品牌名稱：NSC 210902
產(chǎn)品貨號：10011255
NSC 210902
Cayman Chemical Item Number 10011255
See more Inhibitors （483）
Apoptosis （177）
Cancer （566）
Cell Cycle （67）
Signal Transduction （308）
Description
Casein Kinase 2 （CK2） is a serine/threonine-selective protein kinase involved in many signal transduction pathways. CK2 is known to negatively regulate apoptosis, and its activity is increased in many proliferating tissues and tumors, which lends promise as an anticancer drug target. NSC 210902 inhibits CK2 with an IC50 value of 1 µM and competitively inhibits binding of ATP with a Ki value of 0.28 µM.1 NSC 210902 is selective for CK2 as it only minimally inhibits the activities of other protein kinases （e.g., JNK3, GSK3, CDK5, and MSK1）.1 1 Golub, A.G., Yakovenko, O.Y., Bdzhola, V.G., et al. Evaluation of 3-carboxy-4（1H）-quinolones as inhibitors of human protein kinase CK2. J Med Chem 49 6443-6450 （2006）.
Formal Name 1,?4-?dihydro-?4-?oxo-?benzo[h]quinoline-?3-?carboxylic acid
CAS Number 51726-83-1
Molecular Formula C14H9NO3
Formula Weight 239.2
Formulation A crystalline solid
Purity ≥95%
Stability 2 years
Storage -20°C