopotassium salt DuPont-753; Losaprex; Lortaan; Neo-Lotan; Oscaar 124750-99-8 ≥98% 461.01 C22H22ClN6O K CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NN=N[N-]4)CO)Cl.[K+] Ambient Ambient Soluble in water to 100 mM, DMSO to 100 mM, and alcohol. "He P, Li D, Zhang B. Losartan attenuates renal interstitial fibrosis and tubular cell apoptosis in a rat model of obstructive nephropathy. Mol Med Rep. 2014 Aug;10(2):638-44. PMID: 24912579.

Wylie-Sears J, Levine RA, Bischoff J. Losartan inhibits endothelial-to-mesenchymal transformation in mitral valve endothelial cells by blocking transforming growth factor-β-induced phosphorylation of ERK. Biochem Biophys Res Commun. 2014 Apr 18;446(4):870-5. PMID: 24632204.

Gibson TJ. Hypertension, its treatment, hyperuricaemia and gout. Curr Opin Rheumatol. 2013 Mar;25(2):217-22. PMID: 23370375.

Apostolakis S, Krambovitis E, Vlata Z, et al. CX3CR1 receptor is up-regulated in monocytes of coronary artery diseased patients: impact of pre-inflammatory stimuli and renin-angiotensin system modulators. Thromb Res. 2007;121(3):387-395. PMID: 17521710.

Koseki N, Deguchi J, Yamashita A, et al. Establishment fo a novel experimental protocol for drug-induced seizure liability screening based on a locomotor activity assay in zebrafish. J Toxicol Sci. 2014 Aug;39(4):579-600. PMID: 25056783.

Nagata T, Fukuzawa T, Takeda M, et al. Tofogliflozin, a novel sodium-glucose co-transporter 2 inhibitor, improves renal and pancreatic function in db/db mice. Br J Pharmacol. 2013 Oct;170(3):519-531. PMID: 23751087.

" Xi Not dangerous goods.

LKT L5873 Losartan Potassium 5 g 141.8 AT1 antagonist. 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'- biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol monopotassium salt DuPont-753; Losaprex; Lortaan; Neo-Lotan; Oscaar 124750-99-8 ≥98% 461.01 C22H22ClN6O K CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NN=N[N-]4)CO)Cl.[K+] Ambient Ambient Soluble in water to 100 mM, DMSO to 100 mM, and alcohol. "He P, Li D, Zhang B. Losartan attenuates renal interstitial fibrosis and tubular cell apoptosis in a rat model of obstructive nephropathy. Mol Med Rep. 2014 Aug;10(2):638-44. PMID: 24912579.

Gibson TJ. Hypertension, its treatment, hyperuricaemia and gout. Curr Opin Rheumatol. 2013 Mar;25(2):217-22. PMID: 23370375.

" Xi Not dangerous goods.

LKT L5873 Losartan Potassium 25 g 456.8 AT1 antagonist. 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'- biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol monopotassium salt DuPont-753; Losaprex; Lortaan; Neo-Lotan; Oscaar 124750-99-8 ≥98% 461.01 C22H22ClN6O K CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NN=N[N-]4)CO)Cl.[K+] Ambient Ambient Soluble in water to 100 mM, DMSO to 100 mM, and alcohol. "He P, Li D, Zhang B. Losartan attenuates renal interstitial fibrosis and tubular cell apoptosis in a rat model of obstructive nephropathy. Mol Med Rep. 2014 Aug;10(2):638-44. PMID: 24912579.

Gibson TJ. Hypertension, its treatment, hyperuricaemia and gout. Curr Opin Rheumatol. 2013 Mar;25(2):217-22. PMID: 23370375.

" Xi Not dangerous goods.

LKT O9210 Oxcarbazepine 1 g 69.3 α4β2 nAChR desensitizer, delayed-rectifier voltage-gated K+ and voltage-gated Na+ channel blocker. 10,11-Dihydro-10-oxo-5H-dibenz[b,f]azepine-5- carboxamide Trileptal 28721-07-5 ≥98% 252.27 C15H12N2O2 C1C2=CC=CC=C2N(C3=CC=CC=C3C1=O)C(=O)N Ambient Ambient Soluble in DMSO (9mg/mL). "Di Resta C, Ambrosi P, Curia G, et al. Effect of carbamazepine and oxcarbazepine on wild-type and mutant neuronal nicotinic acetylcholine receptors linked to nocturnal frontal lobe epilepsy. Eur J Pharmacol. 2010 Sep 15;643(1):13-20. PMID: 20561518.

Johannessen Landmark C, Johannessen SI. Pharmacological management of epilepsy: recent advances and future prospects. Drugs. 2008;68(14):1925-39. PMID: 18778117.

Huang CW, Huang CC, Lin MW, et al. The synergistic inhibitory actions of oxcarbazepine on voltage-gated sodium and potassium currents in differentiated NG108-15 neuronal cells and model neurons. Int J Neuropsychopharmacol. 2008 Aug;11(5):597-610. PMID: 18184444.

Sitges M, Chiu LM, Guarneros A, et al. Effects of carbamazepine, phenytoin, lamotrigine, oxcarbazepine, topiramate and vinpocetine on Na+ channel-mediated release of [3H]glutamate in hippocampal nerve endings. Neuropharmacology. 2007 Feb;52(2):598-605. PMID: 17070874.

Nishimura M, Nakanishi T, Yasui A, et al. Serum calcium increases the incidence of arrhythmias during acetate hemodialysis. Am J Kidney Dis. 1992 Feb;19(2):149-55. PMID: 1739097.

" None Not dangerous goods.

LKT O9210 Oxcarbazepine 5 g 219.7 α4β2 nAChR desensitizer, delayed-rectifier voltage-gated K+ and voltage-gated Na+ channel blocker. 10,11-Dihydro-10-oxo-5H-dibenz[b,f]azepine-5- carboxamide Trileptal 28721-07-5 ≥98% 252.27 C15H12N2O2 C1C2=CC=CC=C2N(C3=CC=CC=C3C1=O)C(=O)N Ambient Ambient Soluble in DMSO (9mg/mL). "Di Resta C, Ambrosi P, Curia G, et al. Effect of carbamazepine and oxcarbazepine on wild-type and mutant neuronal nicotinic acetylcholine receptors linked to nocturnal frontal lobe epilepsy. Eur J Pharmacol. 2010 Sep 15;643(1):13-20. PMID: 20561518.

Johannessen Landmark C, Johannessen SI. Pharmacological management of epilepsy: recent advances and future prospects. Drugs. 2008;68(14):1925-39. PMID: 18778117.

Nishimura M, Nakanishi T, Yasui A, et al. Serum calcium increases the incidence of arrhythmias during acetate hemodialysis. Am J Kidney Dis. 1992 Feb;19(2):149-55. PMID: 1739097.

" None Not dangerous goods.

LKT O9210 Oxcarbazepine 25 g 808.5 α4β2 nAChR desensitizer, delayed-rectifier voltage-gated K+ and voltage-gated Na+ channel blocker. 10,11-Dihydro-10-oxo-5H-dibenz[b,f]azepine-5- carboxamide Trileptal 28721-07-5 ≥98% 252.27 C15H12N2O2 C1C2=CC=CC=C2N(C3=CC=CC=C3C1=O)C(=O)N Ambient Ambient Soluble in DMSO (9mg/mL). "Di Resta C, Ambrosi P, Curia G, et al. Effect of carbamazepine and oxcarbazepine on wild-type and mutant neuronal nicotinic acetylcholine receptors linked to nocturnal frontal lobe epilepsy. Eur J Pharmacol. 2010 Sep 15;643(1):13-20. PMID: 20561518.

Johannessen Landmark C, Johannessen SI. Pharmacological management of epilepsy: recent advances and future prospects. Drugs. 2008;68(14):1925-39. PMID: 18778117.

Nishimura M, Nakanishi T, Yasui A, et al. Serum calcium increases the incidence of arrhythmias during acetate hemodialysis. Am J Kidney Dis. 1992 Feb;19(2):149-55. PMID: 1739097.

" None Not dangerous goods.

LKT S8014 Substance P, Free Acid 5 mg 107.8 Endogenous tachykinin peptide, involved in inflammation, stress signaling, nociception; NK1 agonist. 71977-09-8 ≥95% 1348.65 C63H97N17O14S CC(C)CC(C(=O)NC(CCSC)C(=O)O)NC(=O)CNC(=O)C(CC1=CC=CC=C1)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CCC(=O)N)NC(=O)C(CCC(=O)N)NC(=O)C3CCCN3C(=O)C(CCCCN)NC(=O)C4CCCN4C(=O)C(CCCN=C(N)N)N Ambient -20°C "Yang L, Liu C, Dang H, et al. Substance P attenuates hyperoxia induced lung injury in neonatal rats. Mol Med Rep. 2014 Feb;9(2):595-9. PMID: 24247295.

Campolongo P, Ratano P, Ciotti MT, et al. Systemic administration of substance P recovers beta amyloid-induced cognitive deficits in rat: involvement of Kv potassium channels. PLoS One. 2013 Nov 12;8(11):e78036. PMID: 24265678.

Yang JH, Guo Z, Zhang T, et al. Restoration of endogenous substance P is associated with inhibition of apoptosis of retinal cells in diabetic rats. Regul Pept. 2013 Nov 10;187:12-6. PMID: 24045094.

Ma W, Zhang X, Shi S, et al. Neuropeptides stimulate human osteoblast activity and promote gap junctional intercellular communication. Neuropeptides. 2013 Jun;47(3):179-86. PMID: 23726661.

Brancati SB, Zádori ZS, Németh J, et al. Substance P induces gastric mucosal protection at supraspinal level via increasing the level of endomorphin-2 in rats. Brain Res Bull. 2013 Feb;91:38-45. PMID: 23328537.

Ping F, Shang J, Zhou J, et al. Activation of neurokinin-1 receptor by substance P inhibits melanogenesis in B16-F10 melanoma cells. Int J Biochem Cell Biol. 2012 Dec;44(12):2342-8. PMID: 23041339.

" Not dangerous goods.

LKT S8014 Substance P, Free Acid 10 mg 183 Endogenous tachykinin peptide, involved in inflammation, stress signaling, nociception; NK1 agonist. 71977-09-8 ≥95% 1348.65 C63H97N17O14S CC(C)CC(C(=O)NC(CCSC)C(=O)O)NC(=O)CNC(=O)C(CC1=CC=CC=C1)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CCC(=O)N)NC(=O)C(CCC(=O)N)NC(=O)C3CCCN3C(=O)C(CCCCN)NC(=O)C4CCCN4C(=O)C(CCCN=C(N)N)N Ambient -20°C "Yang L, Liu C, Dang H, et al. Substance P attenuates hyperoxia induced lung injury in neonatal rats. Mol Med Rep. 2014 Feb;9(2):595-9. PMID: 24247295.

Yang JH, Guo Z, Zhang T, et al. Restoration of endogenous substance P is associated with inhibition of apoptosis of retinal cells in diabetic rats. Regul Pept. 2013 Nov 10;187:12-6. PMID: 24045094.

Ma W, Zhang X, Shi S, et al. Neuropeptides stimulate human osteoblast activity and promote gap junctional intercellular communication. Neuropeptides. 2013 Jun;47(3):179-86. PMID: 23726661.

Ping F, Shang J, Zhou J, et al. Activation of neurokinin-1 receptor by substance P inhibits melanogenesis in B16-F10 melanoma cells. Int J Biochem Cell Biol. 2012 Dec;44(12):2342-8. PMID: 23041339.

" Not dangerous goods.

LKT S8014 Substance P, Free Acid 25 mg 324 Endogenous tachykinin peptide, involved in inflammation, stress signaling, nociception; NK1 agonist. 71977-09-8 ≥95% 1348.65 C63H97N17O14S CC(C)CC(C(=O)NC(CCSC)C(=O)O)NC(=O)CNC(=O)C(CC1=CC=CC=C1)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CCC(=O)N)NC(=O)C(CCC(=O)N)NC(=O)C3CCCN3C(=O)C(CCCCN)NC(=O)C4CCCN4C(=O)C(CCCN=C(N)N)N Ambient -20°C "Yang L, Liu C, Dang H, et al. Substance P attenuates hyperoxia induced lung injury in neonatal rats. Mol Med Rep. 2014 Feb;9(2):595-9. PMID: 24247295.

Yang JH, Guo Z, Zhang T, et al. Restoration of endogenous substance P is associated with inhibition of apoptosis of retinal cells in diabetic rats. Regul Pept. 2013 Nov 10;187:12-6. PMID: 24045094.

Ma W, Zhang X, Shi S, et al. Neuropeptides stimulate human osteoblast activity and promote gap junctional intercellular communication. Neuropeptides. 2013 Jun;47(3):179-86. PMID: 23726661.

Ping F, Shang J, Zhou J, et al. Activation of neurokinin-1 receptor by substance P inhibits melanogenesis in B16-F10 melanoma cells. Int J Biochem Cell Biol. 2012 Dec;44(12):2342-8. PMID: 23041339.

" Not dangerous goods.

LKT S8045 S-Sulforaphane 5 mg 216.3 Synthetic ITC. (+)1-Isothiocyanato-4R-(methylsulfinyl)-butane D-Sulforaphane ≥97% 177.29 C6H11NOS2 CS(=O)CCCCN=C=S 2yrs at -20oC Ambient -20°C Soluble in ethanol, methanol, or ethyl acetate. Miscible with water and/or DMSO. "Abdull Razis AF, Hanlon N, Soltys E, et al. The naturally occurring aliphatic isothiocyanates sulforaphane and erucin are weak agonists but potent non-competitive antagonists of the aryl hydrocarbon receptor. Arch Toxicol. 2012 Oct;86(10):1505-14. PMID: 22643862.

Abdull Razis AF, Bagatta M, De Nicola GR, et al. Induction of epoxide hydrolase and glucuronosyl transferase by isothiocyanates and intact glucosinolates in precision-cut rat liver slices: importance of side-chain substituent and chirality. Arch Toxicol. 2011 Aug;85(8):919-27. PMID: 21132492." Not dangerous goods.

LKT S8045 S-Sulforaphane 10 mg 368.2 Synthetic ITC. (+)1-Isothiocyanato-4R-(methylsulfinyl)-butane D-Sulforaphane ≥97% 177.29 C6H11NOS2 CS(=O)CCCCN=C=S 2yrs at -20oC Ambient -20°C Soluble in ethanol, methanol, or ethyl acetate. Miscible with water and/or DMSO. "Abdull Razis AF, Hanlon N, Soltys E, et al. The naturally occurring aliphatic isothiocyanates sulforaphane and erucin are weak agonists but potent non-competitive antagonists of the aryl hydrocarbon receptor. Arch Toxicol. 2012 Oct;86(10):1505-14. PMID: 22643862.

LKT F4780 Fluoxetine Hydrochloride 1 g 63.8 FIASMA, SERT inhibitor, 5-HT and σ1 antagonist. N-Methyl-γ-[4-(trifluoromethyl)phenoxy]benzene- propanamine hydrochloride Adofen; Fluoxeren; Lovan; Prozac; Sarafem 59333-67-4 ≥98% 345.79 C17H18F3NO HCl CNCCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F.Cl Further dilutions of the stock solution into aqueous buffers or isotonic saline should be made prior to performing biological experiments. Ensure that the residual amount of organic solvent is insignificant, since organic solvents may have physiological effects at low concentrations. Organic solvent-free aqueous solutions of fluoxetine (hydrochloride) can be prepared by directly dissolving the crystalline solid in aqueous buffers. The solubility of fluoxetine (hydrochloride) in PBS, pH 7.2, is approximately 0.2 mg/ml. We do not recommend storing the aqueous solution for more than one day. Ambient Ambient Soluble in methanol, ethanol, acetone, acetonitrile and chloroform. Water to 10 mM, DMSO to 100 mM. DMF to 16 mg/mL.Ethanol to 69mg/mL "Zuo J, Quinn KK, Kye S, et al. Fluoxetine is a potent inhibitor of coxsackievirus replication. Antimicrob Agents Chemother. 2012 Sep;56(9):4838-44. PMID: 22751539.

Krupitsky EM, Zvartau EE, Masalov DV, et al. Naltrexone with or without fluoxetine for preventing relapse to heroin addiction in St. Petersburg, Russia. J Subst Abuse Treat. 2006 Dec;31(4):319-28. PMID: 17084785.

Pälvimäki EP, Roth BL, Majasuo H, et al. Interactions of selective serotonin reuptake inhibitors with the serotonin 5-HT2c receptor. Psychopharmacology (Berl). 1996 Aug;126(3):234-40. PMID: 8876023.

Narita N, Hashimoto K, Tomitaka S, et al. Interactions of selective serotonin reuptake inhibitors with subtypes of sigma receptors in rat brain. Eur J Pharmacol. 1996 Jun 20;307(1):117-9. PMID: 8831113.

Opal MD, Klenotich SC, Morais M, et al. Serotonin 2C receptor antagonists induce fast-onset antidepressant effects. Mol Psychiatry. 2014 Oct;19(10):1106-1114. PMID: 24166413.

Nagano M, Liu M, Inagaki H, et al. Early intervention with fluoxetine reverses abnormalities in the serotonergic system and behavior of rats exposed prenatally to dexamethasone. Neuropharmacology. 2012 Aug;63(2):292-300. PMID: 22710353." Xn Not Dangerous Goods

LKT F4780 Fluoxetine Hydrochloride 5 g 254.3 FIASMA, SERT inhibitor, 5-HT and σ1 antagonist. N-Methyl-γ-[4-(trifluoromethyl)phenoxy]benzene- propanamine hydrochloride Adofen; Fluoxeren; Lovan; Prozac; Sarafem 59333-67-4 ≥98% 345.79 C17H18F3NO HCl CNCCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F.Cl Further dilutions of the stock solution into aqueous buffers or isotonic saline should be made prior to performing biological experiments. Ensure that the residual amount of organic solvent is insignificant, since organic solvents may have physiological effects at low concentrations. Organic solvent-free aqueous solutions of fluoxetine (hydrochloride) can be prepared by directly dissolving the crystalline solid in aqueous buffers. The solubility of fluoxetine (hydrochloride) in PBS, pH 7.2, is approximately 0.2 mg/ml. We do not recommend storing the aqueous solution for more than one day. Ambient Ambient Soluble in methanol, ethanol, acetone, acetonitrile and chloroform. Water to 10 mM, DMSO to 100 mM. DMF to 16 mg/mL.Ethanol to 69mg/mL "Zuo J, Quinn KK, Kye S, et al. Fluoxetine is a potent inhibitor of coxsackievirus replication. Antimicrob Agents Chemother. 2012 Sep;56(9):4838-44. PMID: 22751539.

Opal MD, Klenotich SC, Morais M, et al. Serotonin 2C receptor antagonists induce fast-onset antidepressant effects. Mol Psychiatry. 2014 Oct;19(10):1106-1114. PMID: 24166413.

LKT K1676 Ketoconazole 5 g 96.7 Imidazole; 14-α demethylase inhibitor. cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine Fungarest; Fungoral; Ketoderm. 65277-42-1 ≥98% 531.44 C26H28Cl2N4O4 CC(=O)N1CCN(CC1)C2=CC=C(C=C2)OCC3COC(O3)(CN4C=CN=C4)C5=C(C=C(C=C5)Cl)Cl Ambient Ambient DMSO to 3mg/mL, Ethanol to 7mg/mL "Tsuji G, Takahara M, Uchi H, et al. Identification of ketoconazole as an AhR-Nrf2 activator in cultured human keratinocytes: the basis of its anti-inflammatory effect. J Invest Dermatol. 2012 Jan;132(1):59-68. PMID: 21753779.

Eil C. Ketoconazole binds to the human androgen receptor. Horm Metab Res. 1992 Aug;24(8):367-70. PMID: 1526623.

Witjes FJ, Debruyne FM, Fernandez del Moral P, et al. Ketoconazole high dose in management of hormonally pretreated patients with progressive metastatic prostate cancer. Dutch South-Eastern Urological Cooperative Group. Urology. 1989 May;33(5):411-5. PMID: 2652864.

Loose DS, Kan PB, Hirst MA, et al. Ketoconazole blocks adrenal steroidogenesis by inhibiting cytochrome P450-dependent enzymes. J Clin Invest. 1983 May;71(5):1495-9. PMID: 6304148.

Matsumoto Y, Miyazaki S, Fukunaga DH, et al. Quantitative evaluation of cryptococcal pathogenesis and antifungal drugs using a silkworm infection model with Cryptococcus neoformans. J Appl Microbiol. 2012 Jan;112(1):138-146. PMID: 22040451.

" Xi, T "UN number: 2811 Class: 6.1 Packing group: III

Proper shipping name: TOXIC SOLID, ORGANIC, N.O.S. (Ketoconazole)

Marine pollutant: No"

LKT K1676 Ketoconazole 25 g 317.9 Imidazole; 14-α demethylase inhibitor. cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine Fungarest; Fungoral; Ketoderm. 65277-42-1 ≥98% 531.44 C26H28Cl2N4O4 CC(=O)N1CCN(CC1)C2=CC=C(C=C2)OCC3COC(O3)(CN4C=CN=C4)C5=C(C=C(C=C5)Cl)Cl Ambient Ambient DMSO to 3mg/mL, Ethanol to 7mg/mL "Tsuji G, Takahara M, Uchi H, et al. Identification of ketoconazole as an AhR-Nrf2 activator in cultured human keratinocytes: the basis of its anti-inflammatory effect. J Invest Dermatol. 2012 Jan;132(1):59-68. PMID: 21753779.

Eil C. Ketoconazole binds to the human androgen receptor. Horm Metab Res. 1992 Aug;24(8):367-70. PMID: 1526623.

Loose DS, Kan PB, Hirst MA, et al. Ketoconazole blocks adrenal steroidogenesis by inhibiting cytochrome P450-dependent enzymes. J Clin Invest. 1983 May;71(5):1495-9. PMID: 6304148.

" Xi, T "UN number: 2811 Class: 6.1 Packing group: III

Proper shipping name: TOXIC SOLID, ORGANIC, N.O.S. (Ketoconazole)

Marine pollutant: No"

LKT S8243 Sulbactam Sodium 500 mg 115.5 β-lactamase inhibitor. (2S,5R)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide sodium CP-45899-2; Betamaze 69388-84-7 ≥98% 255.22 C8H10NNaO5S CC1(C(N2C(S1(=O)=O)CC2=O)C(=O)[O-])C.[Na+] Ambient 4°C "Soluble in water. Sparingly soluble in acetone.

" "Li R, Liao JM, Gu CR, et al. Theoretical investigation on reaction of sulbactam with wild-type SHV-1 β-lactamase: acylation, tautomerization, and deacylation. J Phys Chem B. 2011 Sep 1;115(34):10298-310. PMID: 21797222.

Drawz SM, Bonomo RA. Three decades of beta-lactamase inhibitors. Clin Microbiol Rev. 2010 Jan;23(1):160-201. PMID: 20065329.

" Xn Not dangerous goods.

LKT S8243 Sulbactam Sodium 1 g 209.8 β-lactamase inhibitor. (2S,5R)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide sodium CP-45899-2; Betamaze 69388-84-7 ≥98% 255.22 C8H10NNaO5S CC1(C(N2C(S1(=O)=O)CC2=O)C(=O)[O-])C.[Na+] Ambient 4°C "Soluble in water. Sparingly soluble in acetone.

Drawz SM, Bonomo RA. Three decades of beta-lactamase inhibitors. Clin Microbiol Rev. 2010 Jan;23(1):160-201. PMID: 20065329.

" Xn Not dangerous goods.

LKT S8243 Sulbactam Sodium 5 g 819 β-lactamase inhibitor. (2S,5R)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide sodium CP-45899-2; Betamaze 69388-84-7 ≥98% 255.22 C8H10NNaO5S CC1(C(N2C(S1(=O)=O)CC2=O)C(=O)[O-])C.[Na+] Ambient 4°C "Soluble in water. Sparingly soluble in acetone.

Drawz SM, Bonomo RA. Three decades of beta-lactamase inhibitors. Clin Microbiol Rev. 2010 Jan;23(1):160-201. PMID: 20065329.

" Xn Not dangerous goods.

LKT T0095 Baccatin III 5 mg 78.9 Diterpene found in Taxus, used to synthesize taxol. 7,11-Methano-5H-cyclodeca(3,4)benz(1,2-b)oxet-5-one-6,12b-bis(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,- 9,10,11,12,12a,12b-dodecahydro-4,9,11-trihydroxy-4a,- 8,13,13-tetramethyl-,(2aR-(2aα,4β,4aβ,6β,9α,11α,12α,-12aα,12bα))- 27548-93-2 ≥98% 586.63 C31H38O11 CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1O)O)OC(=O)C5=CC=CC=C5)(CO4)OC(=O)C)O)C)OC(=O)C Ambient -20°C Soluble in DMSO or ethanol. Insoluble in water. "Lee YH, Lee YR, Park CS, et al. Baccatin III, a precursor for the semisynthesis of paclitaxel, inhibits the accumulation and suppressive activity of myeloid-derived suppressor cells in tumor-bearing mice. Int Immunopharmacol. 2014 Aug;21(2):487-93. PMID: 24957690.

Chakravarthi BV, Sujay R, Kuriakose GC, et al. Inhibition of cancer cell proliferation and apoptosis-inducing activity of fungal taxol and its precursor baccatin III purified from endophytic Fusarium solani. Cancer Cell Int. 2013 Oct 23;13(1):105. PMID: 24152585.

Lee YH, Lee YR, Kim KH, et al. Baccatin III, a synthetic precursor of taxol, enhances MHC-restricted antigen presentation in dendritic cells. Int Immunopharmacol. 2011 Aug;11(8):985-91. PMID: 21354357.

" Xn, T, Carc., Mut., Xi Not dangerous goods.

LKT T0095 Baccatin III 10 mg 156.2 Diterpene found in Taxus, used to synthesize taxol. 7,11-Methano-5H-cyclodeca(3,4)benz(1,2-b)oxet-5-one-6,12b-bis(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,- 9,10,11,12,12a,12b-dodecahydro-4,9,11-trihydroxy-4a,- 8,13,13-tetramethyl-,(2aR-(2aα,4β,4aβ,6β,9α,11α,12α,-12aα,12bα))- 27548-93-2 ≥98% 586.63 C31H38O11 CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1O)O)OC(=O)C5=CC=CC=C5)(CO4)OC(=O)C)O)C)OC(=O)C Ambient -20°C Soluble in DMSO or ethanol. Insoluble in water. "Lee YH, Lee YR, Park CS, et al. Baccatin III, a precursor for the semisynthesis of paclitaxel, inhibits the accumulation and suppressive activity of myeloid-derived suppressor cells in tumor-bearing mice. Int Immunopharmacol. 2014 Aug;21(2):487-93. PMID: 24957690.

" Xn, T, Carc., Mut., Xi Not dangerous goods.

LKT T0095 Baccatin III 25 mg 333 Diterpene found in Taxus, used to synthesize taxol. 7,11-Methano-5H-cyclodeca(3,4)benz(1,2-b)oxet-5-one-6,12b-bis(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,- 9,10,11,12,12a,12b-dodecahydro-4,9,11-trihydroxy-4a,- 8,13,13-tetramethyl-,(2aR-(2aα,4β,4aβ,6β,9α,11α,12α,-12aα,12bα))- 27548-93-2 ≥98% 586.63 C31H38O11 CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1O)O)OC(=O)C5=CC=CC=C5)(CO4)OC(=O)C)O)C)OC(=O)C Ambient -20°C Soluble in DMSO or ethanol. Insoluble in water. "Lee YH, Lee YR, Park CS, et al. Baccatin III, a precursor for the semisynthesis of paclitaxel, inhibits the accumulation and suppressive activity of myeloid-derived suppressor cells in tumor-bearing mice. Int Immunopharmacol. 2014 Aug;21(2):487-93. PMID: 24957690.

" Xn, T, Carc., Mut., Xi Not dangerous goods.

LKT T0106 Xylosyltaxol 5 mg 403.3 Taxane found in species of Taxus; potential microtubule depolymerization inhibitor. 7-xylosyltaxol 90332-66-4 ≥98% 986.02 C52H59NO18 CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)OC8C(C(C(CO8)O)O)O)C)OC(=O)C Ambient -20°C "Yu SS, Sun QW, Zhang XP, et al. Content and distribution of active components in c*ted and wild Taxus chinensis var. mairei plants. Ying Yong Sheng Tai Xue Bao. 2012 Oct;23(10):2641-7. PMID: 23359921.

Slichenmyer WJ, Von Hoff DD. New natural products in cancer chemotherapy. J Clin Pharmacol. 1990 Sep;30(9):770-88. PMID: 1980498.

" Not dangerous goods.

LKT T0106 Xylosyltaxol 10 mg 647 Taxane found in species of Taxus; potential microtubule depolymerization inhibitor. 7-xylosyltaxol 90332-66-4 ≥98% 986.02 C52H59NO18 CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)OC8C(C(C(CO8)O)O)O)C)OC(=O)C Ambient -20°C "Yu SS, Sun QW, Zhang XP, et al. Content and distribution of active components in c*ted and wild Taxus chinensis var. mairei plants. Ying Yong Sheng Tai Xue Bao. 2012 Oct;23(10):2641-7. PMID: 23359921.

Slichenmyer WJ, Von Hoff DD. New natural products in cancer chemotherapy. J Clin Pharmacol. 1990 Sep;30(9):770-88. PMID: 1980498.

" Not dangerous goods.

LKT T0106 Xylosyltaxol 25 mg 1260.2 Taxane found in species of Taxus; potential microtubule depolymerization inhibitor. 7-xylosyltaxol 90332-66-4 ≥98% 986.02 C52H59NO18 CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)OC8C(C(C(CO8)O)O)O)C)OC(=O)C Ambient -20°C "Yu SS, Sun QW, Zhang XP, et al. Content and distribution of active components in c*ted and wild Taxus chinensis var. mairei plants. Ying Yong Sheng Tai Xue Bao. 2012 Oct;23(10):2641-7. PMID: 23359921.

Slichenmyer WJ, Von Hoff DD. New natural products in cancer chemotherapy. J Clin Pharmacol. 1990 Sep;30(9):770-88. PMID: 1980498.

" Not dangerous goods.

LKT T0100 10-Deacetyltaxol 5 mg 396.2 Taxane found in Taxus; microtubule depolymerization inhibitor. 78432-77-6 ≥98% 811.87 C45H49NO13 CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)O Ambient -20°C Soluble in organic solvents. "Ueda JY, Awale S, Tezuka Y, et al. Growth inhibitory activity of wood of Taxus yunnanensis and its liquid chromatography Fourier-transform mass spectrometry analysis. Planta Med. 2006 Oct;72(13):1241-4. PMID: 16902867.

Shen YC, Chen YJ, Chen CY. Taxane diterpenoids from the seeds of Chinese yew Taxus chinensis. Phytochemistry. 1999 Dec;52(8):1565-9. PMID: 10647221.

Woo DD, Tabancay AP Jr, Wang CJ. Microtubule active taxanes inhibit polycystic kidney disease progression in cpk mice. Kidney Int. 1997 May;51(5):1613-8. PMID: 9150481.

Helson L. Cephalomannine and 10-deacetyltaxol cytotoxicity in human glial and neuroblastoma cell-lines. Int J Oncol. 1993 Feb;2(2):297-9. PMID: 21573554

" Not dangerous goods.

LKT T0100 10-Deacetyltaxol 10 mg 633.8 Taxane found in Taxus; microtubule depolymerization inhibitor. 78432-77-6 ≥98% 811.87 C45H49NO13 CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)O Ambient -20°C Soluble in organic solvents. "Ueda JY, Awale S, Tezuka Y, et al. Growth inhibitory activity of wood of Taxus yunnanensis and its liquid chromatography Fourier-transform mass spectrometry analysis. Planta Med. 2006 Oct;72(13):1241-4. PMID: 16902867.

Shen YC, Chen YJ, Chen CY. Taxane diterpenoids from the seeds of Chinese yew Taxus chinensis. Phytochemistry. 1999 Dec;52(8):1565-9. PMID: 10647221.

Woo DD, Tabancay AP Jr, Wang CJ. Microtubule active taxanes inhibit polycystic kidney disease progression in cpk mice. Kidney Int. 1997 May;51(5):1613-8. PMID: 9150481.

Helson L. Cephalomannine and 10-deacetyltaxol cytotoxicity in human glial and neuroblastoma cell-lines. Int J Oncol. 1993 Feb;2(2):297-9. PMID: 21573554

" Not dangerous goods.

LKT T0100 10-Deacetyltaxol 25 mg 1361.4 Taxane found in Taxus; microtubule depolymerization inhibitor. 78432-77-6 ≥98% 811.87 C45H49NO13 CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)O Ambient -20°C Soluble in organic solvents. "Ueda JY, Awale S, Tezuka Y, et al. Growth inhibitory activity of wood of Taxus yunnanensis and its liquid chromatography Fourier-transform mass spectrometry analysis. Planta Med. 2006 Oct;72(13):1241-4. PMID: 16902867.

Shen YC, Chen YJ, Chen CY. Taxane diterpenoids from the seeds of Chinese yew Taxus chinensis. Phytochemistry. 1999 Dec;52(8):1565-9. PMID: 10647221.

Woo DD, Tabancay AP Jr, Wang CJ. Microtubule active taxanes inhibit polycystic kidney disease progression in cpk mice. Kidney Int. 1997 May;51(5):1613-8. PMID: 9150481.

Helson L. Cephalomannine and 10-deacetyltaxol cytotoxicity in human glial and neuroblastoma cell-lines. Int J Oncol. 1993 Feb;2(2):297-9. PMID: 21573554

" Not dangerous goods.

LKT T0101 7-epi-10-Deacetyltaxol 5 mg 443.8 Taxane found in Taxus; potential microtubule depolymerization inhibitor. 10-Deacetyl-7-epitaxol 78454-17-8 ≥92% 811.87 C45H49NO13 CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)O Ambient -20°C Soluble in organic solvents. "Yu SS, Sun QW, Zhang XP, et al. Content and distribution of active components in c*ted and wild Taxus chinensis var. mairei plants. Ying Yong Sheng Tai Xue Bao. 2012 Oct;23(10):2641-7. PMID: 23359921.

Slichenmyer WJ, Von Hoff DD. New natural products in cancer chemotherapy. J Clin Pharmacol. 1990 Sep;30(9):770-88. PMID: 1980498.

Shen YC, Chen YJ, Chen CY. Taxane diterpenoids from the seeds of Chinese yew Taxus chinensis. Phytochemistry. 1999 Dec;52(8):1565-9. PMID: 10647221." Not dangerous goods.

LKT T0101 7-epi-10-Deacetyltaxol 10 mg 591.4 Taxane found in Taxus; potential microtubule depolymerization inhibitor. 10-Deacetyl-7-epitaxol 78454-17-8 ≥92% 811.87 C45H49NO13 CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)O Ambient -20°C Soluble in organic solvents. "Yu SS, Sun QW, Zhang XP, et al. Content and distribution of active components in c*ted and wild Taxus chinensis var. mairei plants. Ying Yong Sheng Tai Xue Bao. 2012 Oct;23(10):2641-7. PMID: 23359921.

Slichenmyer WJ, Von Hoff DD. New natural products in cancer chemotherapy. J Clin Pharmacol. 1990 Sep;30(9):770-88. PMID: 1980498.

Shen YC, Chen YJ, Chen CY. Taxane diterpenoids from the seeds of Chinese yew Taxus chinensis. Phytochemistry. 1999 Dec;52(8):1565-9. PMID: 10647221." Not dangerous goods.

LKT T0101 7-epi-10-Deacetyltaxol 25 mg 1270.7 Taxane found in Taxus; potential microtubule depolymerization inhibitor. 10-Deacetyl-7-epitaxol 78454-17-8 ≥92% 811.87 C45H49NO13 CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)O Ambient -20°C Soluble in organic solvents. "Yu SS, Sun QW, Zhang XP, et al. Content and distribution of active components in c*ted and wild Taxus chinensis var. mairei plants. Ying Yong Sheng Tai Xue Bao. 2012 Oct;23(10):2641-7. PMID: 23359921.

Slichenmyer WJ, Von Hoff DD. New natural products in cancer chemotherapy. J Clin Pharmacol. 1990 Sep;30(9):770-88. PMID: 1980498.

Shen YC, Chen YJ, Chen CY. Taxane diterpenoids from the seeds of Chinese yew Taxus chinensis. Phytochemistry. 1999 Dec;52(8):1565-9. PMID: 10647221." Not dangerous goods.

LKT T0102 7-Epi-taxol 5 mg 369.8 Taxane found in Taxus; potential microtubule depolymerization inhibitor. 7-Epipaclitaxel; 7-Epitaxol; 7-epi-Paclitaxel; Epitaxol 105454-04-4 ≥95% 853.91 C47H51NO14 CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C Ambient -20°C Soluble in organic solvents. "Yu SS, Sun QW, Zhang XP, et al. Content and distribution of active components in c*ted and wild Taxus chinensis var. mairei plants. Ying Yong Sheng Tai Xue Bao. 2012 Oct;23(10):2641-7. PMID: 23359921.

Shen YC, Chen YJ, Chen CY. Taxane diterpenoids from the seeds of Chinese yew Taxus chinensis. Phytochemistry. 1999 Dec;52(8):1565-9. PMID: 10647221.

Slichenmyer WJ, Von Hoff DD. New natural products in cancer chemotherapy. J Clin Pharmacol. 1990 Sep;30(9):770-88. PMID: 1980498." Not dangerous goods.

LKT T0102 7-Epi-taxol 10 mg 591.4 Taxane found in Taxus; potential microtubule depolymerization inhibitor. 7-Epipaclitaxel; 7-Epitaxol; 7-epi-Paclitaxel; Epitaxol 105454-04-4 ≥95% 853.91 C47H51NO14 CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C Ambient -20°C Soluble in organic solvents. "Yu SS, Sun QW, Zhang XP, et al. Content and distribution of active components in c*ted and wild Taxus chinensis var. mairei plants. Ying Yong Sheng Tai Xue Bao. 2012 Oct;23(10):2641-7. PMID: 23359921.

Shen YC, Chen YJ, Chen CY. Taxane diterpenoids from the seeds of Chinese yew Taxus chinensis. Phytochemistry. 1999 Dec;52(8):1565-9. PMID: 10647221.

Slichenmyer WJ, Von Hoff DD. New natural products in cancer chemotherapy. J Clin Pharmacol. 1990 Sep;30(9):770-88. PMID: 1980498." Not dangerous goods.

LKT T0102 7-Epi-taxol 25 mg 1155.2 Taxane found in Taxus; potential microtubule depolymerization inhibitor. 7-Epipaclitaxel; 7-Epitaxol; 7-epi-Paclitaxel; Epitaxol 105454-04-4 ≥95% 853.91 C47H51NO14 CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C Ambient -20°C Soluble in organic solvents. "Yu SS, Sun QW, Zhang XP, et al. Content and distribution of active components in c*ted and wild Taxus chinensis var. mairei plants. Ying Yong Sheng Tai Xue Bao. 2012 Oct;23(10):2641-7. PMID: 23359921.

Shen YC, Chen YJ, Chen CY. Taxane diterpenoids from the seeds of Chinese yew Taxus chinensis. Phytochemistry. 1999 Dec;52(8):1565-9. PMID: 10647221.

Slichenmyer WJ, Von Hoff DD. New natural products in cancer chemotherapy. J Clin Pharmacol. 1990 Sep;30(9):770-88. PMID: 1980498." Not dangerous goods.

LKT T0096 Cephalomannine 5 mg 231 Diterpene found in Taxus; potential microtubule depolymerization inhibitor. Taxol B 71610-00-9 ≥94% 831.91 C45H53NO14 CC=C(C)C(=O)NC(C1=CC=CC=C1)C(C(=O)OC2CC3(C(C4C(C(CC5C4(CO5)OC(=O)C)O)(C(=O)C(C(=C2C)C3(C)C)OC(=O)C)C)OC(=O)C6=CC=CC=C6)O)O Ambient -20°C Soluble in DMSO. "Li Y, Qin F, Wang SM, et al. Chemical studies on Taxus canadensis. Chem Biodivers. 2013 Oct;10(10):1729-53. PMID: 24130020.

Oshige M, Takenouchi M, Kato Y, et al. Taxol derivatives are selective inhibitors of DNA polymerase alpha. Bioorg Med Chem. 2004 May 15;12(10):2597-601. PMID: 15110841.

Woo DD, Tabancay AP Jr, Wang CJ. Microtubule active taxanes inhibit polycystic kidney disease progression in cpk mice. Kidney Int. 1997 May;51(5):1613-8. PMID: 9150481.

Helson L. Cephalomannine and 10-deacetyltaxol cytotoxicity in human glial and neuroblastoma cell-lines. Int J Oncol. 1993 Feb;2(2):297-9. PMID: 21573554.

" None Not dangerous goods.

LKT T0096 Cephalomannine 10 mg 367 Diterpene found in Taxus; potential microtubule depolymerization inhibitor. Taxol B 71610-00-9 ≥94% 831.91 C45H53NO14 CC=C(C)C(=O)NC(C1=CC=CC=C1)C(C(=O)OC2CC3(C(C4C(C(CC5C4(CO5)OC(=O)C)O)(C(=O)C(C(=C2C)C3(C)C)OC(=O)C)C)OC(=O)C6=CC=CC=C6)O)O Ambient -20°C Soluble in DMSO. "Li Y, Qin F, Wang SM, et al. Chemical studies on Taxus canadensis. Chem Biodivers. 2013 Oct;10(10):1729-53. PMID: 24130020.

Oshige M, Takenouchi M, Kato Y, et al. Taxol derivatives are selective inhibitors of DNA polymerase alpha. Bioorg Med Chem. 2004 May 15;12(10):2597-601. PMID: 15110841.

Woo DD, Tabancay AP Jr, Wang CJ. Microtubule active taxanes inhibit polycystic kidney disease progression in cpk mice. Kidney Int. 1997 May;51(5):1613-8. PMID: 9150481.

Helson L. Cephalomannine and 10-deacetyltaxol cytotoxicity in human glial and neuroblastoma cell-lines. Int J Oncol. 1993 Feb;2(2):297-9. PMID: 21573554.

" None Not dangerous goods.

LKT T0096 Cephalomannine 25 mg 815.4 Diterpene found in Taxus; potential microtubule depolymerization inhibitor. Taxol B 71610-00-9 ≥94% 831.91 C45H53NO14 CC=C(C)C(=O)NC(C1=CC=CC=C1)C(C(=O)OC2CC3(C(C4C(C(CC5C4(CO5)OC(=O)C)O)(C(=O)C(C(=C2C)C3(C)C)OC(=O)C)C)OC(=O)C6=CC=CC=C6)O)O Ambient -20°C Soluble in DMSO. "Li Y, Qin F, Wang SM, et al. Chemical studies on Taxus canadensis. Chem Biodivers. 2013 Oct;10(10):1729-53. PMID: 24130020.

Oshige M, Takenouchi M, Kato Y, et al. Taxol derivatives are selective inhibitors of DNA polymerase alpha. Bioorg Med Chem. 2004 May 15;12(10):2597-601. PMID: 15110841.

Woo DD, Tabancay AP Jr, Wang CJ. Microtubule active taxanes inhibit polycystic kidney disease progression in cpk mice. Kidney Int. 1997 May;51(5):1613-8. PMID: 9150481.

Helson L. Cephalomannine and 10-deacetyltaxol cytotoxicity in human glial and neuroblastoma cell-lines. Int J Oncol. 1993 Feb;2(2):297-9. PMID: 21573554.

" None Not dangerous goods.

LKT G3354 Ginkgolide A 10 mg 54.4 Terpene lactone found in Ginkgo; GSK-3β inhibitor, potential PXR agonist. 15291-75-5 ≥95% 408.4 C20H24O9 CC1C(=O)OC2C1(C34C(=O)OC5C3(C2)C6(C(C5)C(C)(C)C)C(C(=O)OC6O4)O)O Ambient -20°C Insoluble in water. Soluble in DMSO. "Chen Y, Wang C, Hu M, et al. Effects of ginkgolide A on okadaic acid-induced tau hyperphosphorylation and the PI3K-Akt signaling pathway in N2a cells. Planta Med. 2012 Aug;78(12):1337-41. PMID: 22700047.

Weakley SM, Wang X, Mu H, et al. Ginkgolide A-gold nanoparticles inhibit vascular smooth muscle proliferation and migration in vitro and reduce neointimal hyperplasia in a mouse model. J Surg Res. 2011 Nov;171(1):31-9. PMID: 21571322.

Lau AJ, Yang G, Rajaraman G, et al. Human pregnane X receptor agonism by Ginkgo biloba extract: assessment of the role of individual ginkgolides. J Pharmacol Exp Ther. 2010 Dec;335(3):771-80. PMID: 20739453.

Kuribara H, Weintraub ST, Yoshihama T, et al. An anxiolytic-like effect of Ginkgo biloba extract and its constituent, ginkgolide-A, in mice. J Nat Prod. 2003 Oct;66(10):1333-7. PMID: 14575433.

" None Not dangerous goods.

LKT G3354 Ginkgolide A 25 mg 95.1 Terpene lactone found in Ginkgo; GSK-3β inhibitor, potential PXR agonist. 15291-75-5 ≥95% 408.4 C20H24O9 CC1C(=O)OC2C1(C34C(=O)OC5C3(C2)C6(C(C5)C(C)(C)C)C(C(=O)OC6O4)O)O Ambient -20°C Insoluble in water. Soluble in DMSO. "Chen Y, Wang C, Hu M, et al. Effects of ginkgolide A on okadaic acid-induced tau hyperphosphorylation and the PI3K-Akt signaling pathway in N2a cells. Planta Med. 2012 Aug;78(12):1337-41. PMID: 22700047.

Kuribara H, Weintraub ST, Yoshihama T, et al. An anxiolytic-like effect of Ginkgo biloba extract and its constituent, ginkgolide-A, in mice. J Nat Prod. 2003 Oct;66(10):1333-7. PMID: 14575433.

" None Not dangerous goods.

LKT G3354 Ginkgolide A 50 mg 169.9 Terpene lactone found in Ginkgo; GSK-3β inhibitor, potential PXR agonist. 15291-75-5 ≥95% 408.4 C20H24O9 CC1C(=O)OC2C1(C34C(=O)OC5C3(C2)C6(C(C5)C(C)(C)C)C(C(=O)OC6O4)O)O Ambient -20°C Insoluble in water. Soluble in DMSO. "Chen Y, Wang C, Hu M, et al. Effects of ginkgolide A on okadaic acid-induced tau hyperphosphorylation and the PI3K-Akt signaling pathway in N2a cells. Planta Med. 2012 Aug;78(12):1337-41. PMID: 22700047.

Kuribara H, Weintraub ST, Yoshihama T, et al. An anxiolytic-like effect of Ginkgo biloba extract and its constituent, ginkgolide-A, in mice. J Nat Prod. 2003 Oct;66(10):1333-7. PMID: 14575433.

" None Not dangerous goods.

LKT G3355 Ginkgolide B 10 mg 61.1 Terpene lactone found in Ginkgo; GlyR antagonist. 15291-77-7 ≥95% 424.4 C20H24O10 CC1C(=O)OC2C1(C34C(=O)OC5C3(C2O)C6(C(C5)C(C)(C)C)C(C(=O)OC6O4)O)O Ambient -20°C Insoluble in water. Soluble in DMSO. "Liu X, Yan Y, Bao L, et al. Ginkgolide B inhibits platelet release by blocking Syk and p38 MAPK phosphorylation in thrombin-stimulated platelets. Thromb Res. 2014 Sep 6. [Epub ahead of print]. PMID: 25223809.

Botao Y, Ma J, Xiao W, et al. Protective effect of ginkgolide B on high altitude cerebral edema of rats. High Alt Med Biol. 2013 Mar;14(1):61-4. PMID: 23537262.

Wu X, Qian Z, Ke Y, et al. Ginkgolide B preconditioning protects neurons against ischaemia-induced apoptosis. J Cell Mol Med. 2009 Nov-Dec;13(11-12):4474-83. PMID: 19602048.

Wang SJ, Chen HH. Ginkgolide B, a constituent of Ginkgo biloba, facilitates glutamate exocytosis from rat hippocampal nerve terminals. Eur J Pharmacol. 2005 May 9;514(2-3):141-9. PMID: 15910800.

" None Not dangerous goods.

LKT G3355 Ginkgolide B 25 mg 122.3 Terpene lactone found in Ginkgo; GlyR antagonist. 15291-77-7 ≥95% 424.4 C20H24O10 CC1C(=O)OC2C1(C34C(=O)OC5C3(C2O)C6(C(C5)C(C)(C)C)C(C(=O)OC6O4)O)O Ambient -20°C Insoluble in water. Soluble in DMSO. "Liu X, Yan Y, Bao L, et al. Ginkgolide B inhibits platelet release by blocking Syk and p38 MAPK phosphorylation in thrombin-stimulated platelets. Thromb Res. 2014 Sep 6. [Epub ahead of print]. PMID: 25223809.

Botao Y, Ma J, Xiao W, et al. Protective effect of ginkgolide B on high altitude cerebral edema of rats. High Alt Med Biol. 2013 Mar;14(1):61-4. PMID: 23537262.

Wu X, Qian Z, Ke Y, et al. Ginkgolide B preconditioning protects neurons against ischaemia-induced apoptosis. J Cell Mol Med. 2009 Nov-Dec;13(11-12):4474-83. PMID: 19602048.

Wang SJ, Chen HH. Ginkgolide B, a constituent of Ginkgo biloba, facilitates glutamate exocytosis from rat hippocampal nerve terminals. Eur J Pharmacol. 2005 May 9;514(2-3):141-9. PMID: 15910800.

" None Not dangerous goods.

LKT G3355 Ginkgolide B 50 mg 231 Terpene lactone found in Ginkgo; GlyR antagonist. 15291-77-7 ≥95% 424.4 C20H24O10 CC1C(=O)OC2C1(C34C(=O)OC5C3(C2O)C6(C(C5)C(C)(C)C)C(C(=O)OC6O4)O)O Ambient -20°C Insoluble in water. Soluble in DMSO. "Liu X, Yan Y, Bao L, et al. Ginkgolide B inhibits platelet release by blocking Syk and p38 MAPK phosphorylation in thrombin-stimulated platelets. Thromb Res. 2014 Sep 6. [Epub ahead of print]. PMID: 25223809.

Botao Y, Ma J, Xiao W, et al. Protective effect of ginkgolide B on high altitude cerebral edema of rats. High Alt Med Biol. 2013 Mar;14(1):61-4. PMID: 23537262.

