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α2-Macroglobulin (human plasma), (purified)

參   考   價(jià): ￥ 1425

訂  貨  量: ≥1  件

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產(chǎn)品型號(hào)

品       牌Enzo Life Sciences

廠商性質(zhì)代理商

所  在  地深圳市

更新時(shí)間：2022-01-28 14:25:30瀏覽次數(shù)：651次

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供貨周期 兩周 規(guī)格 1*1mg
貨號(hào) BML-SE502-0001 應(yīng)用領(lǐng)域 生物產(chǎn)業(yè)
主要用途 科研
α2-Macroglobulin (human plasma), (purified)
品牌： ENZO產(chǎn)品貨號(hào)： BML-SE502-0001規(guī)格： 1*1mg
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α2-Macroglobulin (human plasma), (purified)

Product Details

MW:725 kDa

Source:Isolated from human plasma that is tested to be negative for HbsAg, anti-HBc, anti-HCV, and anti-HIV-1 and -2.

UniProt ID:P01023

Shipping:Shipped on Blue Ice

Long Term Storage:-20°C

Scientific Background:In addition to binding TGF-β and β-amyloid, α2-macroglobulin covalently binds and inhibits a wide range of proteases, including ADAMs, calpains, cathepsins, chymase, clotting factors, kallikreins, MMPs, neutrophil elastase, and proteinase 3.  It also plays a role in the innate immune system, inhibiting parasitic proteases.  When treated with methylamine, it blocks binding of apoE to lipoprotein receptor-related protein (LRP).

Regulatory Status:RUO - Research Use Only

Product Literature References

Cytotoxicity mechanism of α-MMC in normal liver cells through LRP1 mediated endocytosis and JNK activation: L. Wang, et al.; Toxicology 357, 33 (2016), Abstract;


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