Wu X, Qian Z, Ke Y, et al. Ginkgolide B preconditioning protects neurons against ischaemia-induced apoptosis. J Cell Mol Med. 2009 Nov-Dec;13(11-12):4474-83. PMID: 19602048.

Wang SJ, Chen HH. Ginkgolide B, a constituent of Ginkgo biloba, facilitates glutamate exocytosis from rat hippocampal nerve terminals. Eur J Pharmacol. 2005 May 9;514(2-3):141-9. PMID: 15910800.

" None Not dangerous goods.

LKT G3357 Ginkgolide C 10 mg 136 Diterpene lactone found in Ginkgo; GABA-A, α-1 GlyR, PAF antagonist. (1α,7β)-1,7-Dihydroxyginkolide A BN-52022 15291-76-6 ≥98% 440.4 C20H24O11 CC1C(=O)OC2C1(C34C(=O)OC5C3(C2O)C6(C(C5O)C(C)(C)C)C(C(=O)OC6O4)O)O Ambient -20°C Insoluble in water. Soluble in DMSO. "Cho HJ, Shon YH, Nam KS. Ginkgolide C inhibits platelet aggregation in cAMP- and cGMP-dependent manner by activating MMP-9. Biol Pharm Bull. 2007 Dec;30(12):2340-4. PMID: 18057723.

Huang SH, Duke RK, Chebib M, et al. Ginkgolides, diterpene trilactones of Ginkgo biloba, as antagonists at recombinant alpha1beta2gamma2L GABAA receptors. Eur J Pharmacol. 2004 Jun 28;494(2-3):131-8. PMID: 15212966.

Jaracz S, Nakanishi K, Jensen AA, et al. Ginkgolides and glycine receptors: a structure-activity relationship study. Chemistry. 2004 Mar 19;10(6):1507-18. PMID: 15034895.

Scholtyssek H, Damerau W, Wessel R, et al. Antioxidative activity of ginkgolides against superoxide in an aprotic environment. Chem Biol Interact. 1997 Oct 24;106(3):183-90. PMID: 9413545.

" None Not dangerous goods.

LKT G3357 Ginkgolide C 25 mg 251.5 Diterpene lactone found in Ginkgo; GABA-A, α-1 GlyR, PAF antagonist. (1α,7β)-1,7-Dihydroxyginkolide A BN-52022 15291-76-6 ≥98% 440.4 C20H24O11 CC1C(=O)OC2C1(C34C(=O)OC5C3(C2O)C6(C(C5O)C(C)(C)C)C(C(=O)OC6O4)O)O Ambient -20°C Insoluble in water. Soluble in DMSO. "Cho HJ, Shon YH, Nam KS. Ginkgolide C inhibits platelet aggregation in cAMP- and cGMP-dependent manner by activating MMP-9. Biol Pharm Bull. 2007 Dec;30(12):2340-4. PMID: 18057723.

Jaracz S, Nakanishi K, Jensen AA, et al. Ginkgolides and glycine receptors: a structure-activity relationship study. Chemistry. 2004 Mar 19;10(6):1507-18. PMID: 15034895.

Scholtyssek H, Damerau W, Wessel R, et al. Antioxidative activity of ginkgolides against superoxide in an aprotic environment. Chem Biol Interact. 1997 Oct 24;106(3):183-90. PMID: 9413545.

" None Not dangerous goods.

LKT G3357 Ginkgolide C 50 mg 339.8 Diterpene lactone found in Ginkgo; GABA-A, α-1 GlyR, PAF antagonist. (1α,7β)-1,7-Dihydroxyginkolide A BN-52022 15291-76-6 ≥98% 440.4 C20H24O11 CC1C(=O)OC2C1(C34C(=O)OC5C3(C2O)C6(C(C5O)C(C)(C)C)C(C(=O)OC6O4)O)O Ambient -20°C Insoluble in water. Soluble in DMSO. "Cho HJ, Shon YH, Nam KS. Ginkgolide C inhibits platelet aggregation in cAMP- and cGMP-dependent manner by activating MMP-9. Biol Pharm Bull. 2007 Dec;30(12):2340-4. PMID: 18057723.

Jaracz S, Nakanishi K, Jensen AA, et al. Ginkgolides and glycine receptors: a structure-activity relationship study. Chemistry. 2004 Mar 19;10(6):1507-18. PMID: 15034895.

Scholtyssek H, Damerau W, Wessel R, et al. Antioxidative activity of ginkgolides against superoxide in an aprotic environment. Chem Biol Interact. 1997 Oct 24;106(3):183-90. PMID: 9413545.

" None Not dangerous goods.

LKT R0110 Ractopamine Hydrochloride 1 g 84.3 β1/2-adrenergic agonist. 4-{3-[2-Hydroxy-2-(4-hydroxyphenyl)ethyl]aminobutylphenol hydrochloride 90274-24-1 ≥97% 337.84 C18H23NO3 HCl CC(CCC1=CC=C(C=C1)O)NCC(C2=CC=C(C=C2)O)O.Cl Ambient Ambient Methanol, DMSO. Soluble in water to 31 mg/mL. "Salem M, Levesque H, Moon TW, et al. Anabolic effects of feeding beta2-adrenergic agonists on rainbow trout muscle proteases and proteins. Comp Biochem Physiol A Mol Integr Physiol. 2006 Jun;144(2):145-54. PMID: 16580855.

Page KA, Hartzell DL, Li C, et al. beta-Adrenergic receptor agonists increase apoptosis of adipose tissue in mice. Domest Anim Endocrinol. 2004 Jan;26(1):23-31. PMID: 14732450.

" Xn Not Dangerous Goods

LKT R0110 Ractopamine Hydrochloride 5 g 337.6 β1/2-adrenergic agonist. 4-{3-[2-Hydroxy-2-(4-hydroxyphenyl)ethyl]aminobutylphenol hydrochloride 90274-24-1 ≥97% 337.84 C18H23NO3 HCl CC(CCC1=CC=C(C=C1)O)NCC(C2=CC=C(C=C2)O)O.Cl Ambient Ambient Methanol, DMSO. Soluble in water to 31 mg/mL. "Salem M, Levesque H, Moon TW, et al. Anabolic effects of feeding beta2-adrenergic agonists on rainbow trout muscle proteases and proteins. Comp Biochem Physiol A Mol Integr Physiol. 2006 Jun;144(2):145-54. PMID: 16580855.

Page KA, Hartzell DL, Li C, et al. beta-Adrenergic receptor agonists increase apoptosis of adipose tissue in mice. Domest Anim Endocrinol. 2004 Jan;26(1):23-31. PMID: 14732450.

" Xn Not Dangerous Goods

LKT C4510 Climbazole 5 g 81 14-α demethylase inhibitor. Baypival 38083-17-9 ≥98% 292.76 C15H17ClN2O2 CC(C)(C)C(=O)C(N1C=CN=C1)OC2=CC=C(C=C2)Cl Ambient Ambient "Turner GA, Matheson JR, Li GZ, et al. Enhanced efficacy and sensory properties of an anti-dandruff shampoo containing zinc pyrithione and climbazole. Int J Cosmet Sci. 2013 Feb;35(1):78-83. PMID: 22970742.

Schmidt A. In vitro activity of climbazole, clotrimazole and silver-sulphadiazine against isolates of Malassezia pachydermatis. Zentralbl Veterinarmed B. 1997 Jun;44(4):193-7. PMID: 9230670.

" Xn "UN number: 3077 Class: 9 Packing Group: III

Proper shipping name: Environmentally hazardous substance, solid, n.o.s. (Climbazole)"

LKT C4510 Climbazole 10 g 111 14-α demethylase inhibitor. Baypival 38083-17-9 ≥98% 292.76 C15H17ClN2O2 CC(C)(C)C(=O)C(N1C=CN=C1)OC2=CC=C(C=C2)Cl Ambient Ambient "Turner GA, Matheson JR, Li GZ, et al. Enhanced efficacy and sensory properties of an anti-dandruff shampoo containing zinc pyrithione and climbazole. Int J Cosmet Sci. 2013 Feb;35(1):78-83. PMID: 22970742.

Schmidt A. In vitro activity of climbazole, clotrimazole and silver-sulphadiazine against isolates of Malassezia pachydermatis. Zentralbl Veterinarmed B. 1997 Jun;44(4):193-7. PMID: 9230670.

" Xn "UN number: 3077 Class: 9 Packing Group: III

Proper shipping name: Environmentally hazardous substance, solid, n.o.s. (Climbazole)"

LKT C4510 Climbazole 25 g 231.1 14-α demethylase inhibitor. Baypival 38083-17-9 ≥98% 292.76 C15H17ClN2O2 CC(C)(C)C(=O)C(N1C=CN=C1)OC2=CC=C(C=C2)Cl Ambient Ambient "Turner GA, Matheson JR, Li GZ, et al. Enhanced efficacy and sensory properties of an anti-dandruff shampoo containing zinc pyrithione and climbazole. Int J Cosmet Sci. 2013 Feb;35(1):78-83. PMID: 22970742.

Schmidt A. In vitro activity of climbazole, clotrimazole and silver-sulphadiazine against isolates of Malassezia pachydermatis. Zentralbl Veterinarmed B. 1997 Jun;44(4):193-7. PMID: 9230670.

" Xn "UN number: 3077 Class: 9 Packing Group: III

Proper shipping name: Environmentally hazardous substance, solid, n.o.s. (Climbazole)"

LKT C4517 Clenbuterol Hydrochloride 25 mg 65.6 β2-adrenergic agonist. 4-Amino-alpha-((tert-butylamino)methyl)-3,5-dichlorobenzyl alcohol hydrochloride Clenbuterol hydrochloride, Planipart hydrochloride, Spiropent, Ventipulmin 21898-19-1 ≥98% 313.65 C12H18Cl2N2O HCl CC(C)(C)NCC(C1=CC(=C(C(=C1)Cl)N)Cl)O.Cl Ambient Ambient "Li Y, He J, Sui S, et al. Clenbuterol upregulates histone demethylase JHDM2a via the β2-adrenoceptor/cAMP/PKA/p-CREB signaling pathway. Cell Signal. 2012 Dec;24(12):2297-306. PMID: 22820505.

Abo T, Iida RH, Kaneko S, et al. IGF and myostatin pathways are respectively induced during the earlier and the later stages of skeletal muscle hypertrophy induced by clenbuterol, a β2-adrenergic agonist. Cell Biochem Funct. 2012 Dec;30(8):671-6. PMID: 22696074.

Gleeson LC, Ryan KJ, Griffin EW, et al. The β2-adrenoceptor agonist clenbuterol elicits neuroprotective, anti-inflammatory and neurotrophic actions in the kainic acid model of excitotoxicity. Brain Behav Immun. 2010 Nov;24(8):1354-61. PMID: 20599496.

" T "UN number: 2811 Class: 6.1 Packing Geoup: III

Proper shipping name: Toxic solid, organic, n.o.s. (Clenbuterol hydrochloride)"

LKT C4517 Clenbuterol Hydrochloride 100 mg 187.4 β2-adrenergic agonist. 4-Amino-alpha-((tert-butylamino)methyl)-3,5-dichlorobenzyl alcohol hydrochloride Clenbuterol hydrochloride, Planipart hydrochloride, Spiropent, Ventipulmin 21898-19-1 ≥98% 313.65 C12H18Cl2N2O HCl CC(C)(C)NCC(C1=CC(=C(C(=C1)Cl)N)Cl)O.Cl Ambient Ambient "Li Y, He J, Sui S, et al. Clenbuterol upregulates histone demethylase JHDM2a via the β2-adrenoceptor/cAMP/PKA/p-CREB signaling pathway. Cell Signal. 2012 Dec;24(12):2297-306. PMID: 22820505.

" T "UN number: 2811 Class: 6.1 Packing Geoup: III

Proper shipping name: Toxic solid, organic, n.o.s. (Clenbuterol hydrochloride)"

LKT C4517 Clenbuterol Hydrochloride 250 mg 281.2 β2-adrenergic agonist. 4-Amino-alpha-((tert-butylamino)methyl)-3,5-dichlorobenzyl alcohol hydrochloride Clenbuterol hydrochloride, Planipart hydrochloride, Spiropent, Ventipulmin 21898-19-1 ≥98% 313.65 C12H18Cl2N2O HCl CC(C)(C)NCC(C1=CC(=C(C(=C1)Cl)N)Cl)O.Cl Ambient Ambient "Li Y, He J, Sui S, et al. Clenbuterol upregulates histone demethylase JHDM2a via the β2-adrenoceptor/cAMP/PKA/p-CREB signaling pathway. Cell Signal. 2012 Dec;24(12):2297-306. PMID: 22820505.

" T "UN number: 2811 Class: 6.1 Packing Geoup: III

Proper shipping name: Toxic solid, organic, n.o.s. (Clenbuterol hydrochloride)"

LKT C4532 Clindamycin Hydrochloride 10 mg 47.6 Lincosamide; ribosomal translocation and protein synthesis inhibitor. 7(S)-Chloro-7-deoxylincomycin hydrochloride; Cleocin hydrochloride; Dalacina 21462-39-5 ≥87% 461.44 C18H34Cl2N2O5S HCl CCCC1CC(N(C1)C)C(=O)NC(C2C(C(C(C(O2)SC)O)O)O)C(C)Cl.Cl Ambient Ambient Soluble in water. "Takem EN, D'Alessandro U. Malaria in pregnancy. Mediterr J Hematol Infect Dis. 2013;5(1):e2013010. PMID: 23350023.

Sireesha P, Setty CR. Detection of various types of resistance patterns and their correlation with minimal inhibitory concentrations against clindamycin among methicillin-resistant Staphylococcus aureus isolates. Indian J Med Microbiol. 2012 Apr-Jun;30(2):165-9. PMID: 22664431.

Wilson DN. On the specificity of antibiotics targeting the large ribosomal subunit. Ann N Y Acad Sci. 2011 Dec;1241:1-16. PMID: 22191523.

Schlünzen F, Zarivach R, Harms J, et al. Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria. Nature. 2001 Oct 25;413(6858):814-21. PMID: 11677599.

" None Not dangerous goods.

LKT C4532 Clindamycin Hydrochloride 50 mg 129 Lincosamide; ribosomal translocation and protein synthesis inhibitor. 7(S)-Chloro-7-deoxylincomycin hydrochloride; Cleocin hydrochloride; Dalacina 21462-39-5 ≥87% 461.44 C18H34Cl2N2O5S HCl CCCC1CC(N(C1)C)C(=O)NC(C2C(C(C(C(O2)SC)O)O)O)C(C)Cl.Cl Ambient Ambient Soluble in water. "Takem EN, D'Alessandro U. Malaria in pregnancy. Mediterr J Hematol Infect Dis. 2013;5(1):e2013010. PMID: 23350023.

Wilson DN. On the specificity of antibiotics targeting the large ribosomal subunit. Ann N Y Acad Sci. 2011 Dec;1241:1-16. PMID: 22191523.

Schlünzen F, Zarivach R, Harms J, et al. Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria. Nature. 2001 Oct 25;413(6858):814-21. PMID: 11677599.

" None Not dangerous goods.

LKT C4532 Clindamycin Hydrochloride 100 mg 224.3 Lincosamide; ribosomal translocation and protein synthesis inhibitor. 7(S)-Chloro-7-deoxylincomycin hydrochloride; Cleocin hydrochloride; Dalacina 21462-39-5 ≥87% 461.44 C18H34Cl2N2O5S HCl CCCC1CC(N(C1)C)C(=O)NC(C2C(C(C(C(O2)SC)O)O)O)C(C)Cl.Cl Ambient Ambient Soluble in water. "Takem EN, D'Alessandro U. Malaria in pregnancy. Mediterr J Hematol Infect Dis. 2013;5(1):e2013010. PMID: 23350023.

Wilson DN. On the specificity of antibiotics targeting the large ribosomal subunit. Ann N Y Acad Sci. 2011 Dec;1241:1-16. PMID: 22191523.

Schlünzen F, Zarivach R, Harms J, et al. Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria. Nature. 2001 Oct 25;413(6858):814-21. PMID: 11677599.

" None Not dangerous goods.

LKT C4533 Clindamycin Phosphate 10 mg 47.6 Lincosamide; ribosomal translocation and protein synthesis inhibitor. 7(S)-Chloro-7-deoxylincomycin 2-phosphate; Cleocin phosphate; Clindamycin-2-phosphate 24729-96-2 ≥95% 504.96 C18H34ClN2O8PS CCCC1CC(N(C1)C)C(=O)NC(C2C(C(C(C(O2)SC)OP(=O)(O)O)O)O)C(C)Cl Ambient Ambient Soluble in water (400 mg/mL). Insoluble in ethanol. "Takem EN, D'Alessandro U. Malaria in pregnancy. Mediterr J Hematol Infect Dis. 2013;5(1):e2013010. PMID: 23350023.

Wilson DN. On the specificity of antibiotics targeting the large ribosomal subunit. Ann N Y Acad Sci. 2011 Dec;1241:1-16. PMID: 22191523.

Schlünzen F, Zarivach R, Harms J, et al. Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria. Nature. 2001 Oct 25;413(6858):814-21. PMID: 11677599.

" Xn Not dangerous goods.

LKT C4533 Clindamycin Phosphate 50 mg 129 Lincosamide; ribosomal translocation and protein synthesis inhibitor. 7(S)-Chloro-7-deoxylincomycin 2-phosphate; Cleocin phosphate; Clindamycin-2-phosphate 24729-96-2 ≥95% 504.96 C18H34ClN2O8PS CCCC1CC(N(C1)C)C(=O)NC(C2C(C(C(C(O2)SC)OP(=O)(O)O)O)O)C(C)Cl Ambient Ambient Soluble in water (400 mg/mL). Insoluble in ethanol. "Takem EN, D'Alessandro U. Malaria in pregnancy. Mediterr J Hematol Infect Dis. 2013;5(1):e2013010. PMID: 23350023.

Wilson DN. On the specificity of antibiotics targeting the large ribosomal subunit. Ann N Y Acad Sci. 2011 Dec;1241:1-16. PMID: 22191523.

Schlünzen F, Zarivach R, Harms J, et al. Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria. Nature. 2001 Oct 25;413(6858):814-21. PMID: 11677599.

" Xn Not dangerous goods.

LKT C4533 Clindamycin Phosphate 100 mg 224.3 Lincosamide; ribosomal translocation and protein synthesis inhibitor. 7(S)-Chloro-7-deoxylincomycin 2-phosphate; Cleocin phosphate; Clindamycin-2-phosphate 24729-96-2 ≥95% 504.96 C18H34ClN2O8PS CCCC1CC(N(C1)C)C(=O)NC(C2C(C(C(C(O2)SC)OP(=O)(O)O)O)O)C(C)Cl Ambient Ambient Soluble in water (400 mg/mL). Insoluble in ethanol. "Takem EN, D'Alessandro U. Malaria in pregnancy. Mediterr J Hematol Infect Dis. 2013;5(1):e2013010. PMID: 23350023.

Wilson DN. On the specificity of antibiotics targeting the large ribosomal subunit. Ann N Y Acad Sci. 2011 Dec;1241:1-16. PMID: 22191523.

Schlünzen F, Zarivach R, Harms J, et al. Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria. Nature. 2001 Oct 25;413(6858):814-21. PMID: 11677599.

" Xn Not dangerous goods.

LKT C4534 Clindamycin Palmitate Hydrochloride 10 mg 75.2 Lincosamide; ribosomal translocation and protein synthesis inhibitor. (2S-trans)-Methyl 7-chloro-6,7,8-trideoxy-6-[[(1- methyl-4-propyl-2-pyrrolidinyl)-carbonyl]amino]-1- thio-L-threo-α-D-galacto-octopyranoside palmitate hydrochloride 25507-04-4 ≥98% 699.85 C34H63ClN2O6S HCl CCCCCCCCCCCCCCCC(=O)OC1C(C(C(OC1SC)C(C(C)Cl)NC(=O)C2CC(CN2C)CCC)O)O.Cl Ambient Ambient Soluble in water, ethanol (330 mg/mL). "Takem EN, D'Alessandro U. Malaria in pregnancy. Mediterr J Hematol Infect Dis. 2013;5(1):e2013010. PMID: 23350023.

Wilson DN. On the specificity of antibiotics targeting the large ribosomal subunit. Ann N Y Acad Sci. 2011 Dec;1241:1-16. PMID: 22191523.

Schlünzen F, Zarivach R, Harms J, et al. Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria. Nature. 2001 Oct 25;413(6858):814-21. PMID: 11677599.

" Not dangerous goods.

LKT C4534 Clindamycin Palmitate Hydrochloride 50 mg 274.1 Lincosamide; ribosomal translocation and protein synthesis inhibitor. (2S-trans)-Methyl 7-chloro-6,7,8-trideoxy-6-[[(1- methyl-4-propyl-2-pyrrolidinyl)-carbonyl]amino]-1- thio-L-threo-α-D-galacto-octopyranoside palmitate hydrochloride 25507-04-4 ≥98% 699.85 C34H63ClN2O6S HCl CCCCCCCCCCCCCCCC(=O)OC1C(C(C(OC1SC)C(C(C)Cl)NC(=O)C2CC(CN2C)CCC)O)O.Cl Ambient Ambient Soluble in water, ethanol (330 mg/mL). "Takem EN, D'Alessandro U. Malaria in pregnancy. Mediterr J Hematol Infect Dis. 2013;5(1):e2013010. PMID: 23350023.

Wilson DN. On the specificity of antibiotics targeting the large ribosomal subunit. Ann N Y Acad Sci. 2011 Dec;1241:1-16. PMID: 22191523.

Schlünzen F, Zarivach R, Harms J, et al. Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria. Nature. 2001 Oct 25;413(6858):814-21. PMID: 11677599.

" Not dangerous goods.

LKT C4534 Clindamycin Palmitate Hydrochloride 100 mg 504.8 Lincosamide; ribosomal translocation and protein synthesis inhibitor. (2S-trans)-Methyl 7-chloro-6,7,8-trideoxy-6-[[(1- methyl-4-propyl-2-pyrrolidinyl)-carbonyl]amino]-1- thio-L-threo-α-D-galacto-octopyranoside palmitate hydrochloride 25507-04-4 ≥98% 699.85 C34H63ClN2O6S HCl CCCCCCCCCCCCCCCC(=O)OC1C(C(C(OC1SC)C(C(C)Cl)NC(=O)C2CC(CN2C)CCC)O)O.Cl Ambient Ambient Soluble in water, ethanol (330 mg/mL). "Takem EN, D'Alessandro U. Malaria in pregnancy. Mediterr J Hematol Infect Dis. 2013;5(1):e2013010. PMID: 23350023.

Wilson DN. On the specificity of antibiotics targeting the large ribosomal subunit. Ann N Y Acad Sci. 2011 Dec;1241:1-16. PMID: 22191523.

Schlünzen F, Zarivach R, Harms J, et al. Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria. Nature. 2001 Oct 25;413(6858):814-21. PMID: 11677599.

" Not dangerous goods.

LKT C4535 Clinafloxacin Hydrochloride 100 mg 122.3 Fluoroquinolone; topoisomerase IV and bacterial DNA gyrase inhibitor. 7-(3-Amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid hydrochloride AM-1091; CI-960; PD-12739 105956-99-8 ≥98% 402.24 C17H17ClFN3O3 HCl C1CC1N2C=C(C(=O)C3=CC(=C(C(=C32)Cl)N4CCC(C4)N)F)C(=O)O Ambient Ambient "Sweeney MT, Quesnell R, Tiwari R, et al. In vitro activity and rodent efficacy of clinafloxacin for bovine and swine respiratory disease. Front Microbiol. 2013 Jun 14;4:154. PMID: 23785362.

Ball P, Fernald A, Tillotson G. Therapeutic advances of new fluoroquinolones. Expert Opin Investig Drugs. 1998 May;7(5):761-83. PMID: 15991967.

" Not dangerous goods.

LKT C4535 Clinafloxacin Hydrochloride 250 mg 258.2 Fluoroquinolone; topoisomerase IV and bacterial DNA gyrase inhibitor. 7-(3-Amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid hydrochloride AM-1091; CI-960; PD-12739 105956-99-8 ≥98% 402.24 C17H17ClFN3O3 HCl C1CC1N2C=C(C(=O)C3=CC(=C(C(=C32)Cl)N4CCC(C4)N)F)C(=O)O Ambient Ambient "Sweeney MT, Quesnell R, Tiwari R, et al. In vitro activity and rodent efficacy of clinafloxacin for bovine and swine respiratory disease. Front Microbiol. 2013 Jun 14;4:154. PMID: 23785362.

Ball P, Fernald A, Tillotson G. Therapeutic advances of new fluoroquinolones. Expert Opin Investig Drugs. 1998 May;7(5):761-83. PMID: 15991967.

" Not dangerous goods.

LKT C4535 Clinafloxacin Hydrochloride 1 g 475.7 Fluoroquinolone; topoisomerase IV and bacterial DNA gyrase inhibitor. 7-(3-Amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid hydrochloride AM-1091; CI-960; PD-12739 105956-99-8 ≥98% 402.24 C17H17ClFN3O3 HCl C1CC1N2C=C(C(=O)C3=CC(=C(C(=C32)Cl)N4CCC(C4)N)F)C(=O)O Ambient Ambient "Sweeney MT, Quesnell R, Tiwari R, et al. In vitro activity and rodent efficacy of clinafloxacin for bovine and swine respiratory disease. Front Microbiol. 2013 Jun 14;4:154. PMID: 23785362.

Ball P, Fernald A, Tillotson G. Therapeutic advances of new fluoroquinolones. Expert Opin Investig Drugs. 1998 May;7(5):761-83. PMID: 15991967.

" Not dangerous goods.

LKT C4556 Clofibric Acid 10 g 34.8 Metabolite of clofibrate; PPARα agonist. 2-(4-Chlorophenoxy)-2-methylpropanoic acid Chlorfibrinic acid; Arteriohom; Regulipid 882-09-7 ≥98% 214.65 C10H11ClO3 CC(C)(C(=O)O)OC1=CC=C(C=C1)Cl Ambient Ambient "Yokoyama Y, Xin B, Shigeto T, et al. Clofibric acid, a peroxisome proliferator-activated receptor alpha ligand, inhibits growth of human ovarian cancer. Mol Cancer Ther. 2007 Apr;6(4):1379-86. PMID: 17431116.

Nishimaki-Mogami T, Suzuki K, Okochi E, et al. Bezafibrate and clofibric acid are novel inhibitors of phosphatidylcholine synthesis via the methylation of phosphatidylethanolamine. Biochim Biophys Acta. 1996 Nov 11;1304(1):11-20. PMID: 8944746.

Haughom B, Spydevold O. The mechanism underlying the hypolipemic effect of perfluorooctanoic acid (PFOA), perfluorooctane sulphonic acid (PFOSA) and clofibric acid. Biochim Biophys Acta. 1992 Sep 22;1128(1):65-72. PMID: 1327145.

" Xn Not dangerous goods.

LKT C4556 Clofibric Acid 50 g 55 Metabolite of clofibrate; PPARα agonist. 2-(4-Chlorophenoxy)-2-methylpropanoic acid Chlorfibrinic acid; Arteriohom; Regulipid 882-09-7 ≥98% 214.65 C10H11ClO3 CC(C)(C(=O)O)OC1=CC=C(C=C1)Cl Ambient Ambient "Yokoyama Y, Xin B, Shigeto T, et al. Clofibric acid, a peroxisome proliferator-activated receptor alpha ligand, inhibits growth of human ovarian cancer. Mol Cancer Ther. 2007 Apr;6(4):1379-86. PMID: 17431116.

" Xn Not dangerous goods.

LKT C4557 Clofibrate 1 g 33.9 Fibrate; PPARα agonist. 2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl ester Amotril; Apolan; Ateriosan; Claripex; CPIB; Liprinal; Normet; Recolip; Xyduril 637-07-0 ≥98% 242.7 C12H15ClO3 CCOC(=O)C(C)(C)OC1=CC=C(C=C1)Cl Ambient 4°C Soluble in DMSO or ethanol. Insoluble in water. "Laurora S, Pizzimenti S, Briatore F, et al. Peroxisome proliferator-activated receptor ligands affect growth-related gene expression in human leukemic cells. J Pharmacol Exp Ther. 2003 Jun;305(3):932-42. PMID: 12649303.

Nicholls-Grzemski FA, Calder IC, Priestly BG, et al. Clofibrate-induced in vitro hepatoprotection against acetaminophen is not due to altered glutathione homeostasis. Toxicol Sci. 2000 Jul;56(1):220-8. PMID: 10869471.

" Carc., Xn Not dangerous goods.

LKT C4557 Clofibrate 5 g 141.3 Fibrate; PPARα agonist. 2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl ester Amotril; Apolan; Ateriosan; Claripex; CPIB; Liprinal; Normet; Recolip; Xyduril 637-07-0 ≥98% 242.7 C12H15ClO3 CCOC(=O)C(C)(C)OC1=CC=C(C=C1)Cl Ambient 4°C Soluble in DMSO or ethanol. Insoluble in water. "Laurora S, Pizzimenti S, Briatore F, et al. Peroxisome proliferator-activated receptor ligands affect growth-related gene expression in human leukemic cells. J Pharmacol Exp Ther. 2003 Jun;305(3):932-42. PMID: 12649303.

" Carc., Xn Not dangerous goods.

LKT C4558 Clonidine Hydrochloride 250 mg 61.1 Imidazoline and α2-adrenergic agonist, Nav1.7 Na+ channel blocker. 4205-91-8 ≥98% 266.55 C9H9Cl2N3 HCl C1CN=C(N1)NC2=C(C=CC=C2Cl)Cl.Cl Ambient Ambient "Li CJ, Zhou M, Li HG, et al. Clonidine suppresses the induction of long-term potentiation by inhibiting HCN channels at the schaffer collateral-CA1 synapse in anesthetized adult rats. Cell Mol Neurobiol. 2013 Nov;33(8):1075-86. PMID: 23975095.

Maruta T, Nemoto T, Satoh S, et al. Dexmedetomidine and clonidine inhibit the function of Na(v)1.7 independent of α(2)-adrenoceptor in adrenal chromaffin cells. J Anesth. 2011 Aug;25(4):549-57. PMID: 21607767.

Roh DH, Kim HW, Yoon SY, et al. Intrathecal clonidine suppresses phosphorylation of the N-methyl-D-aspartate receptor NR1 subunit in spinal dorsal horn neurons of rats with neuropathic pain. Anesth Analg. 2008 Aug;107(2):693-700. PMID: 18633054.

Ji XH, Ji JZ, Zhang H, et al. Stimulation of alpha2-adrenoceptors suppresses excitatory synaptic transmission in the medial prefrontal cortex of rat. Neuropsychopharmacology. 2008 Aug;33(9):2263-71. PMID: 17957212.

Bardgett ME, Points M, Ramsey-Faulkner C, et al. The effects of clonidine on discrete-trial delayed spatial alternation in two rat models of memory loss. Neuropsychopharmacology. 2008 Jul;33(8):1980-91. PMID: 17882233.

Ma XJ, Shen FM, Liu AJ, et al. Clonidine, moxonidine, folic acid, and mecobalamin improve baroreflex function in stroke-prone, spontaneously hypertensive rats. Acta Pharmacol Sin. 2007 Oct;28(10):1550-8. PMID: 17883939.

Li CG, Rand MJ. Rilmenidine differs from clonidine in that it lacks histamine-like activity. J Pharm Pharmacol. 1989 Jul;41(7):464-8. PMID: 2570851.

Ernsberger P, Giuliano R, Willette RN, et al. Hypotensive action of clonidine analogues correlates with binding affinity at imidazole and not alpha-2-adrenergic receptors in the rostral ventrolateral medulla. J Hypertens Suppl. 1988 Dec;6(4):S554-7. PMID: 2853758.

" T+ "UN number: 2811 Class: 6.1 Packing group: I

Proper shipping name: Toxic solids, organic, n.o.s. (Clonidine hydrochloride)

Marine pollutant: No. Poison Inhalation Hazard: No"

LKT C4558 Clonidine Hydrochloride 1 g 169.9 Imidazoline and α2-adrenergic agonist, Nav1.7 Na+ channel blocker. 4205-91-8 ≥98% 266.55 C9H9Cl2N3 HCl C1CN=C(N1)NC2=C(C=CC=C2Cl)Cl.Cl Ambient Ambient "Li CJ, Zhou M, Li HG, et al. Clonidine suppresses the induction of long-term potentiation by inhibiting HCN channels at the schaffer collateral-CA1 synapse in anesthetized adult rats. Cell Mol Neurobiol. 2013 Nov;33(8):1075-86. PMID: 23975095.

Li CG, Rand MJ. Rilmenidine differs from clonidine in that it lacks histamine-like activity. J Pharm Pharmacol. 1989 Jul;41(7):464-8. PMID: 2570851.

" T+ "UN number: 2811 Class: 6.1 Packing group: I

Proper shipping name: Toxic solids, organic, n.o.s. (Clonidine hydrochloride)

Marine pollutant: No. Poison Inhalation Hazard: No"

LKT C4646 Clofarabine 10 mg 187.4 Nucleoside (adenosine) analog; DNA chain terminator, ribonucleotide reductase and DNA polymerase inhibitor, A1/2/3 adenosine modulator. (2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol 123318-82-1 ≥98% 303.68 C10H11ClFN5O3 C1=NC2=C(N1C3C(C(C(O3)CO)O)F)N=C(N=C2N)Cl Ambient Ambient 10mM H2O,100mM DMSO "Robak P, Robak T. Older and new purine nucleoside analogs for patients with acute leukemias. Cancer Treat Rev. 2013 Dec;39(8):851-61. PMID: 23566572.

Jensen K, Johnson LA, Jacobson PA, et al. Cytotoxic purine nucleoside analogues bind to A1, A2A, and A3 adenosine receptors. Naunyn Schmiedebergs Arch Pharmacol. 2012 May;385(5):519-25. PMID: 22249336.

Majda K, Lubecka K, Kaufman-Szymczyk A, et al. Clofarabine (2-chloro-2'-fluoro-2'-deoxyarabinosyladenine)--biochemical aspects of anticancer activity. Acta Pol Pharm. 2011 Jul-Aug;68(4):459-66. PMID: 21796927.

Aye Y, Stubbe J. Clofarabine 5'-di and -triphosphates inhibit human ribonucleotide reductase by altering the quaternary structure of its large subunit. Proc Natl Acad Sci U S A. 2011 Jun 14;108(24):9815-20. PMID: 21628579.

Parker WB, Shaddix SC, Chang CH, et al. Effects of 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine on K562 cellular metabolism and the inhibition of human ribonucleotide reductase and DNA polymerases by its 5'-triphosphate. Cancer Res. 1991 May 1;51(9):2386-94. PMID: 1707752.

" "UN number: 2811 Class: 6.1 Packing Group: II

Proper shipping name: Toxic solid, organic, n.o.s. (Clofarabine)"

LKT C4646 Clofarabine 25 mg 375.1 Nucleoside (adenosine) analog; DNA chain terminator, ribonucleotide reductase and DNA polymerase inhibitor, A1/2/3 adenosine modulator. (2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol 123318-82-1 ≥98% 303.68 C10H11ClFN5O3 C1=NC2=C(N1C3C(C(C(O3)CO)O)F)N=C(N=C2N)Cl Ambient Ambient 10mM H2O,100mM DMSO "Robak P, Robak T. Older and new purine nucleoside analogs for patients with acute leukemias. Cancer Treat Rev. 2013 Dec;39(8):851-61. PMID: 23566572.

" "UN number: 2811 Class: 6.1 Packing Group: II

Proper shipping name: Toxic solid, organic, n.o.s. (Clofarabine)"

LKT C4646 Clofarabine 100 mg 1218.8 Nucleoside (adenosine) analog; DNA chain terminator, ribonucleotide reductase and DNA polymerase inhibitor, A1/2/3 adenosine modulator. (2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol 123318-82-1 ≥98% 303.68 C10H11ClFN5O3 C1=NC2=C(N1C3C(C(C(O3)CO)O)F)N=C(N=C2N)Cl Ambient Ambient 10mM H2O,100mM DMSO "Robak P, Robak T. Older and new purine nucleoside analogs for patients with acute leukemias. Cancer Treat Rev. 2013 Dec;39(8):851-61. PMID: 23566572.

" "UN number: 2811 Class: 6.1 Packing Group: II

Proper shipping name: Toxic solid, organic, n.o.s. (Clofarabine)"

LKT C4656 Clopidol 1 g 63.8 Coccidiostat. 3,5-Dichloro-2,6-dimethyl-4-pyridinol Clopindol; Coyden 2971-90-6 ≥98% 192.04 C7H7Cl2NO CC1=C(C(=O)C(=C(N1)C)Cl)Cl Ambient Ambient Practically insoluble in water. "Gerhold RW, Fuller AL, Lollis L, et al. The efficacy of anticoccidial products against Eimeria spp. in northern bobwhites. Avian Dis. 2011 Mar;55(1):59-64. PMID: 21500637.

Arakawa A, Tanaka Y, Baba E, et al. Effects of clopidol on sporulation and infectivity of Eimeria tenella oocysts. Vet Parasitol. 1991 Jan;38(1):55-60. PMID: 2024430.

" Xi Not dangerous goods.

LKT C4656 Clopidol 5 g 140 Coccidiostat. 3,5-Dichloro-2,6-dimethyl-4-pyridinol Clopindol; Coyden 2971-90-6 ≥98% 192.04 C7H7Cl2NO CC1=C(C(=O)C(=C(N1)C)Cl)Cl Ambient Ambient Practically insoluble in water. "Gerhold RW, Fuller AL, Lollis L, et al. The efficacy of anticoccidial products against Eimeria spp. in northern bobwhites. Avian Dis. 2011 Mar;55(1):59-64. PMID: 21500637.

Arakawa A, Tanaka Y, Baba E, et al. Effects of clopidol on sporulation and infectivity of Eimeria tenella oocysts. Vet Parasitol. 1991 Jan;38(1):55-60. PMID: 2024430.

" Xi Not dangerous goods.

LKT C4656 Clopidol 25 g 635.4 Coccidiostat. 3,5-Dichloro-2,6-dimethyl-4-pyridinol Clopindol; Coyden 2971-90-6 ≥98% 192.04 C7H7Cl2NO CC1=C(C(=O)C(=C(N1)C)Cl)Cl Ambient Ambient Practically insoluble in water. "Gerhold RW, Fuller AL, Lollis L, et al. The efficacy of anticoccidial products against Eimeria spp. in northern bobwhites. Avian Dis. 2011 Mar;55(1):59-64. PMID: 21500637.

Arakawa A, Tanaka Y, Baba E, et al. Effects of clopidol on sporulation and infectivity of Eimeria tenella oocysts. Vet Parasitol. 1991 Jan;38(1):55-60. PMID: 2024430.

" Xi Not dangerous goods.

LKT C4657 Clotrimazole 5 g 47.6 Imidazole; 14-α demethylase, H+/K+ ATPase, Na+/K+ ATPase inhibitor. 1-[(2-Chlorophenyl)-diphenylmethyl]-1H-imidazole Canesten; Canifug; Lotrimin; Mycosporin; Rimazole; Trimysten 23593-75-1 ≥97% 344.84 C22H17ClN2 C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CN=C4 Ambient Ambient Soluble in acetone; chloroform; ethyl acetate and DMF. Slightly soluble in water, benzene and toluene. "Wang J, Jia L, Kuang Z, et al. The in vitro and in vivo antitumor effects of clotrimazole on oral squamous cell carcinoma. PLoS One. 2014 Jun 3;9(6):e98885. PMID: 24892421.

Witzke A, Lindner K, Munson K, et al. Inhibition of the gastric H,K-ATPase by clotrimazole. Biochemistry. 2010 Jun 1;49(21):4524-32. PMID: 20423050.

Huy NT, Takano R, Hara S, et al. Enhancement of heme-induced membrane damage by the anti-malarial clotrimazole: the role of colloid-osmotic forces. Biol Pharm Bull. 2004 Mar;27(3):361-5. PMID: 14993803.

Plempel M. On the action kinetics of clotrimazole. Chemotherapy. 1982;28 Suppl 1:22-31. PMID: 6761084.

" Xn Xi Not dangerous goods.

LKT C4657 Clotrimazole 10 g 81.6 Imidazole; 14-α demethylase, H+/K+ ATPase, Na+/K+ ATPase inhibitor. 1-[(2-Chlorophenyl)-diphenylmethyl]-1H-imidazole Canesten; Canifug; Lotrimin; Mycosporin; Rimazole; Trimysten 23593-75-1 ≥97% 344.84 C22H17ClN2 C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CN=C4 Ambient Ambient Soluble in acetone; chloroform; ethyl acetate and DMF. Slightly soluble in water, benzene and toluene. "Wang J, Jia L, Kuang Z, et al. The in vitro and in vivo antitumor effects of clotrimazole on oral squamous cell carcinoma. PLoS One. 2014 Jun 3;9(6):e98885. PMID: 24892421.

Witzke A, Lindner K, Munson K, et al. Inhibition of the gastric H,K-ATPase by clotrimazole. Biochemistry. 2010 Jun 1;49(21):4524-32. PMID: 20423050.

Plempel M. On the action kinetics of clotrimazole. Chemotherapy. 1982;28 Suppl 1:22-31. PMID: 6761084.

" Xn Xi Not dangerous goods.

LKT C4657 Clotrimazole 25 g 163.2 Imidazole; 14-α demethylase, H+/K+ ATPase, Na+/K+ ATPase inhibitor. 1-[(2-Chlorophenyl)-diphenylmethyl]-1H-imidazole Canesten; Canifug; Lotrimin; Mycosporin; Rimazole; Trimysten 23593-75-1 ≥97% 344.84 C22H17ClN2 C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CN=C4 Ambient Ambient Soluble in acetone; chloroform; ethyl acetate and DMF. Slightly soluble in water, benzene and toluene. "Wang J, Jia L, Kuang Z, et al. The in vitro and in vivo antitumor effects of clotrimazole on oral squamous cell carcinoma. PLoS One. 2014 Jun 3;9(6):e98885. PMID: 24892421.

Witzke A, Lindner K, Munson K, et al. Inhibition of the gastric H,K-ATPase by clotrimazole. Biochemistry. 2010 Jun 1;49(21):4524-32. PMID: 20423050.

Plempel M. On the action kinetics of clotrimazole. Chemotherapy. 1982;28 Suppl 1:22-31. PMID: 6761084.

" Xn Xi Not dangerous goods.

LKT C4659 Clobetasol Propionate 100 mg 43.5 Corticosteroid; glucocorticoid agonist. (11β, 16β)-21-Chloro-9-fluoro-11,17-dihydroxy-16- methylpregna-1,4-diene-3,20-dione Clobesol; Dermoval; Dermovate; Dermoxin; Temovate 25122-46-7 ≥98% 466.98 C25H32ClFO5 CCC(=O)OC1(C(CC2C1(CC(C3(C2CCC4=CC(=O)C=CC43C)F)O)C)C)C(=O)CCl Ambient 4°C Soluble in acetone or methylene dichloride. "Cechin SR, Buchwald P. Effects of representative glucocorticoids on TNFα- and CD40L-induced NF-κB activation in sensor cells. Steroids. 2014 Jul;85:36-43. PMID: 24747770.

Lenane P, Macarthur C, Parkin PC, et al. Clobetasol propionate, 0.05%, vs hydrocortisone, 1%, for alopecia areata in children: a randomized clinical trial. JAMA Dermatol. 2014 Jan;150(1):47-50. PMID: 24226568.

" Xi Not dangerous goods.

LKT C4659 Clobetasol Propionate 500 mg 200.2 Corticosteroid; glucocorticoid agonist. (11β, 16β)-21-Chloro-9-fluoro-11,17-dihydroxy-16- methylpregna-1,4-diene-3,20-dione Clobesol; Dermoval; Dermovate; Dermoxin; Temovate 25122-46-7 ≥98% 466.98 C25H32ClFO5 CCC(=O)OC1(C(CC2C1(CC(C3(C2CCC4=CC(=O)C=CC43C)F)O)C)C)C(=O)CCl Ambient 4°C Soluble in acetone or methylene dichloride. "Cechin SR, Buchwald P. Effects of representative glucocorticoids on TNFα- and CD40L-induced NF-κB activation in sensor cells. Steroids. 2014 Jul;85:36-43. PMID: 24747770.

" Xi Not dangerous goods.

LKT C4659 Clobetasol Propionate 1 g 281.5 Corticosteroid; glucocorticoid agonist. (11β, 16β)-21-Chloro-9-fluoro-11,17-dihydroxy-16- methylpregna-1,4-diene-3,20-dione Clobesol; Dermoval; Dermovate; Dermoxin; Temovate 25122-46-7 ≥98% 466.98 C25H32ClFO5 CCC(=O)OC1(C(CC2C1(CC(C3(C2CCC4=CC(=O)C=CC43C)F)O)C)C)C(=O)CCl Ambient 4°C Soluble in acetone or methylene dichloride. "Cechin SR, Buchwald P. Effects of representative glucocorticoids on TNFα- and CD40L-induced NF-κB activation in sensor cells. Steroids. 2014 Jul;85:36-43. PMID: 24747770.

" Xi Not dangerous goods.

LKT C4756 Cloxacillin Sodium Monohydrate 1 g 52.6 β-lactam; penicillin binding protein inhibitor. "4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(3-

(2-chlorophenyl)-5-methyl-4-isoxazolecarboxamido)-3,3-

dimethyl-7-oxo-, monosodium salt, (2S,5R,6R)-

" Bactopen; Cloxapen; Cloxypen; Ekvacillin; Orbenin; Methocillin-S. 7081-44-9 ≥98% 475.88 C19H18ClN3NaO5S H2O CC1=C(C(=NO1)C2=CC=CC=C2Cl)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)[O-].[Na+] Ambient Ambient Soluble in water, methanol, ethanol or pyridine. "Sawai T, Yamaguchi A. Mechanism of beta-lactamase inhibition: differences between sulbactam and other inhibitors. Diagn Microbiol Infect Dis. 1989 Jul-Aug;12(4 Suppl):121S-129S. PMID: 2591172.

Barza M. Antimicrobial spectrum, pharmacology and therapeutic use of antibiotics. Part 2: penicillins. Am J Hosp Pharm. 1977 Jan;34(1):57-67. PMID: 318800.

" Xi, T, T+, Carc. Cat. 3 Not dangerous goods.

LKT C4756 Cloxacillin Sodium Monohydrate 5 g 147 β-lactam; penicillin binding protein inhibitor. "4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(3-

(2-chlorophenyl)-5-methyl-4-isoxazolecarboxamido)-3,3-

dimethyl-7-oxo-, monosodium salt, (2S,5R,6R)-

Barza M. Antimicrobial spectrum, pharmacology and therapeutic use of antibiotics. Part 2: penicillins. Am J Hosp Pharm. 1977 Jan;34(1):57-67. PMID: 318800.

" Xi, T, T+, Carc. Cat. 3 Not dangerous goods.

LKT C4756 Cloxacillin Sodium Monohydrate 25 g 420.1 β-lactam; penicillin binding protein inhibitor. "4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(3-

(2-chlorophenyl)-5-methyl-4-isoxazolecarboxamido)-3,3-

dimethyl-7-oxo-, monosodium salt, (2S,5R,6R)-

Barza M. Antimicrobial spectrum, pharmacology and therapeutic use of antibiotics. Part 2: penicillins. Am J Hosp Pharm. 1977 Jan;34(1):57-67. PMID: 318800.

" Xi, T, T+, Carc. Cat. 3 Not dangerous goods.

LKT C4757 Clozapine 25 mg 40.7 M4 mAChR agonist, 5-HT1A partial agonist, M1/2/3/5 mAChR, D2 antagonist, Kv1.1 K+ channel blocker. "8-chloro-11-(4-methyl-1-piperazinyl)-5H-Dibenzo(b,e)(1,4)diazepine

" Clozaril, Leponex 5786-21-0 ≥97% 326.82 C18H19ClN4 CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl Ambient Ambient Soluble in DMSO or dilute aqueous acid. "Hill AP, Perrin MJ, Heide J, et al. Kinetics of drug interaction with the Kv11.1 potassium channel. Mol Pharmacol. 2014 May;85(5):769-76. PMID: 24586056.

Tanahashi S, Yamamura S, Nakagawa M, et al. Clozapine, but not haloperidol, enhances glial D-serine and L-glutamate release in rat frontal cortex and primary cultured astrocytes. Br J Pharmacol. 2012 Mar;165(5):1543-55. PMID: 21880034.

Wu Y, Blichowski M, Daskalakis ZJ, et al. Evidence that clozapine directly interacts on the GABAB receptor. Neuroreport. 2011 Sep 14;22(13):637-41. PMID: 21753741.

Nord M, Farde L. Antipsychotic occupancy of dopamine receptors in schizophrenia. CNS Neurosci Ther. 2011 Apr;17(2):97-103. PMID: 21143431.

Alvir JM, Lieberman JA, Safferman AZ, et al. Clozapine-induced agranulocytosis. Incidence and risk factors in the United States. N Engl J Med. 1993 Jul 15;329(3):162-7. PMID: 8515788.

" Xn "UN number: 2811 Class: 6.1 Packing group: III

Proper shipping name: Toxic solids, organic, n.o.s. (Clozapine)

Reportable Quantity (RQ)"

LKT C4757 Clozapine 100 mg 67.9 M4 mAChR agonist, 5-HT1A partial agonist, M1/2/3/5 mAChR, D2 antagonist, Kv1.1 K+ channel blocker. "8-chloro-11-(4-methyl-1-piperazinyl)-5H-Dibenzo(b,e)(1,4)diazepine

Wu Y, Blichowski M, Daskalakis ZJ, et al. Evidence that clozapine directly interacts on the GABAB receptor. Neuroreport. 2011 Sep 14;22(13):637-41. PMID: 21753741.

Nord M, Farde L. Antipsychotic occupancy of dopamine receptors in schizophrenia. CNS Neurosci Ther. 2011 Apr;17(2):97-103. PMID: 21143431.

Alvir JM, Lieberman JA, Safferman AZ, et al. Clozapine-induced agranulocytosis. Incidence and risk factors in the United States. N Engl J Med. 1993 Jul 15;329(3):162-7. PMID: 8515788.

" Xn "UN number: 2811 Class: 6.1 Packing group: III

Proper shipping name: Toxic solids, organic, n.o.s. (Clozapine)

Reportable Quantity (RQ)"

LKT C4758 Closantel Sodium 1 g 57.8 Protonophore; chitinase OvCHT1 inhibitor. N-[5-Chloro-4-[(4-chlorophenyl)cyanomethyl]-2- methylphenyl]-2-hydroxy-3,5-di-iodobenzamide Flukiver; Seponver 61438-64-0 ≥98% 686.06 C22H14Cl2l2N2NaO2 CC1=CC(=C(C=C1NC(=O)C2=CC(=CC(=C2[O-])I)I)Cl)C(C#N)C3=CC=C(C=C3)Cl.[Na+] Ambient Ambient Insoluble in water. Gooyit M, Tricoche N, Lustigman S, et al. Dual Protonophore-Chitinase Inhibitors Dramatically Affect O. volvulus Molting. J Med Chem. 2014 Jun 20. [Epub ahead of print]. PMID: 24918716. Not dangerous goods.

LKT C4758 Closantel Sodium 5 g 104.3 Protonophore; chitinase OvCHT1 inhibitor. N-[5-Chloro-4-[(4-chlorophenyl)cyanomethyl]-2- methylphenyl]-2-hydroxy-3,5-di-iodobenzamide Flukiver; Seponver 61438-64-0 ≥98% 686.06 C22H14Cl2l2N2NaO2 CC1=CC(=C(C=C1NC(=O)C2=CC(=CC(=C2[O-])I)I)Cl)C(C#N)C3=CC=C(C=C3)Cl.[Na+] Ambient Ambient Insoluble in water. Gooyit M, Tricoche N, Lustigman S, et al. Dual Protonophore-Chitinase Inhibitors Dramatically Affect O. volvulus Molting. J Med Chem. 2014 Jun 20. [Epub ahead of print]. PMID: 24918716. Not dangerous goods.

LKT C4758 Closantel Sodium 25 g 381.3 Protonophore; chitinase OvCHT1 inhibitor. N-[5-Chloro-4-[(4-chlorophenyl)cyanomethyl]-2- methylphenyl]-2-hydroxy-3,5-di-iodobenzamide Flukiver; Seponver 61438-64-0 ≥98% 686.06 C22H14Cl2l2N2NaO2 CC1=CC(=C(C=C1NC(=O)C2=CC(=CC(=C2[O-])I)I)Cl)C(C#N)C3=CC=C(C=C3)Cl.[Na+] Ambient Ambient Insoluble in water. Gooyit M, Tricoche N, Lustigman S, et al. Dual Protonophore-Chitinase Inhibitors Dramatically Affect O. volvulus Molting. J Med Chem. 2014 Jun 20. [Epub ahead of print]. PMID: 24918716. Not dangerous goods.

LKT C4759 Clozapine N-oxide 5 mg 131.4 Inert clozapine analog, activates specialized GPCRs. CNO 34233-69-7 ≥98% 342.82 C18H19ClN4O C[N+]1(CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl)[O-] Ambient Ambient Water to 10 mM, DMSO to 10 mg/mL, acetone, ether, methanol. "Li JH, Jain S, McMillin SM, et al. A novel experimental strategy to assess the metabolic effects of selective activation of a G(q)-coupled receptor in hepatocytes in vivo. Endocrinology. 2013 Oct;154(10):3539-51. PMID: 23861369.

Wess J, Nakajima K, Jain S. Novel designer receptors to probe GPCR signaling and physiology. Trends Pharmacol Sci. 2013 Jul;34(7):385-92. PMID: 23769625.

Farrell MS, Pei Y, Wan Y, et al. A Gαs DREADD mouse for selective modulation of cAMP production in striatopallidal neurons. Neuropsychopharmacology. 2013 Apr;38(5):854-62. PMID: 23303063.

Alvarez-Curto E, Prihandoko R, Tautermann CS, et al. Developing chemical genetic approaches to explore G protein-coupled receptor function: validation of the use of a receptor activated solely by synthetic ligand (RASSL). Mol Pharmacol. 2011 Dec;80(6):1033-46. PMID: 21880827.

Francis TC, Chandra R, Friend DM, et al. Nucleus accumbens medium spiny neuron subtypes mediate depression-related outcomes to social defeat stress. Biol Psychiatry. 2015 Feb 1;77(3):212-222. PMID: 25173629.

" Xn "UN number: 2811 Class: 6.1 Packing group: III

Proper shipping name: Toxic solids, organic, n.o.s. (Clozapine N-oxide)

Marine pollutant: No Poison inhalation hazard: No"

LKT C4759 Clozapine N-oxide 25 mg 461.1 Inert clozapine analog, activates specialized GPCRs. CNO 34233-69-7 ≥98% 342.82 C18H19ClN4O C[N+]1(CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl)[O-] Ambient Ambient Water to 10 mM, DMSO to 10 mg/mL, acetone, ether, methanol. "Li JH, Jain S, McMillin SM, et al. A novel experimental strategy to assess the metabolic effects of selective activation of a G(q)-coupled receptor in hepatocytes in vivo. Endocrinology. 2013 Oct;154(10):3539-51. PMID: 23861369.

Wess J, Nakajima K, Jain S. Novel designer receptors to probe GPCR signaling and physiology. Trends Pharmacol Sci. 2013 Jul;34(7):385-92. PMID: 23769625.

Farrell MS, Pei Y, Wan Y, et al. A Gαs DREADD mouse for selective modulation of cAMP production in striatopallidal neurons. Neuropsychopharmacology. 2013 Apr;38(5):854-62. PMID: 23303063.

" Xn "UN number: 2811 Class: 6.1 Packing group: III

Proper shipping name: Toxic solids, organic, n.o.s. (Clozapine N-oxide)

Marine pollutant: No Poison inhalation hazard: No"

LKT C5196 C-Myc Peptide 1 mg 60 Peptide, C-Myc fragment, used in protein activity measurement assays; PAC1 agonist, CK2 activator C-Myc (424-434) ≥95% 1203.32 C51H86N12O1 Ambient -20°C "Yaylim I, Ozkan NE, Isitmangil T, et al. CK2 enzyme affinity against c-myc 424-434 substrate in human lung cancer tissue. Asian Pac J Cancer Prev. 2012;13(10):5233-6. PMID: 23244141.

Smith WC, Dinculescu A, Peterson JJ, et al. The surface of visual arrestin that binds to rhodopsin. Mol Vis. 2004 Jun 15;10:392-8. PMID: 15215746.

Cao YJ, Gimpl G, Fahrenholz F. The amino-terminal fragment of the adenylate cyclase activating polypeptide (PACAP) receptor functions as a high affinity PACAP binding domain. Biochem Biophys Res Commun. 1995 Jul 17;212(2):673-80. PMID: 7626082.

" Not dangerous goods.

LKT C5196 C-Myc Peptide 2 mg 101.9 Peptide, C-Myc fragment, used in protein activity measurement assays; PAC1 agonist, CK2 activator C-Myc (424-434) ≥95% 1203.32 C51H86N12O1 Ambient -20°C "Yaylim I, Ozkan NE, Isitmangil T, et al. CK2 enzyme affinity against c-myc 424-434 substrate in human lung cancer tissue. Asian Pac J Cancer Prev. 2012;13(10):5233-6. PMID: 23244141.

Smith WC, Dinculescu A, Peterson JJ, et al. The surface of visual arrestin that binds to rhodopsin. Mol Vis. 2004 Jun 15;10:392-8. PMID: 15215746.

" Not dangerous goods.

LKT C5196 C-Myc Peptide 5 mg 180 Peptide, C-Myc fragment, used in protein activity measurement assays; PAC1 agonist, CK2 activator C-Myc (424-434) ≥95% 1203.32 C51H86N12O1 Ambient -20°C "Yaylim I, Ozkan NE, Isitmangil T, et al. CK2 enzyme affinity against c-myc 424-434 substrate in human lung cancer tissue. Asian Pac J Cancer Prev. 2012;13(10):5233-6. PMID: 23244141.

Smith WC, Dinculescu A, Peterson JJ, et al. The surface of visual arrestin that binds to rhodopsin. Mol Vis. 2004 Jun 15;10:392-8. PMID: 15215746.

" Not dangerous goods.

LKT C5260 C-type Natriuretic Peptide (1-22), pig/human/rat 1 mg 353 Endogenous cardiomodulatory peptide; NPR-B agonist. CNP ≥95% 2797.61 C93H157N27O28S3 Ambient -20°C "Del Ry S. C-type natriuretic peptide: a new cardiac mediator. Peptides. 2013 Feb;40:93-8. PMID: 23262354.

Calvieri C, Rubattu S, Volpe M. Molecular mechanisms underlying cardiac antihypertrophic and antifibrotic effects of natriuretic peptides. J Mol Med (Berl). 2012 Jan;90(1):5-13. PMID: 21826523.

Nishikimi T, Kuwahara K, Nakao K. Current biochemistry, molecular biology, and clinical relevance of natriuretic peptides. J Cardiol. 2011 Mar;57(2):131-40. Erratum in: J Cardiol. 2012 Jan;59(1):98-9. PMID: 21296556.

Del Ry S, Passino C, Emdin M, et al. C-type natriuretic peptide and heart failure. Pharmacol Res. 2006 Nov;54(5):326-33. PMID: 16904335.

LKT C5645 Colchicine 500 mg 61.1 Found in Colchicum; microtubule polymerization inhibitor. N-[(7S)-5,6,7,9-Tetrahydro-1,10,3,10-tetramethoxy-9- oxobenzo[a]heptalen-7-yl]acetamide 64-86-8 ≥97% 399.44 C22H25NO6 CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC Ambient 4°C Soluble in water (40 mg/mL), ethanol (7 mg/ml), DMSO (14 mg/ml), or chloroform. Insoluble in petr. ether. "Dalbeth N, Lauterio TJ, Wolfe HR. Mechanism of Action of Colchicine in the Treatment of Gout. Clin Ther. 2014 Aug 21. [Epub ahead of print]. PMID: 25151572.

Ching JK, Ju JS, Pittman SK, et al. Increased autophagy accelerates colchicine-induced muscle toxicity. Autophagy. 2013 Dec;9(12):2115-25. PMID: 24184927.

" T+ "UN number: 1544 Class: 6.1 Packing group: I

Proper shipping name: Alkaloids, solid, n.o.s. (Colchicine)

Reportable Quantity (RQ): Poison hazard: No"

LKT C5645 Colchicine 1 g 95.1 Found in Colchicum; microtubule polymerization inhibitor. N-[(7S)-5,6,7,9-Tetrahydro-1,10,3,10-tetramethoxy-9- oxobenzo[a]heptalen-7-yl]acetamide 64-86-8 ≥97% 399.44 C22H25NO6 CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC Ambient 4°C Soluble in water (40 mg/mL), ethanol (7 mg/ml), DMSO (14 mg/ml), or chloroform. Insoluble in petr. ether. "Dalbeth N, Lauterio TJ, Wolfe HR. Mechanism of Action of Colchicine in the Treatment of Gout. Clin Ther. 2014 Aug 21. [Epub ahead of print]. PMID: 25151572.

Ching JK, Ju JS, Pittman SK, et al. Increased autophagy accelerates colchicine-induced muscle toxicity. Autophagy. 2013 Dec;9(12):2115-25. PMID: 24184927.

" T+ "UN number: 1544 Class: 6.1 Packing group: I

Proper shipping name: Alkaloids, solid, n.o.s. (Colchicine)

Reportable Quantity (RQ): Poison hazard: No"

LKT C5646 Collagen Binding Fragment 1 mg 107.8 Peptide, fibronectin fragment, used as fibronectin negative control. ≥95% 1248.32 C52H75N14O20S Ambient -20°C Boucaut JC, Darribère T, Poole TJ, et al. Biologically active synthetic peptides as probes of embryonic development: a competitive peptide inhibitor of fibronectin function inhibits gastrulation in amphibian embryos and neural crest cell migration in avian embryos. J Cell Biol. 1984 Nov;99(5):1822-30. PMID: 6490722.

LKT C5646 Collagen Binding Fragment 2 mg 183 Peptide, fibronectin fragment, used as fibronectin negative control. ≥95% 1248.32 C52H75N14O20S Ambient -20°C Boucaut JC, Darribère T, Poole TJ, et al. Biologically active synthetic peptides as probes of embryonic development: a competitive peptide inhibitor of fibronectin function inhibits gastrulation in amphibian embryos and neural crest cell migration in avian embryos. J Cell Biol. 1984 Nov;99(5):1822-30. PMID: 6490722.

LKT C5646 Collagen Binding Fragment 5 mg 324 Peptide, fibronectin fragment, used as fibronectin negative control. ≥95% 1248.32 C52H75N14O20S Ambient -20°C Boucaut JC, Darribère T, Poole TJ, et al. Biologically active synthetic peptides as probes of embryonic development: a competitive peptide inhibitor of fibronectin function inhibits gastrulation in amphibian embryos and neural crest cell migration in avian embryos. J Cell Biol. 1984 Nov;99(5):1822-30. PMID: 6490722.

LKT C5647 Colistin Sulphate 100 mg 40.7 Polymixin, antimicrobial peptide, induces formation of pores in membrane; NADH quinone reductase inhibitor. Biological Potency: 19366 u/mg Belcomycin; Colomycin syrup 1264-72-8 Biological Potency: ≥19366 u/mg 1267.55 C45H85N13O10 H2O4S CCC(C)CCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CCN)CC(C)C)CC(C)C)CCN)CCN)C(C)O Protect from light. Store in a cool, dry place. Ambient 4°C Soluble in water. "Deris ZZ, Akter J, Sivanesan S, et al. A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity. J Antibiot (Tokyo). 2014 Feb;67(2):147-51. PMID: 24169795.

Dai C, Zhang D, Gao R, et al. In vitro toxicity of colistin on primary chick cortex neurons and its potential mechanism. Environ Toxicol Pharmacol. 2013 Sep;36(2):659-66. PMID: 23892071.

Manning AJ, Kuehn MJ. Contribution of bacterial outer membrane vesicles to innate bacterial defense. BMC Microbiol. 2011 Dec 1;11:258. PMID: 22133164.

" T "UN number: 2811 Class: 6.1 Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (Colistin sulphate)"

LKT C5647 Colistin Sulphate 500 mg 119.5 Polymixin, antimicrobial peptide, induces formation of pores in membrane; NADH quinone reductase inhibitor. Biological Potency: 19366 u/mg Belcomycin; Colomycin syrup 1264-72-8 Biological Potency: ≥19366 u/mg 1267.55 C45H85N13O10 H2O4S CCC(C)CCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CCN)CC(C)C)CC(C)C)CCN)CCN)C(C)O Protect from light. Store in a cool, dry place. Ambient 4°C Soluble in water. "Deris ZZ, Akter J, Sivanesan S, et al. A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity. J Antibiot (Tokyo). 2014 Feb;67(2):147-51. PMID: 24169795.

Dai C, Zhang D, Gao R, et al. In vitro toxicity of colistin on primary chick cortex neurons and its potential mechanism. Environ Toxicol Pharmacol. 2013 Sep;36(2):659-66. PMID: 23892071.

Manning AJ, Kuehn MJ. Contribution of bacterial outer membrane vesicles to innate bacterial defense. BMC Microbiol. 2011 Dec 1;11:258. PMID: 22133164.

" T "UN number: 2811 Class: 6.1 Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (Colistin sulphate)"

LKT C5647 Colistin Sulphate 1 g 212.3 Polymixin, antimicrobial peptide, induces formation of pores in membrane; NADH quinone reductase inhibitor. Biological Potency: 19366 u/mg Belcomycin; Colomycin syrup 1264-72-8 Biological Potency: ≥19366 u/mg 1267.55 C45H85N13O10 H2O4S CCC(C)CCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CCN)CC(C)C)CC(C)C)CCN)CCN)C(C)O Protect from light. Store in a cool, dry place. Ambient 4°C Soluble in water. "Deris ZZ, Akter J, Sivanesan S, et al. A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity. J Antibiot (Tokyo). 2014 Feb;67(2):147-51. PMID: 24169795.

Dai C, Zhang D, Gao R, et al. In vitro toxicity of colistin on primary chick cortex neurons and its potential mechanism. Environ Toxicol Pharmacol. 2013 Sep;36(2):659-66. PMID: 23892071.

Manning AJ, Kuehn MJ. Contribution of bacterial outer membrane vesicles to innate bacterial defense. BMC Microbiol. 2011 Dec 1;11:258. PMID: 22133164.

" T "UN number: 2811 Class: 6.1 Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (Colistin sulphate)"

LKT C5647 Colistin Sulphate 5 g 515.7 Polymixin, antimicrobial peptide, induces formation of pores in membrane; NADH quinone reductase inhibitor. Biological Potency: 19366 u/mg Belcomycin; Colomycin syrup 1264-72-8 Biological Potency: ≥19366 u/mg 1267.55 C45H85N13O10 H2O4S CCC(C)CCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CCN)CC(C)C)CC(C)C)CCN)CCN)C(C)O Protect from light. Store in a cool, dry place. Ambient 4°C Soluble in water. "Deris ZZ, Akter J, Sivanesan S, et al. A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity. J Antibiot (Tokyo). 2014 Feb;67(2):147-51. PMID: 24169795.

Dai C, Zhang D, Gao R, et al. In vitro toxicity of colistin on primary chick cortex neurons and its potential mechanism. Environ Toxicol Pharmacol. 2013 Sep;36(2):659-66. PMID: 23892071.

Manning AJ, Kuehn MJ. Contribution of bacterial outer membrane vesicles to innate bacterial defense. BMC Microbiol. 2011 Dec 1;11:258. PMID: 22133164.

" T "UN number: 2811 Class: 6.1 Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (Colistin sulphate)"

LKT C5654 Concanavalin A 50 mg 76 Lectin found in Canavelia, plant mitogen that binds α-D-mannosyl and α-D-glucosyl residues, used to study cell adhesion. ConA 11028-71-0 ≥98% Ambient -20°C Soluble in water. (Hazy) "Wan Y, Tang MH, Chen XC, et al. Inhibitory effect of liposomal quercetin on acute hepatitis and hepatic fibrosis induced by concanavalin A. Braz J Med Biol Res. 2014 Aug;47(8):655-61. PMID: 25098714.

Lei HY, Chang CP. Lectin of Concanavalin A as an anti-hepatoma therapeutic agent. J Biomed Sci. 2009 Jan 19;16:10. PMID: 19272170.

Dwyer JM, Johnson C. The use of concanavalin A to study the immunoregulation of human T cells. Clin Exp Immunol. 1981 Nov;46(2):237-49. PMID: 6461456.

Noonan KD, Burger MM. The relationship of concanavalin A binding to lectin-initiated cell agglutination. J Cell Biol. 1973 Oct;59(1):134-42. PMID: 4201706.

" Xn Not dangerous goods.

LKT C5654 Concanavalin A 250 mg 228.4 Lectin found in Canavelia, plant mitogen that binds α-D-mannosyl and α-D-glucosyl residues, used to study cell adhesion. ConA 11028-71-0 ≥98% Ambient -20°C Soluble in water. (Hazy) "Wan Y, Tang MH, Chen XC, et al. Inhibitory effect of liposomal quercetin on acute hepatitis and hepatic fibrosis induced by concanavalin A. Braz J Med Biol Res. 2014 Aug;47(8):655-61. PMID: 25098714.

Lei HY, Chang CP. Lectin of Concanavalin A as an anti-hepatoma therapeutic agent. J Biomed Sci. 2009 Jan 19;16:10. PMID: 19272170.

Dwyer JM, Johnson C. The use of concanavalin A to study the immunoregulation of human T cells. Clin Exp Immunol. 1981 Nov;46(2):237-49. PMID: 6461456.

Noonan KD, Burger MM. The relationship of concanavalin A binding to lectin-initiated cell agglutination. J Cell Biol. 1973 Oct;59(1):134-42. PMID: 4201706.

" Xn Not dangerous goods.

LKT C5654 Concanavalin A 500 mg 360 Lectin found in Canavelia, plant mitogen that binds α-D-mannosyl and α-D-glucosyl residues, used to study cell adhesion. ConA 11028-71-0 ≥98% Ambient -20°C Soluble in water. (Hazy) "Wan Y, Tang MH, Chen XC, et al. Inhibitory effect of liposomal quercetin on acute hepatitis and hepatic fibrosis induced by concanavalin A. Braz J Med Biol Res. 2014 Aug;47(8):655-61. PMID: 25098714.

Lei HY, Chang CP. Lectin of Concanavalin A as an anti-hepatoma therapeutic agent. J Biomed Sci. 2009 Jan 19;16:10. PMID: 19272170.

Dwyer JM, Johnson C. The use of concanavalin A to study the immunoregulation of human T cells. Clin Exp Immunol. 1981 Nov;46(2):237-49. PMID: 6461456.

Noonan KD, Burger MM. The relationship of concanavalin A binding to lectin-initiated cell agglutination. J Cell Biol. 1973 Oct;59(1):134-42. PMID: 4201706.

" Xn Not dangerous goods.

LKT C5655 α-Conotoxin GI 0.5 mg 132 Peptide toxin found in Conus snails; nAChR inhibitor. ≥95% 1433.63 C55H76N20O18S4 Ambient -20°C "Hann RM, Pagán OR, Gregory LM, et al. The 9-arginine residue of alpha-conotoxin GI is responsible for its selective high affinity for the alphagamma agonist site on the electric organ acetylcholine receptor. Biochemistry. 1997 Jul 22;36(29):9051-6. PMID: 9220994.

Blount K, Johnson A, Prior C, et al. alpha-Conotoxin GI produces tetanic fade at the rat neuromuscular junction. Toxicon. 1992 Aug;30(8):835-42. PMID: 1355934.

" Not dangerous goods.

LKT C5655 α-Conotoxin GI 1 mg 225 Peptide toxin found in Conus snails; nAChR inhibitor. ≥95% 1433.63 C55H76N20O18S4 Ambient -20°C "Hann RM, Pagán OR, Gregory LM, et al. The 9-arginine residue of alpha-conotoxin GI is responsible for its selective high affinity for the alphagamma agonist site on the electric organ acetylcholine receptor. Biochemistry. 1997 Jul 22;36(29):9051-6. PMID: 9220994.

Blount K, Johnson A, Prior C, et al. alpha-Conotoxin GI produces tetanic fade at the rat neuromuscular junction. Toxicon. 1992 Aug;30(8):835-42. PMID: 1355934.

" Not dangerous goods.

LKT C5655 α-Conotoxin GI 2.5 mg 396.1 Peptide toxin found in Conus snails; nAChR inhibitor. ≥95% 1433.63 C55H76N20O18S4 Ambient -20°C "Hann RM, Pagán OR, Gregory LM, et al. The 9-arginine residue of alpha-conotoxin GI is responsible for its selective high affinity for the alphagamma agonist site on the electric organ acetylcholine receptor. Biochemistry. 1997 Jul 22;36(29):9051-6. PMID: 9220994.

Blount K, Johnson A, Prior C, et al. alpha-Conotoxin GI produces tetanic fade at the rat neuromuscular junction. Toxicon. 1992 Aug;30(8):835-42. PMID: 1355934.

" Not dangerous goods.

LKT C5656 α-Conotoxin IMI 0.5 mg 132 Peptide toxin found in Conus snails; α7 nAChR inhibitor. ≥95% 1347.58 C52H74N20O15S4 Ambient -20°C "Yu R, Craik DJ, Kaas Q. Blockade of neuronal α7-nAChR by α-conotoxin ImI explained by computational scanning and energy calculations. PLoS Comput Biol. 2011 Mar;7(3):e1002011. PMID: 21390272.

Wagenaar DA, Gonzalez R, Ries DC, et al. Alpha-conotoxin ImI disrupts central control of swimming in the medicinal leech. Neurosci Lett. 2010 Nov 26;485(3):151-6. PMID: 20833225.

Ellison M, McIntosh JM, Olivera BM. Alpha-conotoxins ImI and ImII. Similar alpha 7 nicotinic receptor antagonists act at different sites. J Biol Chem. 2003 Jan 10;278(2):757-64. PMID: 12384509.

" Not dangerous goods.

LKT C5656 α-Conotoxin IMI 1 mg 225 Peptide toxin found in Conus snails; α7 nAChR inhibitor. ≥95% 1347.58 C52H74N20O15S4 Ambient -20°C "Yu R, Craik DJ, Kaas Q. Blockade of neuronal α7-nAChR by α-conotoxin ImI explained by computational scanning and energy calculations. PLoS Comput Biol. 2011 Mar;7(3):e1002011. PMID: 21390272.

Wagenaar DA, Gonzalez R, Ries DC, et al. Alpha-conotoxin ImI disrupts central control of swimming in the medicinal leech. Neurosci Lett. 2010 Nov 26;485(3):151-6. PMID: 20833225.

Ellison M, McIntosh JM, Olivera BM. Alpha-conotoxins ImI and ImII. Similar alpha 7 nicotinic receptor antagonists act at different sites. J Biol Chem. 2003 Jan 10;278(2):757-64. PMID: 12384509.

" Not dangerous goods.

LKT C5656 α-Conotoxin IMI 2.5 mg 396.1 Peptide toxin found in Conus snails; α7 nAChR inhibitor. ≥95% 1347.58 C52H74N20O15S4 Ambient -20°C "Yu R, Craik DJ, Kaas Q. Blockade of neuronal α7-nAChR by α-conotoxin ImI explained by computational scanning and energy calculations. PLoS Comput Biol. 2011 Mar;7(3):e1002011. PMID: 21390272.

Wagenaar DA, Gonzalez R, Ries DC, et al. Alpha-conotoxin ImI disrupts central control of swimming in the medicinal leech. Neurosci Lett. 2010 Nov 26;485(3):151-6. PMID: 20833225.

Ellison M, McIntosh JM, Olivera BM. Alpha-conotoxins ImI and ImII. Similar alpha 7 nicotinic receptor antagonists act at different sites. J Biol Chem. 2003 Jan 10;278(2):757-64. PMID: 12384509.

" Not dangerous goods.

LKT C5662 Copper Bis-3,5-diisopropylsalicylate 1 g 72.2 Antioxidant. Cu(II) (3,5-diisopropylsalicylate) 21246-18-4 ≥98% 506.11 C26H34O6Cu CC(C)C1=CC(=C(C(=C1)C(=O)O)[O-])C(C)C.CC(C)C1=CC(=C(C(=C1)C(=O)O)[O-])C(C)C.[Cu+2] Ambient Ambient "Qazzaz M, Abdul-Ghani R, Metani M, et al. The antioxidant activity of copper(II) (3,5-diisopropyl salicylate)4 and its protective effect against streptozotocin-induced diabetes mellitus in rats. Biol Trace Elem Res. 2013 Jul;154(1):88-96. PMID: 23677849.

Baquial JG, Sorenson JR. Down-regulation of NADPH-diaphorase (nitric oxide synthase) may account for the pharmacological activities of Cu(II)2 (3,5-diisopropylsalicylate)4. J Inorg Biochem. 1995 Nov 1;60(2):133-48. Erratum in: J Inorg Biochem. 1997 Nov 15;68(3):233. PMID: 8530918.

Denis M. Antioxidant therapy partially blocks immune-induced lung fibrosis. Inflammation. 1995 Apr;19(2):207-19. PMID: 7601506.

Crispens CG Jr, Sorenson JR. Activity of CuDIPS against mammary cancer in C3H HeNCR mice. Anticancer Res. 1992 Jul-Aug;12(4):1271-3. PMID: 1503420.

" Not dangerous goods.

LKT C5662 Copper Bis-3,5-diisopropylsalicylate 5 g 216.4 Antioxidant. Cu(II) (3,5-diisopropylsalicylate) 21246-18-4 ≥98% 506.11 C26H34O6Cu CC(C)C1=CC(=C(C(=C1)C(=O)O)[O-])C(C)C.CC(C)C1=CC(=C(C(=C1)C(=O)O)[O-])C(C)C.[Cu+2] Ambient Ambient "Qazzaz M, Abdul-Ghani R, Metani M, et al. The antioxidant activity of copper(II) (3,5-diisopropyl salicylate)4 and its protective effect against streptozotocin-induced diabetes mellitus in rats. Biol Trace Elem Res. 2013 Jul;154(1):88-96. PMID: 23677849.

Denis M. Antioxidant therapy partially blocks immune-induced lung fibrosis. Inflammation. 1995 Apr;19(2):207-19. PMID: 7601506.

Crispens CG Jr, Sorenson JR. Activity of CuDIPS against mammary cancer in C3H HeNCR mice. Anticancer Res. 1992 Jul-Aug;12(4):1271-3. PMID: 1503420.

" Not dangerous goods.

LKT C5768 Corazonin 1 mg 83.9 Neuropeptide found in insects. 122984-73-0 ≥95% 1369.49 C62H86N18O19 CC(C(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CCC(=O)N)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NCC(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)N)NC(=O)C5CCC(=O)N5)O Ambient -20°C "Tayler TD, Pacheco DA, Hergarden AC, et al. A neuropeptide circuit that coordinates sperm transfer and copulation duration in Drosophila. Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20697-702. PMID: 23197833.

Hillyer JF, Estévez-Lao TY, Funkhouser LJ, et al. Anopheles gambiae corazonin: gene structure, expression and effect on mosquito heart physiology. Insect Mol Biol. 2012 Jun;21(3):343-55. PMID: 22404523.

" Not dangerous goods.

LKT C5768 Corazonin 2 mg 144 Neuropeptide found in insects. 122984-73-0 ≥95% 1369.49 C62H86N18O19 CC(C(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CCC(=O)N)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NCC(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)N)NC(=O)C5CCC(=O)N5)O Ambient -20°C "Tayler TD, Pacheco DA, Hergarden AC, et al. A neuropeptide circuit that coordinates sperm transfer and copulation duration in Drosophila. Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20697-702. PMID: 23197833.

" Not dangerous goods.

LKT C5768 Corazonin 5 mg 252.1 Neuropeptide found in insects. 122984-73-0 ≥95% 1369.49 C62H86N18O19 CC(C(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CCC(=O)N)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NCC(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)N)NC(=O)C5CCC(=O)N5)O Ambient -20°C "Tayler TD, Pacheco DA, Hergarden AC, et al. A neuropeptide circuit that coordinates sperm transfer and copulation duration in Drosophila. Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20697-702. PMID: 23197833.

" Not dangerous goods.

LKT C5770 Corticotropin Releasing Factor, cow 0.5 mg 300.1 Endogenous neuropeptide hormone involved in stress response and mood; CRF agonist. CRF; CRH ≥95% 4697.44 C206H340N60O63S Ambient -20°C "Lowry CA, Moore FL. Regulation of behavioral responses by corticotropin-releasing factor. Gen Comp Endocrinol. 2006 Mar;146(1):19-27. PMID: 16426606.

Arborelius L, Owens MJ, Plotsky PM, et al. The role of corticotropin-releasing factor in depression and anxiety disorders. J Endocrinol. 1999 Jan;160(1):1-12. PMID: 9854171.

Raadsheer FC, van Heerikhuize JJ, Lucassen PJ, et al. Corticotropin-releasing hormone mRNA levels in the paraventricular nucleus of patients with Alzheimer's disease and depression. Am J Psychiatry. 1995 Sep;152(9):1372-6. PMID: 7653697.

Lederis KP, Okawara Y, Richter D, et al. Evolutionary aspects of corticotropin releasing hormones. Prog Clin Biol Res. 1990;342:467-72. PMID: 2200028.

" Not dangerous goods.

LKT C5770 Corticotropin Releasing Factor, cow 1 mg 510 Endogenous neuropeptide hormone involved in stress response and mood; CRF agonist. CRF; CRH ≥95% 4697.44 C206H340N60O63S Ambient -20°C "Lowry CA, Moore FL. Regulation of behavioral responses by corticotropin-releasing factor. Gen Comp Endocrinol. 2006 Mar;146(1):19-27. PMID: 16426606.

Arborelius L, Owens MJ, Plotsky PM, et al. The role of corticotropin-releasing factor in depression and anxiety disorders. J Endocrinol. 1999 Jan;160(1):1-12. PMID: 9854171.

Lederis KP, Okawara Y, Richter D, et al. Evolutionary aspects of corticotropin releasing hormones. Prog Clin Biol Res. 1990;342:467-72. PMID: 2200028.

" Not dangerous goods.

LKT C5770 Corticotropin Releasing Factor, cow 2.5 mg 900.1 Endogenous neuropeptide hormone involved in stress response and mood; CRF agonist. CRF; CRH ≥95% 4697.44 C206H340N60O63S Ambient -20°C "Lowry CA, Moore FL. Regulation of behavioral responses by corticotropin-releasing factor. Gen Comp Endocrinol. 2006 Mar;146(1):19-27. PMID: 16426606.

Arborelius L, Owens MJ, Plotsky PM, et al. The role of corticotropin-releasing factor in depression and anxiety disorders. J Endocrinol. 1999 Jan;160(1):1-12. PMID: 9854171.

Lederis KP, Okawara Y, Richter D, et al. Evolutionary aspects of corticotropin releasing hormones. Prog Clin Biol Res. 1990;342:467-72. PMID: 2200028.

" Not dangerous goods.

LKT "C5771

" Corticosterone 100 mg 32.3 Endogenous steroid hormone involved in immune response and energy homeostasis; mineralocorticoid and glucocorticoid agonist. (11-β)-11,21-Dihydroxypregn-4-ene-3,20-dione Kendall's compound B; Reichstein's substance H; Compound B 50-22-6 ≥96% 346.46 C21H30O4 CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4C(=O)CO)C)O Protect from light. Ambient Ambient Insoluble in water. Soluble in organic solvents. "Angelier F, Wingfield JC. Importance of the glucocorticoid stress response in a changing world: theory, hypotheses and perspectives. Gen Comp Endocrinol. 2013 Sep 1;190:118-28. PMID: 23770214.

Silverman MN, Sternberg EM. Glucocorticoid regulation of inflammation and its functional correlates: from HPA axis to glucocorticoid receptor dysfunction. Ann N Y Acad Sci. 2012 Jul;1261:55-63. PMID: 22823394.

Williams GH. Aldosterone biosynthesis, regulation, and classical mechanism of action. Heart Fail Rev. 2005 Jan;10(1):7-13. PMID: 15947886.

" Xi Not dangerous goods.

LKT "C5771

" Corticosterone 250 mg 47.6 Endogenous steroid hormone involved in immune response and energy homeostasis; mineralocorticoid and glucocorticoid agonist. (11-β)-11,21-Dihydroxypregn-4-ene-3,20-dione Kendall's compound B; Reichstein's substance H; Compound B 50-22-6 ≥96% 346.46 C21H30O4 CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4C(=O)CO)C)O Protect from light. Ambient Ambient Insoluble in water. Soluble in organic solvents. "Angelier F, Wingfield JC. Importance of the glucocorticoid stress response in a changing world: theory, hypotheses and perspectives. Gen Comp Endocrinol. 2013 Sep 1;190:118-28. PMID: 23770214.

Williams GH. Aldosterone biosynthesis, regulation, and classical mechanism of action. Heart Fail Rev. 2005 Jan;10(1):7-13. PMID: 15947886.

" Xi Not dangerous goods.

LKT C5771 Corticosterone 500 mg 81.6 Endogenous steroid hormone involved in immune response and energy homeostasis; mineralocorticoid and glucocorticoid agonist. (11-β)-11,21-Dihydroxypregn-4-ene-3,20-dione Kendall's compound B; Reichstein's substance H; Compound B 50-22-6 ≥96% 346.46 C21H30O4 CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4C(=O)CO)C)O Protect from light. Ambient Ambient Insoluble in water. Soluble in organic solvents. "Angelier F, Wingfield JC. Importance of the glucocorticoid stress response in a changing world: theory, hypotheses and perspectives. Gen Comp Endocrinol. 2013 Sep 1;190:118-28. PMID: 23770214.

Williams GH. Aldosterone biosynthesis, regulation, and classical mechanism of action. Heart Fail Rev. 2005 Jan;10(1):7-13. PMID: 15947886.

" Xi Not dangerous goods.

LKT C5772 Corticotropin Releasing Factor, human/rat 0.5 mg 300.1 Endogenous neuropeptide hormone involved in stress response and mood; CRF agonist. CRF 86784-80-7 ≥98% 4757.49 C208H344N60O63S2 CCC(C)C(C(=O)NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(C(C)O)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC2=CN=CN2)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)O)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)O)C(=O)NC(CCSC)C(=O)NC(C)C(=O)NC(CCCNC(=N)N)C(=O)NC(C)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)N)C(=O)NC(C)C(=O)NC(CC3=CN=CN3)C(=O)NC(CO)C(=O)NC(CC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CCSC)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)O)C(=O)NC(C(C)CC)C(=O)NC(C(C)CC)C(=O)O)NC(=O)C4CCCN4C(=O)C5CCCN5C(=O)C(CCC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CO)N Ambient -20°C "Lowry CA, Moore FL. Regulation of behavioral responses by corticotropin-releasing factor. Gen Comp Endocrinol. 2006 Mar;146(1):19-27. PMID: 16426606.

Arborelius L, Owens MJ, Plotsky PM, et al. The role of corticotropin-releasing factor in depression and anxiety disorders. J Endocrinol. 1999 Jan;160(1):1-12. PMID: 9854171.

Lederis KP, Okawara Y, Richter D, et al. Evolutionary aspects of corticotropin releasing hormones. Prog Clin Biol Res. 1990;342:467-72. PMID: 2200028.

LKT C5772 Corticotropin Releasing Factor, human/rat 1 mg 510 Endogenous neuropeptide hormone involved in stress response and mood; CRF agonist. CRF 86784-80-7 ≥98% 4757.49 C208H344N60O63S2 CCC(C)C(C(=O)NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(C(C)O)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC2=CN=CN2)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)O)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)O)C(=O)NC(CCSC)C(=O)NC(C)C(=O)NC(CCCNC(=N)N)C(=O)NC(C)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)N)C(=O)NC(C)C(=O)NC(CC3=CN=CN3)C(=O)NC(CO)C(=O)NC(CC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CCSC)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)O)C(=O)NC(C(C)CC)C(=O)NC(C(C)CC)C(=O)O)NC(=O)C4CCCN4C(=O)C5CCCN5C(=O)C(CCC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CO)N Ambient -20°C "Lowry CA, Moore FL. Regulation of behavioral responses by corticotropin-releasing factor. Gen Comp Endocrinol. 2006 Mar;146(1):19-27. PMID: 16426606.

Arborelius L, Owens MJ, Plotsky PM, et al. The role of corticotropin-releasing factor in depression and anxiety disorders. J Endocrinol. 1999 Jan;160(1):1-12. PMID: 9854171.

Lederis KP, Okawara Y, Richter D, et al. Evolutionary aspects of corticotropin releasing hormones. Prog Clin Biol Res. 1990;342:467-72. PMID: 2200028.

LKT C5772 Corticotropin Releasing Factor, human/rat 2.5 mg 900.1 Endogenous neuropeptide hormone involved in stress response and mood; CRF agonist. CRF 86784-80-7 ≥98% 4757.49 C208H344N60O63S2 CCC(C)C(C(=O)NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(C(C)O)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC2=CN=CN2)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)O)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)O)C(=O)NC(CCSC)C(=O)NC(C)C(=O)NC(CCCNC(=N)N)C(=O)NC(C)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)N)C(=O)NC(C)C(=O)NC(CC3=CN=CN3)C(=O)NC(CO)C(=O)NC(CC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CCSC)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)O)C(=O)NC(C(C)CC)C(=O)NC(C(C)CC)C(=O)O)NC(=O)C4CCCN4C(=O)C5CCCN5C(=O)C(CCC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CO)N Ambient -20°C "Lowry CA, Moore FL. Regulation of behavioral responses by corticotropin-releasing factor. Gen Comp Endocrinol. 2006 Mar;146(1):19-27. PMID: 16426606.

Arborelius L, Owens MJ, Plotsky PM, et al. The role of corticotropin-releasing factor in depression and anxiety disorders. J Endocrinol. 1999 Jan;160(1):1-12. PMID: 9854171.

Lederis KP, Okawara Y, Richter D, et al. Evolutionary aspects of corticotropin releasing hormones. Prog Clin Biol Res. 1990;342:467-72. PMID: 2200028.

LKT C5773 Cortistatin-14 0.5 mg 359.9 Endogenous neuropeptide, somatostatin analog; somatostatin and ghrelin agonist. "CST-14

" 186901-48-4 ≥95% 1721.02 C81H113N19O19S2 CC(C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCCN)CC2=CNC3=CC=CC=C32)CC4=CC=CC=C4)CC5=CC=CC=C5)CC(=O)N)CCCCN)NC(=O)C6CCCN6)C(=O)NC(CCCCN)C(=O)O)CO)CO)CC7=CC=CC=C7)O Store in a cool, dry place. Ambient -20°C Soluble in water. "Aourz N, Portelli J, Coppens J, et al. Cortistatin-14 Mediates its Anticonvulsant Effects Via sst<sub>2</sub> and sst<sub>3</sub> but Not Ghrelin Receptors. CNS Neurosci Ther. 2014 Mar 31. [Epub ahead of print]. PMID: 24685142.

Markovics A, Szoke É, Sándor K, et al. Comparison of the anti-inflammatory and anti-nociceptive effects of cortistatin-14 and somatostatin-14 in distinct in vitro and in vivo model systems. J Mol Neurosci. 2012 Jan;46(1):40-50. PMID: 21695504.

Broglio F, Arvat E, Benso A, et al. Endocrine activities of cortistatin-14 and its interaction with GHRH and ghrelin in humans. J Clin Endocrinol Metab. 2002 Aug;87(8):3783-90. PMID: 12161511.

" Not dangerous goods.

LKT C5773 Cortistatin-14 1 mg 612.4 Endogenous neuropeptide, somatostatin analog; somatostatin and ghrelin agonist. "CST-14

Broglio F, Arvat E, Benso A, et al. Endocrine activities of cortistatin-14 and its interaction with GHRH and ghrelin in humans. J Clin Endocrinol Metab. 2002 Aug;87(8):3783-90. PMID: 12161511.

" Not dangerous goods.

LKT C5773 Cortistatin-14 2.5 mg 1080.1 Endogenous neuropeptide, somatostatin analog; somatostatin and ghrelin agonist. "CST-14

Broglio F, Arvat E, Benso A, et al. Endocrine activities of cortistatin-14 and its interaction with GHRH and ghrelin in humans. J Clin Endocrinol Metab. 2002 Aug;87(8):3783-90. PMID: 12161511.

" Not dangerous goods.

LKT C5774 Corticotropin Releasing Factor, sheep 0.5 mg 300.1 Endogenous neuropeptide hormone involved in stress response and mood; CRF agonist. CRF; CRH ≥95% 4370.41 C205H339N59O63S Ambient -20°C "Lowry CA, Moore FL. Regulation of behavioral responses by corticotropin-releasing factor. Gen Comp Endocrinol. 2006 Mar;146(1):19-27. PMID: 16426606.

Arborelius L, Owens MJ, Plotsky PM, et al. The role of corticotropin-releasing factor in depression and anxiety disorders. J Endocrinol. 1999 Jan;160(1):1-12. PMID: 9854171.

Lederis KP, Okawara Y, Richter D, et al. Evolutionary aspects of corticotropin releasing hormones. Prog Clin Biol Res. 1990;342:467-72. PMID: 2200028.

" Not dangerous goods.

LKT C5774 Corticotropin Releasing Factor, sheep 1 mg 510 Endogenous neuropeptide hormone involved in stress response and mood; CRF agonist. CRF; CRH ≥95% 4370.41 C205H339N59O63S Ambient -20°C "Lowry CA, Moore FL. Regulation of behavioral responses by corticotropin-releasing factor. Gen Comp Endocrinol. 2006 Mar;146(1):19-27. PMID: 16426606.

Arborelius L, Owens MJ, Plotsky PM, et al. The role of corticotropin-releasing factor in depression and anxiety disorders. J Endocrinol. 1999 Jan;160(1):1-12. PMID: 9854171.

Lederis KP, Okawara Y, Richter D, et al. Evolutionary aspects of corticotropin releasing hormones. Prog Clin Biol Res. 1990;342:467-72. PMID: 2200028.

" Not dangerous goods.

LKT C5774 Corticotropin Releasing Factor, sheep 2.5 mg 900.1 Endogenous neuropeptide hormone involved in stress response and mood; CRF agonist. CRF; CRH ≥95% 4370.41 C205H339N59O63S Ambient -20°C "Lowry CA, Moore FL. Regulation of behavioral responses by corticotropin-releasing factor. Gen Comp Endocrinol. 2006 Mar;146(1):19-27. PMID: 16426606.

Arborelius L, Owens MJ, Plotsky PM, et al. The role of corticotropin-releasing factor in depression and anxiety disorders. J Endocrinol. 1999 Jan;160(1):1-12. PMID: 9854171.

Lederis KP, Okawara Y, Richter D, et al. Evolutionary aspects of corticotropin releasing hormones. Prog Clin Biol Res. 1990;342:467-72. PMID: 2200028.

" Not dangerous goods.

LKT C5782 Coumarin 10 g 34.8 Benzopyrone found in various plants, precursor in synthesis of warfarin; vitamin K inhibitor. 2H-1-Benzopyran-2-one Cumarin; Coumarinic anhydride; Tonka bean camphor 91-64-5 ≥98% 146.14 C9H6O2 C1=CC=C2C(=C1)C=CC(=O)O2 Ambient Ambient Slightly soluble in water. Soluble in alcohol, chloroform, ether, alkali hydroxide solutions or oils. "Kontogiorgis C, Detsi A, Hadjipavlou-Litina D. Coumarin-based drugs: a patent review (2008 -- present). Expert Opin Ther Pat. 2012 Apr;22(4):437-54. PMID: 22475457.

Farinola N, Piller N. Pharmacogenomics: its role in re-establishing coumarin as treatment for lymphedema. Lymphat Res Biol. 2005 Summer;3(2):81-6. PMID: 16000056.

" Carc, Xi, Xn "UN number: 2811 Class: 6.1 Packing group: III

Proper shipping name: Toxic solid, organic n.o.s. (Coumarin)"

LKT C5782 Coumarin 50 g 57.8 Benzopyrone found in various plants, precursor in synthesis of warfarin; vitamin K inhibitor. 2H-1-Benzopyran-2-one Cumarin; Coumarinic anhydride; Tonka bean camphor 91-64-5 ≥98% 146.14 C9H6O2 C1=CC=C2C(=C1)C=CC(=O)O2 Ambient Ambient Slightly soluble in water. Soluble in alcohol, chloroform, ether, alkali hydroxide solutions or oils. "Kontogiorgis C, Detsi A, Hadjipavlou-Litina D. Coumarin-based drugs: a patent review (2008 -- present). Expert Opin Ther Pat. 2012 Apr;22(4):437-54. PMID: 22475457.

Farinola N, Piller N. Pharmacogenomics: its role in re-establishing coumarin as treatment for lymphedema. Lymphat Res Biol. 2005 Summer;3(2):81-6. PMID: 16000056.

" Carc, Xi, Xn "UN number: 2811 Class: 6.1 Packing group: III

Proper shipping name: Toxic solid, organic n.o.s. (Coumarin)"

LKT C6018 C-Peptide, dog 0.5 mg 300.1 Endogenous peptide, connects A and B chains of insulin. ≥95% 3174.54 C137H225N37O49 Ambient -20°C "Hills CE, Brunskill NJ. Intracellular signalling by C-peptide. Exp Diabetes Res. 2008;2008:635158. PMID: 18382618.

Samnegård B, Jacobson SH, Jaremko G, et al. Effects of C-peptide on glomerular and renal size and renal function in diabetic rats. Kidney Int. 2001 Oct;60(4):1258-65. PMID: 11576340.

Sima AA, Zhang W, Sugimoto K, et al. C-peptide prevents and improves chronic Type I diabetic polyneuropathy in the BB/Wor rat. Diabetologia. 2001 Jul;44(7):889-97. PMID: 11508275.

" Not dangerous goods.

LKT C6018 C-Peptide, dog 1 mg 510 Endogenous peptide, connects A and B chains of insulin. ≥95% 3174.54 C137H225N37O49 Ambient -20°C "Hills CE, Brunskill NJ. Intracellular signalling by C-peptide. Exp Diabetes Res. 2008;2008:635158. PMID: 18382618.

Samnegård B, Jacobson SH, Jaremko G, et al. Effects of C-peptide on glomerular and renal size and renal function in diabetic rats. Kidney Int. 2001 Oct;60(4):1258-65. PMID: 11576340.

Sima AA, Zhang W, Sugimoto K, et al. C-peptide prevents and improves chronic Type I diabetic polyneuropathy in the BB/Wor rat. Diabetologia. 2001 Jul;44(7):889-97. PMID: 11508275.

" Not dangerous goods.

LKT C6018 C-Peptide, dog 2.5 mg 900.1 Endogenous peptide, connects A and B chains of insulin. ≥95% 3174.54 C137H225N37O49 Ambient -20°C "Hills CE, Brunskill NJ. Intracellular signalling by C-peptide. Exp Diabetes Res. 2008;2008:635158. PMID: 18382618.

Samnegård B, Jacobson SH, Jaremko G, et al. Effects of C-peptide on glomerular and renal size and renal function in diabetic rats. Kidney Int. 2001 Oct;60(4):1258-65. PMID: 11576340.

Sima AA, Zhang W, Sugimoto K, et al. C-peptide prevents and improves chronic Type I diabetic polyneuropathy in the BB/Wor rat. Diabetologia. 2001 Jul;44(7):889-97. PMID: 11508275.

" Not dangerous goods.

LKT C6019 C-Peptide, human 0.5 mg 300.1 Endogenous peptide, connects A and B chains of insulin. ≥95% 3020.33 C129H211N35O48 Ambient -20°C "Hills CE, Brunskill NJ. Intracellular signalling by C-peptide. Exp Diabetes Res. 2008;2008:635158. PMID: 18382618.

Samnegård B, Jacobson SH, Jaremko G, et al. Effects of C-peptide on glomerular and renal size and renal function in diabetic rats. Kidney Int. 2001 Oct;60(4):1258-65. PMID: 11576340.

Sima AA, Zhang W, Sugimoto K, et al. C-peptide prevents and improves chronic Type I diabetic polyneuropathy in the BB/Wor rat. Diabetologia. 2001 Jul;44(7):889-97. PMID: 11508275.

" Not dangerous goods.

LKT C6019 C-Peptide, human 1 mg 510 Endogenous peptide, connects A and B chains of insulin. ≥95% 3020.33 C129H211N35O48 Ambient -20°C "Hills CE, Brunskill NJ. Intracellular signalling by C-peptide. Exp Diabetes Res. 2008;2008:635158. PMID: 18382618.

Samnegård B, Jacobson SH, Jaremko G, et al. Effects of C-peptide on glomerular and renal size and renal function in diabetic rats. Kidney Int. 2001 Oct;60(4):1258-65. PMID: 11576340.

Sima AA, Zhang W, Sugimoto K, et al. C-peptide prevents and improves chronic Type I diabetic polyneuropathy in the BB/Wor rat. Diabetologia. 2001 Jul;44(7):889-97. PMID: 11508275.

" Not dangerous goods.

LKT C6019 C-Peptide, human 2.5 mg 900.1 Endogenous peptide, connects A and B chains of insulin. ≥95% 3020.33 C129H211N35O48 Ambient -20°C "Hills CE, Brunskill NJ. Intracellular signalling by C-peptide. Exp Diabetes Res. 2008;2008:635158. PMID: 18382618.

Samnegård B, Jacobson SH, Jaremko G, et al. Effects of C-peptide on glomerular and renal size and renal function in diabetic rats. Kidney Int. 2001 Oct;60(4):1258-65. PMID: 11576340.

Sima AA, Zhang W, Sugimoto K, et al. C-peptide prevents and improves chronic Type I diabetic polyneuropathy in the BB/Wor rat. Diabetologia. 2001 Jul;44(7):889-97. PMID: 11508275.

" Not dangerous goods.

LKT C6916 CREBtide 1 mg 276.2 Synthetic peptide, CREB analog; PKD1 and PKA substrate. ≥95% 1699.01 C73H127N29O18 CCC(C)C(C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NC(CO)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(CCCN=C(N)N)C(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCCN)N Ambient -20°C "Rybin VO, Guo J, Harleton E, et al. Regulatory domain determinants that control PKD1 activity. J Biol Chem. 2012 Jun 29;287(27):22609-15. PMID: 22582392.

Colbran JL, Roach PJ, Fiol CJ, et al. cAMP-dependent protein kinase, but not the cGMP-dependent enzyme, rapidly phosphorylates delta-CREB, and a synthetic delta-CREB peptide. Biochem Cell Biol. 1992 Oct-Nov;70(10-11):1277-82. PMID: 1338414.

" Not dangerous goods.

LKT C6916 CREBtide 2 mg 468.2 Synthetic peptide, CREB analog; PKD1 and PKA substrate. ≥95% 1699.01 C73H127N29O18 CCC(C)C(C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NC(CO)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(CCCN=C(N)N)C(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCCN)N Ambient -20°C "Rybin VO, Guo J, Harleton E, et al. Regulatory domain determinants that control PKD1 activity. J Biol Chem. 2012 Jun 29;287(27):22609-15. PMID: 22582392.

" Not dangerous goods.

LKT C6916 CREBtide 5 mg 828.1 Synthetic peptide, CREB analog; PKD1 and PKA substrate. ≥95% 1699.01 C73H127N29O18 CCC(C)C(C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NC(CO)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(CCCN=C(N)N)C(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCCN)N Ambient -20°C "Rybin VO, Guo J, Harleton E, et al. Regulatory domain determinants that control PKD1 activity. J Biol Chem. 2012 Jun 29;287(27):22609-15. PMID: 22582392.

" Not dangerous goods.

LKT C6955 Cromolyn Sodium 1 g 62.5 Mast cell destabilizer; potential TRP antagonist, potential Cl- channel blocker. 5,5'-[(2-Hydroxy-1,3-propanediyl)bis(oxy)]bis[4-oxo-4H-1-benzopyran-2-carboxylic acid] disodium salt Cromolyn disodium salt; Aarane; Alerion; Allergocrom; Cromovet; Fivent; Inostral; Introl; Lomudal; Lomuspray; Nasmil; Opticrom; Rynacrom; Sofro; Vividrin 15826-37-6 ≥98% 512.3 C23H14Na2O11 C1=CC2=C(C(=C1)OCC(COC3=CC=CC4=C3C(=O)C=C(O4)C(=O)[O-])O)C(=O)C=C(O2)C(=O)[O-].[Na+].[Na+] Ambient Ambient Soluble in water. "Zhang A, Chi X, Luo G, et al. Mast cell stabilization alleviates acute lung injury after orthotopic autologous liver transplantation in rats by downregulating inflammation. PLoS One. 2013 Oct 8;8(10):e75262. PMID: 24116032.

Yazid S, Sinniah A, Solito E, et al. Anti-allergic cromones inhibit histamine and eicosanoid release from activated human and murine mast cells by releasing Annexin A1. PLoS One. 2013;8(3):e58963. PMID: 23527056.

Mina Y, Rinkevich-Shop S, Konen E, et al. Mast cell inhibition attenuates myocardial damage, adverse remodeling, and dysfunction during fulminant myocarditis in the rat. J Cardiovasc Pharmacol Ther. 2013 Mar;18(2):152-61. PMID: 23172937.

Yazid S, Leoni G, Getting SJ, et al. Antiallergic cromones inhibit neutrophil recruitment onto vascular endothelium via annexin-A1 mobilization. Arterioscler Thromb Vasc Biol. 2010 Sep;30(9):1718-24. PMID: 20558817.

Heinke S, Szücs G, Norris A, et al. Inhibition of volume-activated chloride currents in endothelial cells by chromones. Br J Pharmacol. 1995 Aug;115(8):1393-8. PMID: 8564197.

" Xi Not dangerous goods.

LKT C6955 Cromolyn Sodium 5 g 212 Mast cell destabilizer; potential TRP antagonist, potential Cl- channel blocker. 5,5'-[(2-Hydroxy-1,3-propanediyl)bis(oxy)]bis[4-oxo-4H-1-benzopyran-2-carboxylic acid] disodium salt Cromolyn disodium salt; Aarane; Alerion; Allergocrom; Cromovet; Fivent; Inostral; Introl; Lomudal; Lomuspray; Nasmil; Opticrom; Rynacrom; Sofro; Vividrin 15826-37-6 ≥98% 512.3 C23H14Na2O11 C1=CC2=C(C(=C1)OCC(COC3=CC=CC4=C3C(=O)C=C(O4)C(=O)[O-])O)C(=O)C=C(O2)C(=O)[O-].[Na+].[Na+] Ambient Ambient Soluble in water. "Zhang A, Chi X, Luo G, et al. Mast cell stabilization alleviates acute lung injury after orthotopic autologous liver transplantation in rats by downregulating inflammation. PLoS One. 2013 Oct 8;8(10):e75262. PMID: 24116032.

Heinke S, Szücs G, Norris A, et al. Inhibition of volume-activated chloride currents in endothelial cells by chromones. Br J Pharmacol. 1995 Aug;115(8):1393-8. PMID: 8564197.

" Xi Not dangerous goods.

LKT C6956 Crotamiton 25 g 115.5 Antipruritic. N-Ethyl-N-(2-methylphenyl)-2-butenamide Crotamitex; Eurax; Euraxil; Veteusan 483-63-6 ≥98% 203.28 C13H17NO CCN(C1=CC=CC=C1C)C(=O)C=CC Ambient Ambient Soluble in methanol and ethanol. "Sekine R, Satoh T, Takaoka A, et al. Anti pruritic effects of topical crotamiton, capsaicin, and a corticosteroid on pruritogen-induced scratching behavior. Exp Dermatol. 2012 Mar;21(3):201-4. PMID: 22379965.

Hsu CK, Hsu MM, Lee JY. Demodicosis: a clinicopathological study. J Am Acad Dermatol. 2009 Mar;60(3):453-62. PMID: 19231642.

" Xn, Xi Not dangerous goods.

LKT C6956 Crotamiton 100 g 415.8 Antipruritic. N-Ethyl-N-(2-methylphenyl)-2-butenamide Crotamitex; Eurax; Euraxil; Veteusan 483-63-6 ≥98% 203.28 C13H17NO CCN(C1=CC=CC=C1C)C(=O)C=CC Ambient Ambient Soluble in methanol and ethanol. "Sekine R, Satoh T, Takaoka A, et al. Anti pruritic effects of topical crotamiton, capsaicin, and a corticosteroid on pruritogen-induced scratching behavior. Exp Dermatol. 2012 Mar;21(3):201-4. PMID: 22379965.

Hsu CK, Hsu MM, Lee JY. Demodicosis: a clinicopathological study. J Am Acad Dermatol. 2009 Mar;60(3):453-62. PMID: 19231642.

" Xn, Xi Not dangerous goods.

LKT C6982 Crustacean Cardioactive Peptide 1 mg 107.8 Neuropeptide hormone found in arthropods. CCAP ≥95% 957.1 C42H56N10O12S2 Ambient -20°C "Lee D, Orchard I, Lange AB. Evidence for a conserved CCAP-signaling pathway controlling ecdysis in a hemimetabolous insect, Rhodnius prolixus. Front Neurosci. 2013 Nov 5;7:207. PMID: 24204330.

Lee D, Vanden Broeck J, Lange AB. Identification and expression of the CCAP receptor in the Chagas' disease vector, Rhodnius prolixus, and its involvement in cardiac control. PLoS One. 2013 Jul 9;8(7):e68897. PMID: 23874803.

Estévez-Lao TY, Boyce DS, Honegger HW, et al. Cardioacceleratory function of the neurohormone CCAP in the mosquito Anopheles gambiae. J Exp Biol. 2013 Feb 15;216(Pt 4):601-13. PMID: 23364571.

LKT C6982 Crustacean Cardioactive Peptide 2 mg 183 Neuropeptide hormone found in arthropods. CCAP ≥95% 957.1 C42H56N10O12S2 Ambient -20°C "Lee D, Orchard I, Lange AB. Evidence for a conserved CCAP-signaling pathway controlling ecdysis in a hemimetabolous insect, Rhodnius prolixus. Front Neurosci. 2013 Nov 5;7:207. PMID: 24204330.

Estévez-Lao TY, Boyce DS, Honegger HW, et al. Cardioacceleratory function of the neurohormone CCAP in the mosquito Anopheles gambiae. J Exp Biol. 2013 Feb 15;216(Pt 4):601-13. PMID: 23364571.

LKT C6982 Crustacean Cardioactive Peptide 5 mg 324 Neuropeptide hormone found in arthropods. CCAP ≥95% 957.1 C42H56N10O12S2 Ambient -20°C "Lee D, Orchard I, Lange AB. Evidence for a conserved CCAP-signaling pathway controlling ecdysis in a hemimetabolous insect, Rhodnius prolixus. Front Neurosci. 2013 Nov 5;7:207. PMID: 24204330.

Estévez-Lao TY, Boyce DS, Honegger HW, et al. Cardioacceleratory function of the neurohormone CCAP in the mosquito Anopheles gambiae. J Exp Biol. 2013 Feb 15;216(Pt 4):601-13. PMID: 23364571.

LKT C7097 Cryptotanshinone 10 mg 67.9 Quinoid diterpene found in species of Salvia; STAT3 inhibitor. 35825-57-1 ≥90% 296.36 C19H20O3 CC1COC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C Hygroscopic and light sensitive Ambient 4°C Soluble in chloroform, methanol "Lu L, Li C, Li D, et al. Cryptotanshinone inhibits human glioma cell proliferation by suppressing STAT3 signaling. Mol Cell Biochem. 2013 Sep;381(1-2):273-82. PMID: 23740516.

Lee HJ, Jung DB, Sohn EJ, et al. Inhibition of Hypoxia Inducible Factor Alpha and Astrocyte-Elevated Gene-1 Mediates Cryptotanshinone Exerted Antitumor Activity in Hypoxic PC-3 Cells. Evid Based Complement Alternat Med. 2012;2012:390957. rratum in: Evid Based Complement Alternat Med. 2013;2013:267352. PMID: 23243443.

Chen W, Luo Y, Liu L, et al. Cryptotanshinone inhibits cancer cell proliferation by suppressing Mammalian target of rapamycin-mediated cyclin D1 expression and Rb phosphorylation. Cancer Prev Res (Phila). 2010 Aug;3(8):1015-25. PMID: 20628002.

Shin DS, Kim HN, Shin KD, et al. Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells. Cancer Res. 2009 Jan 1;69(1):193-202. PMID: 19118003.

Li W, Li J, Ashok M, et al. A cardiovascular drug rescues mice from lethal sepsis by selectively attentuating a late-acting proinflammatory mediator, high mobility group box 1. J Immunol. 2007 Mar 15;178(6):3856-3864. PMID: 17339485.

Zhang Y, Won SH, Jiang C, et al. Tanshinones fmor Chinese medicinal herb Danshen (Salvia miltiorrhiza Bunge) suppress prostate cancer growth and androgen receptor signaling. Pharm Res. 2012 Jun;29(6):1595-1608. PMID: 22281759." N, Xn "UN number: 2811 Class: 6.1 Packing group: III

Proper shipping name: Toxic solids, organic, n.o.s. (Cryptotanshinone) Reportable Quantity (RQ): Marine pollutant: No Poison inhalation hazard: No"

LKT C7097 Cryptotanshinone 25 mg 149.5 Quinoid diterpene found in species of Salvia; STAT3 inhibitor. 35825-57-1 ≥90% 296.36 C19H20O3 CC1COC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C Hygroscopic and light sensitive Ambient 4°C Soluble in chloroform, methanol "Lu L, Li C, Li D, et al. Cryptotanshinone inhibits human glioma cell proliferation by suppressing STAT3 signaling. Mol Cell Biochem. 2013 Sep;381(1-2):273-82. PMID: 23740516.

Proper shipping name: Toxic solids, organic, n.o.s. (Cryptotanshinone) Reportable Quantity (RQ): Marine pollutant: No Poison inhalation hazard: No"

LKT C7097 Cryptotanshinone 100 mg 475.7 Quinoid diterpene found in species of Salvia; STAT3 inhibitor. 35825-57-1 ≥90% 296.36 C19H20O3 CC1COC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C Hygroscopic and light sensitive Ambient 4°C Soluble in chloroform, methanol "Lu L, Li C, Li D, et al. Cryptotanshinone inhibits human glioma cell proliferation by suppressing STAT3 signaling. Mol Cell Biochem. 2013 Sep;381(1-2):273-82. PMID: 23740516.

Proper shipping name: Toxic solids, organic, n.o.s. (Cryptotanshinone) Reportable Quantity (RQ): Marine pollutant: No Poison inhalation hazard: No"

LKT C7098 Crystalline 1 mg 22.5 Dipeptide. H-Trp-Gly-OH ≥95% 261.28 C13H15N3O3 Ambient -20°C

LKT C7098 Crystalline 2 mg 37.5 Dipeptide. H-Trp-Gly-OH ≥95% 261.28 C13H15N3O3 Ambient -20°C

LKT C7098 Crystalline 5 mg 67.4 Dipeptide. H-Trp-Gly-OH ≥95% 261.28 C13H15N3O3 Ambient -20°C

LKT C7602 CTAP 0.5 mg 132 Peptide; μOR agonist. ≥95% 1102.33 C51H67N13O11S CC(C1C(=O)NC(C(SSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCN=C(N)N)CC2=CNC3=CC=CC=C32)CC4=CC=C(C=C4)O)NC(=O)C(CC5=CC=CC=C5)N)(C)C)C(=O)NC(C(C)O)C(=O)N)O Ambient -20°C "Perry CJ, McNally GP. A role for the ventral pallidum in context-induced and primed reinstatement of alcohol seeking. Eur J Neurosci. 2013 Sep;38(5):2762-73. PMID: 23773238.

Saccani F, Anselmi L, Jaramillo I, et al. Protective role of μ opioid receptor activation in intestinal inflammation induced by mesenteric ischemia/reperfusion in mice. J Neurosci Res. 2012 Nov;90(11):2146-53. PMID: 22806643.

Distrutti E, Cipriani S, Renga B, et al. Hydrogen sulphide induces micro opioid receptor-dependent analgesia in a rodent model of visceral pain. Mol Pain. 2010 Jun 11;6:36. PMID: 20540729.

" Not dangerous goods.

LKT C7602 CTAP 1 mg 225 Peptide; μOR agonist. ≥95% 1102.33 C51H67N13O11S CC(C1C(=O)NC(C(SSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCN=C(N)N)CC2=CNC3=CC=CC=C32)CC4=CC=C(C=C4)O)NC(=O)C(CC5=CC=CC=C5)N)(C)C)C(=O)NC(C(C)O)C(=O)N)O Ambient -20°C "Perry CJ, McNally GP. A role for the ventral pallidum in context-induced and primed reinstatement of alcohol seeking. Eur J Neurosci. 2013 Sep;38(5):2762-73. PMID: 23773238.

Distrutti E, Cipriani S, Renga B, et al. Hydrogen sulphide induces micro opioid receptor-dependent analgesia in a rodent model of visceral pain. Mol Pain. 2010 Jun 11;6:36. PMID: 20540729.

" Not dangerous goods.

LKT C7602 CTAP 2.5 mg 396.1 Peptide; μOR agonist. ≥95% 1102.33 C51H67N13O11S CC(C1C(=O)NC(C(SSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCN=C(N)N)CC2=CNC3=CC=CC=C32)CC4=CC=C(C=C4)O)NC(=O)C(CC5=CC=CC=C5)N)(C)C)C(=O)NC(C(C)O)C(=O)N)O Ambient -20°C "Perry CJ, McNally GP. A role for the ventral pallidum in context-induced and primed reinstatement of alcohol seeking. Eur J Neurosci. 2013 Sep;38(5):2762-73. PMID: 23773238.

Distrutti E, Cipriani S, Renga B, et al. Hydrogen sulphide induces micro opioid receptor-dependent analgesia in a rodent model of visceral pain. Mol Pain. 2010 Jun 11;6:36. PMID: 20540729.

" Not dangerous goods.

LKT C7618 C-Telopeptide 0.5 mg 107.8 Endogenous peptide; structural component of collagen. ≥95% 868.91 C34H56N14O13 Ambient -20°C "Kwansa AL, De Vita R, Freeman JW. Mechanical recruitment of N- and C-crosslinks in collagen type I. Matrix Biol. 2013 Nov 21. pii: S0945-053X(13)00141-8. PMID: 24269790.

Wu JJ, Eyre DR. Structural analysis of cross-linking domains in cartilage type XI collagen. Insights on polymeric assembly. J Biol Chem. 1995 Aug 11;270(32):18865-70. PMID: 7642541.

" Not dangerous goods.

LKT C7618 C-Telopeptide 1 mg 183 Endogenous peptide; structural component of collagen. ≥95% 868.91 C34H56N14O13 Ambient -20°C "Kwansa AL, De Vita R, Freeman JW. Mechanical recruitment of N- and C-crosslinks in collagen type I. Matrix Biol. 2013 Nov 21. pii: S0945-053X(13)00141-8. PMID: 24269790.

Wu JJ, Eyre DR. Structural analysis of cross-linking domains in cartilage type XI collagen. Insights on polymeric assembly. J Biol Chem. 1995 Aug 11;270(32):18865-70. PMID: 7642541.

" Not dangerous goods.

LKT C7618 C-Telopeptide 2.5 mg 324 Endogenous peptide; structural component of collagen. ≥95% 868.91 C34H56N14O13 Ambient -20°C "Kwansa AL, De Vita R, Freeman JW. Mechanical recruitment of N- and C-crosslinks in collagen type I. Matrix Biol. 2013 Nov 21. pii: S0945-053X(13)00141-8. PMID: 24269790.

Wu JJ, Eyre DR. Structural analysis of cross-linking domains in cartilage type XI collagen. Insights on polymeric assembly. J Biol Chem. 1995 Aug 11;270(32):18865-70. PMID: 7642541.

" Not dangerous goods.

LKT C7692 CTX IV (6-12) 1 mg 104.9 Snake venom cardiotoxin found in Naja naja atra. ≥98% 899.14 C48H70N10O7 Ambient -20°C "Jayaraman G, Kumar TK, Tsai CC, et al. Elucidation of the solution structure of cardiotoxin analogue V from the Taiwan cobra (Naja naja atra)--identification of structural features important for the lethal action of snake venom cardiotoxins. Protein Sci. 2000 Apr;9(4):637-46. PMID: 10794406.

Jang JY, Krishnaswamy T, Kumar S, et al. Comparison of the hemolytic activity and solution structures of two snake venom cardiotoxin analogues which only differ in their N-terminal amino acid. Biochemistry. 1997 Dec 2;36(48):14635-41. PMID: 9398182.

LKT C7692 CTX IV (6-12) 2 mg 180 Snake venom cardiotoxin found in Naja naja atra. ≥98% 899.14 C48H70N10O7 Ambient -20°C "Jayaraman G, Kumar TK, Tsai CC, et al. Elucidation of the solution structure of cardiotoxin analogue V from the Taiwan cobra (Naja naja atra)--identification of structural features important for the lethal action of snake venom cardiotoxins. Protein Sci. 2000 Apr;9(4):637-46. PMID: 10794406.

LKT C7692 CTX IV (6-12) 5 mg 315.1 Snake venom cardiotoxin found in Naja naja atra. ≥98% 899.14 C48H70N10O7 Ambient -20°C "Jayaraman G, Kumar TK, Tsai CC, et al. Elucidation of the solution structure of cardiotoxin analogue V from the Taiwan cobra (Naja naja atra)--identification of structural features important for the lethal action of snake venom cardiotoxins. Protein Sci. 2000 Apr;9(4):637-46. PMID: 10794406.

LKT C7693 [Arg3,14] CTX IV (3-14) 1 mg 165.1 Snake venom cardiotoxin found in Naja naja atra. ≥98% 1582.91 C74H119N25O14 Ambient -20°C "Jayaraman G, Kumar TK, Tsai CC, et al. Elucidation of the solution structure of cardiotoxin analogue V from the Taiwan cobra (Naja naja atra)--identification of structural features important for the lethal action of snake venom cardiotoxins. Protein Sci. 2000 Apr;9(4):637-46. PMID: 10794406.

LKT C7693 [Arg3,14] CTX IV (3-14) 2 mg 282 Snake venom cardiotoxin found in Naja naja atra. ≥98% 1582.91 C74H119N25O14 Ambient -20°C "Jayaraman G, Kumar TK, Tsai CC, et al. Elucidation of the solution structure of cardiotoxin analogue V from the Taiwan cobra (Naja naja atra)--identification of structural features important for the lethal action of snake venom cardiotoxins. Protein Sci. 2000 Apr;9(4):637-46. PMID: 10794406.

LKT C7693 [Arg3,14] CTX IV (3-14) 5 mg 495 Snake venom cardiotoxin found in Naja naja atra. ≥98% 1582.91 C74H119N25O14 Ambient -20°C "Jayaraman G, Kumar TK, Tsai CC, et al. Elucidation of the solution structure of cardiotoxin analogue V from the Taiwan cobra (Naja naja atra)--identification of structural features important for the lethal action of snake venom cardiotoxins. Protein Sci. 2000 Apr;9(4):637-46. PMID: 10794406.

LKT C7997 C-Type Natriuretic Peptide (1-22), human 0.5 mg 216.1 Endogenous cardiomodulatory peptide; NPR-B agonist. CNP ≥95% 2197.64 C93H157N27O28S3 Ambient -20°C "Burley DS, Cox CD, Zhang J, et al. Natriuretic peptides modulate ATP-sensitive K(+) channels in rat ventricular cardiomyocytes. Basic Res Cardiol. 2014 Mar;109(2):402. PMID: 24477916.

Azer J, Hua R, Krishnaswamy PS, et al. Effects of natriuretic peptides on electrical conduction in the sinoatrial node and atrial myocardium of the heart. J Physiol. 2014 Mar 1;592(Pt 5):1025-45. PMID: 24344164.

De Jonge HR, Tilly BC, Hogema BM, et al. cGMP inhibition of type 3 phosphodiesterase is the major mechanism by which C-type natriuretic peptide activates CFTR in the shark rectal gland. Am J Physiol Cell Physiol. 2014 Feb;306(4):C343-53. PMID: 24259420.

Bükülmez H, Khan F, Bartels CF, et al. Protective effects of C-type natriuretic peptide on linear growth and articular cartilage integrity in a mouse model of inflammatory arthritis. Arthritis Rheumatol. 2014 Jan;66(1):78-89. PMID: 24449577.

" Not dangerous goods.

LKT C7997 C-Type Natriuretic Peptide (1-22), human 1 mg 365.9 Endogenous cardiomodulatory peptide; NPR-B agonist. CNP ≥95% 2197.64 C93H157N27O28S3 Ambient -20°C "Burley DS, Cox CD, Zhang J, et al. Natriuretic peptides modulate ATP-sensitive K(+) channels in rat ventricular cardiomyocytes. Basic Res Cardiol. 2014 Mar;109(2):402. PMID: 24477916.

" Not dangerous goods.

LKT C7997 C-Type Natriuretic Peptide (1-22), human 2.5 mg 648.2 Endogenous cardiomodulatory peptide; NPR-B agonist. CNP ≥95% 2197.64 C93H157N27O28S3 Ambient -20°C "Burley DS, Cox CD, Zhang J, et al. Natriuretic peptides modulate ATP-sensitive K(+) channels in rat ventricular cardiomyocytes. Basic Res Cardiol. 2014 Mar;109(2):402. PMID: 24477916.

" Not dangerous goods.

LKT C7998 C-Type Natriuretic Peptide, chicken 0.5 mg 204.1 Endogenous cardiomodulatory peptide; NPR-B agonist. CNP ≥95% 2241.66 C93H157N29O29S3 Ambient -20°C "Burley DS, Cox CD, Zhang J, et al. Natriuretic peptides modulate ATP-sensitive K(+) channels in rat ventricular cardiomyocytes. Basic Res Cardiol. 2014 Mar;109(2):402. PMID: 24477916.

" T Not dangerous goods.

LKT C7998 C-Type Natriuretic Peptide, chicken 1 mg 348 Endogenous cardiomodulatory peptide; NPR-B agonist. CNP ≥95% 2241.66 C93H157N29O29S3 Ambient -20°C "Burley DS, Cox CD, Zhang J, et al. Natriuretic peptides modulate ATP-sensitive K(+) channels in rat ventricular cardiomyocytes. Basic Res Cardiol. 2014 Mar;109(2):402. PMID: 24477916.

" T Not dangerous goods.

LKT C7998 C-Type Natriuretic Peptide, chicken 2.5 mg 612.4 Endogenous cardiomodulatory peptide; NPR-B agonist. CNP ≥95% 2241.66 C93H157N29O29S3 Ambient -20°C "Burley DS, Cox CD, Zhang J, et al. Natriuretic peptides modulate ATP-sensitive K(+) channels in rat ventricular cardiomyocytes. Basic Res Cardiol. 2014 Mar;109(2):402. PMID: 24477916.

" T Not dangerous goods.

LKT C8017 Cuelure 100 mg 73.5 Hormonal attractant for male Bactrocera flies. 4-(3-Oxobutyl)phenyl acetate Cue-lure; Q-Lure; Pherocon QFF. 3572-06-3 ≥97% 206.24 C12H14O3 CC(=O)CCC1=CC=C(C=C1)OC(=O)C Ambient Ambient Soluble in alcohol, hydrocarbons or ether. Insoluble in water. "

Chang CL, Cho IK, Li QX. Insecticidal activity of basil oil, trans-anethole, estragole, and linalool to adult fruit flies of Ceratitis capitata, Bactrocera dorsalis, and Bactrocera cucurbitae. J Econ Entomol. 2009 Feb;102(1):203-9. PMID: 19253638.

Jang EB, Casana-Giner V, Oliver JE. Field captures of wild melon fly (Diptera: Tephritidae) with an improved male attractant, raspberry ketone formate. J Econ Entomol. 2007 Aug;100(4):1124-8. PMID: 17849860.

" None Not dangerous goods.

LKT C8017 Cuelure 250 mg 136.4 Hormonal attractant for male Bactrocera flies. 4-(3-Oxobutyl)phenyl acetate Cue-lure; Q-Lure; Pherocon QFF. 3572-06-3 ≥97% 206.24 C12H14O3 CC(=O)CCC1=CC=C(C=C1)OC(=O)C Ambient Ambient Soluble in alcohol, hydrocarbons or ether. Insoluble in water. "

" None Not dangerous goods.

LKT C8017 Cuelure 1 g 353 Hormonal attractant for male Bactrocera flies. 4-(3-Oxobutyl)phenyl acetate Cue-lure; Q-Lure; Pherocon QFF. 3572-06-3 ≥97% 206.24 C12H14O3 CC(=O)CCC1=CC=C(C=C1)OC(=O)C Ambient Ambient Soluble in alcohol, hydrocarbons or ether. Insoluble in water. "

" None Not dangerous goods.

LKT C9610 D-Cycloserine 1 g 67.9 NMDA partial agonist, D-Ala-D-Ala ligase inhibitor. D-4-Amino-3-isoxazolidinone Closina; Farmiserina; Micoserina; Oxamycin; Seromycin. 68-41-7 ≥98% 102.09 C3H6N2O2 C1C(C(=O)NO1)N Ambient 4°C Soluble in water. Slightly soluble in methanol or propylene glycol. "Dang YH, Ma XC, Zhang JC, et al. Targeting of NMDA Receptors in the Treatment of Major Depression. Curr Pharm Des. 2014 Jan 10. [Epub ahead of print]. PMID: 24410564.

Prosser GA, de Carvalho LP. Metabolomics Reveal d-Alanine:d-Alanine Ligase As the Target of d-Cycloserine in Mycobacterium tuberculosis. ACS Med Chem Lett. 2013 Dec 12;4(12):1233-1237. PMID: 24478820.

Portero-Tresserra M, Martí-Nicolovius M, Guillazo-Blanch G, et al. D-cycloserine in the basolateral amygdala prevents extinction and enhances reconsolidation of odor-reward associative learning in rats. Neurobiol Learn Mem. 2013 Feb;100:1-11. PMID: 23200640.

" Not dangerous goods.

LKT C9610 D-Cycloserine 5 g 237.8 NMDA partial agonist, D-Ala-D-Ala ligase inhibitor. D-4-Amino-3-isoxazolidinone Closina; Farmiserina; Micoserina; Oxamycin; Seromycin. 68-41-7 ≥98% 102.09 C3H6N2O2 C1C(C(=O)NO1)N Ambient 4°C Soluble in water. Slightly soluble in methanol or propylene glycol. "Dang YH, Ma XC, Zhang JC, et al. Targeting of NMDA Receptors in the Treatment of Major Depression. Curr Pharm Des. 2014 Jan 10. [Epub ahead of print]. PMID: 24410564.

" Not dangerous goods.

LKT C9611 Cyclosporin A 10 mg 65.6 Cyclic peptide; calcineurin inhibitor. Cyclosporine; Ciclosporin; Sandimmun; Neoral 59865-13-3 ≥98% 1202.61 C62H111N11O12 CCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C(C)CC=CC)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C Ambient Ambient Soluble in methanol, ethanol, acetone, ether or chloroform. Very slightly soluble in water. "Lulic D, Burns J, Bae EC, et al. A review of laboratory and clinical data supporting the safety and efficacy of cyclosporin A in traumatic brain injury. Neurosurgery. 2011 May;68(5):1172-86. PMID: 21307793.

Reynolds NJ, Al-Daraji WI. Calcineurin inhibitors and sirolimus: mechanisms of action and applications in dermatology. Clin Exp Dermatol. 2002 Oct;27(7):555-61. PMID: 12464150.

Handschumacher RE, Harding MW, Rice J, et al. Cyclophilin: a specific cytosolic binding protein for cyclosporin A. Science. 1984 Nov 2;226(4674):544-7. PMID: 6238408.

" Repr., Carc., Xn Not dangerous goods.

LKT C9611 Cyclosporin A 50 mg 140.7 Cyclic peptide; calcineurin inhibitor. Cyclosporine; Ciclosporin; Sandimmun; Neoral 59865-13-3 ≥98% 1202.61 C62H111N11O12 CCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C(C)CC=CC)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C Ambient Ambient Soluble in methanol, ethanol, acetone, ether or chloroform. Very slightly soluble in water. "Lulic D, Burns J, Bae EC, et al. A review of laboratory and clinical data supporting the safety and efficacy of cyclosporin A in traumatic brain injury. Neurosurgery. 2011 May;68(5):1172-86. PMID: 21307793.

Reynolds NJ, Al-Daraji WI. Calcineurin inhibitors and sirolimus: mechanisms of action and applications in dermatology. Clin Exp Dermatol. 2002 Oct;27(7):555-61. PMID: 12464150.

Handschumacher RE, Harding MW, Rice J, et al. Cyclophilin: a specific cytosolic binding protein for cyclosporin A. Science. 1984 Nov 2;226(4674):544-7. PMID: 6238408.

" Repr., Carc., Xn Not dangerous goods.

LKT C9611 Cyclosporin A 100 mg 225 Cyclic peptide; calcineurin inhibitor. Cyclosporine; Ciclosporin; Sandimmun; Neoral 59865-13-3 ≥98% 1202.61 C62H111N11O12 CCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C(C)CC=CC)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C Ambient Ambient Soluble in methanol, ethanol, acetone, ether or chloroform. Very slightly soluble in water. "Lulic D, Burns J, Bae EC, et al. A review of laboratory and clinical data supporting the safety and efficacy of cyclosporin A in traumatic brain injury. Neurosurgery. 2011 May;68(5):1172-86. PMID: 21307793.

Reynolds NJ, Al-Daraji WI. Calcineurin inhibitors and sirolimus: mechanisms of action and applications in dermatology. Clin Exp Dermatol. 2002 Oct;27(7):555-61. PMID: 12464150.

Handschumacher RE, Harding MW, Rice J, et al. Cyclophilin: a specific cytosolic binding protein for cyclosporin A. Science. 1984 Nov 2;226(4674):544-7. PMID: 6238408.

" Repr., Carc., Xn Not dangerous goods.

LKT "C9612

" Cyclosporin C 1 mg 67.9 Cyclosporin metabolite; weak calmodulin inhibitor. Thr2-cyclosporine 59787-61-0 ≥98% 1218.61 C62H111N11O13 CC=CCC(C)C(C1C(=O)NC(C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C)C(C)O)O Ambient Ambient Soluble in methanol, ethanol, acetone, ether or chloroform. "Moussaïf M, Jacques P, Schaarwächter P, et al. Cyclosporin C is the main antifungal compound produced by Acremonium luzulae. Appl Environ Microbiol. 1997 May;63(5):1739-43. PMID: 9143111.

Uadia PO, Ezeamuzie IC, Ladan MJ, et al. Antimalarial activity of cyclosporins A, C and D. Afr J Med Med Sci. 1994 Mar;23(1):47-51. PMID: 7839946.

" None Not dangerous goods.

LKT "C9612

" Cyclosporin C 5 mg 271.7 Cyclosporin metabolite; weak calmodulin inhibitor. Thr2-cyclosporine 59787-61-0 ≥98% 1218.61 C62H111N11O13 CC=CCC(C)C(C1C(=O)NC(C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C)C(C)O)O Ambient Ambient Soluble in methanol, ethanol, acetone, ether or chloroform. "Moussaïf M, Jacques P, Schaarwächter P, et al. Cyclosporin C is the main antifungal compound produced by Acremonium luzulae. Appl Environ Microbiol. 1997 May;63(5):1739-43. PMID: 9143111.

Uadia PO, Ezeamuzie IC, Ladan MJ, et al. Antimalarial activity of cyclosporins A, C and D. Afr J Med Med Sci. 1994 Mar;23(1):47-51. PMID: 7839946.

" None Not dangerous goods.

LKT C9613 Cyclosporin D 1 mg 115.5 Cyclosporin metabolite; weak calmodulin inhibitor. Val2-cyclosporine 63775-96-2 ≥98% 1216.64 C63H113N11O12 CC=CCC(C)C(C1C(=O)NC(C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C)C(C)C)O Ambient Ambient Soluble in methanol, ethanol, acetone, ether, ethyl acetate or chloroform. Insoluble in water. "Uadia PO, Ezeamuzie IC, Ladan MJ, et al. Antimalarial activity of cyclosporins A, C and D. Afr J Med Med Sci. 1994 Mar;23(1):47-51. PMID: 7839946.

Sadeg N, Pham-Huy C, Rucay P, et al. In vitro and in vivo comparative studies on immunosuppressive properties of cyclosporines A, C, D and metabolites M1, M17 and M21. Immunopharmacol Immunotoxicol. 1993 Mar-Jun;15(2-3):163-77. PMID: 8349948.

" Xn, Carc, Repr. Not dangerous goods.

LKT C9613 Cyclosporin D 5 mg 434.9 Cyclosporin metabolite; weak calmodulin inhibitor. Val2-cyclosporine 63775-96-2 ≥98% 1216.64 C63H113N11O12 CC=CCC(C)C(C1C(=O)NC(C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C)C(C)C)O Ambient Ambient Soluble in methanol, ethanol, acetone, ether, ethyl acetate or chloroform. Insoluble in water. "Uadia PO, Ezeamuzie IC, Ladan MJ, et al. Antimalarial activity of cyclosporins A, C and D. Afr J Med Med Sci. 1994 Mar;23(1):47-51. PMID: 7839946.

" Xn, Carc, Repr. Not dangerous goods.

LKT C9614 Cyclosporin H 1 mg 115.5 Cyclosporin metabolite; formyl peptide inhibitor. "Csh cyclosporin; Cyclosporine H

" 83602-39-5 ≥96% 1202.61 C62H111N11O12 CCC1C(=O)N(CC(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C(C)CC=CC)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)C)CC(C)C)C)C Ambient Ambient Soluble in DMSO, ethanol, Acetone, chloroform. "Stenfeldt AL, Karlsson J, Wennerås C, et al. Cyclosporin H, Boc-MLF and Boc-FLFLF are antagonists that preferentially inhibit activity triggered through the formyl peptide receptor. Inflammation. 2007 Dec;30(6):224-9. PMID: 17687636.

Yan P, Nanamori M, Sun M, et al. The immunosuppressant cyclosporin A antagonizes human formyl peptide receptor through inhibition of cognate ligand binding. J Immunol. 2006 Nov 15;177(10):7050-8. PMID: 17082621.

de Paulis A, Ciccarelli A, de Crescenzo G, et al. Cyclosporin H is a potent and selective competitive antagonist of human basophil activation by N-formyl-methionyl-leucyl-phenylalanine. J Allergy Clin Immunol. 1996 Jul;98(1):152-64. PMID: 8765829.

" Xn, Carc., Repr. Not dangerous goods.

LKT C9614 Cyclosporin H 5 mg 434.9 Cyclosporin metabolite; formyl peptide inhibitor. "Csh cyclosporin; Cyclosporine H

" Xn, Carc., Repr. Not dangerous goods.

LKT C9615 Cyclosporin B 1 mg 203.8 Cyclic peptide; calcineurin inhibitor. Ala2-cyclosporine 63775-95-1 ≥95% 1188.59 C61H109N11O12 CC=CCC(C)C(C1C(=O)NC(C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C)C)O Ambient Ambient Soluble in methanol, ethanol and acetone. "Iwamoto M, Watashi K, Tsukuda S, et al. Evaluation and identification of hepatitis B virus entry inhibitors using HepG2 cells overexpressing a membrane transporter NTCP. Biochem Biophys Res Commun. 2014 Jan 17;443(3):808-13. PMID: 24342612.

Igarashi K, Hirotani H, Woo JT, et al. Cyclosporine A and FK506 induce osteoclast apoptosis in mouse bone marrow cell cultures. Bone. 2004 Jul;35(1):47-56. PMID: 15207740.

" Not dangerous goods.

LKT C9615 Cyclosporin B 5 mg 679.5 Cyclic peptide; calcineurin inhibitor. Ala2-cyclosporine 63775-95-1 ≥95% 1188.59 C61H109N11O12 CC=CCC(C)C(C1C(=O)NC(C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C)C)O Ambient Ambient Soluble in methanol, ethanol and acetone. "Iwamoto M, Watashi K, Tsukuda S, et al. Evaluation and identification of hepatitis B virus entry inhibitors using HepG2 cells overexpressing a membrane transporter NTCP. Biochem Biophys Res Commun. 2014 Jan 17;443(3):808-13. PMID: 24342612.

Igarashi K, Hirotani H, Woo JT, et al. Cyclosporine A and FK506 induce osteoclast apoptosis in mouse bone marrow cell cultures. Bone. 2004 Jul;35(1):47-56. PMID: 15207740.

" Not dangerous goods.

LKT C9660 Cypermethrin 10 mg 40.7 Synthetic type II pyrethroid insecticide; protein phosphatase inhibitor. 3-(2,2-Dichloroethenyl)-2,2-dimethylcyclopropane- carboxylic acid cyano(3-phenoxyphenyl)methyl ester Ammo; Arrivo; Basathrin; Cymbush; Demon; Ripcord 52315-07-8 ≥98% 416.3 C22H19Cl2NO3 CC1(C(C1C(=O)OC(C#N)C2=CC(=CC=C2)OC3=CC=CC=C3)C=C(Cl)Cl)C Ambient Ambient Soluble in methanol, acetone, xylene or methylene dichloride. Insoluble in water. "Maurya SK, Mishra J, Tripathi VK, et al. Cypermethrin induces astrocyte damage: role of aberrant Ca(2+), ROS, JNK, P38, matrix metalloproteinase 2 and migration related reelin protein. Pestic Biochem Physiol. 2014 May;111:51-9. PMID: 24861934.

Gammon DW. Correlations between in vitro and in vivo mechanisms of pyrethroid insecticide action. Fundam Appl Toxicol. 1985 Feb;5(1):9-23. PMID: 2985459.

" Xn, N "UN number: 2811 Class: 6.1 Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (Cypermethrin)"

LKT C9660 Cypermethrin 25 mg 81.6 Synthetic type II pyrethroid insecticide; protein phosphatase inhibitor. 3-(2,2-Dichloroethenyl)-2,2-dimethylcyclopropane- carboxylic acid cyano(3-phenoxyphenyl)methyl ester Ammo; Arrivo; Basathrin; Cymbush; Demon; Ripcord 52315-07-8 ≥98% 416.3 C22H19Cl2NO3 CC1(C(C1C(=O)OC(C#N)C2=CC(=CC=C2)OC3=CC=CC=C3)C=C(Cl)Cl)C Ambient Ambient Soluble in methanol, acetone, xylene or methylene dichloride. Insoluble in water. "Maurya SK, Mishra J, Tripathi VK, et al. Cypermethrin induces astrocyte damage: role of aberrant Ca(2+), ROS, JNK, P38, matrix metalloproteinase 2 and migration related reelin protein. Pestic Biochem Physiol. 2014 May;111:51-9. PMID: 24861934.

Gammon DW. Correlations between in vitro and in vivo mechanisms of pyrethroid insecticide action. Fundam Appl Toxicol. 1985 Feb;5(1):9-23. PMID: 2985459.

" Xn, N "UN number: 2811 Class: 6.1 Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (Cypermethrin)"

LKT C9660 Cypermethrin 100 mg 244.5 Synthetic type II pyrethroid insecticide; protein phosphatase inhibitor. 3-(2,2-Dichloroethenyl)-2,2-dimethylcyclopropane- carboxylic acid cyano(3-phenoxyphenyl)methyl ester Ammo; Arrivo; Basathrin; Cymbush; Demon; Ripcord 52315-07-8 ≥98% 416.3 C22H19Cl2NO3 CC1(C(C1C(=O)OC(C#N)C2=CC(=CC=C2)OC3=CC=CC=C3)C=C(Cl)Cl)C Ambient Ambient Soluble in methanol, acetone, xylene or methylene dichloride. Insoluble in water. "Maurya SK, Mishra J, Tripathi VK, et al. Cypermethrin induces astrocyte damage: role of aberrant Ca(2+), ROS, JNK, P38, matrix metalloproteinase 2 and migration related reelin protein. Pestic Biochem Physiol. 2014 May;111:51-9. PMID: 24861934.

Gammon DW. Correlations between in vitro and in vivo mechanisms of pyrethroid insecticide action. Fundam Appl Toxicol. 1985 Feb;5(1):9-23. PMID: 2985459.

" Xn, N "UN number: 2811 Class: 6.1 Packing Group: III

Proper shipping name: Toxic solid, organic, n.o.s. (Cypermethrin)"

LKT C9662 Cyproterone Acetate 100 mg 72.2 Steroid; AR antagonist. (1β,2β)-6-Chloro-1,2-dihydro-17-hydroxy-3'H- cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione acetate CPA; Androcur; Cyprostat 427-51-0 ≥98% 416.94 C24H29ClO4 CC(=O)C1(CCC2C1(CCC3C2C=C(C4=CC(=O)C5CC5C34C)Cl)C)OC(=O)C Ambient -20°C Soluble in dichloromethane and methyl alcohol. "Guadalix FJ, Botella Llusiá J. The action mechanism of cyproterone. Acta Ginecol (Madr). 1975 Jul 1;27(1):7-11. PMID: 1146472.

Giorgi EP, Shirley IM, Grant JK, et al. Androgen dynamics in vitro in the human prostate gland. Effect of cyproterone and cyproterone acetate. Biochem J. 1973 Mar;132(3):465-74. PMID: 4125095.

" Xn Not dangerous goods.

LKT C9662 Cyproterone Acetate 250 mg 216.4 Steroid; AR antagonist. (1β,2β)-6-Chloro-1,2-dihydro-17-hydroxy-3'H- cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione acetate CPA; Androcur; Cyprostat 427-51-0 ≥98% 416.94 C24H29ClO4 CC(=O)C1(CCC2C1(CCC3C2C=C(C4=CC(=O)C5CC5C34C)Cl)C)OC(=O)C Ambient -20°C Soluble in dichloromethane and methyl alcohol. "Guadalix FJ, Botella Llusiá J. The action mechanism of cyproterone. Acta Ginecol (Madr). 1975 Jul 1;27(1):7-11. PMID: 1146472.

Giorgi EP, Shirley IM, Grant JK, et al. Androgen dynamics in vitro in the human prostate gland. Effect of cyproterone and cyproterone acetate. Biochem J. 1973 Mar;132(3):465-74. PMID: 4125095.

" Xn Not dangerous goods.

LKT C9662 Cyproterone Acetate 1 g 360.5 Steroid; AR antagonist. (1β,2β)-6-Chloro-1,2-dihydro-17-hydroxy-3'H- cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione acetate CPA; Androcur; Cyprostat 427-51-0 ≥98% 416.94 C24H29ClO4 CC(=O)C1(CCC2C1(CCC3C2C=C(C4=CC(=O)C5CC5C34C)Cl)C)OC(=O)C Ambient -20°C Soluble in dichloromethane and methyl alcohol. "Guadalix FJ, Botella Llusiá J. The action mechanism of cyproterone. Acta Ginecol (Madr). 1975 Jul 1;27(1):7-11. PMID: 1146472.

Giorgi EP, Shirley IM, Grant JK, et al. Androgen dynamics in vitro in the human prostate gland. Effect of cyproterone and cyproterone acetate. Biochem J. 1973 Mar;132(3):465-74. PMID: 4125095.

" Xn Not dangerous goods.

LKT C9670 Cyromazine 25 g 127.1 Triazine, melamine derivative, insect growth regulator. N-Cyclopropyl-1,3,5-triazin-2,4,6-triamine Larvadex; Trigard; Vetrazin 66215-27-8 ≥98% 166.18 C6H10N6 C1CC1NC2=NC(=NC(=N2)N)N Ambient Ambient Soluble in water (1100mg/L). "Darriet F, Zaim M, Corbel V. Laboratory evaluation of cyromazine against insecticide-susceptible and -resistant mosquito larvae. J Am Mosq Control Assoc. 2008 Mar;24(1):123-6. PMID: 18437826.

Mommaerts V, Sterk G, Smagghe G. Hazards and uptake of chitin synthesis inhibitors in bumblebees Bombus terrestris. Pest Manag Sci. 2006 Aug;62(8):752-8. PMID: 16786494.

" Xi Not dangerous goods.

LKT C9670 Cyromazine 100 g 427.6 Triazine, melamine derivative, insect growth regulator. N-Cyclopropyl-1,3,5-triazin-2,4,6-triamine Larvadex; Trigard; Vetrazin 66215-27-8 ≥98% 166.18 C6H10N6 C1CC1NC2=NC(=NC(=N2)N)N Ambient Ambient Soluble in water (1100mg/L). "Darriet F, Zaim M, Corbel V. Laboratory evaluation of cyromazine against insecticide-susceptible and -resistant mosquito larvae. J Am Mosq Control Assoc. 2008 Mar;24(1):123-6. PMID: 18437826.

Mommaerts V, Sterk G, Smagghe G. Hazards and uptake of chitin synthesis inhibitors in bumblebees Bombus terrestris. Pest Manag Sci. 2006 Aug;62(8):752-8. PMID: 16786494.

" Xi Not dangerous goods.

LKT C9710 Cyclopamine 5 mg 61.1 Steroidal jerveratrum alkaloid found in Veratrum; Smo inhibitor. "Spiro(9H-benzo(a)fluorene-9,2'(3'H)-furo(3,2-b)pyridin)-3-

ol, 1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-

octadecahydro-3',6',10,11b-tetramethyl-,

(2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-" 11-Deoxyjervine; 11-Deoxojervine; HSDB 3505. 4449-51-8 ≥98% 411.62 C27H41NO2 CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(CCC6(C5CC4=C3C)C)O)C)NC1 Ambient -20°C Soluble in ethanol (≥20 mg/mL, methanol (0.7 mg/mL). Soluble in DMSO & insoluble in water. "Song M, Ou X, Xiao C, et al. Hedgehog signaling inhibitor cyclopamine induces apoptosis by decreasing Gli2 and Bcl2 expression in human salivary pleomorphic adenoma cells. Biomed Rep. 2013 Mar;1(2):325-329. PMID: 24648943.

Xu L, Wang X, Wan J, et al. Sonic Hedgehog pathway is essential for neuroblastoma cell proliferation and tumor growth. Mol Cell Biochem. 2012 May;364(1-2):235-41. PMID: 22350753.

Stanton BZ, Peng LF. Small-molecule modulators of the Sonic Hedgehog signaling pathway. Mol Biosyst. 2010 Jan;6(1):44-54. PMID: 20024066." Not dangerous goods.

LKT C9711 Cyclovirobuxine D 25 mg 92.5 Found in Buxus; hERG K+ channel inhibitor. Bebuxine; Cyclovirobuxine 860-79-7 ≥98% 402.66 C26H46N2O CC(C1C(CC2(C1(CCC34C2CCC5C3(C4)CCC(C5(C)C)NC)C)C)O)NC Ambient 4°C "Lu J, Sun D, Gao S, et al. Cyclovirobuxine D induces autophagy-associated cell death via the Akt/mTOR pathway in MCF-7 human breast cancer cells. J Pharmacol Sci. 2014;125(1):74-82. PMID: 24758922.

Yu B, Fang TH, Lü GH, et al. Beneficial effect of Cyclovirobuxine D on heart failure rats following myocardial infarction. Fitoterapia. 2011 Sep;82(6):868-77. PMID: 21575690.

Zhao J, Wang Q, Xu J, et al. Cyclovirobuxine D inhibits the currents of HERG potassium channels stably expressed in HEK293 cells. Eur J Pharmacol. 2011 Jun 25;660(2-3):259-67. PMID: 21497594.

Hu D, Liu X, Wang Y, et al. Cyclovirobuxine D ameliorates acute myocardial ischemia by K(ATP) channel opening, nitric oxide release and anti-thrombosis. Eur J Pharmacol. 2007 Aug 13;569(1-2):103-9. PMID: 17555743.

" Not dangerous goods.

LKT C9711 Cyclovirobuxine D 100 mg 231.1 Found in Buxus; hERG K+ channel inhibitor. Bebuxine; Cyclovirobuxine 860-79-7 ≥98% 402.66 C26H46N2O CC(C1C(CC2(C1(CCC34C2CCC5C3(C4)CCC(C5(C)C)NC)C)C)O)NC Ambient 4°C "Lu J, Sun D, Gao S, et al. Cyclovirobuxine D induces autophagy-associated cell death via the Akt/mTOR pathway in MCF-7 human breast cancer cells. J Pharmacol Sci. 2014;125(1):74-82. PMID: 24758922.

Yu B, Fang TH, Lü GH, et al. Beneficial effect of Cyclovirobuxine D on heart failure rats following myocardial infarction. Fitoterapia. 2011 Sep;82(6):868-77. PMID: 21575690.

Zhao J, Wang Q, Xu J, et al. Cyclovirobuxine D inhibits the currents of HERG potassium channels stably expressed in HEK293 cells. Eur J Pharmacol. 2011 Jun 25;660(2-3):259-67. PMID: 21497594.

" Not dangerous goods.

LKT C9711 Cyclovirobuxine D 500 mg 912.8 Found in Buxus; hERG K+ channel inhibitor. Bebuxine; Cyclovirobuxine 860-79-7 ≥98% 402.66 C26H46N2O CC(C1C(CC2(C1(CCC34C2CCC5C3(C4)CCC(C5(C)C)NC)C)C)O)NC Ambient 4°C "Lu J, Sun D, Gao S, et al. Cyclovirobuxine D induces autophagy-associated cell death via the Akt/mTOR pathway in MCF-7 human breast cancer cells. J Pharmacol Sci. 2014;125(1):74-82. PMID: 24758922.

Yu B, Fang TH, Lü GH, et al. Beneficial effect of Cyclovirobuxine D on heart failure rats following myocardial infarction. Fitoterapia. 2011 Sep;82(6):868-77. PMID: 21575690.

Zhao J, Wang Q, Xu J, et al. Cyclovirobuxine D inhibits the currents of HERG potassium channels stably expressed in HEK293 cells. Eur J Pharmacol. 2011 Jun 25;660(2-3):259-67. PMID: 21497594.

" Not dangerous goods.

LKT C9773 L-Cystine 25 g 34.8 Endogenous amino acid, forms disulfide bridges in proteins. L-Cystine "[R-(R*,R*)]-3,3'-dithiobis[2-aminopropanoic acid];

Cystine; Dicysteine; Gelucystine" 56-89-3 ≥98% 240.3 C6H12N2O4S2 C(C(C(=O)O)N)SSCC(C(=O)O)N Ambient Ambient Soluble in aqueous solutions of pH < 2 or pH > 8. "Kolmar H. Biological diversity and therapeutic potential of natural and engineered cystine knot miniproteins. Curr Opin Pharmacol. 2009 Oct;9(5):608-14. PMID: 19523876.

Dröge W, Holm E. Role of cysteine and glutathione in HIV infection and other diseases associated with muscle wasting and immunological dysfunction. FASEB J. 1997 Nov;11(13):1077-89. PMID: 9367343.

" Xi Not dangerous goods.

LKT C9773 L-Cystine 100 g 92.5 Endogenous amino acid, forms disulfide bridges in proteins. L-Cystine "[R-(R*,R*)]-3,3'-dithiobis[2-aminopropanoic acid];

Dröge W, Holm E. Role of cysteine and glutathione in HIV infection and other diseases associated with muscle wasting and immunological dysfunction. FASEB J. 1997 Nov;11(13):1077-89. PMID: 9367343.

" Xi Not dangerous goods.

LKT C9773 L-Cystine 500 g 346.5 Endogenous amino acid, forms disulfide bridges in proteins. L-Cystine "[R-(R*,R*)]-3,3'-dithiobis[2-aminopropanoic acid];

Dröge W, Holm E. Role of cysteine and glutathione in HIV infection and other diseases associated with muscle wasting and immunological dysfunction. FASEB J. 1997 Nov;11(13):1077-89. PMID: 9367343.

" Xi Not dangerous goods.

LKT C9778 Cytarabine 100 mg 34.8 Pyrimidine nucleoside (cytidine) analog; DNA chain terminator, DNA polymerase and RNA polymerase inhibitor. 4-Amino-1-β-D-arabinofuranosyl-2(1H)-pyrimidinone Alexan; Arabitin; Ara-C; Cytosar; Erpalfa; Iretin; Udicil 147-94-4 ≥98% 243.22 C9H13N3O5 C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O Ambient Ambient Soluble in water to 100 mM, DMSO to 50 mM, ethanol. "Abdel-Aziz W, Jiang HY, Hickey RJ, et al. Ara-C affects formation of cancer cell DNA synthesome replication intermediates. Cancer Chemother Pharmacol. 2000;45(4):312-9. PMID: 10755320.

Hiddemann W. Cytosine arabinoside in the treatment of acute myeloid leukemia: the role and place of high-dose regimens. Ann Hematol. 1991 Apr;62(4):119-28. PMID: 2031974.

Lauter CB, Bailey EJ, Lerner AM. Assessment of cytosine arabinoside as an antiviral agent in humans. Antimicrob Agents Chemother. 1974 Nov;6(5):598-602. PMID: 15825312.

" Xn Not dangerous goods.

LKT C9778 Cytarabine 500 mg 92.2 Pyrimidine nucleoside (cytidine) analog; DNA chain terminator, DNA polymerase and RNA polymerase inhibitor. 4-Amino-1-β-D-arabinofuranosyl-2(1H)-pyrimidinone Alexan; Arabitin; Ara-C; Cytosar; Erpalfa; Iretin; Udicil 147-94-4 ≥98% 243.22 C9H13N3O5 C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O Ambient Ambient Soluble in water to 100 mM, DMSO to 50 mM, ethanol. "Abdel-Aziz W, Jiang HY, Hickey RJ, et al. Ara-C affects formation of cancer cell DNA synthesome replication intermediates. Cancer Chemother Pharmacol. 2000;45(4):312-9. PMID: 10755320.

Hiddemann W. Cytosine arabinoside in the treatment of acute myeloid leukemia: the role and place of high-dose regimens. Ann Hematol. 1991 Apr;62(4):119-28. PMID: 2031974.

Lauter CB, Bailey EJ, Lerner AM. Assessment of cytosine arabinoside as an antiviral agent in humans. Antimicrob Agents Chemother. 1974 Nov;6(5):598-602. PMID: 15825312.

" Xn Not dangerous goods.

LKT C9778 Cytarabine 1 g 149.9 Pyrimidine nucleoside (cytidine) analog; DNA chain terminator, DNA polymerase and RNA polymerase inhibitor. 4-Amino-1-β-D-arabinofuranosyl-2(1H)-pyrimidinone Alexan; Arabitin; Ara-C; Cytosar; Erpalfa; Iretin; Udicil 147-94-4 ≥98% 243.22 C9H13N3O5 C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O Ambient Ambient Soluble in water to 100 mM, DMSO to 50 mM, ethanol. "Abdel-Aziz W, Jiang HY, Hickey RJ, et al. Ara-C affects formation of cancer cell DNA synthesome replication intermediates. Cancer Chemother Pharmacol. 2000;45(4):312-9. PMID: 10755320.

Hiddemann W. Cytosine arabinoside in the treatment of acute myeloid leukemia: the role and place of high-dose regimens. Ann Hematol. 1991 Apr;62(4):119-28. PMID: 2031974.

Lauter CB, Bailey EJ, Lerner AM. Assessment of cytosine arabinoside as an antiviral agent in humans. Antimicrob Agents Chemother. 1974 Nov;6(5):598-602. PMID: 15825312.

" Xn Not dangerous goods.

LKT C9779 Cytisine 5 mg 47.6 Alkaloid found in Fabaceae family plants; α3β4 nAChR agonist, α4β2 partial agonist. (-)-Cytisine 485-35-8 ≥98% 190.24 C11H14N2O C1C2CNCC1C3=CC=CC(=O)N3C2 Ambient 4°C "Hajek P, McRobbie H, Myers K. Efficacy of cytisine in helping smokers quit: systematic review and meta-analysis. Thorax. 2013 Nov;68(11):1037-42. PMID: 23404838.

Simeonova R, Vitcheva V, Mitcheva M. Effect of cytisine on some brain and hepatic biochemical parameters in spontaneously hypertensive rats. Interdiscip Toxicol. 2010 Mar;3(1):21-5. PMID: 21217867.

Mineur YS, Somenzi O, Picciotto MR. Cytisine, a partial agonist of high-affinity nicotinic acetylcholine receptors, has antidepressant-like properties in male C57BL/6J mice. Neuropharmacology. 2007 Apr;52(5):1256-62. PMID: 17320916.

" T, Xi "UN number: 1544 Class: 6.1 Packing Group: II

Proper shipping name: Alkaloids, solid, n.o.s. (Cytisine)"

LKT C9779 Cytisine 25 mg 169.9 Alkaloid found in Fabaceae family plants; α3β4 nAChR agonist, α4β2 partial agonist. (-)-Cytisine 485-35-8 ≥98% 190.24 C11H14N2O C1C2CNCC1C3=CC=CC(=O)N3C2 Ambient 4°C "Hajek P, McRobbie H, Myers K. Efficacy of cytisine in helping smokers quit: systematic review and meta-analysis. Thorax. 2013 Nov;68(11):1037-42. PMID: 23404838.

Simeonova R, Vitcheva V, Mitcheva M. Effect of cytisine on some brain and hepatic biochemical parameters in spontaneously hypertensive rats. Interdiscip Toxicol. 2010 Mar;3(1):21-5. PMID: 21217867.

" T, Xi "UN number: 1544 Class: 6.1 Packing Group: II

Proper shipping name: Alkaloids, solid, n.o.s. (Cytisine)"

LKT C9779 Cytisine 100 mg 509.7 Alkaloid found in Fabaceae family plants; α3β4 nAChR agonist, α4β2 partial agonist. (-)-Cytisine 485-35-8 ≥98% 190.24 C11H14N2O C1C2CNCC1C3=CC=CC(=O)N3C2 Ambient 4°C "Hajek P, McRobbie H, Myers K. Efficacy of cytisine in helping smokers quit: systematic review and meta-analysis. Thorax. 2013 Nov;68(11):1037-42. PMID: 23404838.

Simeonova R, Vitcheva V, Mitcheva M. Effect of cytisine on some brain and hepatic biochemical parameters in spontaneously hypertensive rats. Interdiscip Toxicol. 2010 Mar;3(1):21-5. PMID: 21217867.

" T, Xi "UN number: 1544 Class: 6.1 Packing Group: II

Proper shipping name: Alkaloids, solid, n.o.s. (Cytisine)"

LKT C9782 Total Cytotoxicity Test Assay Kit 125 Tests 500 Cytotoxicity measuring kit. Ambient 4°C

LKT C9782 Total Cytotoxicity Test Assay Kit 250 Tests 938.2 Cytotoxicity measuring kit. Ambient 4°C

LKT C9809 Cyclopiazonic Acid 5 mg 97.4 SERCA inhibitor. 18172-33-3 ≥98%, TLC 336.39 C20H20N2O3 CC(=O)C1=C(C2C3C(CC4=C5C3=CNC5=CC=C4)C(N2C1=O)(C)C)O Ambient 4°C DMSO, Methylene Chloride and Methanol. "Pulcini S, Staines HM, Pittman JK, et al. Expression in yeast links field polymorphisms in PfATP6 to in vitro artemisinin resistance and identifies new inhibitor classes. J Infect Dis. 2013 Aug 1;208(3):468-78. PMID: 23599312.

Chericoni S, Testai L, Campeol E, et al. Vasodilator activity of Michelia figo Spreng. (Magnoliaceae) by in vitro functional study. J Ethnopharmacol. 2004 Apr;91(2-3):263-6. PMID: 15120449.

Darby PJ, Kwan CY, Daniel EE. Use of calcium pump inhibitors in the study of calcium regulation in smooth muscle. Biol Signals. 1993 Sep-Oct;2(5):293-304. PMID: 8038861.

" "UN number: 3462 Class: 6.1 Packing Group: II

Proper shipping name: Toxins, extracted from living sources, solid, n.o.s. (Cyclopiazonic acid)"

LKT C9809 Cyclopiazonic Acid 10 mg 168.7 SERCA inhibitor. 18172-33-3 ≥98%, TLC 336.39 C20H20N2O3 CC(=O)C1=C(C2C3C(CC4=C5C3=CNC5=CC=C4)C(N2C1=O)(C)C)O Ambient 4°C DMSO, Methylene Chloride and Methanol. "Pulcini S, Staines HM, Pittman JK, et al. Expression in yeast links field polymorphisms in PfATP6 to in vitro artemisinin resistance and identifies new inhibitor classes. J Infect Dis. 2013 Aug 1;208(3):468-78. PMID: 23599312.

Chericoni S, Testai L, Campeol E, et al. Vasodilator activity of Michelia figo Spreng. (Magnoliaceae) by in vitro functional study. J Ethnopharmacol. 2004 Apr;91(2-3):263-6. PMID: 15120449.

Darby PJ, Kwan CY, Daniel EE. Use of calcium pump inhibitors in the study of calcium regulation in smooth muscle. Biol Signals. 1993 Sep-Oct;2(5):293-304. PMID: 8038861.

" "UN number: 3462 Class: 6.1 Packing Group: II

Proper shipping name: Toxins, extracted from living sources, solid, n.o.s. (Cyclopiazonic acid)"

LKT C9863 Cyproconazole 5 g 65.6 Triazole; 14-α demethylase inhibitor, voltage-gated Ca2+ channel blocker, potential aromatase inhibitor. 94361-06-5 ≥95% 291.78 C15H18ClN3O CC(C1CC1)C(CN2C=NC=N2)(C3=CC=C(C=C3)Cl)O Ambient Ambient "Heusinkveld HJ, Molendijk J, van den Berg M, et al. Azole fungicides disturb intracellular Ca2+ in an additive manner in dopaminergic PC12 cells. Toxicol Sci. 2013 Aug;134(2):374-81. PMID: 23708404.

Hester S, Moore T, Padgett WT, et al. The hepatocarcinogenic conazoles: cyproconazole, epoxiconazole, and propiconazole induce a common set of toxicological and transcriptional responses. Toxicol Sci. 2012 May;127(1):54-65. PMID: 22334560.

Peffer RC, Moggs JG, Pastoor T, et al. Mouse liver effects of cyproconazole, a triazole fungicide: role of the constitutive androstane receptor. Toxicol Sci. 2007 Sep;99(1):315-25. PMID: 17557908.

" Xn Not dangerous goods.

LKT C9863 Cyproconazole 10 g 93.8 Triazole; 14-α demethylase inhibitor, voltage-gated Ca2+ channel blocker, potential aromatase inhibitor. 94361-06-5 ≥95% 291.78 C15H18ClN3O CC(C1CC1)C(CN2C=NC=N2)(C3=CC=C(C=C3)Cl)O Ambient Ambient "Heusinkveld HJ, Molendijk J, van den Berg M, et al. Azole fungicides disturb intracellular Ca2+ in an additive manner in dopaminergic PC12 cells. Toxicol Sci. 2013 Aug;134(2):374-81. PMID: 23708404.

Peffer RC, Moggs JG, Pastoor T, et al. Mouse liver effects of cyproconazole, a triazole fungicide: role of the constitutive androstane receptor. Toxicol Sci. 2007 Sep;99(1):315-25. PMID: 17557908.

" Xn Not dangerous goods.

LKT C9863 Cyproconazole 100 g 515.7 Triazole; 14-α demethylase inhibitor, voltage-gated Ca2+ channel blocker, potential aromatase inhibitor. 94361-06-5 ≥95% 291.78 C15H18ClN3O CC(C1CC1)C(CN2C=NC=N2)(C3=CC=C(C=C3)Cl)O Ambient Ambient "Heusinkveld HJ, Molendijk J, van den Berg M, et al. Azole fungicides disturb intracellular Ca2+ in an additive manner in dopaminergic PC12 cells. Toxicol Sci. 2013 Aug;134(2):374-81. PMID: 23708404.

Peffer RC, Moggs JG, Pastoor T, et al. Mouse liver effects of cyproconazole, a triazole fungicide: role of the constitutive androstane receptor. Toxicol Sci. 2007 Sep;99(1):315-25. PMID: 17557908.

" Xn Not dangerous goods.

LKT C9878 Cytochalasin A 1 mg 75 Mycotoxin produced by Aspergillus; actin polymerization inhibitor, Kv1.5 K+ channel blocker.. 14110-64-6 ≥98% 477.6 C29H35NO5 CC1CCCC(=O)C=CC(=O)OC23C(C=CC1)C(C(=C)C(C2C(NC3=O)CC4=CC=CC=C4)C)O Ambient 4°C "Choi BH, Park JA, Kim KR, et al. Direct block of cloned hKv1.5 channel by cytochalasins, actin-disrupting agents. Am J Physiol Cell Physiol. 2005 Aug;289(2):C425-36. PMID: 15800051.

Menter DG, Sloane BF, Steinert BW, et al. Platelet enhancement of tumor cell adhesion to subendothelial matrix: role of platelet cytoskeleton and platelet membrane. J Natl Cancer Inst. 1987 Nov;79(5):1077-90. PMID: 3479634.

" Repr, T+ "UN number: 3462 Class: 6.1 Packing Group: II

Proper shipping name: Toxins, extracted from living sources, solid, n.o.s. (Cytochalasin A)"

LKT C9878 Cytochalasin A 5 mg 322.6 Mycotoxin produced by Aspergillus; actin polymerization inhibitor, Kv1.5 K+ channel blocker.. 14110-64-6 ≥98% 477.6 C29H35NO5 CC1CCCC(=O)C=CC(=O)OC23C(C=CC1)C(C(=C)C(C2C(NC3=O)CC4=CC=CC=C4)C)O Ambient 4°C "Choi BH, Park JA, Kim KR, et al. Direct block of cloned hKv1.5 channel by cytochalasins, actin-disrupting agents. Am J Physiol Cell Physiol. 2005 Aug;289(2):C425-36. PMID: 15800051.

" Repr, T+ "UN number: 3462 Class: 6.1 Packing Group: II

Proper shipping name: Toxins, extracted from living sources, solid, n.o.s. (Cytochalasin A)"

LKT C9879 Cytochalasin B 1 mg 52.6 Mycotoxin produced by Aspergillus; actin polymerization inhibitor. 14930-96-2 ≥98% 479.61 C29H37NO5 CC1CCCC(C=CC(=O)OC23C(C=CC1)C(C(=C)C(C2C(NC3=O)CC4=CC=CC=C4)C)O)O Ambient 4°C DMSO or Ethanol "Delarue C, Esneu M, Fournier A, et al. Role of the cytoskeleton in the secretory response of the frog adrenal gland to calcitonin gene-related peptide. J Steroid Biochem Mol Biol. 1997 Sep-Oct;63(1-3):21-7. PMID: 9449202.

Reist RH, Dey RD, Durham JP, et al. Inhibition of proliferative activity of pulmonary fibroblasts by tetrandrine. Toxicol Appl Pharmacol. 1993 Sep;122(1):70-6. PMID: 8104360.

Painter RG, Whisenand J, McIntosh AT. Effects of cytochalasin B on actin and myosin association with particle binding sites in mouse macrophages: implications with regard to the mechanism of action of the cytochalasins. J Cell Biol. 1981 Nov;91(2 Pt 1):373-84. PMID: 7198123.

" Repr., T+ "UN number: 3462 Class: 6.1 Packing Group: II

Proper shipping name: Toxins, extracted from living sources, solid, n.o.s. (Cytochalasin B)"

LKT C9879 Cytochalasin B 5 mg 191.2 Mycotoxin produced by Aspergillus; actin polymerization inhibitor. 14930-96-2 ≥98% 479.61 C29H37NO5 CC1CCCC(C=CC(=O)OC23C(C=CC1)C(C(=C)C(C2C(NC3=O)CC4=CC=CC=C4)C)O)O Ambient 4°C DMSO or Ethanol "Delarue C, Esneu M, Fournier A, et al. Role of the cytoskeleton in the secretory response of the frog adrenal gland to calcitonin gene-related peptide. J Steroid Biochem Mol Biol. 1997 Sep-Oct;63(1-3):21-7. PMID: 9449202.

Reist RH, Dey RD, Durham JP, et al. Inhibition of proliferative activity of pulmonary fibroblasts by tetrandrine. Toxicol Appl Pharmacol. 1993 Sep;122(1):70-6. PMID: 8104360.

" Repr., T+ "UN number: 3462 Class: 6.1 Packing Group: II

Proper shipping name: Toxins, extracted from living sources, solid, n.o.s. (Cytochalasin B)"

LKT C9880 Cytochalasin C 1 mg 165.1 Mycotoxin produced by Aspergillus; actin polymerization inhibitor. 22144-76-9 ≥98%, TLC 507.62 C30H37NO6 CC1CC=CC2C(C(=C(C3C2(C(C=CC(C1=O)(C)O)OC(=O)C)C(=O)NC3CC4=CC=CC=C4)C)C)O Ambient 4°C Dichloromethane , Ethyl acetate "Varedi M, Ghahary A, Scott PG, et al. Cytoskeleton regulates expression of genes for transforming growth factor-beta 1 and extracellular matrix proteins in dermal fibroblasts. J Cell Physiol. 1997 Aug;172(2):192-9. PMID: 9258340.

Glinsukon T, Sinlapanapaporn S, Chulasamaya M. Inhibitory effect of cytochalasins on the motility of rat epididymal spermatozoa in vitro. Res Commun Chem Pathol Pharmacol. 1986 Feb;51(2):265-8. PMID: 3961270.

" Repr., T+ "UN number: 3462 Class: 6.1 Packing Group: II

Proper shipping name: Toxins, extracted from living sources, solid, n.o.s. (Cytochalasin C)"

LKT C9880 Cytochalasin C 5 mg 682.6 Mycotoxin produced by Aspergillus; actin polymerization inhibitor. 22144-76-9 ≥98%, TLC 507.62 C30H37NO6 CC1CC=CC2C(C(=C(C3C2(C(C=CC(C1=O)(C)O)OC(=O)C)C(=O)NC3CC4=CC=CC=C4)C)C)O Ambient 4°C Dichloromethane , Ethyl acetate "Varedi M, Ghahary A, Scott PG, et al. Cytoskeleton regulates expression of genes for transforming growth factor-beta 1 and extracellular matrix proteins in dermal fibroblasts. J Cell Physiol. 1997 Aug;172(2):192-9. PMID: 9258340.

" Repr., T+ "UN number: 3462 Class: 6.1 Packing Group: II

Proper shipping name: Toxins, extracted from living sources, solid, n.o.s. (Cytochalasin C)"

LKT C9881 Cytochalasin D 1 mg 165.1 Mycotoxin produced by Aspergillus; actin polymerization inhibitor. 22144-77-0 ≥98% 507.62 C30H37NO6 CC1CC=CC2C(C(=C)C(C3C2(C(C=CC(C1=O)(C)O)OC(=O)C)C(=O)NC3CC4=CC=CC=C4)C)O Ambient 4°C "Wilkins JR, Pike DB, Gibson CC, et al. Differential effects of cyclic stretch on bFGF- and VEGF-induced sprouting angiogenesis. Biotechnol Prog. 2014 Feb 14. [Epub ahead of print]. PMID: 24574264.

Choy JS, Lu X, Yang J, et al. Endothelial actin depolymerization mediates NADPH oxidase-superoxide production during flow reversal. Am J Physiol Heart Circ Physiol. 2014 Jan 1;306(1):H69-77. PMID: 24186098.

Schiller ZA, Schiele NR, Sims JK, et al. Adipogenesis of adipose-derived stem cells may be regulated via the cytoskeleton at physiological oxygen levels in vitro. Stem Cell Res Ther. 2013 Jul 9;4(4):79. PMID: 23838354.

" T, Repr "UN number: 3462 Class: 6.1 Packing Group: II

Proper shipping name: Toxins, extracted from living sources, solid, n.o.s. (Cytochalasin D)"

LKT C9881 Cytochalasin D 5 mg 682.6 Mycotoxin produced by Aspergillus; actin polymerization inhibitor. 22144-77-0 ≥98% 507.62 C30H37NO6 CC1CC=CC2C(C(=C)C(C3C2(C(C=CC(C1=O)(C)O)OC(=O)C)C(=O)NC3CC4=CC=CC=C4)C)O Ambient 4°C "Wilkins JR, Pike DB, Gibson CC, et al. Differential effects of cyclic stretch on bFGF- and VEGF-induced sprouting angiogenesis. Biotechnol Prog. 2014 Feb 14. [Epub ahead of print]. PMID: 24574264.

" T, Repr "UN number: 3462 Class: 6.1 Packing Group: II

Proper shipping name: Toxins, extracted from living sources, solid, n.o.s. (Cytochalasin D)"

LKT C9882 Cytochalasin E 1 mg 78.6 Mycotoxin produced by Aspergillus; actin polymerization inhibitor. 36011-19-5 ≥98% 495.57 C28H33NO7 CC1CC=CC2C3C(O3)(C(C4C2(C(=O)NC4CC5=CC=CC=C5)OC(=O)OC=CC(C1=O)(C)O)C)C Ambient 4°C "Ikewaki N, Yamada A, Inoko H. Depolymerization of actin filament by cytochalasin E induces interleukin-8 production and up-regulates CD54 in the HeLa epithelial cell line. Microbiol Immunol. 2003;47(10):775-83. PMID: 14605444.

Udagawa T, Yuan J, Panigrahy D, et al. Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesis and tumor growth. J Pharmacol Exp Ther. 2000 Aug;294(2):421-7. PMID: 10900214.

Gan Y, Au JL, Lu J, et al. Antiproliferative and cytotoxic effects of geldanamycin, cytochalasin E, suramin and thiacetazone in human prostate xenograft tumor histocultures. Pharm Res. 1998 Nov;15(11):1760-6. PMID: 9834000.

" T+, Repr. "UN number: 3462 Class: 6.1 Packing Group: II

Proper shipping name: Toxins, extracted from living sources, solid, n.o.s. (Cytochalasin E)"

LKT C9882 Cytochalasin E 5 mg 328.1 Mycotoxin produced by Aspergillus; actin polymerization inhibitor. 36011-19-5 ≥98% 495.57 C28H33NO7 CC1CC=CC2C3C(O3)(C(C4C2(C(=O)NC4CC5=CC=CC=C5)OC(=O)OC=CC(C1=O)(C)O)C)C Ambient 4°C "Ikewaki N, Yamada A, Inoko H. Depolymerization of actin filament by cytochalasin E induces interleukin-8 production and up-regulates CD54 in the HeLa epithelial cell line. Microbiol Immunol. 2003;47(10):775-83. PMID: 14605444.

" T+, Repr. "UN number: 3462 Class: 6.1 Packing Group: II

Proper shipping name: Toxins, extracted from living sources, solid, n.o.s. (Cytochalasin E)"

LKT D0010 3H-1,2-Dithiole-3-thione 25 mg 69.3 Found in cruciferous vegetables. D3T; 1,2-Dithiol-3-thione 534-25-8 ≥98% 134.25 C3H2S3 C1=CSSC1=S Ambient Ambient Insoluble in water. Soluble in DMSO (≥10 mg/ml). "Jia J, Xiao Y, Wang W, et al. Differential mechanisms underlying neuroprotection of hydrogen sulfide donors against oxidative stress. Neurochem Int. 2013 Jun;62(8):1072-8. PMID: 23587562.

Pazdro R, Burgess JR. The antioxidant 3H-1,2-dithiole-3-thione potentiates advanced glycation end-product-induced oxidative stress in SH-SY5Y cells. Exp Diabetes Res. 2012;2012:137607. PMID: 22675339.

Dong J, Yan D, Chen SY. Stabilization of Nrf2 protein by D3T provides protection against ethanol-induced apoptosis in PC12 cells. PLoS One. 2011 Feb 3;6(2):e16845. PMID: 21304811.

Kwak MK, Egner PA, Dolan PM, et al. Role of phase 2 enzyme induction in chemoprotection by dithiolethiones. Mutat Res. 2001 Sep 1;480-481:305-15. PMID: 11506823.

Pillon NJ, Croze ML, Vella RE, et al. The lipid peroxidation by-product 4-hydroxy-2-nonenal (4-HNE) induces insulin resistance in skeletal muscle through both carbonyl and oxidative stress. Endocrinology. 2012 May;153(5):2099-2111. PMID: 22396448.

" None Not dangerous goods.

LKT D0010 3H-1,2-Dithiole-3-thione 100 mg 231.1 Found in cruciferous vegetables. D3T; 1,2-Dithiol-3-thione 534-25-8 ≥98% 134.25 C3H2S3 C1=CSSC1=S Ambient Ambient Insoluble in water. Soluble in DMSO (≥10 mg/ml). "Jia J, Xiao Y, Wang W, et al. Differential mechanisms underlying neuroprotection of hydrogen sulfide donors against oxidative stress. Neurochem Int. 2013 Jun;62(8):1072-8. PMID: 23587562.

Dong J, Yan D, Chen SY. Stabilization of Nrf2 protein by D3T provides protection against ethanol-induced apoptosis in PC12 cells. PLoS One. 2011 Feb 3;6(2):e16845. PMID: 21304811.

Kwak MK, Egner PA, Dolan PM, et al. Role of phase 2 enzyme induction in chemoprotection by dithiolethiones. Mutat Res. 2001 Sep 1;480-481:305-15. PMID: 11506823.

" None Not dangerous goods.

LKT D0010 3H-1,2-Dithiole-3-thione 500 mg 912.8 Found in cruciferous vegetables. D3T; 1,2-Dithiol-3-thione 534-25-8 ≥98% 134.25 C3H2S3 C1=CSSC1=S Ambient Ambient Insoluble in water. Soluble in DMSO (≥10 mg/ml). "Jia J, Xiao Y, Wang W, et al. Differential mechanisms underlying neuroprotection of hydrogen sulfide donors against oxidative stress. Neurochem Int. 2013 Jun;62(8):1072-8. PMID: 23587562.

Dong J, Yan D, Chen SY. Stabilization of Nrf2 protein by D3T provides protection against ethanol-induced apoptosis in PC12 cells. PLoS One. 2011 Feb 3;6(2):e16845. PMID: 21304811.

Kwak MK, Egner PA, Dolan PM, et al. Role of phase 2 enzyme induction in chemoprotection by dithiolethiones. Mutat Res. 2001 Sep 1;480-481:305-15. PMID: 11506823.

" None Not dangerous goods.

LKT D0011 Dacarbazine 100 mg 57.8 DNA alkylator. 5-(3,3-Dimethyl-1-triazenyl)-1H-imidazole-4- carboxamide Dacatic; DTIC-Dome; Deticene 4342-03-4 ≥98% 182.18 C6H10N6O CN(C)NN=C1C(=NC=N1)C(=O)N Protect solutions from light. Ambient Ambient Slightly soluble in water and alcohol. "Gallamini A, Di Raimondo F, La Nasa G, et al. Standard therapies versus novel therapies in Hodgkin lymphoma. Immunol Lett. 2013 Sep-Oct;155(1-2):56-9. PMID: 24140162.

Koprowska K, Czy? M. Dacarbazine, a chemotherapeutic against metastatic melanoma and a reference drug for new treatment modalities. Postepy Hig Med Dosw (Online). 2011 Nov 23;65:734-51. PMID: 22173438.

" T Not dangerous goods.

LKT D0011 Dacarbazine 1 g 302.8 DNA alkylator. 5-(3,3-Dimethyl-1-triazenyl)-1H-imidazole-4- carboxamide Dacatic; DTIC-Dome; Deticene 4342-03-4 ≥98% 182.18 C6H10N6O CN(C)NN=C1C(=NC=N1)C(=O)N Protect solutions from light. Ambient Ambient Slightly soluble in water and alcohol. "Gallamini A, Di Raimondo F, La Nasa G, et al. Standard therapies versus novel therapies in Hodgkin lymphoma. Immunol Lett. 2013 Sep-Oct;155(1-2):56-9. PMID: 24140162.

" T Not dangerous goods.

LKT D0025 DAMGO 1 mg 60 Synthetic peptice; μOR agonist. ≥95% 513 C26H35N5O6 CC(C(=O)NCC(=O)N(C)C(CC1=CC=CC=C1)C(=O)NCCO)NC(=O)C(CC2=CC=C(C=C2)O)N Ambient -20°C "Wu Q, Xia S, Lin J, et al. Effects of the altered activity of δ-opioid receptor on the expression of glutamate transporter type 3 induced by chronic exposure to morphine. J Neurol Sci. 2013 Dec 15;335(1-2):174-81. PMID: 24120272.

Alexeeva EV, Nazarova GA, Sudakov SK. Effects of peripheral μ, δ, and Κ-opioid receptor agonists on the levels of anxiety and motor activity of rats. Bull Exp Biol Med. 2012 Sep;153(5):720-1. PMID: 23113268.

Herman MA, Gillis RA, Vicini S, et al. Tonic GABAA receptor conductance in medial subnucleus of the tractus solitarius neurons is inhibited by activation of μ-opioid receptors. J Neurophysiol. 2012 Feb;107(3):1022-31. PMID: 22114164.

Al-Khrasani M, Lackó E, Riba P, et al. The central versus peripheral antinociceptive effects of μ-opioid receptor agonists in the new model of rat visceral pain. Brain Res Bull. 2012 Feb 10;87(2-3):238-43. PMID: 22079588.

" Not dangerous goods.

LKT D0025 DAMGO 2 mg 101.9 Synthetic peptice; μOR agonist. ≥95% 513 C26H35N5O6 CC(C(=O)NCC(=O)N(C)C(CC1=CC=CC=C1)C(=O)NCCO)NC(=O)C(CC2=CC=C(C=C2)O)N Ambient -20°C "Wu Q, Xia S, Lin J, et al. Effects of the altered activity of δ-opioid receptor on the expression of glutamate transporter type 3 induced by chronic exposure to morphine. J Neurol Sci. 2013 Dec 15;335(1-2):174-81. PMID: 24120272.

" Not dangerous goods.

LKT D0025 DAMGO 5 mg 180 Synthetic peptice; μOR agonist. ≥95% 513 C26H35N5O6 CC(C(=O)NCC(=O)N(C)C(CC1=CC=CC=C1)C(=O)NCCO)NC(=O)C(CC2=CC=C(C=C2)O)N Ambient -20°C "Wu Q, Xia S, Lin J, et al. Effects of the altered activity of δ-opioid receptor on the expression of glutamate transporter type 3 induced by chronic exposure to morphine. J Neurol Sci. 2013 Dec 15;335(1-2):174-81. PMID: 24120272.

" Not dangerous goods.

LKT D0033 Daidzin 1 mg 93.8 Isoflavone, phytoestrogen, found in soy. 552-66-9 ≥98% 416.38 C21H20O9 C1=CC(=CC=C1C2=COC3=C(C2=O)C=CC(=C3)OC4C(C(C(C(O4)CO)O)O)O)O Ambient Ambient "Kim DH, Jung HA, Park SJ, et al. The effects of daidzin and its aglycon, daidzein, on the scopolamine-induced memory impairment in male mice. Arch Pharm Res. 2010 Oct;33(10):1685-90. PMID: 21052945.

Kim SH, Heo JH, Kim YS, et al. Protective effect of daidzin against D-galactosamine and lipopolysaccharide-induced hepatic failure in mice. Phytother Res. 2009 May;23(5):701-6. PMID: 19107740.

Li XH, Zhang JC, Sui SF, et al. Effect of daidzin, genistin, and glycitin on osteogenic and adipogenic differentiation of bone marrow stromal cells and adipocytic transdifferentiation of osteoblasts. Acta Pharmacol Sin. 2005 Sep;26(9):1081-6. PMID: 16115375.

" None Not dangerous goods.

LKT D0033 Daidzin 5 mg 309.4 Isoflavone, phytoestrogen, found in soy. 552-66-9 ≥98% 416.38 C21H20O9 C1=CC(=CC=C1C2=COC3=C(C2=O)C=CC(=C3)OC4C(C(C(C(O4)CO)O)O)O)O Ambient Ambient "Kim DH, Jung HA, Park SJ, et al. The effects of daidzin and its aglycon, daidzein, on the scopolamine-induced memory impairment in male mice. Arch Pharm Res. 2010 Oct;33(10):1685-90. PMID: 21052945.

Kim SH, Heo JH, Kim YS, et al. Protective effect of daidzin against D-galactosamine and lipopolysaccharide-induced hepatic failure in mice. Phytother Res. 2009 May;23(5):701-6. PMID: 19107740.

" None Not dangerous goods.

LKT D0044 D-Ala-D-Ala 250 mg 104.9 Peptidoglycan cell wall component. 923-16-0 ≥98% 160.17 C6H12N2O3 CC(C(=O)NC(C)C(=O)O)N Ambient -20°C Kwun MJ, Novotna G, Hesketh AR, et al. In vivo studies suggest that induction of VanS-dependent vancomycin resistance requires binding of the drug to D-Ala-D-Ala termini in the peptidoglycan cell wall. Antimicrob Agents Chemother. 2013 Sep;57(9):4470-80. PMID: 23836175. Not dangerous goods.

LKT D0169 Darifenacin Hydrobromide 10 mg 112.5 M3 mAChR antagonist. Darifenacin hydrobromide 133099-07-7 ≥98% 507.46 C28H31BrN2O2 C1CN(CC1C(C2=CC=CC=C2)(C3=CC=CC=C3)C(=O)N)CCC4=CC5=C(C=C4)OCC5.Br Ambient Ambient "Matsumoto Y, Miyazato M, Yokoyama H, et al. Role of M2 and M3 muscarinic acetylcholine receptor subtypes in activation of bladder afferent pathways in spinal cord injured rats. Urology. 2012 May;79(5):1184.e15-20. PMID: 22386753.

Hegde SS. Muscarinic receptors in the bladder: from basic research to therapeutics. Br J Pharmacol. 2006 Feb;147 Suppl 2:S80-7. PMID: 16465186.

Braverman AS, Tibb AS, Ruggieri MR Sr. M2 and M3 muscarinic receptor activation of urinary bladder contractile signal transduction. I. Normal rat bladder. J Pharmacol Exp Ther. 2006 Feb;316(2):869-74. PMID: 16243961.

" Not dangerous goods.

LKT D0169 Darifenacin Hydrobromide 25 mg 225 M3 mAChR antagonist. Darifenacin hydrobromide 133099-07-7 ≥98% 507.46 C28H31BrN2O2 C1CN(CC1C(C2=CC=CC=C2)(C3=CC=CC=C3)C(=O)N)CCC4=CC5=C(C=C4)OCC5.Br Ambient Ambient "Matsumoto Y, Miyazato M, Yokoyama H, et al. Role of M2 and M3 muscarinic acetylcholine receptor subtypes in activation of bladder afferent pathways in spinal cord injured rats. Urology. 2012 May;79(5):1184.e15-20. PMID: 22386753.

Hegde SS. Muscarinic receptors in the bladder: from basic research to therapeutics. Br J Pharmacol. 2006 Feb;147 Suppl 2:S80-7. PMID: 16465186.

" Not dangerous goods.

LKT D0169 Darifenacin Hydrobromide 100 mg 703.2 M3 mAChR antagonist. Darifenacin hydrobromide 133099-07-7 ≥98% 507.46 C28H31BrN2O2 C1CN(CC1C(C2=CC=CC=C2)(C3=CC=CC=C3)C(=O)N)CCC4=CC5=C(C=C4)OCC5.Br Ambient Ambient "Matsumoto Y, Miyazato M, Yokoyama H, et al. Role of M2 and M3 muscarinic acetylcholine receptor subtypes in activation of bladder afferent pathways in spinal cord injured rats. Urology. 2012 May;79(5):1184.e15-20. PMID: 22386753.

Hegde SS. Muscarinic receptors in the bladder: from basic research to therapeutics. Br J Pharmacol. 2006 Feb;147 Suppl 2:S80-7. PMID: 16465186.

" Not dangerous goods.

LKT D0253 Danazol 100 mg 67.9 Ethisterone derivative, synthetic steroid, used for in vitro fertilization; weak AR agonist. (17α)-Pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol Bonzol; Chronogyn; Danatrol; Danocrine; Danol; Ladogal; Winobanin 17230-88-5 ≥98% 337.46 C22H27NO2 CC12CCC3C(C1CCC2(C#C)O)CCC4=CC5=C(CC34C)C=NO5 Ambient Ambient Soluble in chloroform, acetone. Sparingly soluble in ethanol. Insoluble in water (0.001 mg/mL) "Füst G, Farkas H, Csuka D, et al. Long-term efficacy of danazol treatment in hereditary angioedema. Eur J Clin Invest. 2011 Mar;41(3):256-62. PMID: 20955212.

Kusakabe K, Morishima S, Nakamuta N, et al. Effect of danazol on NK cells and cytokines in the mouse uterus. J Reprod Dev. 2007 Feb;53(1):87-94. PMID: 17077583.

Murakami K, Nomura K, Shinohara K, et al. Danazol inhibits aromatase activity of endometriosis-derived stromal cells by a competitive mechanism. Fertil Steril. 2006 Aug;86(2):291-7. PMID: 16806212.

Floyd WS. Danazol: endocrine and endometrial effects. Int J Fertil. 1980;25(1):75-80. PMID: 6104649.

" Xn, Repr. Not dangerous goods.

LKT D0253 Danazol 250 mg 163.2 Ethisterone derivative, synthetic steroid, used for in vitro fertilization; weak AR agonist. (17α)-Pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol Bonzol; Chronogyn; Danatrol; Danocrine; Danol; Ladogal; Winobanin 17230-88-5 ≥98% 337.46 C22H27NO2 CC12CCC3C(C1CCC2(C#C)O)CCC4=CC5=C(CC34C)C=NO5 Ambient Ambient Soluble in chloroform, acetone. Sparingly soluble in ethanol. Insoluble in water (0.001 mg/mL) "Füst G, Farkas H, Csuka D, et al. Long-term efficacy of danazol treatment in hereditary angioedema. Eur J Clin Invest. 2011 Mar;41(3):256-62. PMID: 20955212.

Kusakabe K, Morishima S, Nakamuta N, et al. Effect of danazol on NK cells and cytokines in the mouse uterus. J Reprod Dev. 2007 Feb;53(1):87-94. PMID: 17077583.

Murakami K, Nomura K, Shinohara K, et al. Danazol inhibits aromatase activity of endometriosis-derived stromal cells by a competitive mechanism. Fertil Steril. 2006 Aug;86(2):291-7. PMID: 16806212.

Floyd WS. Danazol: endocrine and endometrial effects. Int J Fertil. 1980;25(1):75-80. PMID: 6104649.

" Xn, Repr. Not dangerous goods.

LKT D0253 Danazol 1 g 543.6 Ethisterone derivative, synthetic steroid, used for in vitro fertilization; weak AR agonist. (17α)-Pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol Bonzol; Chronogyn; Danatrol; Danocrine; Danol; Ladogal; Winobanin 17230-88-5 ≥98% 337.46 C22H27NO2 CC12CCC3C(C1CCC2(C#C)O)CCC4=CC5=C(CC34C)C=NO5 Ambient Ambient Soluble in chloroform, acetone. Sparingly soluble in ethanol. Insoluble in water (0.001 mg/mL) "Füst G, Farkas H, Csuka D, et al. Long-term efficacy of danazol treatment in hereditary angioedema. Eur J Clin Invest. 2011 Mar;41(3):256-62. PMID: 20955212.

Kusakabe K, Morishima S, Nakamuta N, et al. Effect of danazol on NK cells and cytokines in the mouse uterus. J Reprod Dev. 2007 Feb;53(1):87-94. PMID: 17077583.

Murakami K, Nomura K, Shinohara K, et al. Danazol inhibits aromatase activity of endometriosis-derived stromal cells by a competitive mechanism. Fertil Steril. 2006 Aug;86(2):291-7. PMID: 16806212.

Floyd WS. Danazol: endocrine and endometrial effects. Int J Fertil. 1980;25(1):75-80. PMID: 6104649.

" Xn, Repr. Not dangerous goods.

LKT D0254 Dansyl-YVG 25 mg 276.2 Peptide, substrate of peptidylglycine monooxygenase and peptidylglycine α-amidating enzyme. ≥95% 571.63 C28H34N4O7S Ambient -20°C "Bauman AT, Yukl ET, Alkevich K, et al. The hydrogen peroxide reactivity of peptidylglycine monooxygenase supports a Cu(II)-superoxo catalytic intermediate. J Biol Chem. 2006 Feb 17;281(7):4190-8. PMID: 16330540.

Miller DA, Sayad KU, Kulathila R, et al. Characterization of a bifunctional peptidylglycine alpha-amidating enzyme expressed in Chinese hamster ovary cells. Arch Biochem Biophys. 1992 Nov 1;298(2):380-8. PMID: 1384431.

LKT D0254 Dansyl-YVG 50 mg 469.1 Peptide, substrate of peptidylglycine monooxygenase and peptidylglycine α-amidating enzyme. ≥95% 571.63 C28H34N4O7S Ambient -20°C "Bauman AT, Yukl ET, Alkevich K, et al. The hydrogen peroxide reactivity of peptidylglycine monooxygenase supports a Cu(II)-superoxo catalytic intermediate. J Biol Chem. 2006 Feb 17;281(7):4190-8. PMID: 16330540.

LKT D0254 Dansyl-YVG 125 mg 828.1 Peptide, substrate of peptidylglycine monooxygenase and peptidylglycine α-amidating enzyme. ≥95% 571.63 C28H34N4O7S Ambient -20°C "Bauman AT, Yukl ET, Alkevich K, et al. The hydrogen peroxide reactivity of peptidylglycine monooxygenase supports a Cu(II)-superoxo catalytic intermediate. J Biol Chem. 2006 Feb 17;281(7):4190-8. PMID: 16330540.

LKT D0255 Dantrolene Sodium Heptahydrate 100 mg 73.5 Hydantoin derivative; RyR antagonist, L-type Ca2+ channel blocker. 1-[[[5-(4-Nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidinedione sodium Dantamacrin; Dantrium; F-440, Dantrolene, Sodium Salt Hemiheptahydrate 24868-20-0 ≥98% 399.29 C14H9N4NaO5 31/2 H2O C1C(=O)N=C(N1N=CC2=CC=C(O2)C3=CC=C(C=C3)[N+](=O)[O-])[O-].[Na+] Protect from light. Ambient Ambient Slightly soluble in water; more soluble in alkaline soln. "Jakob R, Beutner G, Sharma VK, et al. Molecular and functional identification of a mitochondrial ryanodine receptor in neurons. Neurosci Lett. 2014 May 23. [Epub ahead of print]. PMID: 24861510.

Bannister RA. Dantrolene-induced inhibition of skeletal L-type Ca2+ current requires RyR1 expression. Biomed Res Int. 2013;2013:390493. PMID: 23509717.

Boys JA, Toledo AH, Anaya-Prado R, et al. Effects of dantrolene on ischemia-reperfusion injury in animal models: a review of outcomes in heart, brain, liver, and kidney. J Investig Med. 2010 Oct;58(7):875-82. PMID: 20517166.

" Not dangerous goods.

LKT D0255 Dantrolene Sodium Heptahydrate 250 mg 136.4 Hydantoin derivative; RyR antagonist, L-type Ca2+ channel blocker. 1-[[[5-(4-Nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidinedione sodium Dantamacrin; Dantrium; F-440, Dantrolene, Sodium Salt Hemiheptahydrate 24868-20-0 ≥98% 399.29 C14H9N4NaO5 31/2 H2O C1C(=O)N=C(N1N=CC2=CC=C(O2)C3=CC=C(C=C3)[N+](=O)[O-])[O-].[Na+] Protect from light. Ambient Ambient Slightly soluble in water; more soluble in alkaline soln. "Jakob R, Beutner G, Sharma VK, et al. Molecular and functional identification of a mitochondrial ryanodine receptor in neurons. Neurosci Lett. 2014 May 23. [Epub ahead of print]. PMID: 24861510.

Bannister RA. Dantrolene-induced inhibition of skeletal L-type Ca2+ current requires RyR1 expression. Biomed Res Int. 2013;2013:390493. PMID: 23509717.

" Not dangerous goods.

LKT D0255 Dantrolene Sodium Heptahydrate 1 g 388.6 Hydantoin derivative; RyR antagonist, L-type Ca2+ channel blocker. 1-[[[5-(4-Nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidinedione sodium Dantamacrin; Dantrium; F-440, Dantrolene, Sodium Salt Hemiheptahydrate 24868-20-0 ≥98% 399.29 C14H9N4NaO5 31/2 H2O C1C(=O)N=C(N1N=CC2=CC=C(O2)C3=CC=C(C=C3)[N+](=O)[O-])[O-].[Na+] Protect from light. Ambient Ambient Slightly soluble in water; more soluble in alkaline soln. "Jakob R, Beutner G, Sharma VK, et al. Molecular and functional identification of a mitochondrial ryanodine receptor in neurons. Neurosci Lett. 2014 May 23. [Epub ahead of print]. PMID: 24861510.

Bannister RA. Dantrolene-induced inhibition of skeletal L-type Ca2+ current requires RyR1 expression. Biomed Res Int. 2013;2013:390493. PMID: 23509717.

" Not dangerous goods.

LKT D0353 Danofloxacin Mesylate 500 mg 121.9 Fluoroquinolone; bacterial DNA gyrase inhibitor. 119487-55-6 ≥98% 453.48 C19H20FN3O3 CH4O3S CN1CC2CC1CN2C3=C(C=C4C(=C3)N(C=C(C4=O)C(=O)O)C5CC5)F Ambient Ambient Soluble in water "Kawai K, Higuchi H, Iwano H, et al. Antimicrobial susceptibilities of Mycoplasma isolated from bovine mastitis in Japan. Anim Sci J. 2013 Nov 21. [Epub ahead of print]. PMID: 24261609.

Yu CH, Liu ZY, Sun LS, et al. Effect of Danofloxacin on Reactive Oxygen Species Production, Lipid Peroxidation and Antioxidant Enzyme Activities in Kidney Tubular Epithelial Cell Line, LLC-PK1. Basic Clin Pharmacol Toxicol. 2013 Jul 15. [Epub ahead of print]. PMID: 23855763.

Archambault M, Harel J, Gouré J, et al. Antimicrobial susceptibilities and resistance genes of Canadian isolates of Actinobacillus pleuropneumoniae. Microb Drug Resist. 2012 Apr;18(2):198-206. PMID: 22204596.

TerHune TN, Skogerboe TL, Shostrom VK, et al. Comparison of pharmacokinetics of danofloxacin and enrofloxacin in calves challenged with Mannheimia haemolytica. Am J Vet Res. 2005 Feb;66(2):342-9. PMID: 15757137.

Raemdonck DL, Tanner AC, Tolling ST, et al. In vitro susceptibility of avian Escherichia coli and Pasteurella multocida to danofloxacin and five other antimicrobials. Avian Dis. 1992 Oct-Dec;36(4):964-7. PMID: 1336664.

" None Not dangerous goods.

LKT D0353 Danofloxacin Mesylate 1 g 187.4 Fluoroquinolone; bacterial DNA gyrase inhibitor. 119487-55-6 ≥98% 453.48 C19H20FN3O3 CH4O3S CN1CC2CC1CN2C3=C(C=C4C(=C3)N(C=C(C4=O)C(=O)O)C5CC5)F Ambient Ambient Soluble in water "Kawai K, Higuchi H, Iwano H, et al. Antimicrobial susceptibilities of Mycoplasma isolated from bovine mastitis in Japan. Anim Sci J. 2013 Nov 21. [Epub ahead of print]. PMID: 24261609.

" None Not dangerous goods.

LKT D0353 Danofloxacin Mesylate 5 g 600.1 Fluoroquinolone; bacterial DNA gyrase inhibitor. 119487-55-6 ≥98% 453.48 C19H20FN3O3 CH4O3S CN1CC2CC1CN2C3=C(C=C4C(=C3)N(C=C(C4=O)C(=O)O)C5CC5)F Ambient Ambient Soluble in water "Kawai K, Higuchi H, Iwano H, et al. Antimicrobial susceptibilities of Mycoplasma isolated from bovine mastitis in Japan. Anim Sci J. 2013 Nov 21. [Epub ahead of print]. PMID: 24261609.

" None Not dangerous goods.

LKT D0368 2-Epi-16-deoxysarcophine 10 mg 234.8 Cembranoid found in Sarcophyton. ≥98% 302.45 C20H30O2 Ambient -20°C Sawant SS, Youssef DT, Reiland J, et al. Biocatalytic and antimetastatic studies of the marine cembranoids sarcophine and 2-epi-16-deoxysarcophine. J Nat Prod. 2006 Jul;69(7):1010-3. PMID: 16872134. Not dangerous goods.

LKT D0375 Dasatinib Monohydrate 25 mg 134.9 Abl, PDGFR, EphR, Src, k-Kit, FYN, LCK, HCK inhibitor. N-(2-chlro-6-methylphenyl)-2-[[6-[4[(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazole carboxamide monohydrate 863127-77-9 ≥98% 506.02 C22H26ClN7O2S H2O CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=NC(=NC(=C3)N4CCN(CC4)CCO)C.O Ambient Ambient Sparingly soluble in water (5.06 mg/ml), and ethanol. Soluble in DMSO (200 mg/ml). "Xie N, Zhong L, Liu L, et al. Autophagy contributes to dasatinib-induced myeloid differentiation of human acute myeloid leukemia cells. Biochem Pharmacol. 2014 May 1;89(1):74-85. PMID: 24607273.

de Wispelaere M, LaCroix AJ, Yang PL. The small molecules AZD0530 and dasatinib inhibit dengue virus RNA replication via Fyn kinase. J Virol. 2013 Jul;87(13):7367-81. PMID: 23616652.

Montero JC, Seoane S, Ocaña A, et al. Inhibition of SRC family kinases and receptor tyrosine kinases by dasatinib: possible combinations in solid tumors. Clin Cancer Res. 2011 Sep 1;17(17):5546-52. PMID: 21670084.

Das J, Chen P, Norris D, et al. 2-aminothiazole as a novel kinase inhibitor template. Structure-activity relationship studies toward the discovery of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (dasatinib, BMS-354825) as a potent pan-Src kinase inhibitor. J Med Chem. 2006 Nov 16;49(23):6819-32. PMID: 17154512.

" Not dangerous goods.

LKT D0375 Dasatinib Monohydrate 100 mg 407.7 Abl, PDGFR, EphR, Src, k-Kit, FYN, LCK, HCK inhibitor. N-(2-chlro-6-methylphenyl)-2-[[6-[4[(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazole carboxamide monohydrate 863127-77-9 ≥98% 506.02 C22H26ClN7O2S H2O CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=NC(=NC(=C3)N4CCN(CC4)CCO)C.O Ambient Ambient Sparingly soluble in water (5.06 mg/ml), and ethanol. Soluble in DMSO (200 mg/ml). "Xie N, Zhong L, Liu L, et al. Autophagy contributes to dasatinib-induced myeloid differentiation of human acute myeloid leukemia cells. Biochem Pharmacol. 2014 May 1;89(1):74-85. PMID: 24607273.

de Wispelaere M, LaCroix AJ, Yang PL. The small molecules AZD0530 and dasatinib inhibit dengue virus RNA replication via Fyn kinase. J Virol. 2013 Jul;87(13):7367-81. PMID: 23616652.

" Not dangerous goods.

LKT D0375 Dasatinib Monohydrate 500 mg 1291 Abl, PDGFR, EphR, Src, k-Kit, FYN, LCK, HCK inhibitor. N-(2-chlro-6-methylphenyl)-2-[[6-[4[(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazole carboxamide monohydrate 863127-77-9 ≥98% 506.02 C22H26ClN7O2S H2O CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=NC(=NC(=C3)N4CCN(CC4)CCO)C.O Ambient Ambient Sparingly soluble in water (5.06 mg/ml), and ethanol. Soluble in DMSO (200 mg/ml). "Xie N, Zhong L, Liu L, et al. Autophagy contributes to dasatinib-induced myeloid differentiation of human acute myeloid leukemia cells. Biochem Pharmacol. 2014 May 1;89(1):74-85. PMID: 24607273.

de Wispelaere M, LaCroix AJ, Yang PL. The small molecules AZD0530 and dasatinib inhibit dengue virus RNA replication via Fyn kinase. J Virol. 2013 Jul;87(13):7367-81. PMID: 23616652.

" Not dangerous goods.

LKT D1624 Deflazacort 100 mg 65.6 Oxazoline; glucocorticoid agonist. 14484-47-0 ≥98% 441.52 C25H31NO6 CC1=NC2(C(O1)CC3C2(CC(C4C3CCC5=CC(=O)C=CC45C)O)C)C(=O)COC(=O)C Ambient Ambient "Hoffman EP, Reeves E, Damsker J, et al. Novel approaches to corticosteroid treatment in Duchenne muscular dystrophy. Phys Med Rehabil Clin N Am. 2012 Nov;23(4):821-8. PMID: 23137739.

Silva EC, Machado DL, Resende MB, et al. Motor function measure scale, steroid therapy and patients with Duchenne muscular dystrophy. Arq Neuropsiquiatr. 2012 Mar;70(3):191-5. PMID: 22392111.

Joshi N, Rajeshwari K. Deflazacort. J Postgrad Med. 2009 Oct-Dec;55(4):296-300. PMID: 20083885.

Marques MJ, Oggiam DS, Barbin IC, et al. Long-term therapy with deflazacort decreases myocardial fibrosis in mdx mice. Muscle Nerve. 2009 Sep;40(3):466-8. PMID: 19623634.

" None Not dangerous goods.

LKT D1624 Deflazacort 250 mg 149.9 Oxazoline; glucocorticoid agonist. 14484-47-0 ≥98% 441.52 C25H31NO6 CC1=NC2(C(O1)CC3C2(CC(C4C3CCC5=CC(=O)C=CC45C)O)C)C(=O)COC(=O)C Ambient Ambient "Hoffman EP, Reeves E, Damsker J, et al. Novel approaches to corticosteroid treatment in Duchenne muscular dystrophy. Phys Med Rehabil Clin N Am. 2012 Nov;23(4):821-8. PMID: 23137739.

Silva EC, Machado DL, Resende MB, et al. Motor function measure scale, steroid therapy and patients with Duchenne muscular dystrophy. Arq Neuropsiquiatr. 2012 Mar;70(3):191-5. PMID: 22392111.

Joshi N, Rajeshwari K. Deflazacort. J Postgrad Med. 2009 Oct-Dec;55(4):296-300. PMID: 20083885.

Marques MJ, Oggiam DS, Barbin IC, et al. Long-term therapy with deflazacort decreases myocardial fibrosis in mdx mice. Muscle Nerve. 2009 Sep;40(3):466-8. PMID: 19623634.

" None Not dangerous goods.

LKT D1624 Deflazacort 1 g 375.1 Oxazoline; glucocorticoid agonist. 14484-47-0 ≥98% 441.52 C25H31NO6 CC1=NC2(C(O1)CC3C2(CC(C4C3CCC5=CC(=O)C=CC45C)O)C)C(=O)COC(=O)C Ambient Ambient "Hoffman EP, Reeves E, Damsker J, et al. Novel approaches to corticosteroid treatment in Duchenne muscular dystrophy. Phys Med Rehabil Clin N Am. 2012 Nov;23(4):821-8. PMID: 23137739.

Silva EC, Machado DL, Resende MB, et al. Motor function measure scale, steroid therapy and patients with Duchenne muscular dystrophy. Arq Neuropsiquiatr. 2012 Mar;70(3):191-5. PMID: 22392111.

Joshi N, Rajeshwari K. Deflazacort. J Postgrad Med. 2009 Oct-Dec;55(4):296-300. PMID: 20083885.

Marques MJ, Oggiam DS, Barbin IC, et al. Long-term therapy with deflazacort decreases myocardial fibrosis in mdx mice. Muscle Nerve. 2009 Sep;40(3):466-8. PMID: 19623634.

" None Not dangerous goods.

LKT D1627 Dehydrocostus Lactone 5 mg 67.9 Sesquiterpene lactone found in Saussurea. (3aS,6aR,9aR,9bS)-3,6,9-trimethylidene-3a,4,5,6a,7,8,9a,9b-octahydroazuleno[5,4-d]furan-2-one 477-43-0 ≥98% 230.3 C15H18O2 C=C1CCC2C(C3C1CCC3=C)OC(=O)C2=C Ambient -20°C "Wang X, Zhang YF, Yu B, et al. Dehydrocostuslactone, a sesquiterpene lactone activates wild-type and ΔF508 mutant CFTR chloride channel. J Asian Nat Prod Res. 2013;15(8):855-66. PMID: 23799322.

Lohberger B, Rinner B, Stuendl N, et al. Sesquiterpene lactones downregulate G2/M cell cycle regulator proteins and affect the invasive potential of human soft tissue sarcoma cells. PLoS One. 2013 Jun 14;8(6):e66300. PMID: 23799090.

Wang CY, Tsai AC, Peng CY, et al. Dehydrocostuslactone suppresses angiogenesis in vitro and in vivo through inhibition of Akt/GSK-3β and mTOR signaling pathways. PLoS One. 2012;7(2):e31195. PMID: 22359572.

Seo MS, Choi EM. The effects of dehydrocostus lactone on osteoblastic MC3T3-E1 cells in redox changes and PI3K/Akt/CREB. Immunopharmacol Immunotoxicol. 2012 Oct;34(5):810-4. PMID: 22324303.

Choi EM. Dehydrocostus lactone prevents mitochondrial dysfunction in osteoblastic MC3T3-E1 cells. Eur J Pharmacol. 2011 Aug 16;664(1-3):1-7. PMID: 21596031.

Luna-Herrera J, Costa MC, González HG, et al. Synergistic antimycobacterial activities of sesquiterpene lactones from Laurus spp. J Antimicrob Chemother. 2007 Mar;59(3):548-52. PMID: 17218447.

Lee HJ, Kim NY, Jang MK, et al. A sesquiterpene, dehydrocostus lactone, inhibits the expression of inducible nitric oxide synthase and TNF-alpha in LPS-activated macrophages. Planta Med. 1999 Mar;65(2):104-8. PMID: 10193198.

" Not dangerous goods.

LKT D1627 Dehydrocostus Lactone 10 mg 115.5 Sesquiterpene lactone found in Saussurea. (3aS,6aR,9aR,9bS)-3,6,9-trimethylidene-3a,4,5,6a,7,8,9a,9b-octahydroazuleno[5,4-d]furan-2-one 477-43-0 ≥98% 230.3 C15H18O2 C=C1CCC2C(C3C1CCC3=C)OC(=O)C2=C Ambient -20°C "Wang X, Zhang YF, Yu B, et al. Dehydrocostuslactone, a sesquiterpene lactone activates wild-type and ΔF508 mutant CFTR chloride channel. J Asian Nat Prod Res. 2013;15(8):855-66. PMID: 23799322.

Seo MS, Choi EM. The effects of dehydrocostus lactone on osteoblastic MC3T3-E1 cells in redox changes and PI3K/Akt/CREB. Immunopharmacol Immunotoxicol. 2012 Oct;34(5):810-4. PMID: 22324303.

Choi EM. Dehydrocostus lactone prevents mitochondrial dysfunction in osteoblastic MC3T3-E1 cells. Eur J Pharmacol. 2011 Aug 16;664(1-3):1-7. PMID: 21596031.

Luna-Herrera J, Costa MC, González HG, et al. Synergistic antimycobacterial activities of sesquiterpene lactones from Laurus spp. J Antimicrob Chemother. 2007 Mar;59(3):548-52. PMID: 17218447.

" Not dangerous goods.

LKT D1627 Dehydrocostus Lactone 25 mg 258.2 Sesquiterpene lactone found in Saussurea. (3aS,6aR,9aR,9bS)-3,6,9-trimethylidene-3a,4,5,6a,7,8,9a,9b-octahydroazuleno[5,4-d]furan-2-one 477-43-0 ≥98% 230.3 C15H18O2 C=C1CCC2C(C3C1CCC3=C)OC(=O)C2=C Ambient -20°C "Wang X, Zhang YF, Yu B, et al. Dehydrocostuslactone, a sesquiterpene lactone activates wild-type and ΔF508 mutant CFTR chloride channel. J Asian Nat Prod Res. 2013;15(8):855-66. PMID: 23799322.

Seo MS, Choi EM. The effects of dehydrocostus lactone on osteoblastic MC3T3-E1 cells in redox changes and PI3K/Akt/CREB. Immunopharmacol Immunotoxicol. 2012 Oct;34(5):810-4. PMID: 22324303.

Choi EM. Dehydrocostus lactone prevents mitochondrial dysfunction in osteoblastic MC3T3-E1 cells. Eur J Pharmacol. 2011 Aug 16;664(1-3):1-7. PMID: 21596031.

Luna-Herrera J, Costa MC, González HG, et al. Synergistic antimycobacterial activities of sesquiterpene lactones from Laurus spp. J Antimicrob Chemother. 2007 Mar;59(3):548-52. PMID: 17218447.

" Not dangerous goods.

LKT D1628 5,6-Dehydrokawain 5 mg 186.6 Kavalactone originally found in Piper methysticum (kava plant). 1952-41-6 ≥98% 228.25 C14H12O3 COC1=CC(=O)OC(=C1)C=CC2=CC=CC=C2 Ambient -20°C "Rao YK, Shih HN, Lee YC, et al. Purification of kavalactones from Alpinia zerumbet and their protective actions against hydrogen peroxide-induced cytotoxicity in PC12 cells. J Biosci Bioeng. 2014 Jun 11. [Epub ahead of print]. PMID: 24929995.

Teng CM, Hsu SY, Lin CH, et al. Antiplatelet action of dehydrokawain derivatives isolated from Alpinia speciosa rhizoma. Chin J Physiol. 1990;33(1):41-8. PMID: 2376215.

" Not dangerous goods.

LKT D1628 5,6-Dehydrokawain 10 mg 288.3 Kavalactone originally found in Piper methysticum (kava plant). 1952-41-6 ≥98% 228.25 C14H12O3 COC1=CC(=O)OC(=C1)C=CC2=CC=CC=C2 Ambient -20°C "Rao YK, Shih HN, Lee YC, et al. Purification of kavalactones from Alpinia zerumbet and their protective actions against hydrogen peroxide-induced cytotoxicity in PC12 cells. J Biosci Bioeng. 2014 Jun 11. [Epub ahead of print]. PMID: 24929995.

Teng CM, Hsu SY, Lin CH, et al. Antiplatelet action of dehydrokawain derivatives isolated from Alpinia speciosa rhizoma. Chin J Physiol. 1990;33(1):41-8. PMID: 2376215.

" Not dangerous goods.

LKT D1643 Delta Sleep Inducing Peptide 1 mg 60 Peptide; GABA potentiator, NMDA negative allosteric modulator. 62568-57-4 ≥95% 848.83 C35H48N10O15 CC(C(=O)NCC(=O)NCC(=O)NC(CC(=O)O)C(=O)NC(C)C(=O)NC(CO)C(=O)NCC(=O)NC(CCC(=O)O)C(=O)O)NC(=O)C(CC1=CNC2=CC=CC=C21)N Ambient -20°C "Bondarenko TI, Sorokina IA, Mayboroda EA, et al. Effect of delta sleep-inducing peptide on oxidative modification of proteins in rat tissues and blood during physiological aging. Bull Exp Biol Med. 2012 Jul;153(3):371-4. PMID: 22866315.

Nurbakov AA, Mikhaleva II, Sapozhnikov AM. Effect of delta-sleep-inducing peptide on expression of heat shock protein 70 kDa in K562 cells. Bull Exp Biol Med. 2009 Jan;147(1):39-41. PMID: 19526126.

Grigor'ev VV, Ivanova TA, Kustova EA, et al. Effects of delta sleep-inducing peptide on pre- and postsynaptic glutamate and postsynaptic GABA receptors in neurons of the cortex, hippocampus, and cerebellum in rats. Bull Exp Biol Med. 2006 Aug;142(2):186-8. PMID: 17369935.

Stanojlovi? OP, Zivanovi? DP, Mirkovi? SD, et al. Antiepileptic activity of delta sleep-inducing peptide and its analogue in metaphit-provoked seizures in rats. Seizure. 2005 Jun;14(4):240-7. PMID: 15911358.

" Not dangerous goods.

LKT D1643 Delta Sleep Inducing Peptide 2 mg 101.9 Peptide; GABA potentiator, NMDA negative allosteric modulator. 62568-57-4 ≥95% 848.83 C35H48N10O15 CC(C(=O)NCC(=O)NCC(=O)NC(CC(=O)O)C(=O)NC(C)C(=O)NC(CO)C(=O)NCC(=O)NC(CCC(=O)O)C(=O)O)NC(=O)C(CC1=CNC2=CC=CC=C21)N Ambient -20°C "Bondarenko TI, Sorokina IA, Mayboroda EA, et al. Effect of delta sleep-inducing peptide on oxidative modification of proteins in rat tissues and blood during physiological aging. Bull Exp Biol Med. 2012 Jul;153(3):371-4. PMID: 22866315.

Nurbakov AA, Mikhaleva II, Sapozhnikov AM. Effect of delta-sleep-inducing peptide on expression of heat shock protein 70 kDa in K562 cells. Bull Exp Biol Med. 2009 Jan;147(1):39-41. PMID: 19526126.

" Not dangerous goods.

LKT D1643 Delta Sleep Inducing Peptide 5 mg 180 Peptide; GABA potentiator, NMDA negative allosteric modulator. 62568-57-4 ≥95% 848.83 C35H48N10O15 CC(C(=O)NCC(=O)NCC(=O)NC(CC(=O)O)C(=O)NC(C)C(=O)NC(CO)C(=O)NCC(=O)NC(CCC(=O)O)C(=O)O)NC(=O)C(CC1=CNC2=CC=CC=C21)N Ambient -20°C "Bondarenko TI, Sorokina IA, Mayboroda EA, et al. Effect of delta sleep-inducing peptide on oxidative modification of proteins in rat tissues and blood during physiological aging. Bull Exp Biol Med. 2012 Jul;153(3):371-4. PMID: 22866315.

Nurbakov AA, Mikhaleva II, Sapozhnikov AM. Effect of delta-sleep-inducing peptide on expression of heat shock protein 70 kDa in K562 cells. Bull Exp Biol Med. 2009 Jan;147(1):39-41. PMID: 19526126.

" Not dangerous goods.

LKT D1644 Deltorphin I 5 mg 228 Opioid peptide; δOR agonist. "Glycinamide,L-tyrosyl-D-alanyl-L-phenylalanyl-L-alpha-aspartyl-L-valyl-L-valyl-

" Deltorphin C; Deltophin 1; Deltorphin I, ala(2)- 122752-15-2 ≥98% 768.87 C37H52N8O10 CC(C)C(C(=O)NC(C(C)C)C(=O)NCC(=O)N)NC(=O)C(CC(=O)O)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(C)NC(=O)C(CC2=CC=C(C=C2)O)N Ambient -20°C "Dai X, Song HJ, Cui SG, et al. The stimulative effects of endogenous opioids on endothelial cell proliferation, migration and angiogenesis in vitro. Eur J Pharmacol. 2010 Feb 25;628(1-3):42-50. PMID: 19932695.

Li SR, Wang T, Wang R, et al. Melatonin enhances antinociceptive effects of delta-, but not mu-opioid agonist in mice. Brain Res. 2005 May 10;1043(1-2):132-8. PMID: 15862526.

" Not dangerous goods.

LKT D1644 Deltorphin I 10 mg 387 Opioid peptide; δOR agonist. "Glycinamide,L-tyrosyl-D-alanyl-L-phenylalanyl-L-alpha-aspartyl-L-valyl-L-valyl-

Li SR, Wang T, Wang R, et al. Melatonin enhances antinociceptive effects of delta-, but not mu-opioid agonist in mice. Brain Res. 2005 May 10;1043(1-2):132-8. PMID: 15862526.

" Not dangerous goods.

LKT D1644 Deltorphin I 25 mg 684.1 Opioid peptide; δOR agonist. "Glycinamide,L-tyrosyl-D-alanyl-L-phenylalanyl-L-alpha-aspartyl-L-valyl-L-valyl-

Li SR, Wang T, Wang R, et al. Melatonin enhances antinociceptive effects of delta-, but not mu-opioid agonist in mice. Brain Res. 2005 May 10;1043(1-2):132-8. PMID: 15862526.

" Not dangerous goods.

LKT D1694 Dexamethasone Acetate Monohydrate 100 mg 54.4 Steroid; glucocorticoid agonist. (11β, 16α)-9-Fluoro-11,17,21-trihydroxy-16- methylpregna-1,4-diene-3,20-dione 21-acetate Dexamethasone 21-Acetate; Decadronal; Dectancyl; Dexacortisyl 55812-90-3 ≥98% 452.52 C24H31FO6 H2O CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COC(=O)C)O)C)O)F)C.O Ambient 4°C "Bartneck M, Peters FM, Warzecha KT, et al. Liposomal encapsulation of dexamethasone modulates cytotoxicity, inflammatory cytokine response, and migratory properties of primary human macrophages. Nanomedicine. 2014 Mar 7. [Epub ahead of print]. PMID: 24607939.

Ni Z, Tang J, Cai Z, et al. A new pathway of glucocorticoid action for asthma treatment through the regulation of PTEN expression. Respir Res. 2011 Apr 14;12:47. PMID: 21489309.

Morgan G. Future drug developments in multiple myeloma: an overview of novel lenalidomide-based combination therapies. Blood Rev. 2010 Nov;24 Suppl 1:S27-32. PMID: 21126634.

" Not dangerous goods.

LKT D1694 Dexamethasone Acetate Monohydrate 500 mg 149.5 Steroid; glucocorticoid agonist. (11β, 16α)-9-Fluoro-11,17,21-trihydroxy-16- methylpregna-1,4-diene-3,20-dione 21-acetate Dexamethasone 21-Acetate; Decadronal; Dectancyl; Dexacortisyl 55812-90-3 ≥98% 452.52 C24H31FO6 H2O CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COC(=O)C)O)C)O)F)C.O Ambient 4°C "Bartneck M, Peters FM, Warzecha KT, et al. Liposomal encapsulation of dexamethasone modulates cytotoxicity, inflammatory cytokine response, and migratory properties of primary human macrophages. Nanomedicine. 2014 Mar 7. [Epub ahead of print]. PMID: 24607939.

Ni Z, Tang J, Cai Z, et al. A new pathway of glucocorticoid action for asthma treatment through the regulation of PTEN expression. Respir Res. 2011 Apr 14;12:47. PMID: 21489309.

Morgan G. Future drug developments in multiple myeloma: an overview of novel lenalidomide-based combination therapies. Blood Rev. 2010 Nov;24 Suppl 1:S27-32. PMID: 21126634.

" Not dangerous goods.

LKT D1694 Dexamethasone Acetate Monohydrate 1 g 265 Steroid; glucocorticoid agonist. (11β, 16α)-9-Fluoro-11,17,21-trihydroxy-16- methylpregna-1,4-diene-3,20-dione 21-acetate Dexamethasone 21-Acetate; Decadronal; Dectancyl; Dexacortisyl 55812-90-3 ≥98% 452.52 C24H31FO6 H2O CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COC(=O)C)O)C)O)F)C.O Ambient 4°C "Bartneck M, Peters FM, Warzecha KT, et al. Liposomal encapsulation of dexamethasone modulates cytotoxicity, inflammatory cytokine response, and migratory properties of primary human macrophages. Nanomedicine. 2014 Mar 7. [Epub ahead of print]. PMID: 24607939.

Ni Z, Tang J, Cai Z, et al. A new pathway of glucocorticoid action for asthma treatment through the regulation of PTEN expression. Respir Res. 2011 Apr 14;12:47. PMID: 21489309.

Morgan G. Future drug developments in multiple myeloma: an overview of novel lenalidomide-based combination therapies. Blood Rev. 2010 Nov;24 Suppl 1:S27-32. PMID: 21126634.

" Not dangerous goods.

LKT D1695 Dexamethasone Phosphate Sodium 100 mg 54.4 Steroid; glucocorticoid agonist. (11β, 16α)-9-Fluoro-11,17,21-trihydroxy-16- methylpregna-1,4-diene-3,20-dione 21-phosphate disodium salt Dexamethasone 21-Phosphate Disodium Salt; Ak-Dex; Baldex; Dalalone; Dezone; Hexadrol; Oradexon; Soldesam 2392-39-4 ≥97% 516.4 C22H28FO8PNa2 CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COP(=O)([O-])[O-])O)C)O)F)C.[Na+].[Na+] Ambient 4°C Soluble in water (500 mg/mL). "Bartneck M, Peters FM, Warzecha KT, et al. Liposomal encapsulation of dexamethasone modulates cytotoxicity, inflammatory cytokine response, and migratory properties of primary human macrophages. Nanomedicine. 2014 Mar 7. [Epub ahead of print]. PMID: 24607939.

Ni Z, Tang J, Cai Z, et al. A new pathway of glucocorticoid action for asthma treatment through the regulation of PTEN expression. Respir Res. 2011 Apr 14;12:47. PMID: 21489309.

Morgan G. Future drug developments in multiple myeloma: an overview of novel lenalidomide-based combination therapies. Blood Rev. 2010 Nov;24 Suppl 1:S27-32. PMID: 21126634.

" Carc., Repr., Xn Not dangerous goods.

LKT D1695 Dexamethasone Phosphate Sodium 500 mg 169.9 Steroid; glucocorticoid agonist. (11β, 16α)-9-Fluoro-11,17,21-trihydroxy-16- methylpregna-1,4-diene-3,20-dione 21-phosphate disodium salt Dexamethasone 21-Phosphate Disodium Salt; Ak-Dex; Baldex; Dalalone; Dezone; Hexadrol; Oradexon; Soldesam 2392-39-4 ≥97% 516.4 C22H28FO8PNa2 CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COP(=O)([O-])[O-])O)C)O)F)C.[Na+].[Na+] Ambient 4°C Soluble in water (500 mg/mL). "Bartneck M, Peters FM, Warzecha KT, et al. Liposomal encapsulation of dexamethasone modulates cytotoxicity, inflammatory cytokine response, and migratory properties of primary human macrophages. Nanomedicine. 2014 Mar 7. [Epub ahead of print]. PMID: 24607939.

Ni Z, Tang J, Cai Z, et al. A new pathway of glucocorticoid action for asthma treatment through the regulation of PTEN expression. Respir Res. 2011 Apr 14;12:47. PMID: 21489309.

Morgan G. Future drug developments in multiple myeloma: an overview of novel lenalidomide-based combination therapies. Blood Rev. 2010 Nov;24 Suppl 1:S27-32. PMID: 21126634.

" Carc., Repr., Xn Not dangerous goods.

LKT D1695 Dexamethasone Phosphate Sodium 1 g 285.4 Steroid; glucocorticoid agonist. (11β, 16α)-9-Fluoro-11,17,21-trihydroxy-16- methylpregna-1,4-diene-3,20-dione 21-phosphate disodium salt Dexamethasone 21-Phosphate Disodium Salt; Ak-Dex; Baldex; Dalalone; Dezone; Hexadrol; Oradexon; Soldesam 2392-39-4 ≥97% 516.4 C22H28FO8PNa2 CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COP(=O)([O-])[O-])O)C)O)F)C.[Na+].[Na+] Ambient 4°C Soluble in water (500 mg/mL). "Bartneck M, Peters FM, Warzecha KT, et al. Liposomal encapsulation of dexamethasone modulates cytotoxicity, inflammatory cytokine response, and migratory properties of primary human macrophages. Nanomedicine. 2014 Mar 7. [Epub ahead of print]. PMID: 24607939.

Ni Z, Tang J, Cai Z, et al. A new pathway of glucocorticoid action for asthma treatment through the regulation of PTEN expression. Respir Res. 2011 Apr 14;12:47. PMID: 21489309.

Morgan G. Future drug developments in multiple myeloma: an overview of novel lenalidomide-based combination therapies. Blood Rev. 2010 Nov;24 Suppl 1:S27-32. PMID: 21126634.

" Carc., Repr., Xn Not dangerous goods.

LKT D1748 Demeclocycline Hydrochloride 100 mg 46 Tetracycline; protein translation inhibitor, potential calpain inhibitor. [4S-(4α,4aα,5aα,6β,12aα)]-7-Chloro-4-(dimethyl- amino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a- pentahydroxy-1,11,-dioxo-2-naphthacenecarboxamide hydrochloride Clortetrin; Demetraciclina; Detravis; Mexocine 64-73-3 ≥85% 501.3 C21H21ClN2O8 HCl CN(C)C1C2CC3C(C4=C(C=CC(=C4C(=C3C(=O)C2(C(=C(C1=O)C(=O)N)O)O)O)O)Cl)O.Cl Ambient 4°C Soluble in water (16 mg/mL), methanol (20 mg/mL). "Kortenoeven ML, Sinke AP, Hadrup N, et al. Demeclocycline attenuates hyponatremia by reducing aquaporin-2 expression in the renal inner medulla. Am J Physiol Renal Physiol. 2013 Dec 15;305(12):F1705-18. PMID: 24154696.

" Xi Not dangerous goods.

LKT D1748 Demeclocycline Hydrochloride 250 mg 68.8 Tetracycline; protein translation inhibitor, potential calpain inhibitor. [4S-(4α,4aα,5aα,6β,12aα)]-7-Chloro-4-(dimethyl- amino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a- pentahydroxy-1,11,-dioxo-2-naphthacenecarboxamide hydrochloride Clortetrin; Demetraciclina; Detravis; Mexocine 64-73-3 ≥85% 501.3 C21H21ClN2O8 HCl CN(C)C1C2CC3C(C4=C(C=CC(=C4C(=C3C(=O)C2(C(=C(C1=O)C(=O)N)O)O)O)O)Cl)O.Cl Ambient 4°C Soluble in water (16 mg/mL), methanol (20 mg/mL). "Kortenoeven ML, Sinke AP, Hadrup N, et al. Demeclocycline attenuates hyponatremia by reducing aquaporin-2 expression in the renal inner medulla. Am J Physiol Renal Physiol. 2013 Dec 15;305(12):F1705-18. PMID: 24154696.

" Xi Not dangerous goods.

LKT D1748 Demeclocycline Hydrochloride 1 g 132.3 Tetracycline; protein translation inhibitor, potential calpain inhibitor. [4S-(4α,4aα,5aα,6β,12aα)]-7-Chloro-4-(dimethyl- amino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a- pentahydroxy-1,11,-dioxo-2-naphthacenecarboxamide hydrochloride Clortetrin; Demetraciclina; Detravis; Mexocine 64-73-3 ≥85% 501.3 C21H21ClN2O8 HCl CN(C)C1C2CC3C(C4=C(C=CC(=C4C(=C3C(=O)C2(C(=C(C1=O)C(=O)N)O)O)O)O)Cl)O.Cl Ambient 4°C Soluble in water (16 mg/mL), methanol (20 mg/mL). "Kortenoeven ML, Sinke AP, Hadrup N, et al. Demeclocycline attenuates hyponatremia by reducing aquaporin-2 expression in the renal inner medulla. Am J Physiol Renal Physiol. 2013 Dec 15;305(12):F1705-18. PMID: 24154696.

" Xi Not dangerous goods.

LKT D1749 Demecolcine 1 mg 57.2 Used to study embryonic cloning; microtubule polymerization inhibitor. 6,7-Dihydro-1,2,3,10-tetramethoxy-7-(methylamino)- benzo[a]heptalen-9(5H)-one N-methyl-N-desacetylcolchicine; Colcemid; Omaine 477-30-5 ≥97% 371.43 C21H25NO5 CNC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC Ambient 4°C Soluble in alcohol, ether, chloroform, benzene or acidified water. "Yang H, Ganguly A, Cabral F. Inhibition of cell migration and cell division correlates with distinct effects of microtubule inhibiting drugs. J Biol Chem. 2010 Oct 15;285(42):32242-50. PMID: 20696757.

Lan GC, Wu YG, Han D, et al. Demecolcine-assisted enucleation of goat oocytes: protocol optimization, mechanism investigation, and application to improve the developmental potential of cloned embryos. Cloning Stem Cells. 2008 Jun;10(2):189-202. PMID: 18373477.

" T "UN number: 2811 Class: 6.1 Packing group: III

Proper shipping name: Toxic solids, organic, n.o.s. (Demecolcine)

Marine pollutant: No Poison inhalation hazard: No."

LKT D1749 Demecolcine 5 mg 138.1 Used to study embryonic cloning; microtubule polymerization inhibitor. 6,7-Dihydro-1,2,3,10-tetramethoxy-7-(methylamino)- benzo[a]heptalen-9(5H)-one N-methyl-N-desacetylcolchicine; Colcemid; Omaine 477-30-5 ≥97% 371.43 C21H25NO5 CNC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC Ambient 4°C Soluble in alcohol, ether, chloroform, benzene or acidified water. "Yang H, Ganguly A, Cabral F. Inhibition of cell migration and cell division correlates with distinct effects of microtubule inhibiting drugs. J Biol Chem. 2010 Oct 15;285(42):32242-50. PMID: 20696757.

" T "UN number: 2811 Class: 6.1 Packing group: III

Proper shipping name: Toxic solids, organic, n.o.s. (Demecolcine)

Marine pollutant: No Poison inhalation hazard: No."

LKT D1749 Demecolcine 10 mg 245.9 Used to study embryonic cloning; microtubule polymerization inhibitor. 6,7-Dihydro-1,2,3,10-tetramethoxy-7-(methylamino)- benzo[a]heptalen-9(5H)-one N-methyl-N-desacetylcolchicine; Colcemid; Omaine 477-30-5 ≥97% 371.43 C21H25NO5 CNC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC Ambient 4°C Soluble in alcohol, ether, chloroform, benzene or acidified water. "Yang H, Ganguly A, Cabral F. Inhibition of cell migration and cell division correlates with distinct effects of microtubule inhibiting drugs. J Biol Chem. 2010 Oct 15;285(42):32242-50. PMID: 20696757.

" T "UN number: 2811 Class: 6.1 Packing group: III

Proper shipping name: Toxic solids, organic, n.o.s. (Demecolcine)

Marine pollutant: No Poison inhalation hazard: No."

LKT D1749 Demecolcine 50 mg 966.3 Used to study embryonic cloning; microtubule polymerization inhibitor. 6,7-Dihydro-1,2,3,10-tetramethoxy-7-(methylamino)- benzo[a]heptalen-9(5H)-one N-methyl-N-desacetylcolchicine; Colcemid; Omaine 477-30-5 ≥97% 371.43 C21H25NO5 CNC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC Ambient 4°C Soluble in alcohol, ether, chloroform, benzene or acidified water. "Yang H, Ganguly A, Cabral F. Inhibition of cell migration and cell division correlates with distinct effects of microtubule inhibiting drugs. J Biol Chem. 2010 Oct 15;285(42):32242-50. PMID: 20696757.

" T "UN number: 2811 Class: 6.1 Packing group: III

Proper shipping name: Toxic solids, organic, n.o.s. (Demecolcine)

Marine pollutant: No Poison inhalation hazard: No."

LKT D1759 Deoxynivalenol 1 mg 140.8 Trichothecene mycotoxin produced by Fusarium. Vomitoxin 51481-10-8 ≥98%, TLC 296.32 C15H20O6 CC1=CC2C(C(C1=O)O)(C3(CC(C(C34CO4)O2)O)C)CO Ambient 4°C Soluble in acetonitrile, methanol and ethyl acetate, slightly soluble in water. "Ovando-Martínez M, Ozsisli B, Anderson J, et al. Analysis of deoxynivalenol and deoxynivalenol-3-glucoside in hard red spring wheat inoculated with Fusarium graminearum. Toxins (Basel). 2013 Dec 17;5(12):2522-32. PMID: 24351715.

Nossol C, Diesing AK, Kahlert S, et al. Deoxynivalenol affects the composition of the basement membrane proteins and influences en route the migration of CD16(+) cells into the intestinal epithelium. Mycotoxin Res. 2013 Nov;29(4):245-54. PMID: 23949948.

He K, Zhou HR, Pestka JJ. Targets and intracellular signaling mechanisms for deoxynivalenol-induced ribosomal RNA cleavage. Toxicol Sci. 2012 Jun;127(2):382-90. PMID: 22491426.

Girardet C, Bonnet MS, Jdir R, et al. Central inflammation and sickness-like behavior induced by the food contaminant deoxynivalenol: a PGE2-independent mechanism. Toxicol Sci. 2011 Nov;124(1):179-91. PMID: 21873375.

" "UN number: 2811 Class: 6.1 Packing Group: II

Proper shipping name: Toxic solids, organic, n.o.s. (Deoxynivalenol)

Marine pollutant: No, Poison inhalation hazard: No"

LKT D1759 Deoxynivalenol 5 mg 567 Trichothecene mycotoxin produced by Fusarium. Vomitoxin 51481-10-8 ≥98%, TLC 296.32 C15H20O6 CC1=CC2C(C(C1=O)O)(C3(CC(C(C34CO4)O2)O)C)CO Ambient 4°C Soluble in acetonitrile, methanol and ethyl acetate, slightly soluble in water. "Ovando-Martínez M, Ozsisli B, Anderson J, et al. Analysis of deoxynivalenol and deoxynivalenol-3-glucoside in hard red spring wheat inoculated with Fusarium graminearum. Toxins (Basel). 2013 Dec 17;5(12):2522-32. PMID: 24351715.

He K, Zhou HR, Pestka JJ. Targets and intracellular signaling mechanisms for deoxynivalenol-induced ribosomal RNA cleavage. Toxicol Sci. 2012 Jun;127(2):382-90. PMID: 22491426.

" "UN number: 2811 Class: 6.1 Packing Group: II

Proper shipping name: Toxic solids, organic, n.o.s. (Deoxynivalenol)

Marine pollutant: No, Poison inhalation hazard: No"

LKT D1767 Dermenkephalin 1 mg 60 Exogenous peptide; δOR-2 agonist. ≥95% 955.17 C44H62N10O10S2 CC(C)CC(C(=O)NC(CCSC)C(=O)NC(CC(=O)O)C(=O)N)NC(=O)C(CC1=CN=CN1)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CCSC)NC(=O)C(CC3=CC=C(C=C3)O)N Ambient -20°C "Mitchell JM, Margolis EB, Coker AR, et al. Intra-VTA deltorphin, but not DPDPE, induces place preference in ethanol-drinking rats: distinct DOR-1 and DOR-2 mechanisms control ethanol consumption and reward. Alcohol Clin Exp Res. 2014 Jan;38(1):195-203. PMID: 24033469.

Fraser GL, Parenteau H, Tu TM, et al. The effects of delta agonists on locomotor activity in habituated and non-habituated rats. Life Sci. 2000 Jul 14;67(8):913-22. PMID: 10946851.

Harasawa I, Fields HL, Meng ID. Delta opioid receptor mediated actions in the rostral ventromedial medulla on tail flick latency and nociceptive modulatory neurons. Pain. 2000 Mar;85(1-2):255-62. PMID: 10692626.

" Not dangerous goods.

LKT D1767 Dermenkephalin 2 mg 101.9 Exogenous peptide; δOR-2 agonist. ≥95% 955.17 C44H62N10O10S2 CC(C)CC(C(=O)NC(CCSC)C(=O)NC(CC(=O)O)C(=O)N)NC(=O)C(CC1=CN=CN1)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CCSC)NC(=O)C(CC3=CC=C(C=C3)O)N Ambient -20°C "Mitchell JM, Margolis EB, Coker AR, et al. Intra-VTA deltorphin, but not DPDPE, induces place preference in ethanol-drinking rats: distinct DOR-1 and DOR-2 mechanisms control ethanol consumption and reward. Alcohol Clin Exp Res. 2014 Jan;38(1):195-203. PMID: 24033469.

Fraser GL, Parenteau H, Tu TM, et al. The effects of delta agonists on locomotor activity in habituated and non-habituated rats. Life Sci. 2000 Jul 14;67(8):913-22. PMID: 10946851.

" Not dangerous goods.

LKT D1767 Dermenkephalin 5 mg 180 Exogenous peptide; δOR-2 agonist. ≥95% 955.17 C44H62N10O10S2 CC(C)CC(C(=O)NC(CCSC)C(=O)NC(CC(=O)O)C(=O)N)NC(=O)C(CC1=CN=CN1)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CCSC)NC(=O)C(CC3=CC=C(C=C3)O)N Ambient -20°C "Mitchell JM, Margolis EB, Coker AR, et al. Intra-VTA deltorphin, but not DPDPE, induces place preference in ethanol-drinking rats: distinct DOR-1 and DOR-2 mechanisms control ethanol consumption and reward. Alcohol Clin Exp Res. 2014 Jan;38(1):195-203. PMID: 24033469.

Fraser GL, Parenteau H, Tu TM, et al. The effects of delta agonists on locomotor activity in habituated and non-habituated rats. Life Sci. 2000 Jul 14;67(8):913-22. PMID: 10946851.

" Not dangerous goods.

LKT D1768 Dermaseptin I 0.5 mg 204.1 Cationic antimicrobial peptide, alters bacterial membrane permeability. Ala-Leu-Trp-Lys-Thr-Met-Leu-Lys-Lys-Leu-Gly-Thr-Met-Ala-Leu-His-Ala-Gly-Lys-Ala-Ala-Leu-Gly-Ala-Ala-Ala-Asp-Thr-Ile-Ser-Gln-Gly-Thr-Gln ≥96% 3455.08 C152H257N43O44S2 CCC(C)C(C(=O)NC(CO)C(=O)NC(CCC(=O)N)C(=O)NCC(=O)NC(C(C)O)C(=O)NC(CCC(=O)N)C(=O)O)NC(=O)C(C(C)O)NC(=O)C(CC(=O)O)NC(=O)C(C)NC(=O)C(C)NC(=O)C(C)NC(=O)CNC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CCCCN)NC(=O)CNC(=O)C(C)NC(=O)C(CC1=CN=CN1)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCSC)NC(=O)C(C(C)O)NC(=O)CNC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(CC(C)C)NC(=O)C(CCSC)NC(=O)C(C(C)O)NC(=O)C(CCCCN)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)C(CC(C)C)NC(=O)C(C)N Ambient -20°C "Jiang Z, Vasil AI, Vasil ML, et al. ""Specificity Determinants"" Improve Therapeutic Indices of Two Antimicrobial Peptides Piscidin 1 and Dermaseptin S4 Against the Gram-negative Pathogens Acinetobacter baumannii and Pseudomonas aeruginosa. Pharmaceuticals (Basel). 2014 Mar 25;7(4):366-91. PMID: 24670666.

Caillon L, Killian JA, Lequin O, et al. Biophysical investigation of the membrane-disrupting mechanism of the antimicrobial and amyloid-like peptide dermaseptin S9. PLoS One. 2013 Oct 11;8(10):e75528. PMID: 24146759.

van Zoggel H, Carpentier G, Dos Santos C, et al. Antitumor and angiostatic activities of the antimicrobial peptide dermaseptin B2. PLoS One. 2012;7(9):e44351. PMID: 23028527.

" Not dangerous goods.

LKT D1768 Dermaseptin I 1 mg 348 Cationic antimicrobial peptide, alters bacterial membrane permeability. Ala-Leu-Trp-Lys-Thr-Met-Leu-Lys-Lys-Leu-Gly-Thr-Met-Ala-Leu-His-Ala-Gly-Lys-Ala-Ala-Leu-Gly-Ala-Ala-Ala-Asp-Thr-Ile-Ser-Gln-Gly-Thr-Gln ≥96% 3455.08 C152H257N43O44S2 CCC(C)C(C(=O)NC(CO)C(=O)NC(CCC(=O)N)C(=O)NCC(=O)NC(C(C)O)C(=O)NC(CCC(=O)N)C(=O)O)NC(=O)C(C(C)O)NC(=O)C(CC(=O)O)NC(=O)C(C)NC(=O)C(C)NC(=O)C(C)NC(=O)CNC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CCCCN)NC(=O)CNC(=O)C(C)NC(=O)C(CC1=CN=CN1)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCSC)NC(=O)C(C(C)O)NC(=O)CNC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(CC(C)C)NC(=O)C(CCSC)NC(=O)C(C(C)O)NC(=O)C(CCCCN)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)C(CC(C)C)NC(=O)C(C)N Ambient -20°C "Jiang Z, Vasil AI, Vasil ML, et al. ""Specificity Determinants"" Improve Therapeutic Indices of Two Antimicrobial Peptides Piscidin 1 and Dermaseptin S4 Against the Gram-negative Pathogens Acinetobacter baumannii and Pseudomonas aeruginosa. Pharmaceuticals (Basel). 2014 Mar 25;7(4):366-91. PMID: 24670666.

van Zoggel H, Carpentier G, Dos Santos C, et al. Antitumor and angiostatic activities of the antimicrobial peptide dermaseptin B2. PLoS One. 2012;7(9):e44351. PMID: 23028527.

" Not dangerous goods.

LKT D1768 Dermaseptin I 2.5 mg 612.4 Cationic antimicrobial peptide, alters bacterial membrane permeability. Ala-Leu-Trp-Lys-Thr-Met-Leu-Lys-Lys-Leu-Gly-Thr-Met-Ala-Leu-His-Ala-Gly-Lys-Ala-Ala-Leu-Gly-Ala-Ala-Ala-Asp-Thr-Ile-Ser-Gln-Gly-Thr-Gln ≥96% 3455.08 C152H257N43O44S2 CCC(C)C(C(=O)NC(CO)C(=O)NC(CCC(=O)N)C(=O)NCC(=O)NC(C(C)O)C(=O)NC(CCC(=O)N)C(=O)O)NC(=O)C(C(C)O)NC(=O)C(CC(=O)O)NC(=O)C(C)NC(=O)C(C)NC(=O)C(C)NC(=O)CNC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CCCCN)NC(=O)CNC(=O)C(C)NC(=O)C(CC1=CN=CN1)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCSC)NC(=O)C(C(C)O)NC(=O)CNC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(CC(C)C)NC(=O)C(CCSC)NC(=O)C(C(C)O)NC(=O)C(CCCCN)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)C(CC(C)C)NC(=O)C(C)N Ambient -20°C "Jiang Z, Vasil AI, Vasil ML, et al. ""Specificity Determinants"" Improve Therapeutic Indices of Two Antimicrobial Peptides Piscidin 1 and Dermaseptin S4 Against the Gram-negative Pathogens Acinetobacter baumannii and Pseudomonas aeruginosa. Pharmaceuticals (Basel). 2014 Mar 25;7(4):366-91. PMID: 24670666.

van Zoggel H, Carpentier G, Dos Santos C, et al. Antitumor and angiostatic activities of the antimicrobial peptide dermaseptin B2. PLoS One. 2012;7(9):e44351. PMID: 23028527.

" Not dangerous goods.

LKT D1769 Dermorphin 1 mg 228 Opioid peptide; μOR agonist. "Tyrosyl-alanyl-phenylalanyl-glycyl-tyrosyl-prolyl-serinamide

" 77614-16-5 ≥96% 802.88 C40H50N8O10 CC(C(=O)NC(CC1=CC=CC=C1)C(=O)NCC(=O)NC(CC2=CC=C(C=C2)O)C(=O)N3CCCC3C(=O)NC(CO)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)O)N Store in a cool, dry place. Ambient -20°C "Mizoguchi H, Bagetta G, Sakurada T, et al. Dermorphin tetrapeptide analogs as potent and long-lasting analgesics with pharmacological profiles distinct from morphine. Peptides. 2011 Feb;32(2):421-7. PMID: 21126548.

Guzevatykh LS, Voronina TA, Emel'ianova TG, et al. Comparative analysis of analgesic activities of dermorphin, [DPro6]-dermorphin, and their C-terminal tripeptides. Izv Akad Nauk Ser Biol. 2007 Sep-Oct;(5):577-82. PMID: 18038625.

" Not dangerous goods.

LKT D1769 Dermorphin 2 mg 387 Opioid peptide; μOR agonist. "Tyrosyl-alanyl-phenylalanyl-glycyl-tyrosyl-prolyl-serinamide

" Not dangerous goods.

LKT D1769 Dermorphin 5 mg 684.1 Opioid peptide; μOR agonist. "Tyrosyl-alanyl-phenylalanyl-glycyl-tyrosyl-prolyl-serinamide

" Not dangerous goods.

LKT D1770 Dermorphin Analog 5 mg 60 Synthetic peptide; dermorphin analog; δOR and μOR agonist. ≥95% 902.03 C44H59N11O10 Ambient -20°C "Vonhof S, Barone FC, Price WJ, et al. Receptor binding and biological activity of the dermorphin analog Tyr-D-Arg(2)-Phe-Sar (TAPS). Eur J Pharmacol. 2001 Mar 23;416(1-2):83-93. PMID: 11282116.

Ukai M, Kobayashi T, Mori K, et al. Attenuation of memory with Tyr-D-Arg-Phe-beta-Ala-NH2, a novel dermorphin analog with high affinity for mu-opioid receptors. Eur J Pharmacol. 1995 Dec 20;287(3):245-9. PMID: 8991797.

Paakkari P, Paakkari I, Vonhof S, et al. Dermorphin analog Tyr-D-Arg2-Phe-sarcosine-induced opioid analgesia and respiratory stimulation: the role of mu 1-receptors? J Pharmacol Exp Ther. 1993 Aug;266(2):544-50. PMID: 8394909.

LKT D1770 Dermorphin Analog 10 mg 101.9 Synthetic peptide; dermorphin analog; δOR and μOR agonist. ≥95% 902.03 C44H59N11O10 Ambient -20°C "Vonhof S, Barone FC, Price WJ, et al. Receptor binding and biological activity of the dermorphin analog Tyr-D-Arg(2)-Phe-Sar (TAPS). Eur J Pharmacol. 2001 Mar 23;416(1-2):83-93. PMID: 11282116.

LKT D1770 Dermorphin Analog 25 mg 180 Synthetic peptide; dermorphin analog; δOR and μOR agonist. ≥95% 902.03 C44H59N11O10 Ambient -20°C "Vonhof S, Barone FC, Price WJ, et al. Receptor binding and biological activity of the dermorphin analog Tyr-D-Arg(2)-Phe-Sar (TAPS). Eur J Pharmacol. 2001 Mar 23;416(1-2):83-93. PMID: 11282116.

LKT D1774 Desloratadine 100 mg 88.3 Loratadine metabolite; FIASMA, histamine H1 antagonist. 8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H- benzo[5,6]cyclohepta[1,2,b]pyridine Clarinex 100643-71-8 ≥97% 310.82 C19H19ClN2 C1CC2=C(C=CC(=C2)Cl)C(=C3CCNCC3)C4=C1C=CC=N4 Ambient 4°C Soluble in methanol and ethanol. "Doetkotte R, Opitz K, Kiianmaa K, et al. Reduction of voluntary ethanol consumption in alcohol-preferring Alko alcohol (AA) rats by desoxypeganine and galanthamine. Eur J Pharmacol. 2005 Oct 17;522(1-3):72-7. PMID: 16209867.

Glass DJ, Harper AS. Assessing satisfaction with desloratadine and fexofenadine in allergy patients who report dissatisfaction with loratadine. BMC Fam Pract. 2003 Aug 13;4:10. PMID: 12917016.

Walsh GM. Second-generation antihistamines in asthma therapy: is there a protective effect? Am J Respir Med. 2002;1(1):27-34. PMID: 14720073.

" Not dangerous goods.

LKT D1774 Desloratadine 500 mg 339.8 Loratadine metabolite; FIASMA, histamine H1 antagonist. 8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H- benzo[5,6]cyclohepta[1,2,b]pyridine Clarinex 100643-71-8 ≥97% 310.82 C19H19ClN2 C1CC2=C(C=CC(=C2)Cl)C(=C3CCNCC3)C4=C1C=CC=N4 Ambient 4°C Soluble in methanol and ethanol. "Doetkotte R, Opitz K, Kiianmaa K, et al. Reduction of voluntary ethanol consumption in alcohol-preferring Alko alcohol (AA) rats by desoxypeganine and galanthamine. Eur J Pharmacol. 2005 Oct 17;522(1-3):72-7. PMID: 16209867.

Glass DJ, Harper AS. Assessing satisfaction with desloratadine and fexofenadine in allergy patients who report dissatisfaction with loratadine. BMC Fam Pract. 2003 Aug 13;4:10. PMID: 12917016.

Walsh GM. Second-generation antihistamines in asthma therapy: is there a protective effect? Am J Respir Med. 2002;1(1):27-34. PMID: 14720073.

" Not dangerous goods.

LKT D1774 Desloratadine 1 g 543.6 Loratadine metabolite; FIASMA, histamine H1 antagonist. 8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H- benzo[5,6]cyclohepta[1,2,b]pyridine Clarinex 100643-71-8 ≥97% 310.82 C19H19ClN2 C1CC2=C(C=CC(=C2)Cl)C(=C3CCNCC3)C4=C1C=CC=N4 Ambient 4°C Soluble in methanol and ethanol. "Doetkotte R, Opitz K, Kiianmaa K, et al. Reduction of voluntary ethanol consumption in alcohol-preferring Alko alcohol (AA) rats by desoxypeganine and galanthamine. Eur J Pharmacol. 2005 Oct 17;522(1-3):72-7. PMID: 16209867.

Glass DJ, Harper AS. Assessing satisfaction with desloratadine and fexofenadine in allergy patients who report dissatisfaction with loratadine. BMC Fam Pract. 2003 Aug 13;4:10. PMID: 12917016.

Walsh GM. Second-generation antihistamines in asthma therapy: is there a protective effect? Am J Respir Med. 2002;1(1):27-34. PMID: 14720073.

" Not dangerous goods.

LKT D1776 Desmopressin 1 mg 149.9 Synthetic arginine derivative; V2R agonist. "1-(3-mercaptopropanoic acid)-8-D-arginine vasopressin

" Minirin; Desmospray; Adiuretin SD. 16679-58-6 ≥95% 1069.1 C46H64N14O12S2 C1CC(N(C1)C(=O)C2CSSCCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)C(=O)NC(CCCN=C(N)N)C(=O)NCC(=O)N Store in a cool, dry place. Ambient -20°C "Colucci G, Stutz M, Rochat S, et al. The effect of desmopressin on platelet function: a selective enhancement of procoagulant COAT-platelets in patients with primary platelet function defects. Blood. 2014 Jan 17. [Epub ahead of print]. PMID: 24443440.

Leissinger C, Carcao M, Gill JC, et al. Desmopressin (DDAVP) in the management of patients with congenital bleeding disorders. Haemophilia. 2014 Mar;20(2):158-67. PMID: 23937614.

Juul KV, Klein BM, Sandström R, et al. Gender difference in antidiuretic response to desmopressin. Am J Physiol Renal Physiol. 2011 May;300(5):F1116-22. PMID: 21367921.

Slusarz MJ, Slusarz R, Ciarkowski J. Investigation of mechanism of desmopressin binding in vasopressin V2 receptor versus vasopressin V1a and oxytocin receptors: molecular dynamics simulation of the agonist-bound state in the membrane-aqueous system. Biopolymers. 2006 Apr 5;81(5):321-38. PMID: 16333859.

" Not dangerous goods.

LKT D1776 Desmopressin 2 mg 255 Synthetic arginine derivative; V2R agonist. "1-(3-mercaptopropanoic acid)-8-D-arginine vasopressin

Leissinger C, Carcao M, Gill JC, et al. Desmopressin (DDAVP) in the management of patients with congenital bleeding disorders. Haemophilia. 2014 Mar;20(2):158-67. PMID: 23937614.

Juul KV, Klein BM, Sandström R, et al. Gender difference in antidiuretic response to desmopressin. Am J Physiol Renal Physiol. 2011 May;300(5):F1116-22. PMID: 21367921.

" Not dangerous goods.

LKT D1776 Desmopressin 5 mg 450 Synthetic arginine derivative; V2R agonist. "1-(3-mercaptopropanoic acid)-8-D-arginine vasopressin

Leissinger C, Carcao M, Gill JC, et al. Desmopressin (DDAVP) in the management of patients with congenital bleeding disorders. Haemophilia. 2014 Mar;20(2):158-67. PMID: 23937614.

Juul KV, Klein BM, Sandström R, et al. Gender difference in antidiuretic response to desmopressin. Am J Physiol Renal Physiol. 2011 May;300(5):F1116-22. PMID: 21367921.

" Not dangerous goods.

LKT D1777 Desmopressin Acetate 1 mg 149.9 Synthetic peptide, vasopressin derivative; V2 agonist. 16679-58-6 ≥95% 1069.24 C46H64N14O12S2 C1CC(N(C1)C(=O)C2CSSCCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)C(=O)NC(CCCN=C(N)N)C(=O)NCC(=O)N Store in a cool, dry place. Ambient -20°C "Colucci G, Stutz M, Rochat S, et al. The effect of desmopressin on platelet function: a selective enhancement of procoagulant COAT-platelets in patients with primary platelet function defects. Blood. 2014 Jan 17. [Epub ahead of print]. PMID: 24443440.

Leissinger C, Carcao M, Gill JC, et al. Desmopressin (DDAVP) in the management of patients with congenital bleeding disorders. Haemophilia. 2014 Mar;20(2):158-67. PMID: 23937614.

Juul KV, Klein BM, Sandström R, et al. Gender difference in antidiuretic response to desmopressin. Am J Physiol Renal Physiol. 2011 May;300(5):F1116-22. PMID: 21367921.

" Not dangerous goods.

LKT D1777 Desmopressin Acetate 2 mg 255 Synthetic peptide, vasopressin derivative; V2 agonist. 16679-58-6 ≥95% 1069.24 C46H64N14O12S2 C1CC(N(C1)C(=O)C2CSSCCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)C(=O)NC(CCCN=C(N)N)C(=O)NCC(=O)N Store in a cool, dry place. Ambient -20°C "Colucci G, Stutz M, Rochat S, et al. The effect of desmopressin on platelet function: a selective enhancement of procoagulant COAT-platelets in patients with primary platelet function defects. Blood. 2014 Jan 17. [Epub ahead of print]. PMID: 24443440.

Leissinger C, Carcao M, Gill JC, et al. Desmopressin (DDAVP) in the management of patients with congenital bleeding disorders. Haemophilia. 2014 Mar;20(2):158-67. PMID: 23937614.

Juul KV, Klein BM, Sandström R, et al. Gender difference in antidiuretic response to desmopressin. Am J Physiol Renal Physiol. 2011 May;300(5):F1116-22. PMID: 21367921.

" Not dangerous goods.

LKT D1777 Desmopressin Acetate 5 mg 450 Synthetic peptide, vasopressin derivative; V2 agonist. 16679-58-6 ≥95% 1069.24 C46H64N14O12S2 C1CC(N(C1)C(=O)C2CSSCCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)C(=O)NC(CCCN=C(N)N)C(=O)NCC(=O)N Store in a cool, dry place. Ambient -20°C "Colucci G, Stutz M, Rochat S, et al. The effect of desmopressin on platelet function: a selective enhancement of procoagulant COAT-platelets in patients with primary platelet function defects. Blood. 2014 Jan 17. [Epub ahead of print]. PMID: 24443440.

Leissinger C, Carcao M, Gill JC, et al. Desmopressin (DDAVP) in the management of patients with congenital bleeding disorders. Haemophilia. 2014 Mar;20(2):158-67. PMID: 23937614.

Juul KV, Klein BM, Sandström R, et al. Gender difference in antidiuretic response to desmopressin. Am J Physiol Renal Physiol. 2011 May;300(5):F1116-22. PMID: 21367921.

" Not dangerous goods.

LKT D1792 Dextromethorphan Hydrobromide Hydrate 5 g 59.2 σ1/2and μ/κ/δ-OR agonist, α3β4/α4β2/α7 nAChR, SERT, NET, NMDA antagonist. D-(+)-3-methoxy-17-methyl- (9α,13α,14α)- morphinan ( )-3-Methoxy-N-methylmorphinon; delta-Methorphan 6700-34-1 ≥98% 370.3 C18H25NO HBr H2O CN1CCC23CCCCC2C1CC4=C3C=C(C=C4)OC.O.Br Ambient Ambient Soluble in water (15 mg/mL). "Burns JM, Boyer EW. Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82. PMID: 24648790.

Wu K, Lin TH, Liou HC, et al. Dextromethorphan inhibits osteoclast differentiation by suppressing RANKL-induced nuclear factor-κB activation. Osteoporos Int. 2013 Aug;24(8):2201-14. PMID: 23400250.

Damaj MI, Flood P, Ho KK, et al. Effect of dextrometorphan and dextrorphan on nicotine and neuronal nicotinic receptors: in vitro and in vivo selectivity. J Pharmacol Exp Ther. 2005 Feb;312(2):780-5. PMID: 15356218.

Zhang W, Wang T, Qin L, et al. Neuroprotective effect of dextromethorphan in the MPTP Parkinson's disease model: role of NADPH oxidase. FASEB J. 2004 Mar;18(3):589-91. PMID: 14734632.

Chou YC, Liao JF, Chang WY, et al. Binding of dimemorfan to sigma-1 receptor and its anticonvulsant and locomotor effects in mice, compared with dextromethorphan and dextrorphan. Brain Res. 1999 Mar 13;821(2):516-9. PMID: 10064839.

" Not dangerous goods.

LKT D1792 Dextromethorphan Hydrobromide Hydrate 10 g 107.8 σ1/2and μ/κ/δ-OR agonist, α3β4/α4β2/α7 nAChR, SERT, NET, NMDA antagonist. D-(+)-3-methoxy-17-methyl- (9α,13α,14α)- morphinan ( )-3-Methoxy-N-methylmorphinon; delta-Methorphan 6700-34-1 ≥98% 370.3 C18H25NO HBr H2O CN1CCC23CCCCC2C1CC4=C3C=C(C=C4)OC.O.Br Ambient Ambient Soluble in water (15 mg/mL). "Burns JM, Boyer EW. Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82. PMID: 24648790.

Wu K, Lin TH, Liou HC, et al. Dextromethorphan inhibits osteoclast differentiation by suppressing RANKL-induced nuclear factor-κB activation. Osteoporos Int. 2013 Aug;24(8):2201-14. PMID: 23400250.

Zhang W, Wang T, Qin L, et al. Neuroprotective effect of dextromethorphan in the MPTP Parkinson's disease model: role of NADPH oxidase. FASEB J. 2004 Mar;18(3):589-91. PMID: 14734632.

" Not dangerous goods.

LKT D1792 Dextromethorphan Hydrobromide Hydrate 50 g 430.8 σ1/2and μ/κ/δ-OR agonist, α3β4/α4β2/α7 nAChR, SERT, NET, NMDA antagonist. D-(+)-3-methoxy-17-methyl- (9α,13α,14α)- morphinan ( )-3-Methoxy-N-methylmorphinon; delta-Methorphan 6700-34-1 ≥98% 370.3 C18H25NO HBr H2O CN1CCC23CCCCC2C1CC4=C3C=C(C=C4)OC.O.Br Ambient Ambient Soluble in water (15 mg/mL). "Burns JM, Boyer EW. Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82. PMID: 24648790.

Wu K, Lin TH, Liou HC, et al. Dextromethorphan inhibits osteoclast differentiation by suppressing RANKL-induced nuclear factor-κB activation. Osteoporos Int. 2013 Aug;24(8):2201-14. PMID: 23400250.

Zhang W, Wang T, Qin L, et al. Neuroprotective effect of dextromethorphan in the MPTP Parkinson's disease model: role of NADPH oxidase. FASEB J. 2004 Mar;18(3):589-91. PMID: 14734632.

" Not dangerous goods.

LKT D1849 4′-Demethylepipodophyllotoxin 500 mg 88.1 Podophyllotoxin derivative found in Podophyllum; topoisomerase II inhibitor. "Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5ah)-one,

5,8,8a,9-tetrahydro-9-hydroxy-5-(4-hydroxy-3,5-

dimethoxyphenyl)-, (5R-(5-alpha,5a-beta,8a-alpha,9-beta))-" 6559-91-7 ≥98% 400.38 C21H20O8 COC1=CC(=CC(=C1O)OC)C2C3C(COC3=O)C(C4=CC5=C(C=C24)OCO5)O Ambient -20°C "Xiao L, Zhao W, Li HM, et al. Design and synthesis of the novel DNA topoisomerase II inhibitors: esterification and amination substituted 4'-demethylepipodophyllotoxin derivates exhibiting anti-tumor activity by activating ATM/ATR signaling pathways. Eur J Med Chem. 2014 Jun 10;80:267-77. PMID: 24793877.

Yang TM, Guo SF, Chen CR, et al. Anti-osteosarcoma effects and mechanisms of 4-O-amino-phenol-4'-demethylepipodophyllotoxin ether. J Pharm Pharmacol. 2008 Feb;60(2):179-88. PMID: 18237465.

" Not dangerous goods.

LKT D1849 4′-Demethylepipodophyllotoxin 1 g 137.1 Podophyllotoxin derivative found in Podophyllum; topoisomerase II inhibitor. "Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5ah)-one,

5,8,8a,9-tetrahydro-9-hydroxy-5-(4-hydroxy-3,5-

Yang TM, Guo SF, Chen CR, et al. Anti-osteosarcoma effects and mechanisms of 4-O-amino-phenol-4'-demethylepipodophyllotoxin ether. J Pharm Pharmacol. 2008 Feb;60(2):179-88. PMID: 18237465.

" Not dangerous goods.

LKT D1849 4′-Demethylepipodophyllotoxin 5 g 508.1 Podophyllotoxin derivative found in Podophyllum; topoisomerase II inhibitor. "Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5ah)-one,

5,8,8a,9-tetrahydro-9-hydroxy-5-(4-hydroxy-3,5-

Yang TM, Guo SF, Chen CR, et al. Anti-osteosarcoma effects and mechanisms of 4-O-amino-phenol-4'-demethylepipodophyllotoxin ether. J Pharm Pharmacol. 2008 Feb;60(2):179-88. PMID: 18237465.

" Not dangerous goods.

LKT D1859 2-Deoxy-D-glucose 1 g 68.5 Glucose metabolism inhibitor, N-linked glycosylation inhibitor. 154-17-6 ≥98% 164.16 C6H12O5 C1C(C(C(OC1O)CO)O)O Ambient Ambient "Kaira K, Murakami H, Endo M, et al. Biological correlation of (18)F-FDG uptake on PET in pulmonary neuroendocrine tumors. Anticancer Res. 2013 Oct;33(10):4219-28. PMID: 24122985.

Andresen L, Skovbakke SL, Persson G, et al. 2-deoxy D-glucose prevents cell surface expression of NKG2D ligands through inhibition of N-linked glycosylation. J Immunol. 2012 Feb 15;188(4):1847-55. PMID: 22227571.

Shutt DC, O'Dorisio MS, Aykin-Burns N, et al. 2-deoxy-D-glucose induces oxidative stress and cell killing in human neuroblastoma cells. Cancer Biol Ther. 2010 Jun 1;9(11):853-61. PMID: 20364116.

Nowak M, Carrasquillo JA, Yarboro CH, et al. A pilot study of the use of 2-[18F]-fluoro-2-deoxy-D-glucose-positron emission tomography to assess the distribution of activated lymphocytes in patients with systemic lupus erythematosus. Arthritis Rheum. 2004 Apr;50(4):1233-8. PMID: 15077306.

Böhmer R, Rommel K. The behaviour of different markers of the mucosal extracellular space in rat small intestine. Acta Hepatogastroenterol (Stuttg). 1975 Dec;22(6):398-403. PMID: 1211066.

" Xn, Xi Not dangerous goods.

LKT D1859 2-Deoxy-D-glucose 5 g 230.6 Glucose metabolism inhibitor, N-linked glycosylation inhibitor. 154-17-6 ≥98% 164.16 C6H12O5 C1C(C(C(OC1O)CO)O)O Ambient Ambient "Kaira K, Murakami H, Endo M, et al. Biological correlation of (18)F-FDG uptake on PET in pulmonary neuroendocrine tumors. Anticancer Res. 2013 Oct;33(10):4219-28. PMID: 24122985.

Shutt DC, O'Dorisio MS, Aykin-Burns N, et al. 2-deoxy-D-glucose induces oxidative stress and cell killing in human neuroblastoma cells. Cancer Biol Ther. 2010 Jun 1;9(11):853-61. PMID: 20364116.

Böhmer R, Rommel K. The behaviour of different markers of the mucosal extracellular space in rat small intestine. Acta Hepatogastroenterol (Stuttg). 1975 Dec;22(6):398-403. PMID: 1211066.

" Xn, Xi Not dangerous goods.

LKT D1859 2-Deoxy-D-glucose 25 g 958.5 Glucose metabolism inhibitor, N-linked glycosylation inhibitor. 154-17-6 ≥98% 164.16 C6H12O5 C1C(C(C(OC1O)CO)O)O Ambient Ambient "Kaira K, Murakami H, Endo M, et al. Biological correlation of (18)F-FDG uptake on PET in pulmonary neuroendocrine tumors. Anticancer Res. 2013 Oct;33(10):4219-28. PMID: 24122985.

Shutt DC, O'Dorisio MS, Aykin-Burns N, et al. 2-deoxy-D-glucose induces oxidative stress and cell killing in human neuroblastoma cells. Cancer Biol Ther. 2010 Jun 1;9(11):853-61. PMID: 20364116.

Böhmer R, Rommel K. The behaviour of different markers of the mucosal extracellular space in rat small intestine. Acta Hepatogastroenterol (Stuttg). 1975 Dec;22(6):398-403. PMID: 1211066.

" Xn, Xi Not dangerous goods.

LKT D3208 Diclazuril 500 mg 72.2 Coccidiostat, GAPDH inhibitor. 2,6-Dichloro-a-(4-chlorophenyl)-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)benzeneacetonitrile R-64433; Clinacox 101831-37-2 ≥98% 407.64 C17H10Cl2N4O2 C1=CC(=CC=C1C(C#N)C2=C(C=C(C=C2Cl)N3C(=O)NC(=O)C=N3)Cl)Cl Ambient Ambient Insoluble in water. "Oz HS, Tobin T. Diclazuril Protects against Maternal Gastrointestinal Syndrome and Congenital Toxoplasmosis. Int J Clin Med. 2014 Jan 1;5(3):93-101. PMID: 24851194.

Wang C, Han C, Li T, et al. Nuclear translocation and accumulation of glyceraldehyde-3-phosphate dehydrogenase involved in diclazuril-induced apoptosis in Eimeria tenella (E. tenella). Vet Res. 2013 May 7;44:29. PMID: 23651214.

" None Not dangerous goods.

LKT D3208 Diclazuril 1 g 121.3 Coccidiostat, GAPDH inhibitor. 2,6-Dichloro-a-(4-chlorophenyl)-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)benzeneacetonitrile R-64433; Clinacox 101831-37-2 ≥98% 407.64 C17H10Cl2N4O2 C1=CC(=CC=C1C(C#N)C2=C(C=C(C=C2Cl)N3C(=O)NC(=O)C=N3)Cl)Cl Ambient Ambient Insoluble in water. "Oz HS, Tobin T. Diclazuril Protects against Maternal Gastrointestinal Syndrome and Congenital Toxoplasmosis. Int J Clin Med. 2014 Jan 1;5(3):93-101. PMID: 24851194.

" None Not dangerous goods.

LKT D3208 Diclazuril 5 g 475.7 Coccidiostat, GAPDH inhibitor. 2,6-Dichloro-a-(4-chlorophenyl)-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)benzeneacetonitrile R-64433; Clinacox 101831-37-2 ≥98% 407.64 C17H10Cl2N4O2 C1=CC(=CC=C1C(C#N)C2=C(C=C(C=C2Cl)N3C(=O)NC(=O)C=N3)Cl)Cl Ambient Ambient Insoluble in water. "Oz HS, Tobin T. Diclazuril Protects against Maternal Gastrointestinal Syndrome and Congenital Toxoplasmosis. Int J Clin Med. 2014 Jan 1;5(3):93-101. PMID: 24851194.

" None Not dangerous goods.

LKT D3212 2′,3′-Dideoxycytidine 100 mg 108.8 Pyrimidine nucleoside (cytidine) analog; DNA chain terminator, RT inhibitor. Zalcitabine; ddCyd; Hivid 7481-89-2 ≥98% 211.22 C9H13N3O3 C1CC(OC1CO)N2C=CC(=NC2=O)N Ambient Ambient Moderately soluble in water. "Shelton MJ, O'Donnell AM, Morse GD. Zalcitabine. Ann Pharmacother. 1993 Apr;27(4):480-9. PMID: 8097417.

Balzarini J. Anti-retroviral activity and molecular-biochemical action mechanism of 2',3'-dideoxynucleoside analogs and 9-(2-phosphonylmethoxyethyl) purine derivatives. Verh K Acad Geneeskd Belg. 1991;53(1):61-98. PMID: 1647085.

" Xn Not dangerous goods.

LKT D3212 2′,3′-Dideoxycytidine 250 mg 224.3 Pyrimidine nucleoside (cytidine) analog; DNA chain terminator, RT inhibitor. Zalcitabine; ddCyd; Hivid 7481-89-2 ≥98% 211.22 C9H13N3O3 C1CC(OC1CO)N2C=CC(=NC2=O)N Ambient Ambient Moderately soluble in water. "Shelton MJ, O'Donnell AM, Morse GD. Zalcitabine. Ann Pharmacother. 1993 Apr;27(4):480-9. PMID: 8097417.

" Xn Not dangerous goods.

LKT D3212 2′,3′-Dideoxycytidine 500 mg 380.5 Pyrimidine nucleoside (cytidine) analog; DNA chain terminator, RT inhibitor. Zalcitabine; ddCyd; Hivid 7481-89-2 ≥98% 211.22 C9H13N3O3 C1CC(OC1CO)N2C=CC(=NC2=O)N Ambient Ambient Moderately soluble in water. "Shelton MJ, O'Donnell AM, Morse GD. Zalcitabine. Ann Pharmacother. 1993 Apr;27(4):480-9. PMID: 8097417.

" Xn Not dangerous goods.

LKT D3214 2′,3′-Dideoxyinosine 1 mg 43.5 Nucleoside (guanosine) analog; DNA chain terminator, RT inhibitor. "2',3'-Dideoxyinosine

" Didanosine; Dideoxyinosine; ddI; ddIno; Videx 69655-05-6 ≥98% 236.23 C10H12N4O3 C1CC(OC1CO)N2C=NC3=C2NC=NC3=O Ambient -20°C Soluble in DMSO, polyethylene glycol. "Ribera E, Tuset M, Martín M, et al. Characteristics of antiretroviral drugs. Enferm Infecc Microbiol Clin. 2011 May;29(5):362-91. PMID: 21531048.

Phillips KE, Munson AE. 2'3'-Dideoxyinosine inhibits the humoral immune response in female B6C3F1 mice by targeting the B lymphocyte. Toxicol Appl Pharmacol. 1997 Aug;145(2):260-7. PMID: 9266798.

" Not dangerous goods.

LKT D3214 2′,3′-Dideoxyinosine 5 mg 176.5 Nucleoside (guanosine) analog; DNA chain terminator, RT inhibitor. "2',3'-Dideoxyinosine

Phillips KE, Munson AE. 2'3'-Dideoxyinosine inhibits the humoral immune response in female B6C3F1 mice by targeting the B lymphocyte. Toxicol Appl Pharmacol. 1997 Aug;145(2):260-7. PMID: 9266798.

" Not dangerous goods.

LKT D3214 2′,3′-Dideoxyinosine 25 mg 577.6 Nucleoside (guanosine) analog; DNA chain terminator, RT inhibitor. "2',3'-Dideoxyinosine

Phillips KE, Munson AE. 2'3'-Dideoxyinosine inhibits the humoral immune response in female B6C3F1 mice by targeting the B lymphocyte. Toxicol Appl Pharmacol. 1997 Aug;145(2):260-7. PMID: 9266798.

" Not dangerous goods.

LKT D3218 Diethylstilbestrol 1 g 27.2 Synthetic non-steroid endocrine disrupter; ER agonist. 4,4'-[(1E)-1,2-Diethyl-1,2-ethenediyl]bisphenol Stilbestrol; DES; Apstil; Cyren A; Stilbetin 56-53-1 ≥98% 268.35 C18H20O2 CCC(=C(CC)C1=CC=C(C=C1)O)C2=CC=C(C=C2)O Ambient Ambient Soluble in alcohol, ether, chloroform or fatty oils. Insoluble in water. "Ingle JN, Ahmann DL, Green SJ, et al. Randomized clinical trial of diethylstilbestrol versus tamoxifen in postmenopausal women with advanced breast cancer. N Engl J Med. 1981 Jan 1;304(1):16-21. PMID: 7001242.

Dieckmann WJ, Davis ME, Rynkiewicz LM, et al. Does the administration of diethylstilbestrol during pregnancy have therapeutic value? Am J Obstet Gynecol. 1953 Nov;66(5):1062-81. PMID: 13104505.

" T, N Not dangerous goods.

LKT D3218 Diethylstilbestrol 5 g 122.3 Synthetic non-steroid endocrine disrupter; ER agonist. 4,4'-[(1E)-1,2-Diethyl-1,2-ethenediyl]bisphenol Stilbestrol; DES; Apstil; Cyren A; Stilbetin 56-53-1 ≥98% 268.35 C18H20O2 CCC(=C(CC)C1=CC=C(C=C1)O)C2=CC=C(C=C2)O Ambient Ambient Soluble in alcohol, ether, chloroform or fatty oils. Insoluble in water. "Ingle JN, Ahmann DL, Green SJ, et al. Randomized clinical trial of diethylstilbestrol versus tamoxifen in postmenopausal women with advanced breast cancer. N Engl J Med. 1981 Jan 1;304(1):16-21. PMID: 7001242.

Dieckmann WJ, Davis ME, Rynkiewicz LM, et al. Does the administration of diethylstilbestrol during pregnancy have therapeutic value? Am J Obstet Gynecol. 1953 Nov;66(5):1062-81. PMID: 13104505.

" T, N Not dangerous goods.

LKT D3218 Diethylstilbestrol 10 g 217.4 Synthetic non-steroid endocrine disrupter; ER agonist. 4,4'-[(1E)-1,2-Diethyl-1,2-ethenediyl]bisphenol Stilbestrol; DES; Apstil; Cyren A; Stilbetin 56-53-1 ≥98% 268.35 C18H20O2 CCC(=C(CC)C1=CC=C(C=C1)O)C2=CC=C(C=C2)O Ambient Ambient Soluble in alcohol, ether, chloroform or fatty oils. Insoluble in water. "Ingle JN, Ahmann DL, Green SJ, et al. Randomized clinical trial of diethylstilbestrol versus tamoxifen in postmenopausal women with advanced breast cancer. N Engl J Med. 1981 Jan 1;304(1):16-21. PMID: 7001242.

Dieckmann WJ, Davis ME, Rynkiewicz LM, et al. Does the administration of diethylstilbestrol during pregnancy have therapeutic value? Am J Obstet Gynecol. 1953 Nov;66(5):1062-81. PMID: 13104505.

" T, N Not dangerous goods.

LKT D3219 Diflubenzuron 10 g 115.5 Benzoylurea, insect growth regulator; chitin synthesis inhibitor. "N-(((4-chlorophenyl)amino)carbonyl)- 2,6-difluoro- benzamide

" Difluron; Dimilin; Duphacid; Micromite. 35367-38-5 ≥95% 310.68 C14H9ClF2N2O2 C1=CC(=C(C(=C1)F)C(=O)NC(=O)NC2=CC=C(C=C2)Cl)F Ambient 4°C Soluble in acetone (0.65 gm/100ml at 20oC), DMSO or methanol. "Merzendorfer H, Kim HS, Chaudhari SS, et al. Genomic and proteomic studies on the effects of the insect growth regulator diflubenzuron in the model beetle species Tribolium castaneum. Insect Biochem Mol Biol. 2012 Apr;42(4):264-76. PMID: 22212827.

Zhang J, Zhu KY. Characterization of a chitin synthase cDNA and its increased mRNA level associated with decreased chitin synthesis in Anopheles quadrimaculatus exposed to diflubenzuron. Insect Biochem Mol Biol. 2006 Sep;36(9):712-25. PMID: 16935220.

Fetterer RH, Urban JF Jr, Miller RW. Effects of the chitin synthesis inhibitor diflubenzuron on development of Ascaris suum and Haemonchus contortus. Vet Parasitol. 1989 Jul 15;32(2-3):181-92. PMID: 2505433.

" N Not dangerous goods.

LKT D3219 Diflubenzuron 25 g 206 Benzoylurea, insect growth regulator; chitin synthesis inhibitor. "N-(((4-chlorophenyl)amino)carbonyl)- 2,6-difluoro- benzamide

" N Not dangerous goods.

LKT D3219 Diflubenzuron 100 g 630.1 Benzoylurea, insect growth regulator; chitin synthesis inhibitor. "N-(((4-chlorophenyl)amino)carbonyl)- 2,6-difluoro- benzamide

" N Not dangerous goods.

LKT D3223 Difloxacin Hydrochloride 5 g 84.3 Fluoroquinolone; bacterial DNA gyrase inhibitor. 91296-86-5 ≥98% 435.85 C21H19F2N3O3 CN1CCN(CC1)C2=C(C=C3C(=C2)N(C=C(C3=O)C(=O)O)C4=CC=C(C=C4)F)F.Cl Ambient Ambient "Schink AK, Kadlec K, Hauschild T, et al. Susceptibility of canine and feline bacterial pathogens to pradofloxacin and comparison with other fluoroquinolones approved for companion animals. Vet Microbiol. 2013 Feb 22;162(1):119-26. PMID: 22939523.

Awji EG, Tassew DD, Lee JS, et al. Comparative mutant prevention concentration and mechanism of resistance to veterinary fluoroquinolones in Staphylococcus pseudintermedius. Vet Dermatol. 2012 Aug;23(4):376-80, e68-9. PMID: 22409306.

" Not dangerous goods.

LKT D3223 Difloxacin Hydrochloride 25 g 281.2 Fluoroquinolone; bacterial DNA gyrase inhibitor. 91296-86-5 ≥98% 435.85 C21H19F2N3O3 CN1CCN(CC1)C2=C(C=C3C(=C2)N(C=C(C3=O)C(=O)O)C4=CC=C(C=C4)F)F.Cl Ambient Ambient "Schink AK, Kadlec K, Hauschild T, et al. Susceptibility of canine and feline bacterial pathogens to pradofloxacin and comparison with other fluoroquinolones approved for companion animals. Vet Microbiol. 2013 Feb 22;162(1):119-26. PMID: 22939523.

" Not dangerous goods.

LKT D3223 Difloxacin Hydrochloride 100 g 843.9 Fluoroquinolone; bacterial DNA gyrase inhibitor. 91296-86-5 ≥98% 435.85 C21H19F2N3O3 CN1CCN(CC1)C2=C(C=C3C(=C2)N(C=C(C3=O)C(=O)O)C4=CC=C(C=C4)F)F.Cl Ambient Ambient "Schink AK, Kadlec K, Hauschild T, et al. Susceptibility of canine and feline bacterial pathogens to pradofloxacin and comparison with other fluoroquinolones approved for companion animals. Vet Microbiol. 2013 Feb 22;162(1):119-26. PMID: 22939523.

" Not dangerous goods.

LKT D3227 Dihydromethysticin 5 mg 186.6 Kavalactone originally found in Piper methysticum (kava plant); Voltage-gated Na+ and L-type Ca2+ channel blocker. 2H-Pyran-2-one,6-(2-(1,3-benzodioxol-5-yl)ethyl)-5,6-dihydro-4-methoxy-, (S)-; 7,8-Dihydromethysticin 19902-91-1 ≥98% 276.28 C15H16O5 COC1=CC(=O)OC(C1)CCC2=CC3=C(C=C2)OCO3 Ambient -20°C "Narayanapillai SC, Balbo S, Leitzman P, et al. Dihydromethysticin (DHM) from kava blocks tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis and differentially reduces DNA damage in A/J mice. Carcinogenesis. 2014 Jul 22. [Epub ahead of print]. PMID: 25053626.

Xuan TD, Elzaawely AA, Fukuta M, et al. Herbicidal and Fungicidal Activities of Lactones in Kava (Piper methysticum). J Agric Food Chem. 2006 Feb 8;54(3):720-5. PMID: 16448174.

Friese J, Gleitz J. Kavain, dihydrokavain, and dihydromethysticin non-competitively inhibit the specific binding of [3H]-batrachotoxinin-A 20-alpha-benzoate to receptor site 2 of voltage-gated Na+ channels. Planta Med. 1998 Jun;64(5):458-9. PMID: 9690349.

Backhauss C, Krieglstein J. Extract of kava (Piper methysticum) and its methysticin constituents protect brain tissue against ischemic damage in rodents. Eur J Pharmacol. 1992 May 14;215(2-3):265-9. PMID: 1396990.

" None Not dangerous goods.

LKT D3227 Dihydromethysticin 10 mg 288.3 Kavalactone originally found in Piper methysticum (kava plant); Voltage-gated Na+ and L-type Ca2+ channel blocker. 2H-Pyran-2-one,6-(2-(1,3-benzodioxol-5-yl)ethyl)-5,6-dihydro-4-methoxy-, (S)-; 7,8-Dihydromethysticin 19902-91-1 ≥98% 276.28 C15H16O5 COC1=CC(=O)OC(C1)CCC2=CC3=C(C=C2)OCO3 Ambient -20°C "Narayanapillai SC, Balbo S, Leitzman P, et al. Dihydromethysticin (DHM) from kava blocks tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis and differentially reduces DNA damage in A/J mice. Carcinogenesis. 2014 Jul 22. [Epub ahead of print]. PMID: 25053626.

Xuan TD, Elzaawely AA, Fukuta M, et al. Herbicidal and Fungicidal Activities of Lactones in Kava (Piper methysticum). J Agric Food Chem. 2006 Feb 8;54(3):720-5. PMID: 16448174.

" None Not dangerous goods.

LKT D3229 7,8-Dihydrokawain 5 mg 186.6 Kavalactone originally found in Piper methysticum (kava plant). DHK; Dihydrokawain; Marindinin 587-63-3 ≥98% 232.28 C14H16O3 COC1=CC(=O)OC(C1)CCC2=CC=CC=C2 Ambient -20°C Soluble in DMSO and methanol. Xuan TD, Elzaawely AA, Fukuta M, et al. Herbicidal and Fungicidal Activities of Lactones in Kava (Piper methysticum). J Agric Food Chem. 2006 Feb 8;54(3):720-5. PMID: 16448174. None Not dangerous goods.

LKT D3229 7,8-Dihydrokawain 10 mg 288.3 Kavalactone originally found in Piper methysticum (kava plant). DHK; Dihydrokawain; Marindinin 587-63-3 ≥98% 232.28 C14H16O3 COC1=CC(=O)OC(C1)CCC2=CC=CC=C2 Ambient -20°C Soluble in DMSO and methanol. Xuan TD, Elzaawely AA, Fukuta M, et al. Herbicidal and Fungicidal Activities of Lactones in Kava (Piper methysticum). J Agric Food Chem. 2006 Feb 8;54(3):720-5. PMID: 16448174. None Not dangerous goods.

LKT D3230 1-(2,4-Dihydroxy-6-methoxy-phenyl)-3-hydroxy-3-phenyl-propan-1-one 5 mg 268.9 Minor kavalactone originally found in Piper methysticum (kava plant). ≥98% 288.3 C16H16O5 Ambient -20°C Chantrapromma S, Jeerapong J, Kruahong T, et al. 1-(2,6-Dihydr-oxy-4-methoxy-phen-yl)-3-phenyl-propan-1-one. Acta Crystallogr Sect E Struct Rep Online. 2010 Apr 21;66(Pt 5):o1120-1. PMID: 21579171. Not dangerous goods.

LKT D3230 1-(2,4-Dihydroxy-6-methoxy-phenyl)-3-hydroxy-3-phenyl-propan-1-one 10 mg 461 Minor kavalactone originally found in Piper methysticum (kava plant). ≥98% 288.3 C16H16O5 Ambient -20°C Chantrapromma S, Jeerapong J, Kruahong T, et al. 1-(2,6-Dihydr-oxy-4-methoxy-phen-yl)-3-phenyl-propan-1-one. Acta Crystallogr Sect E Struct Rep Online. 2010 Apr 21;66(Pt 5):o1120-1. PMID: 21579171. Not dangerous goods.

LKT D3231 1-(2,4-Dihydroxy-6-methoxy-phenyl)-3-hydroxy-3-(4-methoxy-phenyl)-propan-1-one 5 mg 268.9 Minor kavalactone originally found in Piper methysticum (kava plant). ≥98% 318.32 C17H18O6 Ambient -20°C Chantrapromma S, Jeerapong J, Kruahong T, et al. 1-(2,6-Dihydr-oxy-4-methoxy-phen-yl)-3-phenyl-propan-1-one. Acta Crystallogr Sect E Struct Rep Online. 2010 Apr 21;66(Pt 5):o1120-1. PMID: 21579171. Not dangerous goods.

LKT D3231 1-(2,4-Dihydroxy-6-methoxy-phenyl)-3-hydroxy-3-(4-methoxy-phenyl)-propan-1-one 10 mg 461 Minor kavalactone originally found in Piper methysticum (kava plant). ≥98% 318.32 C17H18O6 Ambient -20°C Chantrapromma S, Jeerapong J, Kruahong T, et al. 1-(2,6-Dihydr-oxy-4-methoxy-phen-yl)-3-phenyl-propan-1-one. Acta Crystallogr Sect E Struct Rep Online. 2010 Apr 21;66(Pt 5):o1120-1. PMID: 21579171. Not dangerous goods.

LKT D3301 Diaveridine 1 g 58.9 Coccidiostat; dihydrofolate reductase inhibitor. 5-[(3,4-Dimethoxyphenyl)methyl]-2,4-pyrimidine- diamine Diaveridin 5355-16-8 ≥98% 260.29 C13H16N4O2 COC1=C(C=C(C=C1)CC2=CN=C(N=C2N)N)OC Ambient Ambient Soluble in HCl or chloroform (1:600). "Ono T, Sekiya T, Takahashi Y, et al. The genotoxicity of diaveridine and trimethoprim. Environ Toxicol Pharmacol. 1997 Sep;3(4):297-306. PMID: 21781790.

Cirioni O, Giacometti A, Scalise G. In-vitro activity of atovaquone, sulphamethoxazole and dapsone alone and combined with inhibitors of dihydrofolate reductase and macrolides against Pneumocystis carinii. J Antimicrob Chemother. 1997 Jan;39(1):45-51. PMID: 9044027.

Walzer PD, Kim CK, Foy JM, et al. Inhibitors of folic acid synthesis in the treatment of experimental Pneumocystis carinii pneumonia. Antimicrob Agents Chemother. 1988 Jan;32(1):96-103. PMID: 3258144.

" Xi Not dangerous goods.

LKT D3301 Diaveridine 10 g 315.1 Coccidiostat; dihydrofolate reductase inhibitor. 5-[(3,4-Dimethoxyphenyl)methyl]-2,4-pyrimidine- diamine Diaveridin 5355-16-8 ≥98% 260.29 C13H16N4O2 COC1=C(C=C(C=C1)CC2=CN=C(N=C2N)N)OC Ambient Ambient Soluble in HCl or chloroform (1:600). "Ono T, Sekiya T, Takahashi Y, et al. The genotoxicity of diaveridine and trimethoprim. Environ Toxicol Pharmacol. 1997 Sep;3(4):297-306. PMID: 21781790.

" Xi Not dangerous goods.

LKT D3302 Diaveridine Hydrochloride 1 g 54.4 Coccidiostat; dihydrofolate reductase inhibitor. 5-[(3,4-Dimethoxyphenyl)methyl]-2,4-pyrimidine- diamine HCl ≥98% 296.74 C13H16N4O2 HCl COC1=C(C=C(C=C1)CC2=CN=C(N=C2N)N)OC Ambient Ambient Soluble in water. "Ono T, Sekiya T, Takahashi Y, et al. The genotoxicity of diaveridine and trimethoprim. Environ Toxicol Pharmacol. 1997 Sep;3(4):297-306. PMID: 21781790.

" Xi Not dangerous goods.

LKT D3302 Diaveridine Hydrochloride 10 g 285.4 Coccidiostat; dihydrofolate reductase inhibitor. 5-[(3,4-Dimethoxyphenyl)methyl]-2,4-pyrimidine- diamine HCl ≥98% 296.74 C13H16N4O2 HCl COC1=C(C=C(C=C1)CC2=CN=C(N=C2N)N)OC Ambient Ambient Soluble in water. "Ono T, Sekiya T, Takahashi Y, et al. The genotoxicity of diaveridine and trimethoprim. Environ Toxicol Pharmacol. 1997 Sep;3(4):297-306. PMID: 21781790.

" Xi Not dangerous goods.

LKT D3303 Diacerein 50 mg 84.3 Anthraquinone; IL-1β inhibitor. diacetylrhein 13739-02-1 ≥98% 368.29 C19H12O8 CC(=O)OC1=CC=CC2=C1C(=O)C3=C(C=C(C=C3C2=O)C(=O)O)OC(=O)C Ambient Ambient "Gadotti VM, Martins DF, Pinto HF, et al. Diacerein decreases visceral pain through inhibition of glutamatergic neurotransmission and cytokine signaling in mice. Pharmacol Biochem Behav. 2012 Oct;102(4):549-54. PMID: 22750064.

Boileau C, Tat SK, Pelletier JP, et al. Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling. Arthritis Res Ther. 2008;10(3):R71. PMID: 18578867.

Fidelix TS, Soares BG, Trevisani VF. Diacerein for osteoarthritis. Cochrane Database Syst Rev. 2006 Jan 25;(1):CD005117. PMID: 16437519.

" Xi Not dangerous goods.

LKT D3303 Diacerein 250 mg 309.4 Anthraquinone; IL-1β inhibitor. diacetylrhein 13739-02-1 ≥98% 368.29 C19H12O8 CC(=O)OC1=CC=CC2=C1C(=O)C3=C(C=C(C=C3C2=O)C(=O)O)OC(=O)C Ambient Ambient "Gadotti VM, Martins DF, Pinto HF, et al. Diacerein decreases visceral pain through inhibition of glutamatergic neurotransmission and cytokine signaling in mice. Pharmacol Biochem Behav. 2012 Oct;102(4):549-54. PMID: 22750064.

Fidelix TS, Soares BG, Trevisani VF. Diacerein for osteoarthritis. Cochrane Database Syst Rev. 2006 Jan 25;(1):CD005117. PMID: 16437519.

" Xi Not dangerous goods.

LKT D3304 Dibenzoylmethane, 98% 10 g 32.3 Aromatic 1,3-diketone acetylacetone derivative found in Glycyrrhiza (licorice); cytoprotective. 1,3-Diphenyl-1,3-propanedione Phenyl Phenacyl Ketone; γ-Hydroxychalkone 120-46-7 ≥98% 224.25 C15H12O2 C1=CC=C(C=C1)C(=O)CC(=O)C2=CC=CC=C2 Ambient Ambient Insoluble in water. Soluble in ether, chloroform, and aqueous NaOH. "Heged?s C, Lakatos P, Kiss-Szikszai A, et al. Cytoprotective dibenzoylmethane derivatives protect cells from oxidative stress-induced necrotic cell death. Pharmacol Res. 2013 Jun;72:25-34. PMID: 23523665.

Anand P, Sung B, Kunnumakkara AB, et al. Suppression of pro-inflammatory and proliferative pathways by diferuloylmethane (curcumin) and its analogues dibenzoylmethane, dibenzoylpropane, and dibenzylideneacetone: role of Michael acceptors and Michael donors. Biochem Pharmacol. 2011 Dec 15;82(12):1901-9. PMID: 21924245.

Lin W, Hong JL, Shen G, et al. Pharmacokinetics of dietary cancer chemopreventive compound dibenzoylmethane in rats and the impact of nanoemulsion and genetic knockout of Nrf2 on its disposition. Biopharm Drug Dispos. 2011 Mar;32(2):65-75. PMID: 21341276.

Dietary feeding of dibenzoylmethane inhibits prostate cancer in transgenic adenocarcinoma of the mouse prostate model. Khor TO, Yu S, Barve A, et al. Cancer Res. 2009 Sep 1;69(17):7096-102. PMID: 19706764.

Thimmulappa RK, Rangasamy T, Alam J, et al. Dibenzoylmethane activates Nrf2-dependent detoxification pathway and inhibits benzo(a)pyrene induced DNA adducts in lungs. Med Chem. 2008 Sep;4(5):473-81. PMID: 18782044.

Shen G, Khor TO, Hu R, et al. Chemoprevention of familial adenomatous polyposis by natural dietary compounds sulforaphane and dibenzoylmethane alone and in combination in ApcMin/+ mouse. Cancer Res. 2007 Oct 15;67(20):9937-44. PMID: 17942926.

" None Not dangerous goods.

LKT D3304 Dibenzoylmethane, 98% 25 g 45.3 Aromatic 1,3-diketone acetylacetone derivative found in Glycyrrhiza (licorice); cytoprotective. 1,3-Diphenyl-1,3-propanedione Phenyl Phenacyl Ketone; γ-Hydroxychalkone 120-46-7 ≥98% 224.25 C15H12O2 C1=CC=C(C=C1)C(=O)CC(=O)C2=CC=CC=C2 Ambient Ambient Insoluble in water. Soluble in ether, chloroform, and aqueous NaOH. "Heged?s C, Lakatos P, Kiss-Szikszai A, et al. Cytoprotective dibenzoylmethane derivatives protect cells from oxidative stress-induced necrotic cell death. Pharmacol Res. 2013 Jun;72:25-34. PMID: 23523665.

" None Not dangerous goods.

LKT D3304 Dibenzoylmethane, 98% 100 g 129.5 Aromatic 1,3-diketone acetylacetone derivative found in Glycyrrhiza (licorice); cytoprotective. 1,3-Diphenyl-1,3-propanedione Phenyl Phenacyl Ketone; γ-Hydroxychalkone 120-46-7 ≥98% 224.25 C15H12O2 C1=CC=C(C=C1)C(=O)CC(=O)C2=CC=CC=C2 Ambient Ambient Insoluble in water. Soluble in ether, chloroform, and aqueous NaOH. "Heged?s C, Lakatos P, Kiss-Szikszai A, et al. Cytoprotective dibenzoylmethane derivatives protect cells from oxidative stress-induced necrotic cell death. Pharmacol Res. 2013 Jun;72:25-34. PMID: 23523665.

" None Not dangerous goods.

LKT D3320 Difenoconazole 5 g 56.3 Triazole; 14-α demethylase inhibitor, potential aromatase inhibitor. 1-((2-(2-chloro-4-(4-chlorophenoxy)phenyl)-4-methyl-1,3-dioxolan-2-yl)methyl)-1H-1,2,4-triazole 119446-68-3 ≥98% 406.26 C19H17Cl2N3O3 CC1COC(O1)(CN2C=NC=N2)C3=C(C=C(C=C3)OC4=CC=C(C=C4)Cl)Cl Ambient Ambient "Kjærstad MB, Taxvig C, Nellemann C, et al. Endocrine disrupting effects in vitro of conazole antifungals used as pesticides and pharmaceuticals. Reprod Toxicol. 2010 Dec;30(4):573-82. PMID: 20708073.

Hinfray N, Porcher JM, Brion F. Inhibition of rainbow trout (Oncorhynchus mykiss) P450 aromatase activities in brain and ovarian microsomes by various environmental substances. Comp Biochem Physiol C Toxicol Pharmacol. 2006 Nov;144(3):252-62. PMID: 17081805.

Sanderson JT, Boerma J, Lansbergen GW, et al. Induction and inhibition of aromatase (CYP19) activity by various classes of pesticides in H295R human adrenocortical carcinoma cells. Toxicol Appl Pharmacol. 2002 Jul 1;182(1):44-54. PMID: 12127262.

" Xn, Xi Not dangerous goods.

LKT D3320 Difenoconazole 10 g 84.3 Triazole; 14-α demethylase inhibitor, potential aromatase inhibitor. 1-((2-(2-chloro-4-(4-chlorophenoxy)phenyl)-4-methyl-1,3-dioxolan-2-yl)methyl)-1H-1,2,4-triazole 119446-68-3 ≥98% 406.26 C19H17Cl2N3O3 CC1COC(O1)(CN2C=NC=N2)C3=C(C=C(C=C3)OC4=CC=C(C=C4)Cl)Cl Ambient Ambient "Kjærstad MB, Taxvig C, Nellemann C, et al. Endocrine disrupting effects in vitro of conazole antifungals used as pesticides and pharmaceuticals. Reprod Toxicol. 2010 Dec;30(4):573-82. PMID: 20708073.

" Xn, Xi Not dangerous goods.

LKT D3320 Difenoconazole 100 g 346.9 Triazole; 14-α demethylase inhibitor, potential aromatase inhibitor. 1-((2-(2-chloro-4-(4-chlorophenoxy)phenyl)-4-methyl-1,3-dioxolan-2-yl)methyl)-1H-1,2,4-triazole 119446-68-3 ≥98% 406.26 C19H17Cl2N3O3 CC1COC(O1)(CN2C=NC=N2)C3=C(C=C(C=C3)OC4=CC=C(C=C4)Cl)Cl Ambient Ambient "Kjærstad MB, Taxvig C, Nellemann C, et al. Endocrine disrupting effects in vitro of conazole antifungals used as pesticides and pharmaceuticals. Reprod Toxicol. 2010 Dec;30(4):573-82. PMID: 20708073.

" Xn, Xi Not dangerous goods.

LKT D3322 Diflunisal 5 g 47.6 NSAID; COX-1/2 inhibitor. 2',4'-Difluoro-4-hydroxy-[1,1'-biphenyl]-3-carboxylic acid Adomal; Difludol; Dolisal; Dolobid; Dolobis; Flovacil; Fluniget; Fluodonil 22494-42-4 ≥98% 250.2 C13H8F2O3 C1=CC(=C(C=C1C2=C(C=C(C=C2)F)F)C(=O)O)O Ambient Ambient Sparingly soluble in water. "Hu G, Li X, Sun X, et al. Identification of old drugs as potential inhibitors of HIV-1 integrase - human LEDGF/p75 interaction via molecular docking. J Mol Model. 2012 Dec;18(12):4995-5003. PMID: 22733274.

Lawton GM, Chapman PJ. Diflunisal--a long-acting non-steroidal anti-inflammatory drug. A review of its pharmacology and effectiveness in management of postoperative dental pain. Aust Dent J. 1993 Aug;38(4):265-71. PMID: 8216032.

" Xn Not dangerous goods.

LKT D3322 Diflunisal 10 g 95.1 NSAID; COX-1/2 inhibitor. 2',4'-Difluoro-4-hydroxy-[1,1'-biphenyl]-3-carboxylic acid Adomal; Difludol; Dolisal; Dolobid; Dolobis; Flovacil; Fluniget; Fluodonil 22494-42-4 ≥98% 250.2 C13H8F2O3 C1=CC(=C(C=C1C2=C(C=C(C=C2)F)F)C(=O)O)O Ambient Ambient Sparingly soluble in water. "Hu G, Li X, Sun X, et al. Identification of old drugs as potential inhibitors of HIV-1 integrase - human LEDGF/p75 interaction via molecular docking. J Mol Model. 2012 Dec;18(12):4995-5003. PMID: 22733274.

" Xn Not dangerous goods.

LKT D3322 Diflunisal 50 g 339.8 NSAID; COX-1/2 inhibitor. 2',4'-Difluoro-4-hydroxy-[1,1'-biphenyl]-3-carboxylic acid Adomal; Difludol; Dolisal; Dolobid; Dolobis; Flovacil; Fluniget; Fluodonil 22494-42-4 ≥98% 250.2 C13H8F2O3 C1=CC(=C(C=C1C2=C(C=C(C=C2)F)F)C(=O)O)O Ambient Ambient Sparingly soluble in water. "Hu G, Li X, Sun X, et al. Identification of old drugs as potential inhibitors of HIV-1 integrase - human LEDGF/p75 interaction via molecular docking. J Mol Model. 2012 Dec;18(12):4995-5003. PMID: 22733274.

" Xn Not dangerous goods.

LKT D3328 Dihydrokainic Acid 10 mg 279.5 NMDA agonist, GLT-1 inhibitor. 2-Carboxy-4-isopropyl-3-pyrrolidineacetic acid 52497-36-6 ≥98% 215.25 C10H17NO4 CC(C)C1CNC(C1CC(=O)O)C(=O)O Ambient Ambient Soluble in water (>110mg/mL). "Smith KL, John CS, Sypek EI, et al. Exploring the role of central astrocytic glutamate uptake in ethanol reward in mice. Alcohol Clin Exp Res. 2014 May;38(5):1307-14. PMID: 24655029.

Nie H, Weng HR. Impaired glial glutamate uptake induces extrasynaptic glutamate spillover in the spinal sensory synapses of neuropathic rats. J Neurophysiol. 2010 May;103(5):2570-80. PMID: 20220084.

" Xi Not dangerous goods.

LKT D3328 Dihydrokainic Acid 25 mg 635.4 NMDA agonist, GLT-1 inhibitor. 2-Carboxy-4-isopropyl-3-pyrrolidineacetic acid 52497-36-6 ≥98% 215.25 C10H17NO4 CC(C)C1CNC(C1CC(=O)O)C(=O)O Ambient Ambient Soluble in water (>110mg/mL). "Smith KL, John CS, Sypek EI, et al. Exploring the role of central astrocytic glutamate uptake in ethanol reward in mice. Alcohol Clin Exp Res. 2014 May;38(5):1307-14. PMID: 24655029.

Nie H, Weng HR. Impaired glial glutamate uptake induces extrasynaptic glutamate spillover in the spinal sensory synapses of neuropathic rats. J Neurophysiol. 2010 May;103(5):2570-80. PMID: 20220084.

" Xi Not dangerous goods.

LKT D3330 Dihydrotanshinone 10 mg 136 Found in Salvia; fatty acid synthase and AChE inhibitor, mineralocorticoid and glucocorticoid antagonist. 87205-99-0 ≥90% 278.3 C18H14O3 CC1COC2=C1C(=O)C(=O)C3=C2C=CC4=C3C=CC=C4C Ambient 4°C Soluble in chloroform and acetone "Cheung J, Beri V, Shiomi K, et al. Acetylcholinesterase Complexes with the Natural Product Inhibitors Dihydrotanshinone I and Territrem B: Binding Site Assignment from Inhibitor Competition and Validation Through Crystal Structure Determination. J Mol Neurosci. 2014 Feb 27. [Epub ahead of print]. PMID: 24573600.

Suk FM, Jou WJ, Lin RJ, et al. 15,16-Dihydrotanshinone I-induced apoptosis in human colorectal cancer cells: involvement of ATF3. Anticancer Res. 2013 Aug;33(8):3225-31. PMID: 23898083.

Jang TS, Zhang H, Kim G, et al. Bioassay-guided isolation of fatty acid synthase inhibitory diterpenoids from the roots of Salvia miltiorrhiza Bunge. Arch Pharm Res. 2012 Mar;35(3):481-6. PMID: 22477195.

Trinh HT, Chae SJ, Joh EH, et al. Tanshinones isolated from the rhizome of Salvia miltiorrhiza inhibit passive cutaneous anaphylaxis reaction in mice. J Ethnopharmacol. 2010 Oct 28;132(1):344-8. PMID: 20732401.

Liu Q, Zhang Y, Lin Z, et al. Danshen extract 15,16-dihydrotanshinone I functions as a potential modulator against metabolic syndrome through multi-target pathways. J Steroid Biochem Mol Biol. 2010 Jun;120(4-5):155-63. PMID: 20380878.

Lam FF, Yeung JH, Chan KM, et al. Dihydrotanshinone, a lipophilic component of Salvia miltiorrhiza (danshen), relaxes rat coronary artery by inhibition of calcium channels. J Ethnopharmacol. 2008 Sep 26;119(2):318-21. PMID: 18682284.

Park JW, Lee SH, Yang MK, et al. 15,16-dihydrotanshinone I, a major component from Salvia miltiorrhiza Bunge (Dansham), inhibits rabbit platelet aggregation by suppressing intracellular calcium mobilization. Arch Pharm Res. 2008 Jan;31(1):47-53. PMID: 18277607.

Bian W, Chen F, Bai L, et al. Dihydrotanshinone I inhibits angiogenesis both in vitro and in vivo. Acta Biochim Biophys Sin (Shanghai). 2008 Jan;40(1):1-6. PMID: 18180848.

" Xn, N Not dangerous goods.

LKT D3330 Dihydrotanshinone 25 mg 292.2 Found in Salvia; fatty acid synthase and AChE inhibitor, mineralocorticoid and glucocorticoid antagonist. 87205-99-0 ≥90% 278.3 C18H14O3 CC1COC2=C1C(=O)C(=O)C3=C2C=CC4=C3C=CC=C4C Ambient 4°C Soluble in chloroform and acetone "Cheung J, Beri V, Shiomi K, et al. Acetylcholinesterase Complexes with the Natural Product Inhibitors Dihydrotanshinone I and Territrem B: Binding Site Assignment from Inhibitor Competition and Validation Through Crystal Structure Determination. J Mol Neurosci. 2014 Feb 27. [Epub ahead of print]. PMID: 24573600.

Suk FM, Jou WJ, Lin RJ, et al. 15,16-Dihydrotanshinone I-induced apoptosis in human colorectal cancer cells: involvement of ATF3. Anticancer Res. 2013 Aug;33(8):3225-31. PMID: 23898083.

Bian W, Chen F, Bai L, et al. Dihydrotanshinone I inhibits angiogenesis both in vitro and in vivo. Acta Biochim Biophys Sin (Shanghai). 2008 Jan;40(1):1-6. PMID: 18180848.

" Xn, N Not dangerous goods.

LKT D3330 Dihydrotanshinone 100 mg 883.3 Found in Salvia; fatty acid synthase and AChE inhibitor, mineralocorticoid and glucocorticoid antagonist. 87205-99-0 ≥90% 278.3 C18H14O3 CC1COC2=C1C(=O)C(=O)C3=C2C=CC4=C3C=CC=C4C Ambient 4°C Soluble in chloroform and acetone "Cheung J, Beri V, Shiomi K, et al. Acetylcholinesterase Complexes with the Natural Product Inhibitors Dihydrotanshinone I and Territrem B: Binding Site Assignment from Inhibitor Competition and Validation Through Crystal Structure Determination. J Mol Neurosci. 2014 Feb 27. [Epub ahead of print]. PMID: 24573600.

Suk FM, Jou WJ, Lin RJ, et al. 15,16-Dihydrotanshinone I-induced apoptosis in human colorectal cancer cells: involvement of ATF3. Anticancer Res. 2013 Aug;33(8):3225-31. PMID: 23898083.

Bian W, Chen F, Bai L, et al. Dihydrotanshinone I inhibits angiogenesis both in vitro and in vivo. Acta Biochim Biophys Sin (Shanghai). 2008 Jan;40(1):1-6. PMID: 18180848.

" Xn, N Not dangerous goods.

LKT D3331 α,β-Dihydroresveratrol 10 mg 121.9 Polyphenol found in various plant sources, resveratrol metabolite; potential voltage-gated K+ channel modulator. a, b-Dihydro-3,4',5'-trihydroxystilbene 58436-28-5 ≥98% 230.26 C14H14O3 C1=CC(=CC=C1CCC2=CC(=CC(=C2)O)O)O Ambient -20°C "Bode LM, Bunzel D, Huch M, et al. In vivo and in vitro metabolism of trans-resveratrol by human gut microbiota. Am J Clin Nutr. 2013 Feb;97(2):295-309. PMID: 23283496.

Alfaras I, Juan ME, Planas JM. trans-Resveratrol reduces precancerous colonic lesions in dimethylhydrazine-treated rats. J Agric Food Chem. 2010 Jul 14;58(13):8104-10. PMID: 20521815.

Orsini F, Verotta L, Lecchi M, et al. Resveratrol derivatives and their role as potassium channels modulators. J Nat Prod. 2004 Mar;67(3):421-6. PMID: 15043422.

" Not dangerous goods.

LKT D3331 α,β-Dihydroresveratrol 25 mg 253.1 Polyphenol found in various plant sources, resveratrol metabolite; potential voltage-gated K+ channel modulator. a, b-Dihydro-3,4',5'-trihydroxystilbene 58436-28-5 ≥98% 230.26 C14H14O3 C1=CC(=CC=C1CCC2=CC(=CC(=C2)O)O)O Ambient -20°C "Bode LM, Bunzel D, Huch M, et al. In vivo and in vitro metabolism of trans-resveratrol by human gut microbiota. Am J Clin Nutr. 2013 Feb;97(2):295-309. PMID: 23283496.

Alfaras I, Juan ME, Planas JM. trans-Resveratrol reduces precancerous colonic lesions in dimethylhydrazine-treated rats. J Agric Food Chem. 2010 Jul 14;58(13):8104-10. PMID: 20521815.

Orsini F, Verotta L, Lecchi M, et al. Resveratrol derivatives and their role as potassium channels modulators. J Nat Prod. 2004 Mar;67(3):421-6. PMID: 15043422.

" Not dangerous goods.

LKT D3331 α,β-Dihydroresveratrol 100 mg 750.1 Polyphenol found in various plant sources, resveratrol metabolite; potential voltage-gated K+ channel modulator. a, b-Dihydro-3,4',5'-trihydroxystilbene 58436-28-5 ≥98% 230.26 C14H14O3 C1=CC(=CC=C1CCC2=CC(=CC(=C2)O)O)O Ambient -20°C "Bode LM, Bunzel D, Huch M, et al. In vivo and in vitro metabolism of trans-resveratrol by human gut microbiota. Am J Clin Nutr. 2013 Feb;97(2):295-309. PMID: 23283496.

Alfaras I, Juan ME, Planas JM. trans-Resveratrol reduces precancerous colonic lesions in dimethylhydrazine-treated rats. J Agric Food Chem. 2010 Jul 14;58(13):8104-10. PMID: 20521815.

Orsini F, Verotta L, Lecchi M, et al. Resveratrol derivatives and their role as potassium channels modulators. J Nat Prod. 2004 Mar;67(3):421-6. PMID: 15043422.

" Not dangerous goods.

LKT D3348 11,12-Dimethoxydihydrokawain 5 mg 268.9 Kawain derivative, lactone found in Piper methysticum (kava plant). ≥97% 292.33 C16H20O5 Ambient -20°C Insoluble in water. Soluble in DMSO. He XG, Lin LZ, Lian LZ. Electrospray high performance liquid chromatography-mass spectrometry in phytochemical analysis of kava (Piper methysticum) extract. Planta Med. 1997 Feb;63(1):70-4. PMID: 17252331. Not dangerous goods.

LKT D3348 11,12-Dimethoxydihydrokawain 10 mg 461 Kawain derivative, lactone found in Piper methysticum (kava plant). ≥97% 292.33 C16H20O5 Ambient -20°C Insoluble in water. Soluble in DMSO. He XG, Lin LZ, Lian LZ. Electrospray high performance liquid chromatography-mass spectrometry in phytochemical analysis of kava (Piper methysticum) extract. Planta Med. 1997 Feb;63(1):70-4. PMID: 17252331. Not dangerous goods.

LKT D3351 4-Dimethylaminopyridine 10 g 27.2 Acyl transfer catalyst, involved in peptide synthesis. DMAP; Pyridine, 4-(dimethylamino)-;N,N-Dimethyl- pyridin-4-amine 1122-58-3 ≥98% 122.17 C7H10N2 CN(C)C1=CC=NC=C1 Ambient Ambient Soluble in methanol (0.1g/mL). "Wang J, Niu S, Zhao B, et al. Catalytic synthesis of sulfated polysaccharides. II: comparative studies of solution conformation and antioxidant activities. Carbohydr Polym. 2014 Jul 17;107:221-31. PMID: 24702939.

Lahsasni SA. Microwave- and ultrasound-assisted synthesis of some acyclonucleobases based on a uracil moiety using dmap as base. Nucleosides Nucleotides Nucleic Acids. 2013;32(8):439-52. PMID: 23895354.

Hayashi T, Sun Y, Tamura T, et al. Semisynthetic lectin-4-dimethylaminopyridine conjugates for labeling and profiling glycoproteins on live cell surfaces. J Am Chem Soc. 2013 Aug 21;135(33):12252-8. PMID: 23889132.

" T+ "UN number: 2811 Class: 6.1 Packing Group: II

Proper shipping name: Toxic solid, organic, n.o.s. (N,N-Dimethylpyridin-4-amine)"

LKT D3351 4-Dimethylaminopyridine 25 g 54.4 Acyl transfer catalyst, involved in peptide synthesis. DMAP; Pyridine, 4-(dimethylamino)-;N,N-Dimethyl- pyridin-4-amine 1122-58-3 ≥98% 122.17 C7H10N2 CN(C)C1=CC=NC=C1 Ambient Ambient Soluble in methanol (0.1g/mL). "Wang J, Niu S, Zhao B, et al. Catalytic synthesis of sulfated polysaccharides. II: comparative studies of solution conformation and antioxidant activities. Carbohydr Polym. 2014 Jul 17;107:221-31. PMID: 24702939.

" T+ "UN number: 2811 Class: 6.1 Packing Group: II

Proper shipping name: Toxic solid, organic, n.o.s. (N,N-Dimethylpyridin-4-amine)"

LKT D3351 4-Dimethylaminopyridine 100 g 163.2 Acyl transfer catalyst, involved in peptide synthesis. DMAP; Pyridine, 4-(dimethylamino)-;N,N-Dimethyl- pyridin-4-amine 1122-58-3 ≥98% 122.17 C7H10N2 CN(C)C1=CC=NC=C1 Ambient Ambient Soluble in methanol (0.1g/mL). "Wang J, Niu S, Zhao B, et al. Catalytic synthesis of sulfated polysaccharides. II: comparative studies of solution conformation and antioxidant activities. Carbohydr Polym. 2014 Jul 17;107:221-31. PMID: 24702939.

" T+ "UN number: 2811 Class: 6.1 Packing Group: II

Proper shipping name: Toxic solid, organic, n.o.s. (N,N-Dimethylpyridin-4-amine)"

LKT D3353 Diminazene Aceturate 1 g 54.4 Diamidine; ACE2 activator, DNA polymerase inhibitor. "Glycine, N-acetyl-, compd. with 4,4'-(1-triazene-1,3-

diyl)bis(benzenecarboximidamide) (2:1)" Azidin; Ganasag; Berenil; Beronal; Bevenil. 908-54-3 ≥98% 515.52 C22H29N9O6 CC(=O)NCC(=O)O.C1=CC(=CC=C1C(=N)N)NN=NC2=CC=C(C=C2)C(=N)N Ambient Ambient Soluble in 14 parts water (20oC). Slightly soluble in alcohol. "Mecca AP, Regenhardt RW, O'Connor TE, et al. Cerebroprotection by angiotensin-(1-7) in endothelin-1-induced ischaemic stroke. Exp Physiol. 2011 Oct;96(10):1084-96. doi: 10.1113/expphysiol.2011.058578. Epub 2011 Jun 17. PMID: 21685445.

Peregrine AS, Mamman M. Pharmacology of diminazene: a review. Acta Trop. 1993 Sep;54(3-4):185-203. PMID: 7902657.

Marcus SL, Kopelman R, Koll B, et al. Effects of exogenous polyamine and trypanocides on the DNA polymerase activities from Trypanosoma brucei brucei, mouse thymus and murine leukemia virus. Mol Biochem Parasitol. 1982 Apr;5(4):231-43. PMID: 6178972.

Shenov V, Gjymishka A, Jarajapu YP, et al. Diminazene attenuates pulmonary hypertension and improves angiogenic progenitor cell functions in experimental models. Am J Respir Crit Care Med. 2013 Mar 15;187(6):648-657. PMID: 23370913.

" None Not dangerous goods.

LKT D3353 Diminazene Aceturate 5 g 194.1 Diamidine; ACE2 activator, DNA polymerase inhibitor. "Glycine, N-acetyl-, compd. with 4,4'-(1-triazene-1,3-

Peregrine AS, Mamman M. Pharmacology of diminazene: a review. Acta Trop. 1993 Sep;54(3-4):185-203. PMID: 7902657.

" None Not dangerous goods.

LKT D3353 Diminazene Aceturate 25 g 606.7 Diamidine; ACE2 activator, DNA polymerase inhibitor. "Glycine, N-acetyl-, compd. with 4,4'-(1-triazene-1,3-

Peregrine AS, Mamman M. Pharmacology of diminazene: a review. Acta Trop. 1993 Sep;54(3-4):185-203. PMID: 7902657.

" None Not dangerous goods.

LKT D3355 Diosgenin 5 g 54.6 Steroidal saponin found in Dioscorea. (25R)-5-Spirosten-3beta-ol; 3beta-Hydroxy-5-spirostene 512-04-9 ≥98% 414.62 C27H42O3 CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CC=C6C5(CCC(C6)O)C)C)C)OC1 Ambient Ambient Soluble in CHCl3 (20mg/mL). "He Z, Chen H, Li G, et al. Diosgenin inhibits the migration of human breast cancer MDA-MB-231 cells by suppressing Vav2 activity. Phytomedicine. 2014 Mar 18. [Epub ahead of print]. PMID: 24656238.

Tohda C, Urano T, Umezaki M, et al. Diosgenin is an exogenous activator of 1,25D3-MARRS/Pdia3/ERp57 and improves Alzheimer's disease pathologies in 5XFAD mice. Sci Rep. 2012;2:535. PMID: 22837815.

Uemura T, Goto T, Kang MS, et al. Diosgenin, the main aglycon of fenugreek, inhibits LXRα activity in HepG2 cells and decreases plasma and hepatic triglycerides in obese diabetic mice. J Nutr. 2011 Jan;141(1):17-23. PMID: 21106928.

Jung DH, Park HJ, Byun HE, et al. Diosgenin inhibits macrophage-derived inflammatory mediators through downregulation of CK2, JNK, NF-kappaB and AP-1 activation. Int Immunopharmacol. 2010 Sep;10(9):1047-54. PMID: 20601188.

" None Not dangerous goods.

LKT D3355 Diosgenin 100 g 604.2 Steroidal saponin found in Dioscorea. (25R)-5-Spirosten-3beta-ol; 3beta-Hydroxy-5-spirostene 512-04-9 ≥98% 414.62 C27H42O3 CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CC=C6C5(CCC(C6)O)C)C)C)OC1 Ambient Ambient Soluble in CHCl3 (20mg/mL). "He Z, Chen H, Li G, et al. Diosgenin inhibits the migration of human breast cancer MDA-MB-231 cells by suppressing Vav2 activity. Phytomedicine. 2014 Mar 18. [Epub ahead of print]. PMID: 24656238.

Tohda C, Urano T, Umezaki M, et al. Diosgenin is an exogenous activator of 1,25D3-MARRS/Pdia3/ERp57 and improves Alzheimer's disease pathologies in 5XFAD mice. Sci Rep. 2012;2:535. PMID: 22837815.

" None Not dangerous goods.

LKT D3356 Diosmetin 1 g 236.3 O-methylated flavone found in vetch and various fruits. "

benzopyran-4-one " Cyanidenon-4'-methyl ether 1479; Luteolin-4'-methyl ether 520-34-3 ≥98% 300.26 C16H12O6 COC1=C(C=C(C=C1)C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O Ambient Ambient Sparingly soluble in water (<1 mg/ml). Soluble in acetonitrile, DMSO (60 mg/ml), and ethanol (17 mg/ml). "Liao W, Ning Z, Chen L, et al. Intracellular Antioxidant Detoxifying Effects of Diosmetin on 2,2-Azobis(2-amidinopropane) Dihydrochloride (AAPH)-Induced Oxidative Stress through Inhibition of Reactive Oxygen Species Generation. J Agric Food Chem. 2014 Aug 27;62(34):8648-54. PMID: 25075433.

Yu G, Wan R, Yin G, et al. Diosmetin ameliorates the severity of cerulein-induced acute pancreatitis in mice by inhibiting the activation of the nuclear factor-κB. Int J Clin Exp Pathol. 2014 Apr 15;7(5):2133-42. PMID: 24966921.

Androutsopoulos VP, Mahale S, Arroo RR, et al. Anticancer effects of the flavonoid diosmetin on cell cycle progression and proliferation of MDA-MB 468 breast cancer cells ue to CYP1 activation. Oncol Rep. 2009 Jun;21(6):1525-8. PMID: 19424633.

Hsu YL, Kuo PL. Diosmetin induces human osteoblastic differentiation through the protein kinase C/p38 and extracellular signal-regulated kinase 1/2 pathway. J Bone Miner Res. 2008 Jun;23(6):949-60. PMID: 18269307.

" Xn Not dangerous goods.

LKT D3356 Diosmetin 5 g 582.3 O-methylated flavone found in vetch and various fruits. "

" Xn Not dangerous goods.

LKT D3356 Diosmetin 25 g 1820.1 O-methylated flavone found in vetch and various fruits. "

" Xn Not dangerous goods.

LKT D3357 Diosmin 1 g 20.4 Flavone found in Teucrium. 7-[[6-O-(6-Deoxy-a-L-mannopyranosyl)-β-D-gluco- pyranosyl]oxy]-5-hydroxy-2-(3-hydroxy-4-methoxy- phenyl)-4H-1-benzopyran-4-one Diosmil; Diovenor; Flebosmil; Hemerven; Insuven; Litosmil; Tovene; Varinon; Venosmine 520-27-4 ≥95% 608.54 C28H32O15 CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=CC(=C4C(=C3)OC(=CC4=O)C5=CC(=C(C=C5)OC)O)O)O)O)O)O)O)O Ambient Ambient "Senthamizhselvan O, Manivannan J, Silambarasan T, et al. Diosmin pretreatment improves cardiac function and suppresses oxidative stress in rat heart after ischemia/reperfusion. Eur J Pharmacol. 2014 Aug 5;736:131-7. PMID: 24769512.

Liu X, Zhang X, Zhang J, et al. Diosmin protects against cerebral ischemia/reperfusion injury through activating JAK2/STAT3 signal pathway in mice. Neuroscience. 2014 May 30;268:318-27. PMID: 24680937.

Queenthy SS, John B. Diosmin exhibits anti-hyperlipidemic effects in isoproterenol induced myocardial infarcted rats. Eur J Pharmacol. 2013 Oct 15;718(1-3):213-8. PMID: 24036254.

Tahir M, Rehman MU, Lateef A, et al. Diosmin abrogates chemically induced hepatocarcinogenesis via alleviation of oxidative stress, hyperproliferative and inflammatory markers in murine model. Toxicol Lett. 2013 Jul 18;220(3):205-18. PMID: 23665045.

Tong N, Zhang Z, Zhang W, et al. Diosmin alleviates retinal edema by protecting the blood-retinal barrier and reducing retinal vascular permeability during ischemia/reperfusion injury. PLoS One. 2013 Apr 24;8(4):e61794. PMID: 23637907.

" Xn Not dangerous goods.

LKT D3357 Diosmin 5 g 40.7 Flavone found in Teucrium. 7-[[6-O-(6-Deoxy-a-L-mannopyranosyl)-β-D-gluco- pyranosyl]oxy]-5-hydroxy-2-(3-hydroxy-4-methoxy- phenyl)-4H-1-benzopyran-4-one Diosmil; Diovenor; Flebosmil; Hemerven; Insuven; Litosmil; Tovene; Varinon; Venosmine 520-27-4 ≥95% 608.54 C28H32O15 CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=CC(=C4C(=C3)OC(=CC4=O)C5=CC(=C(C=C5)OC)O)O)O)O)O)O)O)O Ambient Ambient "Senthamizhselvan O, Manivannan J, Silambarasan T, et al. Diosmin pretreatment improves cardiac function and suppresses oxidative stress in rat heart after ischemia/reperfusion. Eur J Pharmacol. 2014 Aug 5;736:131-7. PMID: 24769512.

Queenthy SS, John B. Diosmin exhibits anti-hyperlipidemic effects in isoproterenol induced myocardial infarcted rats. Eur J Pharmacol. 2013 Oct 15;718(1-3):213-8. PMID: 24036254.

" Xn Not dangerous goods.

LKT D3357 Diosmin 25 g 122.3 Flavone found in Teucrium. 7-[[6-O-(6-Deoxy-a-L-mannopyranosyl)-β-D-gluco- pyranosyl]oxy]-5-hydroxy-2-(3-hydroxy-4-methoxy- phenyl)-4H-1-benzopyran-4-one Diosmil; Diovenor; Flebosmil; Hemerven; Insuven; Litosmil; Tovene; Varinon; Venosmine 520-27-4 ≥95% 608.54 C28H32O15 CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=CC(=C4C(=C3)OC(=CC4=O)C5=CC(=C(C=C5)OC)O)O)O)O)O)O)O)O Ambient Ambient "Senthamizhselvan O, Manivannan J, Silambarasan T, et al. Diosmin pretreatment improves cardiac function and suppresses oxidative stress in rat heart after ischemia/reperfusion. Eur J Pharmacol. 2014 Aug 5;736:131-7. PMID: 24769512.

Queenthy SS, John B. Diosmin exhibits anti-hyperlipidemic effects in isoproterenol induced myocardial infarcted rats. Eur J Pharmacol. 2013 Oct 15;718(1-3):213-8. PMID: 24036254.

" Xn Not dangerous goods.

LKT D3362 Dipyridamole 1 g 31.4 PDE and adenosine deaminase inhibitor. 2,2',2'',2'''-[(4,8-Di-1-piperidinylpyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetrakisethanol Anginal; Cardoxin; Coridil; Dipyridan; Gulliostin; Natyl; Persantine; Piroan; Protangix 58-32-2 ≥98% 504.63 C24H40N8O4 C1CCN(CC1)C2=NC(=NC3=C2N=C(N=C3N4CCCCC4)N(CCO)CCO)N(CCO)CCO Ambient -20°C Soluble in methanol, chloroform and ethanol. Slightly soluble in water. "Massaro M, Scoditti E, Carluccio MA, et al. Dipyridamole decreases inflammatory metalloproteinase-9 expression and release by human monocytes. Thromb Haemost. 2013 Feb;109(2):280-9. PMID: 23238437.

Alberts MJ. Antithrombotic therapy for secondary stroke prevention. Continuum (Minneap Minn). 2011 Dec;17(6 2ndary Stroke Prevention):1255-66. PMID: 22810029.

Zhuplatov SB, Masaki T, Blumenthal DK, et al. Mechanism of dipyridamole's action in inhibition of venous and arterial smooth muscle cell proliferation. Basic Clin Pharmacol Toxicol. 2006 Dec;99(6):431-9. PMID: 17169124.

" Xi Not dangerous goods.

LKT D3362 Dipyridamole 5 g 97.8 PDE and adenosine deaminase inhibitor. 2,2',2'',2'''-[(4,8-Di-1-piperidinylpyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetrakisethanol Anginal; Cardoxin; Coridil; Dipyridan; Gulliostin; Natyl; Persantine; Piroan; Protangix 58-32-2 ≥98% 504.63 C24H40N8O4 C1CCN(CC1)C2=NC(=NC3=C2N=C(N=C3N4CCCCC4)N(CCO)CCO)N(CCO)CCO Ambient -20°C Soluble in methanol, chloroform and ethanol. Slightly soluble in water. "Massaro M, Scoditti E, Carluccio MA, et al. Dipyridamole decreases inflammatory metalloproteinase-9 expression and release by human monocytes. Thromb Haemost. 2013 Feb;109(2):280-9. PMID: 23238437.

Alberts MJ. Antithrombotic therapy for secondary stroke prevention. Continuum (Minneap Minn). 2011 Dec;17(6 2ndary Stroke Prevention):1255-66. PMID: 22810029.

" Xi Not dangerous goods.

LKT D3362 Dipyridamole 25 g 325.2 PDE and adenosine deaminase inhibitor. 2,2',2'',2'''-[(4,8-Di-1-piperidinylpyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetrakisethanol Anginal; Cardoxin; Coridil; Dipyridan; Gulliostin; Natyl; Persantine; Piroan; Protangix 58-32-2 ≥98% 504.63 C24H40N8O4 C1CCN(CC1)C2=NC(=NC3=C2N=C(N=C3N4CCCCC4)N(CCO)CCO)N(CCO)CCO Ambient -20°C Soluble in methanol, chloroform and ethanol. Slightly soluble in water. "Massaro M, Scoditti E, Carluccio MA, et al. Dipyridamole decreases inflammatory metalloproteinase-9 expression and release by human monocytes. Thromb Haemost. 2013 Feb;109(2):280-9. PMID: 23238437.

Alberts MJ. Antithrombotic therapy for secondary stroke prevention. Continuum (Minneap Minn). 2011 Dec;17(6 2ndary Stroke Prevention):1255-66. PMID: 22810029.

" Xi Not dangerous goods.

LKT D3372 Disodium Cycloheptylaminomethylene Diphosphate 25 mg 67 Bisphosphonate; squalene synthase inhibitor. Incadronate disodium hydrate 138330-18-4 ≥98% 331.15 C8H17NNa2O6P2 C1CCCC(CC1)CC(P(=O)(O)[O-])P(=O)(O)[O-].[Na+].[Na+] Ambient Ambient "Miwa A, Takezako N, Hayakawa H, et al. YM-175 induces apoptosis of human native monocyte-lineage cells via inhibition of prenylation. Am J Hematol. 2012 Dec;87(12):1084-8. PMID: 23044853.

Li C, Mori S, Li J, et al. Long-term effect of incadronate disodium (YM-175) on fracture healing of femoral shaft in growing rats. J Bone Miner Res. 2001 Mar;16(3):429-36. PMID: 11277259.

Li J, Mori S, Mashiba T, et al. Preadministration of incadronate disodium can prevent bone loss in rat proximal tibial metaphysis when induced by hindlimb immobilization by bandage. Bone. 1998 Nov;23(5):459-63. PMID: 9823453.

Gen M. Effects of bisphosphonates on vitamin A-induced bone resorption in thyroparathyroidectomized rat. Nihon Seikeigeka Gakkai Zasshi. 1995 Nov;69(11):1193-207. PMID: 8568374.

Amin D, Cornell SA, Gustafson SK, et al. Bisphosphonates used for the treatment of bone disorders inhibit squalene synthase and cholesterol biosynthesis. J Lipid Res. 1992 Nov;33(11):1657-63. PMID: 1464749.

" Not dangerous goods.

LKT D3372 Disodium Cycloheptylaminomethylene Diphosphate 100 mg 164.1 Bisphosphonate; squalene synthase inhibitor. Incadronate disodium hydrate 138330-18-4 ≥98% 331.15 C8H17NNa2O6P2 C1CCCC(CC1)CC(P(=O)(O)[O-])P(=O)(O)[O-].[Na+].[Na+] Ambient Ambient "Miwa A, Takezako N, Hayakawa H, et al. YM-175 induces apoptosis of human native monocyte-lineage cells via inhibition of prenylation. Am J Hematol. 2012 Dec;87(12):1084-8. PMID: 23044853.

Li C, Mori S, Li J, et al. Long-term effect of incadronate disodium (YM-175) on fracture healing of femoral shaft in growing rats. J Bone Miner Res. 2001 Mar;16(3):429-36. PMID: 11277259.

Gen M. Effects of bisphosphonates on vitamin A-induced bone resorption in thyroparathyroidectomized rat. Nihon Seikeigeka Gakkai Zasshi. 1995 Nov;69(11):1193-207. PMID: 8568374.

" Not dangerous goods.

LKT D3372 Disodium Cycloheptylaminomethylene Diphosphate 250 mg 335 Bisphosphonate; squalene synthase inhibitor. Incadronate disodium hydrate 138330-18-4 ≥98% 331.15 C8H17NNa2O6P2 C1CCCC(CC1)CC(P(=O)(O)[O-])P(=O)(O)[O-].[Na+].[Na+] Ambient Ambient "Miwa A, Takezako N, Hayakawa H, et al. YM-175 induces apoptosis of human native monocyte-lineage cells via inhibition of prenylation. Am J Hematol. 2012 Dec;87(12):1084-8. PMID: 23044853.

Li C, Mori S, Li J, et al. Long-term effect of incadronate disodium (YM-175) on fracture healing of femoral shaft in growing rats. J Bone Miner Res. 2001 Mar;16(3):429-36. PMID: 11277259.

Gen M. Effects of bisphosphonates on vitamin A-induced bone resorption in thyroparathyroidectomized rat. Nihon Seikeigeka Gakkai Zasshi. 1995 Nov;69(11):1193-207. PMID: 8568374.

" Not dangerous goods.

LKT D3374 Disulfiram 50 g 33.1 Aldehyde dehydrogenase, 26S proteasome, MGMT inhibitor. Tetraethylthioperoxydicarbonic diamide Tetraethylthiuram disulfide; Teturamin; TTD; Cronetal; Abstensil; Antadix; Antietanol; Exhoran; Antabuse; Etabus; Esperal; Tetradine; Noxal; Tetraetil 97-77-8 ≥98% 296.54 C10H20N2S4 CCN(CC)C(=S)SSC(=S)N(CC)CC Ambient Ambient Soluble in alcohol (330 mg/mL), ether, acetone, benzene, or chloroform. Practically insoluble in water. "Paranjpe A, Zhang R, Ali-Osman F, et al. Disulfiram is a direct and potent inhibitor of human O6-methylguanine-DNA methyltransferase (MGMT) in brain tumor cells and mouse brain and markedly increases the alkylating DNA damage. Carcinogenesis. 2014 Mar;35(3):692-702. PMID: 24193513.

Wickström M, Danielsson K, Rickardson L, et al. Pharmacological profiling of disulfiram using human tumor cell lines and human tumor cells from patients. Biochem Pharmacol. 2007 Jan 1;73(1):25-33. PMID: 17026967.

Bouma MJ, Snowdon D, Fairlamb AH, et al. Activity of disulfiram (bis(diethylthiocarbamoyl)disulphide) and ditiocarb (diethyldithiocarbamate) against metronidazole-sensitive and -resistant Trichomonas vaginalis and Tritrichomonas foetus. J Antimicrob Chemother. 1998 Dec;42(6):817-20. PMID: 10052908.

Wright C, Moore RD. Disulfiram treatment of alcoholism. Am J Med. 1990 Jun;88(6):647-55. Review. Erratum in: Am J Med 1991 Oct;91(4):446. PMID: 2189310.

" Xn, N Not dangerous goods.

LKT D3374 Disulfiram 100 g 55 Aldehyde dehydrogenase, 26S proteasome, MGMT inhibitor. Tetraethylthioperoxydicarbonic diamide Tetraethylthiuram disulfide; Teturamin; TTD; Cronetal; Abstensil; Antadix; Antietanol; Exhoran; Antabuse; Etabus; Esperal; Tetradine; Noxal; Tetraetil 97-77-8 ≥98% 296.54 C10H20N2S4 CCN(CC)C(=S)SSC(=S)N(CC)CC Ambient Ambient Soluble in alcohol (330 mg/mL), ether, acetone, benzene, or chloroform. Practically insoluble in water. "Paranjpe A, Zhang R, Ali-Osman F, et al. Disulfiram is a direct and potent inhibitor of human O6-methylguanine-DNA methyltransferase (MGMT) in brain tumor cells and mouse brain and markedly increases the alkylating DNA damage. Carcinogenesis. 2014 Mar;35(3):692-702. PMID: 24193513.

Wright C, Moore RD. Disulfiram treatment of alcoholism. Am J Med. 1990 Jun;88(6):647-55. Review. Erratum in: Am J Med 1991 Oct;91(4):446. PMID: 2189310.

" Xn, N Not dangerous goods.

LKT D3374 Disulfiram 250 g 82.3 Aldehyde dehydrogenase, 26S proteasome, MGMT inhibitor. Tetraethylthioperoxydicarbonic diamide Tetraethylthiuram disulfide; Teturamin; TTD; Cronetal; Abstensil; Antadix; Antietanol; Exhoran; Antabuse; Etabus; Esperal; Tetradine; Noxal; Tetraetil 97-77-8 ≥98% 296.54 C10H20N2S4 CCN(CC)C(=S)SSC(=S)N(CC)CC Ambient Ambient Soluble in alcohol (330 mg/mL), ether, acetone, benzene, or chloroform. Practically insoluble in water. "Paranjpe A, Zhang R, Ali-Osman F, et al. Disulfiram is a direct and potent inhibitor of human O6-methylguanine-DNA methyltransferase (MGMT) in brain tumor cells and mouse brain and markedly increases the alkylating DNA damage. Carcinogenesis. 2014 Mar;35(3):692-702. PMID: 24193513.

Wright C, Moore RD. Disulfiram treatment of alcoholism. Am J Med. 1990 Jun;88(6):647-55. Review. Erratum in: Am J Med 1991 Oct;91(4):446. PMID: 2189310.

" Xn, N Not dangerous goods.

LKT D3429 Dihydrocytochalasin B 1 mg 200.2 Mycotoxin derivative; actin polymerization inhibitor, Kv1.1-A-type K+ channel converter. 39156-67-7 ≥98% 481.62 C29H39NO5 CC1CCCC(CCC(=O)OC23C(C=CC1)C(C(=C)C(C2C(NC3=O)CC4=CC=CC=C4)C)O)O Ambient 4°C Acetone, DMSO, 100% Ethanol, Methanol "Makioka A, Kumagai M, Kobayashi S, et al. Different effects of cytochalasins on the growth and differentiation of Entamoeba invadens. Parasitol Res. 2004 May;93(1):68-71. PMID: 15103555.

Reshetnikova G, Barkan R, Popov B, et al. Disruption of the actin cytoskeleton leads to inhibition of mitogen-induced cyclin E expression, Cdk2 phosphorylation, and nuclear accumulation of the retinoblastoma protein-related p107 protein. Exp Cell Res. 2000 Aug 25;259(1):35-53. PMID: 10942577.

Jing J, Chikvashvili D, Singer-Lahat D, et al. Fast inactivation of a brain K+ channel composed of Kv1.1 and Kvbeta1.1 subunits modulated by G protein beta gamma subunits. EMBO J. 1999 Mar 1;18(5):1245-56. PMID: 10064591.

" "UN number: 2811 Class: 6.1 Packing Group: II

Proper shipping name: Toxic solids, organic, n.o.s. (Dihydrocytochalasin B)

Poison inhalation hazard: No"

LKT D3429 Dihydrocytochalasin B 5 mg 825.1 Mycotoxin derivative; actin polymerization inhibitor, Kv1.1-A-type K+ channel converter. 39156-67-7 ≥98% 481.62 C29H39NO5 CC1CCCC(CCC(=O)OC23C(C=CC1)C(C(=C)C(C2C(NC3=O)CC4=CC=CC=C4)C)O)O Ambient 4°C Acetone, DMSO, 100% Ethanol, Methanol "Makioka A, Kumagai M, Kobayashi S, et al. Different effects of cytochalasins on the growth and differentiation of Entamoeba invadens. Parasitol Res. 2004 May;93(1):68-71. PMID: 15103555.

" "UN number: 2811 Class: 6.1 Packing Group: II

Proper shipping name: Toxic solids, organic, n.o.s. (Dihydrocytochalasin B)

Poison inhalation hazard: No"

LKT D3431 3,4-Dihydroxyphenyl Ethanol 10 mg 78.6 Polyphenol found in olive oil, antioxidant. 2-(3,4-Dihydroxyphenyl)ethyl alcohol 3-Hydroxytyrosol 10597-60-1 ≥95% 154.16 C8H10O3 C1=CC(=C(C=C1CCO)O)O Ambient 4°C "Scoditti E, Nestola A, Massaro M, et al. Hydroxytyrosol suppresses MMP-9 and COX-2 activity and expression in activated human monocytes via PKCα and PKCβ1 inhibition. Atherosclerosis. 2014 Jan;232(1):17-24. PMID: 24401212.

Cao K, Xu J, Zou X, et al. Hydroxytyrosol prevents diet-induced metabolic syndrome and attenuates mitochondrial abnormalities in obese mice. Free Radic Biol Med. 2013 Dec 6;67C:396-407. PMID: 24316371.

Li S, Han Z, Ma Y, et al. Hydroxytyrosol inhibits cholangiocarcinoma tumor growth: An in vivo and in vitro study. Oncol Rep. 2014 Jan;31(1):145-52. PMID: 24247752.

Cabrerizo S, De La Cruz JP, López-Villodres JA, et al. Role of the inhibition of oxidative stress and inflammatory mediators in the neuroprotective effects of hydroxytyrosol in rat brain slices subjected to hypoxia reoxygenation. J Nutr Biochem. 2013 Dec;24(12):2152-7. PMID: 24231104.

Correa JA, López-Villodres JA, Asensi R, et al. Virgin olive oil polyphenol hydroxytyrosol acetate inhibits in vitro platelet aggregation in human whole blood: comparison with hydroxytyrosol and acetylsalicylic acid. Br J Nutr. 2009 Apr;101(8):1157-64. PMID: 18775097.

" U/A Not dangerous goods.

LKT D3431 3,4-Dihydroxyphenyl Ethanol 25 mg 149.9 Polyphenol found in olive oil, antioxidant. 2-(3,4-Dihydroxyphenyl)ethyl alcohol 3-Hydroxytyrosol 10597-60-1 ≥95% 154.16 C8H10O3 C1=CC(=C(C=C1CCO)O)O Ambient 4°C "Scoditti E, Nestola A, Massaro M, et al. Hydroxytyrosol suppresses MMP-9 and COX-2 activity and expression in activated human monocytes via PKCα and PKCβ1 inhibition. Atherosclerosis. 2014 Jan;232(1):17-24. PMID: 24401212.

Li S, Han Z, Ma Y, et al. Hydroxytyrosol inhibits cholangiocarcinoma tumor growth: An in vivo and in vitro study. Oncol Rep. 2014 Jan;31(1):145-52. PMID: 24247752.

" U/A Not dangerous goods.

LKT D3431 3,4-Dihydroxyphenyl Ethanol 100 mg 515.7 Polyphenol found in olive oil, antioxidant. 2-(3,4-Dihydroxyphenyl)ethyl alcohol 3-Hydroxytyrosol 10597-60-1 ≥95% 154.16 C8H10O3 C1=CC(=C(C=C1CCO)O)O Ambient 4°C "Scoditti E, Nestola A, Massaro M, et al. Hydroxytyrosol suppresses MMP-9 and COX-2 activity and expression in activated human monocytes via PKCα and PKCβ1 inhibition. Atherosclerosis. 2014 Jan;232(1):17-24. PMID: 24401212.

Li S, Han Z, Ma Y, et al. Hydroxytyrosol inhibits cholangiocarcinoma tumor growth: An in vivo and in vitro study. Oncol Rep. 2014 Jan;31(1):145-52. PMID: 24247752.

" U/A Not dangerous goods.

LKT D3447 Diltiazem Hydrochloride 1 g 51.7 Benzothiazepine; L-type Ca2+ channel blocker, potential CNG channel blocker. [(2S,3S)-5-(2-dimethylaminoethyl)-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl] acetate 33286-22-5 ≥98% 450.98 C22H26N2O4S HCl CC(=O)OC1C(SC2=CC=CC=C2N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC.Cl Ambient Ambient "Mieth A, Revermann M, Babelova A, et al. L-type calcium channel inhibitor diltiazem prevents aneurysm formation by blood pressure-independent anti-inflammatory effects. Hypertension. 2013 Dec;62(6):1098-104. PMID: 24082061.

Matsushita S, Kurihara H, Watanabe M, et al. Inhibition of connexin43 dephosphorylation is involved in protective effects of diltiazem on cardiac function during hypoxic injury. Histol Histopathol. 2011 Mar;26(3):315-22. PMID: 21210344.

Podda MV, D'Ascenzo M, Leone L, et al. Functional role of cyclic nucleotide-gated channels in rat medial vestibular nucleus neurons. J Physiol. 2008 Feb 1;586(3):803-15. PMID: 18048449.

Joyal M, Cremer K, Pieper J, et al. Effects of diltiazem during tachycardia-induced angina pectoris. Am J Cardiol. 1986 Jan 1;57(1):10-4. PMID: 3942050.

" Not dangerous goods.

LKT D3447 Diltiazem Hydrochloride 5 g 203.8 Benzothiazepine; L-type Ca2+ channel blocker, potential CNG channel blocker. [(2S,3S)-5-(2-dimethylaminoethyl)-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl] acetate 33286-22-5 ≥98% 450.98 C22H26N2O4S HCl CC(=O)OC1C(SC2=CC=CC=C2N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC.Cl Ambient Ambient "Mieth A, Revermann M, Babelova A, et al. L-type calcium channel inhibitor diltiazem prevents aneurysm formation by blood pressure-independent anti-inflammatory effects. Hypertension. 2013 Dec;62(6):1098-104. PMID: 24082061.

Podda MV, D'Ascenzo M, Leone L, et al. Functional role of cyclic nucleotide-gated channels in rat medial vestibular nucleus neurons. J Physiol. 2008 Feb 1;586(3):803-15. PMID: 18048449.

Joyal M, Cremer K, Pieper J, et al. Effects of diltiazem during tachycardia-induced angina pectoris. Am J Cardiol. 1986 Jan 1;57(1):10-4. PMID: 3942050.

" Not dangerous goods.

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